Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: A collaborative meta-analysis

Journal of the American College of Cardiology

Volumn 61, Issue 9, 2013, Pages 957-970

  Chan, Kenneth ^a   Patel, Riyaz S ^a,b,c   Newcombe, Paul ^d   Nelson, Christopher P ^e   Qasim, Atif ^f   Epstein, Stephen E ^g   Burnett, Susan ^g   Vaccarino, Viola L ^h   Zafari, A Maziar ^h   Shah, Svati H ⁱ   Anderson, Jeffrey L ^j   Carlquist, John F ^j   Hartiala, Jaana ⁱ   Allayee, Hooman ⁱ   Hinohara, Kunihiko ^l   Lee, Bok Soo ^m   Erl, Anna ⁿ   Ellis, Katrina L ^o   Goel, Anuj ^p   Schaefer, Arne S ^q   El Mokhtari, Nour Eddine ^q,r   Goldstein, Benjamin A ^s   Hlatky, Mark A ^s   Go, Alan S ^t   Shen, Gong Qing ^u   Gong, Yan ^v   Pepine, Carl ^v   Laxton, Ross C ^a   Whittaker, John C ^w   Tang, W H Wilson ^w   Johnson, Julie A ^v   Wang, Qing K ^u   Assimes, Themistocles L ^s   Nöthlings, Ute ^q,u   Farrall, Martin ^k,p   Watkins, Hugh ^p,x   Richards, A Mark ^o   Cameron, Vicky A ^o   Muendlein, Axel ^y   Drexel, Heinz ^y   Koch, Werner ⁿ   Park, Jeong Euy ^m   Kimura, Akinori ^l   Shen, Wei Feng ^z   Simpson, Iain A ^aa   Hazen, Stanley L ^q,u   Horne, Benjamin D ^j   Hauser, Elizabeth R ⁱ   Quyyumi, Arshed A ^c   Reilly, Muredach P ^f   Samani, Nilesh J ^e   Ye, Shu ^a   more..

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MRC BIOSTATISTICS UNIT   (United Kingdom)

^e GLENFIELD HOSPITAL   (United Kingdom)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

^g WASHINGTON HOSPITAL CENTER   (United States)

^h EMORY UNIVERSITY   (United States)

ⁱ DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j INTERMOUNTAIN MEDICAL CENTER   (United States)

^k UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^l TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^m Sungkyunkwan University   (South Korea)

ⁿ TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^o UNIVERSITY OF OTAGO   (New Zealand)

^p UNIVERSITY OF OXFORD   (United Kingdom)

^q UNIVERSITY OF KIEL   (Germany)

^r Stroke Unit Neurologie   (Germany)

^s STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^t DIVISION OF RESEARCH   (United States)

^u LERNER RESEARCH INSTITUTE   (United States)

^v UNIVERSITY OF FLORIDA   (United States)

^w LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^x UNIVERSITY OF OXFORD   (United Kingdom)

^y Vorarlberg Institute for Vascular Investigation and Treatment VIVIT   (Austria)

^z SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^aa UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

more..

Author keywords

9p21; angiography; coronary artery disease; meta analysis; myocardial infarction; single nucleotide polymorphism

Indexed keywords

ADULT; AGED; ALLELE; ANGIOCARDIOGRAPHY; ARTICLE; CHROMOSOME 9P; COHORT ANALYSIS; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; FEMALE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HEART INFARCTION; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

CHROMOSOMES, HUMAN, PAIR 9; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; GENETIC LOCI; HUMANS; MYOCARDIAL INFARCTION; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84875453250     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2012.10.051     Document Type: Article

References (42)

