Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes

Journal of Experimental Medicine

Volumn 207, Issue 6, 2010, Pages 1145-1152

  Westerberg, Lisa S ^a,b,c   Meelu, Parool ^a,b   Baptista, Marisa ^c   Eston, Michelle A ^a,b   Adamovich, David A ^a,b   Cotta de Almeida, Vinicius ^a,b,d   Seed, Brian ^a,b   Rosen, Michael K ^e   Vandenberghe, Peter ^f   Thrasher, Adrian J ^g   Klein, Christoph ^h   Alt, Frederick W ^b   Snapper, Scott B ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d INSTITUTO OSWALDO CRUZ   (Brazil)

^e UNIVERSITY OF TEXAS AT DALLAS   (United States)

^f UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

^h HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CELL SURFACE RECEPTOR; CHEMOKINE; WISKOTT ALDRICH SYNDROME PROTEIN;

ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; GENE MUTATION; GENOMIC INSTABILITY; LYMPHOCYTE; MOUSE; NEUTROPENIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

ACTINS; AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; B-LYMPHOCYTES; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CYTOSKELETON; GENETIC DISEASES, X-LINKED; GENOMIC INSTABILITY; HUMANS; LYMPHOCYTES; MICE; MUTANT PROTEINS; MUTATION; NEUTROPENIA; RECEPTORS, CELL SURFACE; T-LYMPHOCYTES; WISKOTT-ALDRICH SYNDROME PROTEIN;

EID: 77953497134     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20091245     Document Type: Article

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