메뉴 건너뛰기




Volumn 26, Issue 6, 2014, Pages 341-352

The open conformation of WASP regulates its nuclear localization and gene transcription in myeloid cells

Author keywords

RNA polymerase II; Wiskott Aldrich syndrome protein; X linked neutropenia

Indexed keywords

F ACTIN; GENOMIC DNA; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; PROTEIN TYROSINE PHOSPHATASE RECEPTOR C; RNA POLYMERASE II; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG; ACTIN; NONO PROTEIN, HUMAN; NUCLEAR MATRIX PROTEIN; OCTAMER TRANSCRIPTION FACTOR; PROTEIN BINDING; RNA BINDING PROTEIN; WISKOTT ALDRICH SYNDROME PROTEIN;

EID: 84901505549     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxt072     Document Type: Article
Times cited : (13)

References (37)
  • 1
    • 0001102239 scopus 로고
    • Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea
    • Aldrich, R. A., Steinberg, A. G. and Campbell, D. C. 1954. Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea. Pediatrics 13:133.
    • (1954) Pediatrics , vol.13 , pp. 133
    • Aldrich, R.A.1    Steinberg, A.G.2    Campbell, D.C.3
  • 2
    • 0027937223 scopus 로고
    • Isolation of a novel gene mutated in Wiskott-Aldrich syndrome
    • Derry, J. M., Ochs, H. D. and Francke, U. 1994. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Cell 78:635.
    • (1994) Cell , vol.78 , pp. 635
    • Derry, J.M.1    Ochs, H.D.2    Francke, U.3
  • 4
    • 33749343053 scopus 로고    scopus 로고
    • Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia
    • Ancliff, P. J., Blundell, M. P., Cory, G. O. et al. 2006. Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia. Blood 108:2182.
    • (2006) Blood , vol.108 , pp. 2182
    • Ancliff, P.J.1    Blundell, M.P.2    Cory, G.O.3
  • 5
    • 0035093787 scopus 로고    scopus 로고
    • Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia
    • Devriendt, K., Kim, A. S., Mathijs, G. et al. 2001. Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia. Nat. Genet. 27:313.
    • (2001) Nat. Genet. , vol.27 , pp. 313
    • Devriendt, K.1    Kim, A.S.2    Mathijs, G.3
  • 6
    • 77649153819 scopus 로고    scopus 로고
    • WASP: a key immunological multitasker
    • Thrasher, A. J. and Burns, S. O. 2010. WASP: a key immunological multitasker. Nat. Rev. Immunol. 10:182.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 182
    • Thrasher, A.J.1    Burns, S.O.2
  • 7
    • 0242558357 scopus 로고    scopus 로고
    • The verprolin-like central (vc) region of Wiskott-Aldrich syndrome protein induces Arp2/3 complexdependent actin nucleation
    • Hüfner, K., Higgs, H. N., Pollard, T. D., Jacobi, C., Aepfelbacher, M. and Linder, S. 2001. The verprolin-like central (vc) region of Wiskott-Aldrich syndrome protein induces Arp2/3 complexdependent actin nucleation. J. Biol. Chem. 276:35761.
    • (2001) J. Biol. Chem. , vol.276 , pp. 35761
    • Hüfner, K.1    Higgs, H.N.2    Pollard, T.D.3    Jacobi, C.4    Aepfelbacher, M.5    Linder, S.6
  • 8
    • 0033576288 scopus 로고    scopus 로고
    • Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization
    • Higgs, H. N., Blanchoin, L. and Pollard, T. D. 1999. Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization. Biochemistry 38:15212.
    • (1999) Biochemistry , vol.38 , pp. 15212
    • Higgs, H.N.1    Blanchoin, L.2    Pollard, T.D.3
  • 9
    • 9444221962 scopus 로고    scopus 로고
    • Mechanisms of WASp-mediated hematologic and immunologic disease
    • Burns, S., Cory, G. O., Vainchenker, W. and Thrasher, A. J. 2004. Mechanisms of WASp-mediated hematologic and immunologic disease. Blood 104:3454.
    • (2004) Blood , vol.104 , pp. 3454
