메뉴 건너뛰기




Volumn 25, Issue 3, 2014, Pages 1060-1068

Enhancement of gastrointestinal absorption of isoliquiritigenin by nanostructured lipid carrier

Author keywords

Gastrointestinal absorption in situ; Isoliquiritigenin; Nanostructured lipid carriers; Pharmacokinetics; Relative bioavailability

Indexed keywords

BIOCHEMISTRY; CONTROLLED DRUG DELIVERY; FLAVONOIDS; PHARMACOKINETICS; SOLS; TARGETED DRUG DELIVERY;

EID: 84901618947     PISSN: 09218831     EISSN: 15685527     Source Type: Journal    
DOI: 10.1016/j.apt.2014.02.012     Document Type: Article
Times cited : (30)

References (54)
  • 1
    • 0031919215 scopus 로고    scopus 로고
    • Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata
    • DOI 10.1016/S0968-0896(97)10034-7, PII S0968089697100347
    • H. Haraguchi, H. Ishikawa, K. Mizutani, Y. Tamura, and T. Kinoshita Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata Bioorg. Med. Chem. 6 1998 339 347 (Pubitemid 28144484)
    • (1998) Bioorganic and Medicinal Chemistry , vol.6 , Issue.3 , pp. 339-347
    • Haraguchi, H.1    Ishikawa, H.2    Mizutani, K.3    Tamura, Y.4    Kinoshita, T.5
  • 3
    • 41549142696 scopus 로고    scopus 로고
    • Isoliquiritigenin inhibits tumor growth and protects the kidney and liver against chemotherapy-induced toxicity in a mouse xenograft model of colon carcinoma
    • DOI 10.1254/jphs.FP0071498
    • C.K. Lee, S.H. Son, K.K. Park, J.H. Park, S.S. Lim, and W.Y. Chung Isoliquiritigenin inhibits tumor growth and protects the kidney and liver against chemotherapyinduced toxicity in a mouse xenograft model of colon carcinoma J. Pharmacol. Sci. 106 2008 444 451 (Pubitemid 351468597)
    • (2008) Journal of Pharmacological Sciences , vol.106 , Issue.3 , pp. 444-451
    • Chang, K.L.1    Seung, H.S.2    Kwang, K.P.3    Park, J.H.Y.4    Soon, S.L.5    Won, Y.C.6
  • 4
    • 34047236705 scopus 로고    scopus 로고
    • Isoliquiritigenin inhibits IκB kinase activity and ROS generation to block TNF-α induced expression of cell adhesion molecules on human endothelial cells
    • DOI 10.1016/j.bcp.2007.01.015, PII S0006295207000275
    • S. Kumar, A. Sharma, B. Madan, V. Singhal, and B. Ghosh Isoliquiritigenin inhibits Ikappa B kinase activity and ROS generation to block TNF-Alpha induced expression of cell adhesion molecules on human endothelial cells Biochem. Pharmacol. 73 2007 1602 1612 (Pubitemid 46533973)
    • (2007) Biochemical Pharmacology , vol.73 , Issue.10 , pp. 1602-1612
    • Kumar, S.1    Sharma, A.2    Madan, B.3    Singhal, V.4    Ghosh, B.5
  • 5
    • 41149091553 scopus 로고    scopus 로고
    • Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kB in Raw264.7 macrophages
    • J.Y. Kim, S.J. Park, K.J. Yun, Y.W. Cho, H.J. Park, and K.T. Lee Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kB in Raw264.7 macrophages Eur. J. Pharmacol. 584 2008 175 184
    • (2008) Eur. J. Pharmacol. , vol.584 , pp. 175-184
    • Kim, J.Y.1    Park, S.J.2    Yun, K.J.3    Cho, Y.W.4    Park, H.J.5    Lee, K.T.6
  • 6
    • 3042545271 scopus 로고    scopus 로고
    • 2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development
    • DOI 10.1111/j.1349-7006.2004.tb03230.x
    • T. Takahashi, N. Takasuka, M. Iigo, M. Baba, H. Nishino, H. Tsuda, and T. Okuyama Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development Cancer Sci. 95 2004 448 453 (Pubitemid 38832690)
    • (2004) Cancer Science , vol.95 , Issue.5 , pp. 448-453
