Regulation of WASp by phosphorylation activation or other functions?

Communicative and Integrative Biology

Volumn 3, Issue 2, 2010, Pages 101-105

  Dovas, Athanassios ^a   Cox, Dianne ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Actin polymerisation; Activation; Localisation; Phosphorylation; Protein degradation; Wiskott aldrich syndrome protein

Indexed keywords

EID: 77956163491     PISSN: None     EISSN: 19420889     Source Type: Journal    
DOI: 10.4161/cib.3.2.10759     Document Type: Review

References (43)

1. Takenawa T, Suetsugu S. The WASP-WAVE protein network: connecting the membrane to the cytoskel-eton. Nat Rev Mol Cell Biol 2007; 8:37-48.
2. Kurisu S, Takenawa T. The WASP and WAVE family proteins. Genome Biol 2009; 10:226.
3. Pollitt A, Insall RH. WASP and SCAR/WAVE pro-teins: the drivers of actin assembly. J Cell Sci 2009; 122:2575-8.
4. Symons M, Derry JMJ, Karlak B, Jiang S, Lemahieu V, McCormick F, et al. Wiskott-Ald rich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell 1996; 84:723-34.
5. Aspenström P, Lindberg U, Hall A. Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Ald rich syndrome. Curr Biol 1996; 6:70-5.
6. Higgs HN, Pollard TD. Activation by Cdc42 and PIP2 of Wiskott-Aldrich Syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex. J Cell Biol 2000; 150:1311-20.
7. Rohatgi R, Ho HY, Kirschner MW. Mechanism of N-WASP activation by CDC42 and phosphati-dylinositol 4,5-bisphosphate. J Cell Biol 2000; 150:1299-310.
8. Cammer M, Gevrey J-C, Lorenz M, Dovas A, Condeelis J, Cox D. The mechanism of CSF-1 induced wasp activation in vivo: A role for PI3-kinase and CDC42. J Biol Chem 2009; 284:23302-11.
9. Cannon JL, Labno CM, Bosco G, Seth A, McGavin MHK, Siminovitch KA, et al. WASP recruitment to the T cell:APC contact site pccurs independently of Cdc42 activation. Immunity 2001; 15:249-59.
10. Mao YS, Yamaga M, Zhu X, Wei Y, Sun H-Q, Wang J, et al. Essential and unique roles of PIP5K-γ and -α in Fcγ receptor-mediated phagocytosis. J Cell Biol 2009; 184:281-96.
11. Padrick SB, Cheng HC, Ismail AM, Panchal SC, Doolittle LK, Kim S, et al. Hierarcical regulation of WASP/WAVE proteins. Mol Cell 2008; 32:426-38.
12. Rivera GM, Briceño CA, Takeshima F, Snapper SB, Mayer BJ. Inducible clustering of membrane-tageted SH3 domains of the adaptor protein Nck triggers localized actin polymerization. Curr Biol 2004; 14:11-22.
13. Cheng H-C, Skehan BM, Campellone KG, Leong JM, Rosen MK. Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF. Nature 2008; 454:1009-14.
14. Campellone KG, Cheng H-C, Robbins D, Siripala AD, McGhie EJ, Hayward RD, et al. Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF synergistically activate actin assembly. PLoS Pathog 2008; 4:10000191.
15. Sallee NA, Rivera GM, Dueber JE, Vasilescu D, Mullins RD, Mayer BJ, Lim WA. The pathogen protein EspF hijacks actin polymerization using mimicry and multivalency. Nature 2008; 454:1005-8.
16. Cory GOC, Cramer R, Blancholn L, Ridley AJ. Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP. Mol Cell 2003; 11:1229-39.
17. Yokoyama N, Lougheed J, Miller WT. Phosphorylation of WASP by the Cdc42-associated Kinase ACK1. DUAL HYDROXYAMINO ACID SPECIFICITY IN A TYROSINE KINASE. J Biol Chem 2005; 280:42219-26.
18. Baba Y, Nonoyama S, Matsushita M, Yamadori T, Hashimoto S, Imai K, et al. Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway. Blood 1999; 93:2003-12.
19. Burton EA, Oliver TN, Pendergast AM. Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway. Mol Cell Biol 2005; 25:8834-43.
20. Torres E, Rosen MK. Contingent phosphorylation/ dephosphorylation provides a mechanism of molecular memory in WASP. Mol Cell 2003; 11:1215-27.
21. Torres E, Rosen MK. Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich Syndrome Protein (WASP)/ Neuronal WASP. J Biol Chem 2006; 281:3513-20