    • Burns, S.1    Cory, G.O.2    Vainchenker, W.3    Thrasher, A.J.4
  • 10
    • 39649094147 scopus 로고    scopus 로고
    • Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells
    • Bouma, G., Burns, S. and Thrasher, A. J. 2007. Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells. Blood 110:4278.
    • (2007) Blood , vol.110 , pp. 4278
    • Bouma, G.1    Burns, S.2    Thrasher, A.J.3
  • 12
    • 0030816363 scopus 로고    scopus 로고
    • Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulation
    • Gallego, M. D., Santamaría, M., Peña, J. and Molina, I. J. 1997. Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulation. Blood 90:3089.
    • (1997) Blood , vol.90 , pp. 3089
    • Gallego, M.D.1    Santamaría, M.2    Peña, J.3    Molina, I.J.4
  • 13
    • 0032118427 scopus 로고    scopus 로고
    • Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation
    • Snapper, S. B., Rosen, F. S., Mizoguchi, E. et al. 1998. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity 9:81.
    • (1998) Immunity , vol.9 , pp. 81
    • Snapper, S.B.1    Rosen, F.S.2    Mizoguchi, E.3
  • 14
    • 0033230229 scopus 로고    scopus 로고
    • Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes
    • Zhang, J., Shehabeldin, A., da Cruz, L. A. et al. 1999. Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J. Exp. Med. 190:1329.
    • (1999) J. Exp. Med. , vol.190 , pp. 1329
    • Zhang, J.1    Shehabeldin, A.2    da Cruz, L.A.3
  • 15
    • 0034192223 scopus 로고    scopus 로고
    • Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis
    • Lorenzi, R., Brickell, P. M., Katz, D. R., Kinnon, C. and Thrasher, A. J. 2000. Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis. Blood 95:2943.
    • (2000) Blood , vol.95 , pp. 2943
    • Lorenzi, R.1    Brickell, P.M.2    Katz, D.R.3    Kinnon, C.4    Thrasher, A.J.5
  • 16
    • 77953497134 scopus 로고    scopus 로고
    • Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes
    • Westerberg, L. S., Meelu, P., Baptista, M. et al. 2010. Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes. J. Exp. Med. 207:1145.
    • (2010) J. Exp. Med. , vol.207 , pp. 1145
    • Westerberg, L.S.1    Meelu, P.2    Baptista, M.3
  • 17
    • 0034624753 scopus 로고    scopus 로고
    • Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein
    • Kim, A. S., Kakalis, L. T., Abdul-Manan, N., Liu, G. A. and Rosen, M. K. 2000. Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature 404:151.
    • (2000) Nature , vol.404 , pp. 151
    • Kim, A.S.1    Kakalis, L.T.2    Abdul-Manan, N.3    Liu, G.A.4    Rosen, M.K.5
  • 18
    • 0347915637 scopus 로고    scopus 로고
    • Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation
    • Badour, K., Zhang, J., Shi, F., Leng, Y., Collins, M. and Siminovitch, K. A. 2004. Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation. J. Exp. Med. 199:99.
    • (2004) J. Exp. Med. , vol.199 , pp. 99
    • Badour, K.1    Zhang, J.2    Shi, F.3    Leng, Y.4    Collins, M.5    Siminovitch, K.A.6
  • 19
    • 0038392871 scopus 로고    scopus 로고
    • Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP
    • Torres, E. and Rosen, M. K. 2003. Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP. Mol. Cell 11:1215.
    • (2003) Mol. Cell , vol.11 , pp. 1215
    • Torres, E.1    Rosen, M.K.2
  • 20
    • 33645643086 scopus 로고    scopus 로고
    • Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP
    • Torres, E. and Rosen, M. K. 2006. Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP. J. Biol. Chem. 281:3513.
    • (2006) J. Biol. Chem. , vol.281 , pp. 3513
    • Torres, E.1    Rosen, M.K.2
  • 21
    • 1542304700 scopus 로고    scopus 로고