    • Takahashi, T.1    Takasuka, N.2    Iigo, M.3    Baba, M.4    Nishino, H.5    Tsuda, H.6    Okuyama, T.7
  • 7
    • 64949183401 scopus 로고    scopus 로고
    • Induction of cell cycle arrest in prostate cancer cells by the dietary compound isoliquiritigenin
    • Y.M. Lee, Y. Lim do, H.J. Choi, J.I. Jung, W.Y. Chung, and J.H. Park Induction of cell cycle arrest in prostate cancer cells by the dietary compound isoliquiritigenin J. Med. Food 12 2009 8 14
    • (2009) J. Med. Food , vol.12 , pp. 8-14
    • Lee, Y.M.1    Lim Do, Y.2    Choi, H.J.3    Jung, J.I.4    Chung, W.Y.5    Park, J.H.6
  • 9
    • 0028929077 scopus 로고
    • Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta
    • S.M. Yu, and S.C. Kuo Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta Br. J. Pharmacol. 114 1995 1587 1594
    • (1995) Br. J. Pharmacol. , vol.114 , pp. 1587-1594
    • Yu, S.M.1    Kuo, S.C.2
  • 10
    • 0026659990 scopus 로고
    • Inhibitory effects of some natural products on the activation of hyaluronidase and their anti-Allergic actions
    • H. Kakegawa, H. Matsumoto, and T. Satoh Inhibitory effects of some natural products on the activation of hyaluronidase and their anti-Allergic actions Chem. Pharm. Bull. 40 1992 1439 1442
    • (1992) Chem. Pharm. Bull. , vol.40 , pp. 1439-1442
    • Kakegawa, H.1    Matsumoto, H.2    Satoh, T.3
  • 11
  • 13
    • 32644454395 scopus 로고    scopus 로고
    • Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats
    • DOI 10.1016/j.phrs.2005.12.008, PII S1043661806000041
    • C. Zhan, and J. Yang Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats Pharmacol. Res. 53 2006 303 309 (Pubitemid 43247544)
    • (2006) Pharmacological Research , vol.53 , Issue.3 , pp. 303-309
    • Zhan, C.1    Yang, J.2
  • 14
    • 55549096745 scopus 로고    scopus 로고
    • SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMPactivated protein kinase activation
    • F. Lan, J.M. Cacicedo, N. Ruderman, and Y. Ido SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMPactivated protein kinase activation J. Biol. Chem. 283 2008 27628 27635
    • (2008) J. Biol. Chem. , vol.283 , pp. 27628-27635
    • Lan, F.1    Cacicedo, J.M.2    Ruderman, N.3    Ido, Y.4
  • 18
    • 69049089697 scopus 로고    scopus 로고
    • Determination and pharmacokinetics of Isoliquiritigenin in rat plasma by reverse phase high-performance liquid chromatography after intravenous administration
    • X.Y. Zhang, J.P. Liu, H. Qiao, J.M. Ni, and Y.B. Shi Determination and pharmacokinetics of Isoliquiritigenin in rat plasma by reverse phase high-performance liquid chromatography after intravenous administration Chromatographia 70 2009 423 430
    • (2009) Chromatographia , vol.70 , pp. 423-430
    • Zhang, X.Y.1    Liu, J.P.2    Qiao, H.3    Ni, J.M.4    Shi, Y.B.5
  • 19
    • 84877812976 scopus 로고    scopus 로고
    • Preparation of isoliquiritigenin-loaded nanostructured lipid carrier and the in vivo evaluation in tumor-bearing mice
    • X.Y. Zhang, H. Qiao, J.M. Ni, Y.B. Shi, and Y. Qiang Preparation of isoliquiritigenin-loaded nanostructured lipid carrier and the in vivo evaluation in tumor-bearing mice Eur. J. Pharm. Sci. 49 2013 411 422
    • (2013) Eur. J. Pharm. Sci. , vol.49 , pp. 411-422
    • Zhang, X.Y.1    Qiao, H.2    Ni, J.M.3    Shi, Y.B.4    Qiang, Y.5
  • 20
    • 84891771025 scopus 로고    scopus 로고
    • Pharmacokinetics, biodistribution and bioavailability of isoliquiritigenin after intravenous and oral administration