1. N.J. Samani, J. Erdmann, A.S. Hall Genomewide association analysis of coronary artery disease N Engl J Med 357 2007 443 453
2. A. Helgadottir, G. Thorleifsson, A. Manolescu A common variant on chromosome 9p21 affects the risk of myocardial infarction Science 316 2007 1491 1493
3. R. McPherson, A. Pertsemlidis, N. Kavaslar A common allele on chromosome 9 associated with coronary heart disease Science 316 2007 1488 1491
4. H. Schunkert, A. Gotz, P. Braund Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease Circulation 117 2008 1675 1684
5. G.E. Palomaki, S. Melillo, L.A. Bradley Association between 9p21 genomic markers and heart disease: a meta-analysis JAMA 303 2010 648 656
6. G.D. Kitsios, I.J. Dahabreh, T.A. Trikalinos, C.H. Schmid, G.S. Huggins, D.M. Kent Heterogeneity of the phenotypic definition of coronary artery disease and its impact on genetic association studies Circ Cardiovasc Genet 4 2011 58 67
7. B.D. Horne, J.F. Carlquist, J.B. Muhlestein, T.L. Bair, J.L. Anderson Association of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease Circ Cardiovasc Genet 1 2008 85 92
8. M.P. Reilly, M. Li, J. He Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies Lancet 377 2011 383 392
9. K.L. Ellis, A.P. Pilbrow, C.M. Frampton A common variant at chromosome 9P21.3 is associated with age of onset of coronary disease but not subsequent mortality Circ Cardiovasc Genet 3 2010 286 293
10. C.J. O'Donnell, M. Kavousi, A.V. Smith Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction Circulation 124 2011 2855 2864
11. T.L. Assimes, J.W. Knowles, A. Basu Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study Hum Mol Genet 17 2008 2320 2328
12. S. Dandona, A.F. Stewart, L. Chen Gene dosage of the common variant 9p21 predicts severity of coronary artery disease J Am Coll Cardiol 56 2010 479 486
13. R.S. Patel, S. Su, I.J. Neeland The chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease Eur Heart J 31 2010 3017 3023
14. J.L. Anderson, B.D. Horne, M.J. Kolek Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility Am Heart J 156 2008 1155 1162.e2
15. S.N. Chen, C.M. Ballantyne, A.M. Gotto Jr., A.J. Marian The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis BMC Cardiovasc Disord 9 2009 3
16. J.S. Alpert, K. Thygesen, E. Antman, J.P. Bassand Myocardial infarction redefined - a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction J Am Coll Cardiol 36 2000 959 969
17. J.P.T. Higgins, S. Green Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0 2011 The Cochrane Collaboration http://www.cochrane.org/training/cochrane-handbook Accessed March 21, 2012
18. Little J, Higgins JPT, editors. The HuGENetTM HuGE Review Handbook, Version 1.0. http://www.med.uottawa.ca/public-health-genomics/web/assets/ documents/huge-review-handbook-v1-0.pdf Accessed March 21, 2012
19. R. DerSimonian, R. Kacker Random-effects model for meta-analysis of clinical trials: an update Contemp Clin Trials 28 2007 105 114
20. J.P. Higgins, S.G. Thompson, J.J. Deeks, D.G. Altman Measuring inconsistency in meta-analyses BMJ 327 2003 557 560
21. M. Egger, G. Davey Smith, M. Schneider, C. Minder Bias in meta-analysis detected by a simple, graphical test BMJ 315 1997 629 634
22. P.J. Newcombe, C. Verzilli, J.P. Casas, A.D. Hingorani, L. Smeeth, J.C. Whittaker Multilocus Bayesian meta-analysis of gene-disease associations Am J Hum Genet 84 2009 567 580
23. H.M. Broadbent, J.F. Peden, S. Lorkowski Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p Hum Mol Genet 17 2008 806 814
24. K. Chan, A. Motterle, R.C. Laxton, S. Ye Common variant on chromosome 9p21 predicts severity of coronary artery disease J Am Coll Cardiol 57 2011 1497 1498 author reply 1498-9
25. Y. Gong, A.L. Beitelshees, R.M. Cooper-DeHoff Chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease Circ Cardiovasc Genet 4 2011 169 178
26. C.J. O'Donnell, L.A. Cupples, R.B. D'Agostino Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study BMC Med Genet 8 Suppl 1 2007 S4
27. S. Ye, J. Willeit, F. Kronenberg, Q. Xu, S. Kiechl Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study J Am Coll Cardiol 52 2008 378 384
28. C. Cluett, M.M. McDermott, J. Guralnik The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people Circ Cardiovasc Genet 2 2009 347 353
29. J.M. Murabito, C.C. White, M. Kavousi Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies Circ Cardiovasc Genet 5 2012 100 112
30. R.S. Patel, D.J. Eapen, A.M. Zafari, V. Vaccarino, A.A. Quyyumi Letter by Patel et al regarding article "Chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease" Circ Cardiovasc Genet 4 2011 e11 author reply e12
31. O. Jarinova, A.F. Stewart, R. Roberts Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus Arterioscler Thromb Vasc Biol 29 2009 1671 1677
32. A. Visel, Y. Zhu, D. May Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice Nature 464 2010 409 412
33. J.B. Kim, A. Deluna, I.N. Mungrue Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice Circulation 126 2012 1896 1906
34. A. Motterle, X. Pu, H. Wood Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells Hum Mol Genet 21 2012 4021 4029
35. H. Gonzalez-Navarro, Y.N. Abu Nabah, A. Vinue p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis J Am Coll Cardiol 55 2010 2258 2268
36. K. Hinohara, T. Nakajima, M. Takahashi Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations J Hum Genet 53 2008 357 359
37. P. Hoppmann, A. Erl, S. Turk No association of chromosome 9p21.3 variation with clinical and angiographic outcomes after placement of drug-eluting stents J Am Coll Cardiol Intv 2 2009 1149 1155
38. M. Krawczak, S. Nikolaus, H. von Eberstein, P.J. Croucher, N.E. El Mokhtari, S. Schreiber PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships Community Genet 9 2006 55 61
39. A. Muendlein, C.H. Saely, S. Rhomberg Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease Atherosclerosis 205 2009 174 180
40. G.Q. Shen, L. Li, S. Rao Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease Arterioscler Thromb Vasc Biol 28 2008 360 365
41. W. Wang, W.H. Peng, L. Lu Polymorphism on chromosome 9p21.3 contributes to early-onset and severity of coronary artery disease in non-diabetic and type 2 diabetic patients Chin Med J (Engl) 124 2011 66 71
42. S. Ye, L. Dunleavey, W. Bannister Independent effects of the -219 G>T and epsilon 2/ epsilon 3/ epsilon 4 polymorphisms in the apolipoprotein E gene on coronary artery disease: the Southampton Atherosclerosis Study Eur J Hum Genet 11 2003 437 443