Obesity and pancreatic cancer

Surgical Oncology

Volumn 23, Issue 2, 2014, Pages 61-71

  Preziosi, Giuseppe ^a   Oben, Jude A ^b   Fusai, Giuseppe ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Hyper insulenemia; Obesity; Pancreatic cancer; Risk factors

Indexed keywords

ESTROGEN; INSULIN; SOMATOMEDIN C; TESTOSTERONE;

ADULTHOOD; BODY FAT; BODY MASS; BODY WEIGHT; CANCER INCIDENCE; CANCER SURVIVAL; DIABETES MELLITUS; DISEASE ASSOCIATION; DNA DAMAGE; EMBASE; EPIDEMIC; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; MEDLINE; META ANALYSIS; METABOLIC SYNDROME X; OBESITY; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PATHOGENESIS; PATHOPHYSIOLOGY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SELF REPORT; SEX DIFFERENCE; SMOKING HABIT; UNDERWEIGHT; WAIST CIRCUMFERENCE; WEIGHT CHANGE; WEIGHT GAIN; WEIGHT REDUCTION; COMPLICATION; EPIDEMIOLOGY; PANCREATIC NEOPLASMS; UNITED KINGDOM;

GREAT BRITAIN; HUMANS; OBESITY; PANCREATIC NEOPLASMS; RISK FACTORS;

EID: 84901655370     PISSN: 09607404     EISSN: 18793320     Source Type: Journal    
DOI: 10.1016/j.suronc.2014.02.003     Document Type: Review

References (110)

1. J. Ferlay, H.R. Shin, F. Bray, D. Forman, C. Mathers, and D.M. Parkin Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 Int J Cancer 127 2010 2893 2917
2. J.T. McPhee, J.S. Hill, G.F. Whalen, M. Zayaruzny, D.E. Litwin, and M.E. Sullivan et al. Perioperative mortality for pancreatectomy: a national perspective Ann Surg 246 2007 246 253 (Pubitemid 47196522)
3. B. Gudjonsson Cancer of the pancreas. 50 years of surgery Cancer 60 1987 2284 2303 (Pubitemid 17153498)
4. S. Iodice, S. Gandini, P. Maisonneuve, and A.B. Lowenfels Tobacco and the risk of pancreatic cancer: a review and meta-analysis Langenbecks Arch Surg 393 2008 535 545
5. D.T. Silverman, J.A. Dunn, R.N. Hoover, M. Schiffman, K.D. Lillemoe, and J.B. Schoenberg et al. Cigarette smoking and pancreas cancer: a case-control study based on direct interviews J Natl Cancer Inst 86 1994 1510 1516 (Pubitemid 24330214)
6. J.T. Magruder, D. Elahi, and D.K. Andersen Diabetes and pancreatic cancer: chicken or egg? Pancreas 40 2011 339 351
7. B.B. Kahn, and J.S. Flier Obesity and insulin resistance J Clin Invest 106 2000 473 481 (Pubitemid 30666380)
8. AICR. World Cancer Research Fund/American Institute for Cancer Research Food, nutrition, physical activity, and the prevention of cancer: a global perspective 2007
9. A.G. Renehan, M. Tyson, M. Egger, R.F. Heller, and M. Zwahlen Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies Lancet 371 2008 569 578 (Pubitemid 351232031)
10. D. Aune, D.C. Greenwood, D.S. Chan, R. Vieira, A.R. Vieira, and D.A. Navarro Rosenblatt et al. Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies Ann Oncol 23 4 2012 Apr 843 852
11. A.A. Arslan, K.J. Helzlsouer, C. Kooperberg, X.O. Shu, E. Steplowski, and H.B. Bueno-de-Mesquita et al. Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan) Arch Intern Med 170 2010 791 802
12. L. Jiao, A. Berrington de Gonzalez, P. Hartge, R.M. Pfeiffer, Y. Park, and D.M. Freedman et al. Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts Cancer Causes Control 21 2010 1305 1314