    • H. Qiao, X.Y. Zhang, T. Wang, L. Liang, W. Chang, and H.X. Xia Pharmacokinetics, biodistribution and bioavailability of isoliquiritigenin after intravenous and oral administration Pharm. Biol. 52 2014 228 236
    • (2014) Pharm. Biol. , vol.52 , pp. 228-236
    • Qiao, H.1    Zhang, X.Y.2    Wang, T.3    Liang, L.4    Chang, W.5    Xia, H.X.6
  • 22
    • 39049139244 scopus 로고    scopus 로고
    • Lipid carriers: A versatile delivery vehicle for proteins and peptides
    • DOI 10.1248/yakushi.128.269
    • M. Rawat, D. Singh, and S. Saraf Lipid carrier: a versatile delivery vehicle for proteins and peptides Yakugaku. Zasshi. 128 2008 269 280 (Pubitemid 351237899)
    • (2008) Yakugaku Zasshi , vol.128 , Issue.2 , pp. 269-280
    • Rawat, M.1    Singh, D.2    Saraf, S.3    Saraf, S.4
  • 24
    • 2242472082 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations
    • R.H. Müller, M. Radtke, and S.A. Wissing Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations Adv. Drug Deliv. Rev. 54 Suppl. 1 2002 S131 S155
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , Issue.SUPPL. 1
    • Müller, R.H.1    Radtke, M.2    Wissing, S.A.3
  • 25
    • 77953283407 scopus 로고    scopus 로고
    • Lipid nanoparticles: Effect on bioavailability and pharmacokinetic changes
    • E.B. Souto, and R.H. Müller Lipid nanoparticles: effect on bioavailability and pharmacokinetic changes Handb. Exp. Pharmacol. 197 2010 115 141
    • (2010) Handb. Exp. Pharmacol. , vol.197 , pp. 115-141
    • Souto, E.B.1    Müller, R.H.2
  • 26
    • 35648978975 scopus 로고    scopus 로고
    • Preparation and characterization of monocaprate nanostructured lipid carriers
    • DOI 10.1016/j.colsurfa.2007.06.003, PII S0927775707006255, Engineering Particle Technology
    • X.H. Lin, X.W. Li, L.Q. Zheng, L. Yu, Q.Q. Zhang, and W.C. Liu Preparation and characterization of monocaprate nanostructured lipid carriers Colloids Surf. A Physicochem. Eng. Asp. 311 2007 106 111 (Pubitemid 350026290)
    • (2007) Colloids and Surfaces A: Physicochemical and Engineering Aspects , vol.311 , Issue.1-3 , pp. 106-111
    • Lin, X.1    Li, X.2    Zheng, L.3    Yu, L.4    Zhang, Q.5    Liu, W.6
  • 27
    • 0037151496 scopus 로고    scopus 로고
    • Nanostructured lipid matrices for improved microencapsulation of drugs
    • R.H. Müller, M. Radtke, and S.A. Wissing Nanostructured lipid matrices for improved microencapsulation of drugs Int. J. Pharm. 242 2002 121 128
    • (2002) Int. J. Pharm. , vol.242 , pp. 121-128
    • Müller, R.H.1    Radtke, M.2    Wissing, S.A.3
  • 28
    • 79960190356 scopus 로고    scopus 로고
    • Nanostructured lipid carrier versus solid lipid nanoparticles of simvastatin: Comparative analysis of characteristics, pharmacokinetics and tissue uptake
    • R. Tiwari, and K. Pathak Nanostructured lipid carrier versus solid lipid nanoparticles of simvastatin: comparative analysis of characteristics, pharmacokinetics and tissue uptake Int. J. Pharm. 415 2011 232 243
    • (2011) Int. J. Pharm. , vol.415 , pp. 232-243
    • Tiwari, R.1    Pathak, K.2
  • 29
    • 84869159030 scopus 로고    scopus 로고
    • Nanostructured lipid carriers: A potential drug carrier for cancer chemotherapy
    • 159-159
    • S. Selvamuthukumar, and R. Velmurugan Nanostructured lipid carriers: a potential drug carrier for cancer chemotherapy Lipids Health Dis. 11 2012 159-159
    • (2012) Lipids Health Dis. , vol.11