    • Focal adhesion kinase regulation of N-WASP subcellular localization and function
    • Wu, X., Suetsugu, S., Cooper, L. A., Takenawa, T. and Guan, J. L. 2004. Focal adhesion kinase regulation of N-WASP subcellular localization and function. J. Biol. Chem. 279:9565.
    • (2004) J. Biol. Chem. , vol.279 , pp. 9565
    • Wu, X.1    Suetsugu, S.2    Cooper, L.A.3    Takenawa, T.4    Guan, J.L.5
  • 22
    • 0034282711 scopus 로고    scopus 로고
    • Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold
    • Westphal, R. S., Soderling, S. H., Alto, N. M., Langeberg, L. K. and Scott, J. D. 2000. Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. EMBO J. 19:4589.
    • (2000) EMBO J. , vol.19 , pp. 4589
    • Westphal, R.S.1    Soderling, S.H.2    Alto, N.M.3    Langeberg, L.K.4    Scott, J.D.5
  • 23
    • 0029815611 scopus 로고    scopus 로고
    • N-WASP, a novel actindepolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases
    • Miki, H., Miura, K. and Takenawa, T. 1996. N-WASP, a novel actindepolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. EMBO J. 15:5326.
    • (1996) EMBO J. , vol.15 , pp. 5326
    • Miki, H.1    Miura, K.2    Takenawa, T.3
  • 24
    • 33745762947 scopus 로고    scopus 로고
    • Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners
    • Wu, X., Yoo, Y., Okuhama, N. N., Tucker, P. W., Liu, G. and Guan, J. L. 2006. Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners. Nat. Cell Biol. 8:756.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 756
    • Wu, X.1    Yoo, Y.2    Okuhama, N.N.3    Tucker, P.W.4    Liu, G.5    Guan, J.L.6
  • 25
    • 77955600265 scopus 로고    scopus 로고
    • Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome
    • Taylor, M. D., Sadhukhan, S., Kottangada, P. et al. 2010. Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome. Sci. Transl. Med. 2:37ra44.
    • (2010) Sci. Transl. Med. , vol.2
    • Taylor, M.D.1    Sadhukhan, S.2    Kottangada, P.3
  • 26
    • 0142211212 scopus 로고    scopus 로고
    • Translocation of N-WASP by nuclear localization and export signals into the nucleus modulates expression of HSP90
    • Suetsugu, S. and Takenawa, T. 2003. Translocation of N-WASP by nuclear localization and export signals into the nucleus modulates expression of HSP90. J. Biol. Chem. 278:42515.
    • (2003) J. Biol. Chem. , vol.278 , pp. 42515
    • Suetsugu, S.1    Takenawa, T.2
  • 27
    • 9944222181 scopus 로고    scopus 로고
    • WAVE1 intranuclear trafficking is essential for genomic and cytoskeletal dynamics during fertilization: cell-cycle-dependent shuttling between M-phase and interphase nuclei
    • Rawe, V. Y., Payne, C., Navara, C. and Schatten, G. 2004. WAVE1 intranuclear trafficking is essential for genomic and cytoskeletal dynamics during fertilization: cell-cycle-dependent shuttling between M-phase and interphase nuclei. Dev. Biol. 276:253.
    • (2004) Dev. Biol. , vol.276 , pp. 253
    • Rawe, V.Y.1    Payne, C.2    Navara, C.3    Schatten, G.4
  • 28
    • 0029984570 scopus 로고    scopus 로고
    • Nucleocytoplasmic transport
    • Görlich, D. and Mattaj, I. W. 1996. Nucleocytoplasmic transport. Science 271:1513.
    • (1996) Science , vol.271 , pp. 1513
    • Görlich, D.1    Mattaj, I.W.2
  • 29
    • 0037160142 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation
    • Cory, G. O., Garg, R., Cramer, R., and Ridley, A. J. 2002. Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. J. Biol. Chem. 277:45115.
    • (2002) J. Biol. Chem. , vol.277 , pp. 45115
    • Cory, G.O.1    Garg, R.2    Cramer, R.3    Ridley, A.J.4
  • 30
    • 77956163491 scopus 로고    scopus 로고