13. J.M. Genkinger, D. Spiegelman, K.E. Anderson, L. Bernstein, P.A. van den Brandt, and E.E. Calle et al. A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk Int J Cancer 129 2011 1708 1717
14. N. Abate Insulin resistance and obesity. The role of fat distribution pattern Diabetes Care 19 1996 292 294 (Pubitemid 26070359)
15. B. Larsson, K. Svardsudd, L. Welin, L. Wilhelmsen, P. Bjorntorp, and G. Tibblin Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913 Br Med J (Clin Res Ed) 288 1984 1401 1404 (Pubitemid 14088431)
16. P. Bjorntorp Fat cell distribution and metabolism Ann N Y Acad Sci 499 1987 66 72
17. A. Berrington de Gonzalez, S. Sweetland, and E. Spencer A meta-analysis of obesity and the risk of pancreatic cancer Br J Cancer 89 2003 519 523 (Pubitemid 37026437)
18. S.C. Larsson, N. Orsini, and A. Wolk Body mass index and pancreatic cancer risk: a meta-analysis of prospective studies Int J Cancer 120 2007 1993 1998 (Pubitemid 46418379)
19. H.B. Bueno de Mesquita, C.J. Moerman, S. Runia, and P. Maisonneuve Are energy and energy-providing nutrients related to exocrine carcinoma of the pancreas? Int J Cancer 46 1990 435 444 (Pubitemid 20291100)
20. G.R. Howe, M. Jain, and A.B. Miller Dietary factors and risk of pancreatic cancer: results of a Canadian population-based case-control study Int J Cancer 45 1990 604 608 (Pubitemid 20146115)
21. P. Ghadirian, A. Simard, J. Baillargeon, P. Maisonneuve, and P. Boyle Nutritional factors and pancreatic cancer in the francophone community in Montreal, Canada Int J Cancer 47 1991 1 6
22. W. Zatonski, K. Przewozniak, G.R. Howe, P. Maisonneuve, A.M. Walker, and P. Boyle Nutritional factors and pancreatic cancer: a case-control study from south-west Poland Int J Cancer 48 1991 390 394
23. D.T. Silverman, C.A. Swanson, G. Gridley, S. Wacholder, R.S. Greenberg, and L.M. Brown et al. Dietary and nutritional factors and pancreatic cancer: a case-control study based on direct interviews J Natl Cancer Inst 90 1998 1710 1719 (Pubitemid 28539090)
24. A.J. Hanley, K.C. Johnson, P.J. Villeneuve, and Y. Mao Physical activity, anthropometric factors and risk of pancreatic cancer: results from the Canadian enhanced cancer surveillance system Int J Cancer 94 2001 140 147 (Pubitemid 32801763)
25. G.D. Friedman, and S.K. van den Eeden Risk factors for pancreatic cancer: an exploratory study Int J Epidemiol 22 1993 30 37 (Pubitemid 23083951)
26. A. Shibata, T.M. Mack, A. Paganini-Hill, R.K. Ross, and B.E. Henderson A prospective study of pancreatic cancer in the elderly Int J Cancer 58 1994 46 49 (Pubitemid 24213968)
27. S.M. Gapstur, P.H. Gann, W. Lowe, K. Liu, L. Colangelo, and A. Dyer Abnormal glucose metabolism and pancreatic cancer mortality JAMA 283 2000 2552 2558 (Pubitemid 30324198)
28. D.S. Michaud, E. Giovannucci, W.C. Willett, G.A. Colditz, M.J. Stampfer, and C.S. Fuchs Physical activity, obesity, height, and the risk of pancreatic cancer JAMA 286 2001 921 929 (Pubitemid 33010338)
29. R.Z. Stolzenberg-Solomon, P. Pietinen, P.R. Taylor, J. Virtamo, and D. Albanes A prospective study of medical conditions, anthropometry, physical activity, and pancreatic cancer in male smokers (Finland) Cancer Causes Control 13 2002 417 426 (Pubitemid 34666597)
30. E.E. Calle, C. Rodriguez, K. Walker-Thurmond, and M.J. Thun Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults N Engl J Med 348 2003 1625 1638 (Pubitemid 36459468)
