Can aggregation of insulin govern its fate in the intestine? Implications for oral delivery of the drug

International Journal of Pharmaceutics

Volumn 471, Issue 1-2, 2014, Pages 65-68

  Smirnova, Ekaterina ^a   Safenkova, Irina ^a   Stein Margolina, Vita ^a   Shubin, Vladimir ^a   Gurvits, Bella ^a  

^a BACH INSTITUTE OF BIOCHEMISTRY   (Russian Federation)

Author keywords

Arginine; Human recombinant insulin; Oral delivery; Peptides; Protein aggregation; Supramolecular structures

Indexed keywords

ARGININE; INSULIN; LYSINE; PEPTIDE; ANTIDIABETIC AGENT; PROTEIN AGGREGATE;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG STABILITY; DRUG TRANSFORMATION; ORAL DRUG ADMINISTRATION; PH; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; BIOLOGICAL MODEL; CHEMISTRY; DOSE RESPONSE; HUMAN; INTESTINE; KINETICS; METABOLISM; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION;

ADMINISTRATION, ORAL; ARGININE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INTESTINES; KINETICS; LYSINE; MODELS, BIOLOGICAL; PROTEIN AGGREGATES; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION;

EID: 84901465131     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.05.025     Document Type: Article

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