    • Selvamuthukumar, S.1    Velmurugan, R.2
  • 30
    • 84868353989 scopus 로고    scopus 로고
    • Nanostructured lipid carriers system: Recent advances in drug delivery
    • M.A. Iqbal, S. Md, J.K. Sahni, S. Baboota, S. Dang, and J. Ali Nanostructured lipid carriers system: recent advances in drug delivery J. Drug Target. 20 2012 813 830
    • (2012) J. Drug Target. , vol.20 , pp. 813-830
    • Iqbal, M.A.1    Md, S.2    Sahni, J.K.3    Baboota, S.4    Dang, S.5    Ali, J.6
  • 31
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review
    • DOI 10.1016/S0168-3659(99)00248-5, PII S0168365999002485
    • H. Maeda, J. Wu, T. Sawa, Y. Matsumura, and K. Hori Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review J. Control. Release 65 2000 271 284 (Pubitemid 30122932)
    • (2000) Journal of Controlled Release , vol.65 , Issue.1-2 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3    Matsumura, Y.4    Hori, K.5
  • 32
    • 70350074027 scopus 로고    scopus 로고
    • Formulation optimization of dihydroartemisinin nanostructured lipid carrier using response surface methodology
    • X.Y. Zhang, J.P. Liu, H. Qiao, H. Liu, J.M. Ni, W.L. Zhang, and Y.B. Shi Formulation optimization of dihydroartemisinin nanostructured lipid carrier using response surface methodology Powder Technol. 197 2010 120 128
    • (2010) Powder Technol. , vol.197 , pp. 120-128
    • Zhang, X.Y.1    Liu, J.P.2    Qiao, H.3    Liu, H.4    Ni, J.M.5    Zhang, W.L.6    Shi, Y.B.7
  • 33
    • 0023923405 scopus 로고
    • Intestinal absorption kinetics of various model drugs in relation to partition coefficients
    • T. Nook, E. Doelker, and P. Buri Intestinal absorption kinetics of various model drugs in relation to partition coefficients Int. J. Pharm. 43 1988 119 129 (Pubitemid 18097535)
    • (1988) International Journal of Pharmaceutics , vol.43 , Issue.1-2 , pp. 119-129
    • Nook, T.1    Doelker, E.2    Buri, P.3
  • 35
    • 1542379038 scopus 로고    scopus 로고
    • Study on the release of albendazole nanoparticles in vitro and its correlation with uptake in stomach and intestinal absorption kinetics in rats
    • X.N. Zhang, J. Chen, and Q. Zhang Study on the release of albendazole anoparticles in vitro and its correlation with uptake in stomach and intestinal absorption kinetics in rats Chin. Pharm. J. 38 12 2003 932 935 (Pubitemid 38297677)
    • (2003) Chinese Pharmaceutical Journal , vol.38 , Issue.12 , pp. 932-935
    • Zhang, X.-N.1    Chen, J.2    Zhang, Q.3
  • 36
    • 0026074310 scopus 로고
    • The effect of site of administration in the gastrointestinal tract on the absorption of insulin from nanocapsules in diabetic rats
    • C. Michel, M. Aprahamian, L. Defontaine, P. Couvreur, and C. Damgé The effect of site of administration in the gastrointestinal tract on the absorption of insulin from nanocapsules in diabetic rats J. Pharm. Pharmacol. 43 1991 1 5
    • (1991) J. Pharm. Pharmacol. , vol.43 , pp. 1-5
    • Michel, C.1    Aprahamian, M.2    Defontaine, L.3    Couvreur, P.4    Damgé, C.5
  • 37
    • 38749133769 scopus 로고    scopus 로고
    • Transport characteristics of ginkgolide B by Caco-2 cells and examination of ginkgolide B oral absorption potential using rat in situ intestinal loop method
    • DOI 10.1016/j.ijpharm.2007.09.026, PII S0378517307007697
    • H. Lv, G. Wang, X. Wu, L. Xie, C. Huang, H. Li, Y. Liang, H. Hao, and J. Sun Transport characteristics of ginkgolide B by Caco-2 cells and examination of ginkgolide B oral absorption potential using rat in situ intestinal loop method Int. J. Pharm. 351 2008 31 35 (Pubitemid 351186840)