31. I.M. Lee, H.D. Sesso, Y. Oguma, and R.S. Paffenbarger Jr. Physical activity, body weight, and pancreatic cancer mortality Br J Cancer 88 2003 679 683 (Pubitemid 36411443)
32. B. Isaksson, F. Jonsson, N.L. Pedersen, J. Larsson, M. Feychting, and J. Permert Lifestyle factors and pancreatic cancer risk: a cohort study from the Swedish Twin Registry Int J Cancer 98 2002 480 482 (Pubitemid 34188695)
33. S. Kuriyama, Y. Tsubono, A. Hozawa, T. Shimazu, Y. Suzuki, and Y. Koizumi et al. Obesity and risk of cancer in Japan Int J Cancer 113 2005 148 157 (Pubitemid 39507322)
34. A.V. Patel, C. Rodriguez, L. Bernstein, A. Chao, M.J. Thun, and E.E. Calle Obesity, recreational physical activity, and risk of pancreatic cancer in a large U.S. Cohort Cancer Epidemiol Biomarkers Prev 14 2005 459 466 (Pubitemid 40270112)
35. P.J. Sinner, K.H. Schmitz, K.E. Anderson, and A.R. Folsom Lack of association of physical activity and obesity with incident pancreatic cancer in elderly women Cancer Epidemiol Biomarkers Prev 14 2005 1571 1573 (Pubitemid 40807365)
36. G.D. Batty, M.J. Shipley, R.J. Jarrett, E. Breeze, M.G. Marmot, and G.D. Smith Obesity and overweight in relation to organ-specific cancer mortality in London (UK): findings from the original Whitehall study Int J Obes (Lond) 29 2005 1267 1274 (Pubitemid 43080307)
37. S.W. Oh, Y.S. Yoon, and S.A. Shin Effects of excess weight on cancer incidences depending on cancer sites and histologic findings among men: Korea National Health Insurance Corporation Study J Clin Oncol 23 2005 4742 4754 (Pubitemid 46224078)
38. K. Rapp, J. Schroeder, J. Klenk, S. Stoehr, H. Ulmer, and H. Concin et al. Obesity and incidence of cancer: a large cohort study of over 145,000 adults in Austria Br J Cancer 93 2005 1062 1067 (Pubitemid 41548403)
39. S.C. Larsson, J. Permert, N. Hakansson, I. Naslund, L. Bergkvist, and A. Wolk Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population-based cohorts Br J Cancer 93 2005 1310 1315 (Pubitemid 41679420)
40. A. Lukanova, O. Bjor, R. Kaaks, P. Lenner, B. Lindahl, and G. Hallmans et al. Body mass index and cancer: results from the Northern Sweden Health and Disease Cohort Int J Cancer 118 2006 458 466 (Pubitemid 41779087)
41. U. Nothlings, and L.N. Kolonel Risk factors for pancreatic cancer in the Hawai'i-Los Angeles Multiethnic Cohort Study Hawaii Med J 65 2006 26 28
42. A. Berrington de Gonzalez, E.A. Spencer, H.B. Bueno-de-Mesquita, A. Roddam, R. Stolzenberg-Solomon, and J. Halkjaer et al. Anthropometry, physical activity, and the risk of pancreatic cancer in the European prospective investigation into cancer and nutrition Cancer Epidemiol Biomarkers Prev 15 2006 879 885 (Pubitemid 43823512)
43. C. Samanic, W.H. Chow, G. Gridley, B. Jarvholm, and J.F. Fraumeni Jr. Relation of body mass index to cancer risk in 362,552 Swedish men Cancer Causes Control 17 2006 901 909 (Pubitemid 44078281)
44. U. Nothlings, L.R. Wilkens, S.P. Murphy, J.H. Hankin, B.E. Henderson, and L.N. Kolonel Body mass index and physical activity as risk factors for pancreatic cancer: the Multiethnic Cohort Study Cancer Causes Control 18 2007 165 175 (Pubitemid 46215313)
