CCR7 directs the recruitment of T cells into inflamed pancreatic islets of nonobese diabetic (NOD) mice

Immunologic Research

Volumn 58, Issue 2-3, 2014, Pages 351-357

  Shan, Zhongyan ^a,b   Xu, Baohui ^a   Mikulowska Menni, Anna ^a   Michie, Sara A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Cell trafficking; Chemokines; Diabetes; Endothelial cells; T lymphocytes

Indexed keywords

CHEMOKINE RECEPTOR CCR7; INSULIN; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MESSENGER RNA; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; SECONDARY LYMPHOID TISSUE CHEMOKINE; CELL ADHESION MOLECULE; L-SELECTIN COUNTER-RECEPTORS; MADCAM1 PROTEIN, MOUSE; MEMBRANE ANTIGEN; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL DESTRUCTION; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; IMMUNOHISTOLOGY; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; LASER CAPTURE MICRODISSECTION; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; T LYMPHOCYTE; VENULE; ANIMAL; CELL MOTION; DISEASE MODEL; GENE EXPRESSION; GENETICS; IMMUNOLOGY; METABOLISM; PANCREAS ISLET; PANCREATITIS; PATHOLOGY;

ANIMALS; ANTIGENS, SURFACE; CELL ADHESION MOLECULES; CELL MOVEMENT; CHEMOKINE CCL19; CHEMOKINE CCL21; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; ISLETS OF LANGERHANS; MEMBRANE PROTEINS; MICE; MICE, INBRED NOD; PANCREATITIS; RECEPTORS, CCR7; T-LYMPHOCYTES;

EID: 84901587931     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-014-8500-9     Document Type: Review

References (38)