    • (2008) International Journal of Pharmaceutics , vol.351 , Issue.1-2 , pp. 31-35
    • Lv, H.1    Wang, G.2    Wu, X.3    Xie, L.4    Huang, C.5    Li, H.6    Liang, Y.7    Hao, H.8    Sun, J.9
  • 38
    • 0029953050 scopus 로고    scopus 로고
    • Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery
    • 117-139; 36
    • N. Rouge, P. Buri, and E. Doelker Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery Int. J. Pharm. 136 1996 117-139; 36
    • (1996) Int. J. Pharm. , vol.136
    • Rouge, N.1    Buri, P.2    Doelker, E.3
  • 40
    • 34247567472 scopus 로고    scopus 로고
    • Intestinal absorption of novel-dipeptide prodrugs of saquinavir in rats
    • DOI 10.1016/j.ijpharm.2006.11.058, PII S0378517306010362
    • R. Jain, S. Duvvuri, V. Kansara, N.K. Mandava, and A.K. Mitra Intestinal absorption of novel-dipeptide prodrugs of saquinavir in rats Int. J. Pharm. 336 2007 233 240 (Pubitemid 46670646)
    • (2007) International Journal of Pharmaceutics , vol.336 , Issue.2 , pp. 233-240
    • Jain, R.1    Duvvuri, S.2    Kansara, V.3    Mandava, N.K.4    Mitra, A.K.5
  • 41
    • 40849086344 scopus 로고    scopus 로고
    • Improvement of intestinal absorption of water-soluble macromolecules by various polyamines: Intestinal mucosal toxicity and absorption-enhancing mechanism of spermine
    • Y. Gao, L. He, H. Katsumi, T. Sakane, T. Fujita, and A. Yamamoto Improvement of intestinal absorption of water-soluble macromolecules by various polyamines: intestinal mucosal toxicity and absorption-enhancing mechanism of spermine Int. J. Pharm. 354 2008 126 134
    • (2008) Int. J. Pharm. , vol.354 , pp. 126-134
    • Gao, Y.1    He, L.2    Katsumi, H.3    Sakane, T.4    Fujita, T.5    Yamamoto, A.6
  • 42
    • 0027286068 scopus 로고
    • Second peak of plasma diazepam concentration and enterogastric circulation
    • Y.M. Ma, and R.Y. Sun Second peak of plasma diazepam concentration and enterogastric circulation Acta Pharmacol. Sin. 14 1993 218 221
    • (1993) Acta Pharmacol. Sin. , vol.14 , pp. 218-221
    • Ma, Y.M.1    Sun, R.Y.2
  • 43
    • 27644442245 scopus 로고    scopus 로고
    • Absorption and enterohepatic circulation of baicalin in rats
    • DOI 10.1016/j.lfs.2005.04.072, PII S0024320505007356
    • J. Xing, X. Chen, and D. Zhong Absorption and enterohepatic circulation of baicalin in rats Life Sci. 78 2005 140 146 (Pubitemid 41560966)
    • (2005) Life Sciences , vol.78 , Issue.2 , pp. 140-146
    • Xing, J.1    Chen, X.2    Zhong, D.3
  • 44
    • 78549252139 scopus 로고    scopus 로고
    • Phenomena of double peaks in the tetrandrine concentration time curves
    • D.S. Meng, and Y.M. Hu Phenomena of double peaks in the tetrandrine concentration time curves Chin. J. Clin. Pharm. 8 1999 303 305
    • (1999) Chin. J. Clin. Pharm. , vol.8 , pp. 303-305
    • Meng, D.S.1    Hu, Y.M.2
  • 46
    • 0023425558 scopus 로고
    • The influence of variable gastric emptying and intestinal transit rates on the plasma level curve of cimetidine: An explanation for the double peak phenomenon
    • R.L. Oberle, and G.L. Amidon The influence of variable gastric emptying and intestinal transit rates on the plasma level curve of cimetidine: an explanation for the double peak phenomenon J. Pharm. Biopharm. 15 1987 529 544
    • (1987) J. Pharm. Biopharm. , vol.15 , pp. 529-544