45. J. Luo, M. Iwasaki, M. Inoue, S. Sasazuki, T. Otani, and W. Ye et al. Body mass index, physical activity and the risk of pancreatic cancer in relation to smoking status and history of diabetes: a large-scale population-based cohort study in Japan-the JPHC study Cancer Causes Control 18 2007 603 612 (Pubitemid 46883677)
46. B.A. Verhage, L.J. Schouten, R.A. Goldbohm, and P.A. van den Brandt Anthropometry and pancreatic cancer risk: an illustration of the importance of microscopic verification Cancer Epidemiol Biomarkers Prev 16 2007 1449 1454 (Pubitemid 47076877)
47. R.Z. Stolzenberg-Solomon, K. Adams, M. Leitzmann, C. Schairer, D.S. Michaud, and A. Hollenbeck et al. Adiposity, physical activity, and pancreatic cancer in the National Institutes of Health-AARP Diet and Health Cohort Am J Epidemiol 167 2008 586 597 (Pubitemid 351323320)
48. S.H. Jee, J.E. Yun, E.J. Park, E.R. Cho, I.S. Park, and J.W. Sull et al. Body mass index and cancer risk in Korean men and women Int J Cancer 123 2008 1892 1896
49. J. Luo, K.L. Margolis, H.O. Adami, A. LaCroix, and W. Ye Obesity and risk of pancreatic cancer among postmenopausal women: the Women's Health Initiative (United States) Br J Cancer 99 2008 527 531
50. C.L. Meinhold, A. Berrington de Gonzalez, D. Albanes, S.J. Weinstein, P.R. Taylor, and J. Virtamo et al. Predictors of fasting serum insulin and glucose and the risk of pancreatic cancer in smokers Cancer Causes Control 20 2009 681 690
51. D. Johansen, A. Borgstrom, B. Lindkvist, and J. Manjer Different markers of alcohol consumption, smoking and body mass index in relation to risk of pancreatic cancer. A prospective cohort study within the Malmo Preventive Project Pancreatology 9 2009 677 686
52. R.J. Stevens, A.W. Roddam, E.A. Spencer, K.L. Pirie, G.K. Reeves, and J. Green et al. Factors associated with incident and fatal pancreatic cancer in a cohort of middle-aged women Int J Cancer 124 2009 2400 2405
53. G. Andreotti, L. Hou, L.E. Beane Freeman, R. Mahajan, S. Koutros, and J. Coble et al. Body mass index, agricultural pesticide use, and cancer incidence in the agricultural health study cohort Cancer Causes Control 21 2010 1759 1775
54. G.K. Reeves, K. Pirie, V. Beral, J. Green, E. Spencer, and D. Bull Cancer incidence and mortality in relation to body mass index in the million women study: cohort study Bmj 335 2007 1134
55. M. Inoue, K. Tajima, T. Takezaki, N. Hamajima, K. Hirose, and H. Ito et al. Epidemiology of pancreatic cancer in Japan: a nested case-control study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC) Int J Epidemiol 32 2003 257 262 (Pubitemid 36622272)
56. T.I. Nilsen, and L.J. Vatten A prospective study of lifestyle factors and the risk of pancreatic cancer in Nord-Trondelag, Norway Cancer Causes Control 11 2000 645 652 (Pubitemid 30636364)
57. G.D. Batty, M. Kivimaki, D. Morrison, R. Huxley, G.D. Smith, and R. Clarke et al. Risk factors for pancreatic cancer mortality: extended follow-up of the original Whitehall Study Cancer Epidemiol Biomarkers Prev 18 2009 673 675
58. C. Samanic, G. Gridley, W.H. Chow, J. Lubin, R.N. Hoover, and J.F. Fraumeni Jr. Obesity and cancer risk among white and black United States veterans Cancer Causes Control 15 2004 35 43 (Pubitemid 38339970)