22. Badour K, Zhang J, Shi F, Leng Y, Collins M, Siminovitch KA. Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich Syndrome Protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation. J Exp Med 2004; 199:99-111.
23. Park H, Cox D. Cdc42 Regulates Fc( receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich Syndrome Protein (WASP) and Neural-WASP. Mol Biol Cell 2009; 20:4500-8.
24. Caron E. Regulation by phopshorylation: yet another twist in the WASP story. Dev Cell 2003; 4:772-3.
25. Devriendt K, Kim AS, Mathijs G, Frints SGM, Schwartz M, Van den Oord JJ, et al. Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia. Nat Gen 2001; 27:313-7.
26. Ancliff PJ, Blundell MP, Cory GO, Calle Y, Worth A, Kempski H, et al. Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia. Blood 2006; 108:2182-9.
27. Cory GOC, Garg R, Cramer R, Ridley AJ. Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. J Biol Chem 2002; 277:45115-21.
28. Suetsugu S, Hattori M, Miki H, Tezuka T, Yamamoto T, Mikoshiba K, Takenawa T. Sustained activation of N-WASP through phosphorylation is essential for neurite extension. Dev Cell 2002; 3:645-58.
29. Dovas A, Gevrey J-C, Grossi A, Park H, Abou-Kheir W, Cox D. Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages. J Cell Sci 2009; 122:3873-82.
30. Peterson JR, Bickford LC, Morgan D, Kim AS, Ouerfelli O, Kirschner MW, Rosen MK. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat Struct Mol Biol 2004; 11:747-55.
31. Adamovich DA, Nakamura F, Worth A, Burns S, Thrasher AJ, Hartwig JH, Snapper SB. Activating mutations of N-WASP alter Shigella pathogenesis. Biochem Biophys Res Commun 2009; 384:284-9.
32. Tsuboi S, Meerloo J. Wiskott-Aldrich Syndrome protein is a key regulator of the phagocytic cup formation in macrophages. J Biol Chem 2007; 282:34194-203.
33. Blundell MP, Bouma G, Metelo J, Worth A, Calle Y, Cowell LA, et al. Phosphorylation of WASP is a key regulator of activity and stability in vivo. Proc Natl Acad Sci USA 2009; 106:15738-43.
34. Lutskiy MI, Shcherbina A, Bachli ET, Cooley J, Remold-O'Donnell E. WASP localizes to the membrane skeleton of platelets. Br J Haematol 2007; 139:98-105.
35. Shcherbina A, Miki H, Kenney DM, Rosen FS, Takenawa T, Remold-O'Donnell E. WASP and N-WASP in human platelets differ in sensitivity to protease calpain. Blood 2001; 98:2988-91.
36. Wu X, Suetsugu S, Cooper LA, Takenawa T, Guan JL. Focal adhesion kinase regulation of N-WASP subcellular localization and function. J Biol Chem 2004; 279:9565-76.
37. Oda A, Ochs H, Druker BJ, Ozaki K, Watanabe C, Handa M, et al. Collagen induces tyrosine phosphorylation of Wiskott-Aldrych Syndrome protein in human platelets. Blood 1998; 92:1852-8.
38. Gismondi A, Cifaldi L, Mazza C, Giliani S, Parolini S, Morrone S, et al. Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect. Blood 2004; 104:436-43.
39. Guinamard R, Aspenström P, Fougereau M, Chavrier P, Guillemot J-C. Tyrosine phosphorylation of the Wiskott-Aldrich Syndrome protein by Lyn and Btk is regulated by CDC42. FEBS Lett 1998; 434:431-6.
40. Soriani A, Moran B, De Virgilio M, Kawakami T, Altman A, Lowell C, et al. A role for PKC( in outside-in (IIb(3 signaling. J Thromb Hemost 2006; 4:648-55.
41. Oda A, Ochs H, Lasky LA, Spencer S, Ozaki K, Fujihara M, et al. CrkL is an adapter for Wiskott-Aldrich syndrome protein. Blood 2001; 97:2633-9.
42. Gross BS, Wilde JI, Quek L, Chapel H, Nelson DL, WatfcrT SP Regulation and Function of WASp in Platelets by the Collagen Receptor, Glycoprotein VI. Blood 1999; 94:4166-76.
43. Chellaiah MA, Kuppuswamy D, Lasky L, Linder S. Phosphorylation of a Wiscott-Aldrich Syndrome Protein-associated signal complex is critical in osteoclast bone resorption. J Biol Chem 2007; 282:10104-16.