1. Gowans J, Knight E. The route of recirculation of lymphocytes in the rat. Proc R Soc Lond Ser B. 1964;159:257-82.
2. Neyt K, Perros F, GeurtsvanKessel CH, Hammad H, Lambrecht BN. Tertiary lymphoid organs in infection and autoimmunity. Trends Immunol. 2012;33:297-305.
3. Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell. 1991;67:1033-6. (Pubitemid 121001517)
4. Okada T, Ngo VN, Ekland EH, Forster R, Lipp M, Littman DR, Cyster JG. Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J Exp Med. 2002;196:65-75. (Pubitemid 34747312)
5. Stein JV, Rot A, Luo Y, Narasimhaswamy M, Nakano H, Gunn MD, Matsuzawa A, Quackenbush EJ, Dorf ME, von Andrian UH. The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, Exodus-2) triggers lymphocyte function-associated antigen-1 arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules. J Exp Med. 2000;191:61-75. (Pubitemid 30043648)
6. Warnock RA, Campbell JJ, Dorf ME, Matsuzawa A, McEvoy LM, Butcher EC. The role of chemokines in the microenvironmental control of T versus B cell arrest in Peyer's patch high endothelial venules. J Exp Med. 2000;191:77-88. (Pubitemid 30043649)
7. Faveeuw C, Gagnerault MC, Lepault F. Expression of homing and adhesion molecules in infiltrated islets of Langerhans and salivary glands of nonobese diabetic mice. J Immunol. 1994;152:5969-78. (Pubitemid 24174179)
8. Hanninen A, Taylor C, Streeter PR, Stark LS, Sarte JM, Shizuru JA, Simell O, Michie SA. Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium. J Clin Invest. 1993;92:2509-15. (Pubitemid 23333561)
9. Warnock RA, Askari S, Butcher EC, von Andrian UH. Molecular mechanisms of lymphocyte homing to peripheral lymph nodes. J Exp Med. 1998;187:205-16. (Pubitemid 28060436)
10. Hanninen A, Jaakkola I, Jalkanen S. Mucosal addressin is required for the development of diabetes in nonobese diabetic mice. J Immunol. 1998;160:6018-25. (Pubitemid 28298064)
11. Yang XD, Sytwu HK, McDevitt HO, Michie SA. Involvement of beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the development of diabetes in obese diabetic mice. Diabetes. 1997;46:1542-7. (Pubitemid 27411227)
12. Bouma G, Coppens JM, Mourits S, Nikolic T, Sozzani S, Drexhage HA, Versnel MA. Evidence for an enhanced adhesion of DC to fibronectin and a role of CCL19 and CCL21 in the accumulation of DC around the pre-diabetic islets in NOD mice. Eur J Immunol. 2005;35:2386-96. (Pubitemid 41179759)
13. Hjelmstrom P, Fjell J, Nakagawa T, Sacca R, Cuff CA, Ruddle NH. Lymphoid tissue homing chemokines are expressed in chronic inflammation. Am J Pathol. 2000;156:1133-8. (Pubitemid 30659989)
14. Martin AP, Grisotto MG, Canasto-Chibuque C, Kunkel SL, Bromberg JS, Furtado GC, Lira SA. Islet expression of M3 uncovers a key role for chemokines in the development and recruitment of diabetogenic cells in NOD mice. Diabetes. 2008;57:387-94.
15. Mikulowska-Mennis A, Taylor TB, Vishnu P, Michie SA, Raja R, Horner N, Kunitake ST. High-quality RNA from cells isolated by laser capture microdissection. Biotechniques. 2002;33:176-9. (Pubitemid 34791135)
16. Xu B, Wagner N, Pham L, Magno V, Shan Z, Butcher EC, Michie SA. Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) involves L-selectin/PNAd, a4b1 integrin/VCAM-1 and LFA-1 adhesion pathways. J Exp Med. 2003;197:1255-67. (Pubitemid 36617772)
17. Luther SA, Bidgol A, Hargreaves DC, Schmidt A, Xu Y, Paniyadi J, Matloubian M, Cyster JG. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol. 2002;169:424-33. (Pubitemid 34686164)
18. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999;401:708-12.
19. Chen SC, Vassileva G, Kinsley D, Holzmann S, Manfra D, Wiekowski MT, Romani N, Lira SA. Ectopic expression of the murine chemokines CCL21a and CCL21b induces the formation of lymph node-like structures in pancreas, but not skin, of transgenic mice. J Immunol. 2002;168:1001-8. (Pubitemid 34094462)
20. Fan L, Reilly CR, Luo Y, Dorf ME, Lo D. Cutting edge: ectopic expression of the chemokine TCA4/SLC is sufficient to trigger lymphoid neogenesis. J Immunol. 2000;164:3955-9. (Pubitemid 30215047)
21. Martin AP, Coronel EC, Sano G, Chen SC, Vassileva G, Canasto- Chibuque C, Sedgwick JD, Frenette PS, Lipp M, Furtado GC, Lira SA. A novel model for lymphocytic infiltration of the thyroid gland generated by transgenic expression of the CC chemokine CCL21. J Immunol. 2004;173:4791-8. (Pubitemid 39387758)
22. Weninger W, Carlsen HS, Goodarzi M, Moazed F, Crowley MA, Baekkevold ES, Cavanagh LL, von Andrian UH. Naive T cell recruitment to nonlymphoid tissues: a role for endothelium-expressed CC chemokine ligand 21 in autoimmune disease and lymphoid neogenesis. J Immunol. 2003;170:4638-48. (Pubitemid 36519970)
23. Alt C, Laschinger M, Engelhardt B. Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis. Eur J Immunol. 2002;32:2133-44. (Pubitemid 34965876)
24. Debes GF, Hopken UE, Hamann A. In vivo differentiated cytokine-producing CD4(+) T cells express functional CCR7. J Immunol. 2002;168:5441-7. (Pubitemid 34556121)
25. Herold KC, Vignali DA, Cooke A, Bluestone JA. Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol. 2013;13:243-56.
26. Drayton DL, Ying X, Lee J, Lesslauer W, Ruddle NH. Ectopic LT alpha beta directs lymphoid organ neogenesis with concomitant expression of peripheral node addressin and a HEV-restricted sulfotransferase. J Exp Med. 2003;197:1153-63. (Pubitemid 36570070)
27. Qu P, Ji RC, Kato S. Expression of CCL21 and 5′-Nase on pancreatic lymphatics in nonobese diabetic mice. Pancreas. 2005;31:148-55. (Pubitemid 41077144)
28. Dailey MO, Fathman CG, Butcher EC, Pillemer E, Weissman I. Abnormal migration of T lymphocyte clones. J Immunol. 1982;128:2134-6. (Pubitemid 12086498)
29. Savinov AY, Wong FS, Stonebraker AC, Chervonsky AV. Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8 + T cells. J Exp Med. 2003;197:643-56. (Pubitemid 36314659)
30. Ettinger R, Munson SH, Chao CC, Vadeboncoeur M, Toma J, McDevitt HO. A critical role for lymphotoxin-beta receptor in the development of diabetes in nonobese diabetic mice. J Exp Med. 2001;193:1333-40.
31. Wu Q, Salomon B, Chen M, Wang Y, Hoffman LM, Bluestone JA, Fu YX. Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor. J Exp Med. 2001;193:1327-32. (Pubitemid 32524783)
32. Ploix C, Lo D, Carson MJ. A ligand for the chemokine receptor CCR7 can influence the homeostatic proliferation of CD4 T cells and progression of autoimmunity. J Immunol. 2001;167:6724-30. (Pubitemid 33144161)
33. Carvalho-Pinto C, Garcia MI, Gomez L, Ballesteros A, Zaballos A, Flores JM, Mellado M, Rodriguez-Frade JM, Balomenos D, Martinez AC. Leukocyte attraction through the CCR5 receptor controls progress from insulitis to diabetes in non-obese diabetic mice. Eur J Immunol. 2004;34:548-57. (Pubitemid 39272795)
34. Frigerio S, Junt T, Lu B, Gerard C, Zumsteg U, Hollander GA, Piali L. Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nat Med. 2002;8:1414-20. (Pubitemid 36024137)
35. Kim SH, Cleary MM, Fox HS, Chantry D, Sarvetnick N. CCR4-bearing T cells participate in autoimmune diabetes. J Clin Invest. 2002;110:1675-86. (Pubitemid 35424246)
36. Forster R, Schubel A, Breitfeld D, Kremmer E, Renner-Muller I, Wolf E, Lipp M. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell. 1999;99:23-33. (Pubitemid 29468627)
37. Martin AP, Marinkovic T, Canasto-Chibuque C, Latif R, Unkeless JC, Davies TF, Takahama Y, Furtado GC, Lira SA. CCR7 deficiency in NOD mice leads to thyroiditis and primary hypothyroidism. J Immunol. 2009;183:3073-80.
38. Turley S, Poirot L, Hattori M, Benoist C, Mathis D. Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med. 2003;198: 1527-37. (Pubitemid 37467167)