59. A. Berrington de Gonzalez, J.E. Yun, S.Y. Lee, A.P. Klein, and S.H. Jee Pancreatic cancer and factors associated with the insulin resistance syndrome in the Korean cancer prevention study Cancer Epidemiol Biomarkers Prev 17 2008 359 364 (Pubitemid 351272787)
60. Y. Lin, S. Kikuchi, A. Tamakoshi, K. Yagyu, Y. Obata, and Y. Inaba et al. Obesity, physical activity and the risk of pancreatic cancer in a large Japanese cohort Int J Cancer 120 2007 2665 2671 (Pubitemid 46651289)
61. K. Nakamura, C. Nagata, K. Wada, Y. Tamai, M. Tsuji, and N. Takatsuka et al. Cigarette smoking and other lifestyle factors in relation to the risk of pancreatic cancer death: a prospective cohort study in Japan Jpn J Clin Oncol 41 2011 225 231
62. J.L. Lyon, M.L. Slattery, A.W. Mahoney, and L.M. Robison Dietary intake as a risk factor for cancer of the exocrine pancreas Cancer Epidemiol Biomarkers Prev 2 1993 513 518
63. H.B. Bueno de Mesquita, P. Maisonneuve, C.J. Moerman, and A.M. Walker Anthropometric and reproductive variables and exocrine carcinoma of the pancreas: a population-based case-control study in The Netherlands Int J Cancer 52 1992 24 29
64. A. Wolk, G. Gridley, M. Svensson, O. Nyren, J.K. McLaughlin, and J.F. Fraumeni et al. A prospective study of obesity and cancer risk (Sweden) Cancer Causes Control 12 2001 13 21 (Pubitemid 32125897)
65. H. Moller, A. Mellemgaard, K. Lindvig, and J.H. Olsen Obesity and cancer risk: a Danish record-linkage study Eur J Cancer 30A 1994 344 350 (Pubitemid 24152476)
66. S.Y. Pan, K.C. Johnson, A.M. Ugnat, S.W. Wen, and Y. Mao Association of obesity and cancer risk in Canada Am J Epidemiol 159 2004 259 268 (Pubitemid 38141655)
67. J.A. Istvan, T.W. Cunningham, and L. Garfinkel Cigarette smoking and body weight in the cancer prevention study I Int J Epidemiol 21 1992 849 853
68. J.P. Fryzek, M. Schenk, M. Kinnard, J.K. Greenson, and D.H. Garabrant The association of body mass index and pancreatic cancer in residents of southeastern Michigan, 1996-1999 Am J Epidemiol 162 2005 222 228 (Pubitemid 41373526)
69. L.N. Anderson, M. Cotterchio, and S. Gallinger Lifestyle, dietary, and medical history factors associated with pancreatic cancer risk in Ontario, Canada Cancer Causes Control 20 2009 825 834
70. D. Li, J.S. Morris, J. Liu, M.M. Hassan, R.S. Day, and M.L. Bondy et al. Body mass index and risk, age of onset, and survival in patients with pancreatic cancer JAMA 301 2009 2553 2562
71. M. Ogren, M. Hedberg, G. Berglund, A. Borgstrom, and L. Janzon Risk of pancreatic carcinoma in smokers enhanced by weight gain. Results from 10-year follow-up of the Malmo preventive project cohort study Int J Pancreatol 20 1996 95 101 (Pubitemid 26422413)
72. H. Obana, S. Hori, T. Kashimoto, and N. Kunita Polycyclic aromatic hydrocarbons in human fat and liver Bull Environ Contam Toxicol 27 1981 23 27 (Pubitemid 11004493)
73. M. Soler, M. Porta, N. Malats, L. Guarner, S. Costafreda, and J.M. Gubern et al. Learning from case reports: diagnostic issues in an epidemiologic study of pancreatic cancer J Clin Epidemiol 51 1998 1215 1221 (Pubitemid 29009521)
74. D.T. Silverman, M. Schiffman, and S. Devesa Diagnostic certainty in pancreatic cancer J Clin Epidemiol 49 1996 601 603
75. C.A. Eberle, P.M. Bracci, and E.A. Holly Anthropometric factors and pancreatic cancer in a population-based case-control study in the San Francisco Bay area Cancer Causes Control 16 2005 1235 1244 (Pubitemid 46179507)