    • Regulation of WASp by phosphorylation: activation or other functions? Commun
    • Dovas, A. and Cox, D. 2010. Regulation of WASp by phosphorylation: activation or other functions? Commun. Integr. Biol. 3:101.
    • (2010) Integr. Biol. , vol.3 , pp. 101
    • Dovas, A.1    Cox, D.2
  • 31
    • 0034795423 scopus 로고    scopus 로고
    • N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility
    • Snapper, S. B., Takeshima, F., Antón, I. et al. 2001. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat. Cell Biol. 3:897.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 897
    • Snapper, S.B.1    Takeshima, F.2    Antón, I.3
  • 32
    • 0037032415 scopus 로고    scopus 로고
    • PSF and p54(nrb)/NonO-multifunctional nuclear proteins
    • Shav-Tal, Y. and Zipori, D. 2002. PSF and p54(nrb)/NonO-multifunctional nuclear proteins. FEBS Lett. 531:109.
    • (2002) FEBS Lett. , vol.531 , pp. 109
    • Shav-Tal, Y.1    Zipori, D.2
  • 33
    • 2442435550 scopus 로고    scopus 로고
    • p54(nrb) associates with the 5' splice site within large transcription/splicing complexes
    • Kameoka, S., Duque, P. and Konarska, M. M. 2004. p54(nrb) associates with the 5' splice site within large transcription/splicing complexes. EMBO J. 23:1782.
    • (2004) EMBO J. , vol.23 , pp. 1782
    • Kameoka, S.1    Duque, P.2    Konarska, M.M.3
  • 34
    • 0031780282 scopus 로고    scopus 로고
    • Follicular large cell lymphoma with immunoblastic features in a child with Wiskott-Aldrich syndrome: an unusual immunodeficiency-related neoplasm not associated with Epstein-Barr virus
    • Kroft, S. H., Finn, W. G., Singleton, T. P., Ross, C. W., Sheldon, S. and Schnitzer, B. 1998. Follicular large cell lymphoma with immunoblastic features in a child with Wiskott-Aldrich syndrome: an unusual immunodeficiency-related neoplasm not associated with Epstein-Barr virus. Am. J. Clin. Pathol. 110:95.
    • (1998) Am. J. Clin. Pathol. , vol.110 , pp. 95
    • Kroft, S.H.1    Finn, W.G.2    Singleton, T.P.3    Ross, C.W.4    Sheldon, S.5    Schnitzer, B.6
  • 35
    • 1842857595 scopus 로고    scopus 로고
    • Development of diffuse large cell lymphoma from follicular lymphoma with multiple immunoglobulin heavy chain gene rearrangement occurring in a patient with Wiskott-Aldrich syndrome
    • Kawakami, K., Yamaguchi, M., Watanabe, Y. and Murata, T. 2002. Development of diffuse large cell lymphoma from follicular lymphoma with multiple immunoglobulin heavy chain gene rearrangement occurring in a patient with Wiskott-Aldrich syndrome. Int. J. Hematol. 76:196.
    • (2002) Int. J. Hematol. , vol.76 , pp. 196
    • Kawakami, K.1    Yamaguchi, M.2    Watanabe, Y.3    Murata, T.4
  • 36
    • 79955021525 scopus 로고    scopus 로고
    • Hodgkin's and non-Hodgkin's lymphomas occurring in two brothers with Wiskott-Aldrich syndrome and review of the literature
    • Du, S., Scuderi, R., Malicki, D. M., Willert, J., Bastian, J. and Weidner, N. 2011. Hodgkin's and non-Hodgkin's lymphomas occurring in two brothers with Wiskott-Aldrich syndrome and review of the literature. Pediatr. Dev. Pathol. 14:64.
    • (2011) Pediatr. Dev. Pathol. , vol.14 , pp. 64
    • Du, S.1    Scuderi, R.2    Malicki, D.M.3    Willert, J.4    Bastian, J.5    Weidner, N.6
  • 37
    • 34548447079 scopus 로고    scopus 로고
    • Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia
    • Moulding, D. A., Blundell, M. P., Spiller, D. G. et al. 2007. Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia. J. Exp. Med. 204:2213.
    • (2007) J. Exp. Med. , vol.204 , pp. 2213
    • Moulding, D.A.1    Blundell, M.P.2    Spiller, D.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.