    • Oberle, R.L.1    Amidon, G.L.2
  • 47
    • 0035940059 scopus 로고    scopus 로고
    • Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics
    • DOI 10.1016/S0169-409X(01)00152-1, PII S0169409X01001521
    • N. Hussain, V. Jaitley, and A.T. Florence Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics Adv. Drug Deliv. Rev. 50 2001 107 142 (Pubitemid 32727279)
    • (2001) Advanced Drug Delivery Reviews , vol.50 , Issue.1-2 , pp. 107-142
    • Hussain, N.1    Jaitley, V.2    Florence, A.T.3
  • 48
    • 34250308874 scopus 로고    scopus 로고
    • Studies on oral absorption of stearic acid SLN by a novel fluorometric method
    • DOI 10.1016/j.colsurfb.2007.03.002, PII S0927776507001166
    • H. Yuan, J. Chen, Y.Z. Du, F.Q. Hu, S. Zeng, and H.L. Zhao Studies on oral absorption of stearic acid SLN by a novel fluorometric method Colloids Surf. B Biointerfaces 58 2007 157 164 (Pubitemid 46921452)
    • (2007) Colloids and Surfaces B: Biointerfaces , vol.58 , Issue.2 , pp. 157-164
    • Yuan, H.1    Chen, J.2    Du, Y.-Z.3    Hu, F.-Q.4    Zeng, S.5    Zhao, H.-L.6
  • 49
    • 24944496710 scopus 로고    scopus 로고
    • Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration
    • DOI 10.1016/j.jconrel.2005.06.006, PII S0168365905002701
    • K. Manjunath, and V. Venkateswarlu Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration J. Control. Release 107 2005 215 228 (Pubitemid 41319672)
    • (2005) Journal of Controlled Release , vol.107 , Issue.2 , pp. 215-228
    • Manjunath, K.1    Venkateswarlu, V.2
  • 51
    • 33344479101 scopus 로고    scopus 로고
    • Gastro-intestinal patch system for the delivery of erythropoietin
    • DOI 10.1016/j.jconrel.2005.11.009, PII S0168365905006504
    • N. Venkatesan, K. Uchino, K. Amagase, Y. Ito, N. Shibata, and K. Takada Gastrointestinal patch system for the delivery of erythropoietin J. Control. Release 111 2006 19 26 (Pubitemid 43289990)
    • (2006) Journal of Controlled Release , vol.111 , Issue.1-2 , pp. 19-26
    • Venkatesan, N.1    Uchino, K.2    Amagase, K.3    Ito, Y.4    Shibata, N.5    Takada, K.6
  • 52
    • 7444255422 scopus 로고    scopus 로고
    • Altered chemical and biological activities of all-trans retinoic acid incorporated in solid lipid nanoparticle powders
    • S.J. Lim, M.K. Lee, and C.K. Kim Altered chemical and biological activities of all-trans retinoic acid incorporated in solid lipid nanoparticle powders J. Control. Release 100 2004 53 61
    • (2004) J. Control. Release , vol.100 , pp. 53-61
    • Lim, S.J.1    Lee, M.K.2    Kim, C.K.3
  • 53
    • 39149108776 scopus 로고    scopus 로고
    • Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update
    • N.L. Trevaskis, W.N. Charman, and C.J.H. Porter Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update Adv. Drug Deliv. Rev. 60 2008 702 716
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 702-716
    • Trevaskis, N.L.1    Charman, W.N.2    Porter, C.J.H.3
  • 54
    • 0037436923 scopus 로고    scopus 로고
    • Bioadhesive microspheres as a controlled drug delivery system
    • DOI 10.1016/S0378-5173(03)00087-5
    • J.K. Vasir, K. Tambwekar, and S. Garg Bioadhesive microspheres as a controlled drug delivery system Int. J. Pharm. 255 2003 13 32 (Pubitemid 36369587)
    • (2003) International Journal of Pharmaceutics , vol.255 , Issue.1-2 , pp. 13-32
    • Vasir, J.K.1    Tambwekar, K.2    Garg, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.