76. A. Ansary-Moghaddam, R. Huxley, F. Barzi, C. Lawes, T. Ohkubo, and X. Fang et al. The effect of modifiable risk factors on pancreatic cancer mortality in populations of the Asia-Pacific region Cancer Epidemiol Biomarkers Prev 15 2006 2435 2440 (Pubitemid 46048301)
77. 2 max J Appl Physiol 66 1989 2206 2210 (Pubitemid 19142371)
78. D.E. Kelley, and B.H. Goodpaster Effects of physical activity on insulin action and glucose tolerance in obesity Med Sci Sports Exerc 31 1999 S619 S623
79. L. Jiao, P.N. Mitrou, J. Reedy, B.I. Graubard, A.R. Hollenbeck, and A. Schatzkin et al. A combined healthy lifestyle score and risk of pancreatic cancer in a large cohort study Arch Intern Med 169 2009 764 770
80. WHO IaI The Asia-Pacific perspective: redefining obesity and its treatment 2000
81. M.W. Rajala, and P.E. Scherer Minireview: the adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis Endocrinology 144 2003 3765 3773 (Pubitemid 37088727)
82. G.M. Reaven Banting lecture 1988. Role of insulin resistance in human disease Diabetes 37 1988 1595 1607 (Pubitemid 19004941)
83. B.L. Wajchenberg Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome Endocr Rev 21 2000 697 738 (Pubitemid 32113289)
84. R.Z. Stolzenberg-Solomon, S. Weinstein, M. Pollak, Y. Tao, P.R. Taylor, and J. Virtamo et al. Prediagnostic adiponectin concentrations and pancreatic cancer risk in male smokers Am J Epidemiol 168 2008 1047 1055
85. S.M. Shafie, and R. Hilf Insulin receptor levels and magnitude of insulin-induced responses in 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats Cancer Res 41 1981 826 829 (Pubitemid 11136320)
86. J.A. Williams, and I.D. Goldfine The insulin-pancreatic acinar axis Diabetes 34 1985 980 986 (Pubitemid 16236516)
87. J.R. Henderson, P.M. Daniel, and P.A. Fraser The pancreas as a single organ: the influence of the endocrine upon the exocrine part of the gland Gut 22 1981 158 167 (Pubitemid 11151034)
88. W.E. Fisher, L.G. Boros, and W.J. Schirmer Insulin promotes pancreatic cancer: evidence for endocrine influence on exocrine pancreatic tumors J Surg Res 63 1996 310 313 (Pubitemid 26197211)
89. F. Wang, J. Larsson, T.E. Adrian, T. Gasslander, and J. Permert In vitro influences between pancreatic adenocarcinoma cells and pancreatic islets J Surg Res 79 1998 13 19 (Pubitemid 28427589)
90. M.B. Schneider, H. Matsuzaki, J. Haorah, A. Ulrich, J. Standop, and X.Z. Ding et al. Prevention of pancreatic cancer induction in hamsters by metformin Gastroenterology 120 2001 1263 1270 (Pubitemid 32246678)
91. J. Liu, K. Kazakoff, P.M. Pour, and T.E. Adrian The intracellular mechanism of insulin resistance in the hamster pancreatic ductal adenocarcinoma model Pancreas 17 1998 359 366 (Pubitemid 28516091)
92. K. Kazakoff, T. Cardesa, J. Liu, T.E. Adrian, D. Bagchi, and M. Bagchi et al. Effects of voluntary physical exercise on high-fat diet-promoted pancreatic carcinogenesis in the hamster model Nutr Cancer 26 1996 265 279 (Pubitemid 26362066)
93. R.H. Bell Jr., P.J. McCullough, and P.M. Pour Influence of diabetes on susceptibility to experimental pancreatic cancer Am J Surg 155 1988 159 164 (Pubitemid 18063541)
