Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor-kappa B activity

American Journal of Surgery

Volumn 205, Issue 4, 2013, Pages 387-396

  Krosch, Tara C K ^a   Sangwan, Veena ^a   Banerjee, Sulagna ^a   Mujumdar, Nameeta ^a   Dudeja, Vikas ^a   Saluja, Ashok K ^a   Vickers, Selwyn M ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Autophagy; Heat shock protein; Neuroblastoma; NF B; Triptolide

Indexed keywords

CASPASE 3; CASPASE 7; HEAT SHOCK PROTEIN 100; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MYOSIN LIGHT CHAIN; TRIPTOLIDE; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; AUTOPHAGY; CALCIUM CELL LEVEL; CANCER CELL CULTURE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NEUROBLASTOMA; PRIORITY JOURNAL; TREATMENT RESPONSE;

ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; CALCIUM; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CELL SURVIVAL; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXY COMPOUNDS; FLUORESCENT ANTIBODY TECHNIQUE; HEAT-SHOCK PROTEINS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; NEUROBLASTOMA; NF-KAPPA B; PHENANTHRENES; REAL-TIME POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL;

EID: 84875238979     PISSN: 00029610     EISSN: 18791883     Source Type: Journal    
DOI: 10.1016/j.amjsurg.2013.01.008     Document Type: Article

References (30)

1. H. Shimada, I.M. Ambros, and L.P. Dehner Terminology and morphologic criteria of neuroblastic tumors: recommendations by the International Neuroblastoma Pathology Committee Cancer 86 1999 349 363
2. J.M. Maris Recent advances in neuroblastoma N Engl J Med 362 2010 2202 2211
3. F. Speleman, K. De Preter, and J. Vandesompele Neuroblastoma genetics and phenotype: a tale of heterogeneity Semin Cancer Biol 21 2011 238 244
4. T. Tengchaisri, R. Chawengkirttikul, and N. Rachaphaew Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters Cancer Lett 133 1998 169 175
5. S. Yang, J. Chen, and Z. Guo Triptolide inhibits the growth and metastasis of solid tumors Mol Cancer Ther 2 2003 65 72
6. D. Borja-Cacho, Y. Yokoyama, and R.K. Chugh TRAIL and triptolide: an effective combination that induces apoptosis in pancreatic cancer cells J Gastrointest Surg 14 2010 252 260
7. N. Mujumdar, T.N. Mackenzie, and V. Dudeja Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways Gastroenterology 139 2010 598 608
8. P.A. Phillips, V. Dudeja, and J.A. McCarroll Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70 Cancer Res 67 2007 9407 9416
9. K.A. Clawson, D. Borja-Cacho, and M.B. Antonoff Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinoma J Surg Res 163 2010 244 249
10. M.B. Antonoff, R. Chugh, and D. Borja-Cacho Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo Surgery 146 2009 282 290
11. M.B. Antonoff, R. Chugh, and S.J. Skube Role of Hsp-70 in triptolide-mediated cell death of neuroblastoma J Surg Res 163 2010 72 78
12. W.S. Orr, J.W. Denbo, and K.R. Saab Liposome-encapsulated curcumin suppresses neuroblastoma growth through nuclear factor-kappa B inhibition Surgery 151 2012 736 744
13. V. Dudeja, N. Mujumdar, and P. Phillips Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms Gastroenterology 136 2009 1772 1782
14. M. Karin Nuclear factor-kappaB in cancer development and progression Nature 441 2006 431 436
15. G. Bonizzi, and M. Karin The two NF-kappaB activation pathways and their role in innate and adaptive immunity Trends Immunol 25 2004 280 288
16. N. Aravindan, R. Madhusoodhanan, and S. Ahmad Curcumin inhibits NFkappaB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells Cancer Biol Ther 7 2008 569 576
17. N. Mizushima Autophagy: process and function Genes Dev 21 2007 2861 2873
18. S. Modak, and N.K. Cheung Neuroblastoma: therapeutic strategies for a clinical enigma Cancer Treat Rev 36 2010 307 317
19. I. Ora, and A. Eggert Progress in treatment and risk stratification of neuroblastoma: impact on future clinical and basic research Semin Cancer Biol 21 2011 217 228
20. V. Dudeja, R.K. Chugh, and V. Sangwan Prosurvival role of heat shock factor 1 in the pathogenesis of pancreatobiliary tumors Am J Physiol Gastrointest Liver Physiol 300 2011 G948 G955
21. M. Jaattela Multiple cell death pathways as regulators of tumour initiation and progression Oncogene 23 2004 2746 2756
22. B. Xu, X. Guo, and S. Mathew Triptolide simultaneously induces reactive oxygen species, inhibits NF-kappaB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines Cancer Lett 291 2010 200 208
23. D. Qiu, G. Zhao, and Y. Aoki Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation J Biol Chem 274 1999 13443 13450
24. G. Zhao, L.T. Vaszar, and D. Qiu Anti-inflammatory effects of triptolide in human bronchial epithelial cells Am J Physiol Lung Cell Mol Physiol 279 2000 L958 L966
25. W. Zhu, H. Hu, and P. Qiu Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-kappaB-related mechanism Oncol Rep 22 2009 1397 1401
26. W. Zhu, Y. Ou, and Y. Li A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway Mol Pharmacol 75 2009 812 819
27. C. Wu, P. Wang, and J. Rao Triptolide alleviates hepatic ischemia/reperfusion injury by attenuating oxidative stress and inhibiting NF-kappaB activity in mice J Surg Res 166 2011 e205 e213
28. M.W. Harr, and C.W. Distelhorst Apoptosis and autophagy: decoding calcium signals that mediate life or death Cold Spring Harb Perspect Biol 2 2010 a005579
29. S.P. Yu, L.M. Canzoniero, and D.W. Choi Ion homeostasis and apoptosis Curr Opin Cell Biol 13 2001 405 411
30. W. Jia, H.H. Pua, and Q.J. Li Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes J Immunol 186 2011 1564 1574