94. P.M. Pour, K. Kazakoff, and K. Carlson Inhibition of streptozotocin- induced islet cell tumors and N-nitrosobis(2-oxopropyl)amine-induced pancreatic exocrine tumors in Syrian hamsters by exogenous insulin Cancer Res 50 1990 1634 1639 (Pubitemid 20090484)
95. P.M. Pour, and K. Stepan Modification of pancreatic carcinogenesis in the hamster model. VIII. Inhibitory effect of exogenous insulin J Natl Cancer Inst 72 1984 1205 1208 (Pubitemid 14101622)
96. M.A. Lawlor, and D.R. Alessi PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 114 2001 2903 2910 (Pubitemid 32821530)
97. M. Prisco, G. Romano, F. Peruzzi, B. Valentinis, and R. Baserga Insulin and IGF-I receptors signaling in protection from apoptosis Horm Metab Res 31 1999 80 89 (Pubitemid 29169480)
98. E. Ohmura, M. Okada, N. Onoda, Y. Kamiya, H. Murakami, and T. Tsushima et al. Insulin-like growth factor I and transforming growth factor alpha as autocrine growth factors in human pancreatic cancer cell growth Cancer Res 50 1990 103 107 (Pubitemid 20030002)
99. L. Bonelli, H. Aste, P. Bovo, G. Cavallini, M. Felder, and R. Gusmaroli et al. Exocrine pancreatic cancer, cigarette smoking, and diabetes mellitus: a case-control study in northern Italy Pancreas 27 2003 143 149 (Pubitemid 36950726)
100. P. Maisonneuve, A.B. Lowenfels, H.B. Bueno-de-Mesquita, P. Ghadirian, P.A. Baghurst, and W.A. Zatonski et al. Past medical history and pancreatic cancer risk: results from a multicenter case-control study Ann Epidemiol 20 2010 92 98
101. A.E. Butler, R. Galasso, A. Matveyenko, R.A. Rizza, S. Dry, and P.C. Butler Pancreatic duct replication is increased with obesity and type 2 diabetes in humans Diabetologia 53 2010 21 26
102. S.H. Jee, H. Ohrr, J.W. Sull, J.E. Yun, M. Ji, and J.M. Samet Fasting serum glucose level and cancer risk in Korean men and women JAMA 293 2005 194 202 (Pubitemid 40095870)
103. R.Z. Stolzenberg-Solomon, B.I. Graubard, S. Chari, P. Limburg, P.R. Taylor, and J. Virtamo et al. Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers JAMA 294 2005 2872 2878 (Pubitemid 41785868)
104. V.J. Carey, E.E. Walters, G.A. Colditz, C.G. Solomon, W.C. Willett, and B.A. Rosner et al. Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurses' Health Study Am J Epidemiol 145 1997 614 619 (Pubitemid 27154864)
105. H. Wahrenberg, K. Hertel, B.M. Leijonhufvud, L.G. Persson, E. Toft, and P. Arner Use of waist circumference to predict insulin resistance: retrospective study BMJ 330 2005 1363 1364 (Pubitemid 40839563)
106. P. Bjorntorp Metabolic implications of body fat distribution Diabetes Care 14 1991 1132 1143
107. S.O. Olusi Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans Int J Obes Relat Metab Disord 26 2002 1159 1164
108. M. Wang, J.L. Abbruzzese, H. Friess, W.N. Hittelman, D.B. Evans, and M.C. Abbruzzese et al. DNA adducts in human pancreatic tissues and their potential role in carcinogenesis Cancer Res 58 1998 38 41 (Pubitemid 28027713)
109. A. Tchernof, and J.P. Despres Sex steroid hormones, sex hormone-binding globulin, and obesity in men and women Horm Metab Res 32 2000 526 536 (Pubitemid 32176082)
110. A.B. Miller, T.H. Barclay, N.W. Choi, M.G. Grace, C. Wall, and M. Plante et al. A study of cancer, parity and age at first pregnancy J Chronic Dis 33 1980 595 605 (Pubitemid 10003337)