-
1
-
-
77952503692
-
The failure of Exubera: Are we beating a dead horse?
-
Heinemann L. The failure of Exubera: are we beating a dead horse? J Diabetes Sci Technol. 2008;2(3):518-29.
-
(2008)
J Diabetes Sci Technol
, vol.2
, Issue.3
, pp. 518-529
-
-
Heinemann, L.1
-
2
-
-
65349159341
-
Intra-dermal insulin lispro application with a new microneedle delivery system led to a substantially more rapid insulin absorption than subcutaneous injection
-
Pettis RJ, Hompesch M, Kapitza C, Harvey NG, Ginsberg B, Heinemann L. Intra-dermal insulin lispro application with a new microneedle delivery system led to a substantially more rapid insulin absorption than subcutaneous injection. Diabetes. 2006;55(Suppl 1):A26.
-
(2006)
Diabetes
, vol.55
, Issue.SUPPL. 1
-
-
Pettis, R.J.1
Hompesch, M.2
Kapitza, C.3
Harvey, N.G.4
Ginsberg, B.5
Heinemann, L.6
-
4
-
-
33751529712
-
Alternative routes of insulin delivery
-
Lassmann-Vague V, Raccah D. Alternative routes of insulin delivery. Diabetes Metab. 2006;32(5 Pt 2):513-22.
-
(2006)
Diabetes Metab
, vol.32
, Issue.5 PART 2
, pp. 513-522
-
-
Lassmann-Vague, V.1
Raccah, D.2
-
5
-
-
1542498664
-
Alternative routes of insulin delivery
-
Owens DR, Zinman B, Bolli G. Alternative routes of insulin delivery. Diabet Med. 2003;20(11):886-98.
-
(2003)
Diabet Med
, vol.20
, Issue.11
, pp. 886-898
-
-
Owens, D.R.1
Zinman, B.2
Bolli, G.3
-
6
-
-
34548031589
-
Peptide drug delivery strategies for the treatment of diabetes
-
Sadrzadeh N, Glembourtt MJ, Stevenson CL. Peptide drug delivery strategies for the treatment of diabetes. J Pharm Sci. 2007;96(8):1925-54.
-
(2007)
J Pharm Sci
, vol.96
, Issue.8
, pp. 1925-1954
-
-
Sadrzadeh, N.1
Glembourtt, M.J.2
Stevenson, C.L.3
-
7
-
-
36248965689
-
Current challenges in non-invasive insulin delivery systems: A comparative review
-
Khafagy el-S, Morishita M, Onuki Y, Takayama K. Current challenges in non-invasive insulin delivery systems: a comparative review. Adv Drug Deliv Rev. 2007;59(15):1521-46.
-
(2007)
Adv Drug Deliv Rev
, vol.59
, Issue.15
, pp. 1521-1546
-
-
Khafagy, E.-S.1
Morishita, M.2
Onuki, Y.3
Takayama, K.4
-
8
-
-
0013177942
-
Oral insulin 1922-1992: The history of continuous ambition and failure
-
Berger M, Gries FA, eds. Germany: Thieme Publishing Group
-
Berger M. Oral insulin 1922-1992: the history of continuous ambition and failure. In: Frontiers in insulin pharmacology. Berger M, Gries FA, eds. Germany: Thieme Publishing Group; 1993. pp. 144-8.
-
(1993)
Frontiers in Insulin Pharmacology
, pp. 144-148
-
-
Berger, M.1
-
9
-
-
9444230519
-
Dose-response effect of a single administration of oral hexyl-insulin monoconjugate 2 in healthy nondiabetic subjects
-
Wajcberg E, Miyazaki Y, Triplitt C, Cersosimo E, DeFronzo RA. Dose-response effect of a single administration of oral hexyl-insulin monoconjugate 2 in healthy nondiabetic subjects. Diabetes Care. 2004;27(12):2868-73.
-
(2004)
Diabetes Care
, vol.27
, Issue.12
, pp. 2868-2873
-
-
Wajcberg, E.1
Miyazaki, Y.2
Triplitt, C.3
Cersosimo, E.4
DeFronzo, R.A.5
-
10
-
-
1942487690
-
A novel per-oral insulin formulation: Proof of concept study in non-diabetic subjects
-
Kidron M, Dinh S, Menachem Y, Abbas R, Variano B, Goldberg M, Arbit E, Bar-On H. A novel per-oral insulin formulation: proof of concept study in non-diabetic subjects. Diabet Med. 2004;21(4):354-7.
-
(2004)
Diabet Med
, vol.21
, Issue.4
, pp. 354-357
-
-
Kidron, M.1
Dinh, S.2
Menachem, Y.3
Abbas, R.4
Variano, B.5
Goldberg, M.6
Arbit, E.7
Bar-On, H.8
-
11
-
-
4043146718
-
Oral insulin: Proof of concept in type 2 diabetes patients
-
Kapitza C, Arbit E, Abbas R, Goldberg M, Hompesch M, Heinemann L, Heise T. Oral insulin: proof of concept in type 2 diabetes patients. Diabetes. 2003;52(Suppl 1):A37.
-
(2003)
Diabetes
, vol.52
, Issue.SUPPL. 1
-
-
Kapitza, C.1
Arbit, E.2
Abbas, R.3
Goldberg, M.4
Hompesch, M.5
Heinemann, L.6
Heise, T.7
-
12
-
-
31144470164
-
Oral insulin as first-line therapy in type 2 diabetes: A randomized controlled pilot study
-
Heise T, Kapitza C, Nosek L, Becket P, Gelfand R, Goldberg M, Arbit E. Oral insulin as first-line therapy in type 2 diabetes: a randomized controlled pilot study. Diabetologia. 2004;47(Suppl 1):A5.
-
(2004)
Diabetologia
, vol.47
, Issue.SUPPL. 1
-
-
Heise, T.1
Kapitza, C.2
Nosek, L.3
Becket, P.4
Gelfand, R.5
Goldberg, M.6
Arbit, E.7
-
13
-
-
85039639780
-
Reduction of postprandial blood glucose excursions by an optimized formulation of oral insulin
-
Heise T, Nosek L, Arbit E, Beckett P, Gelfand R, Porter KM, Goldberg M, Kapitza C. Reduction of postprandial blood glucose excursions by an optimized formulation of oral insulin. Diabetes. 2005;54(Suppl 1):A103.
-
(2005)
Diabetes
, vol.54
, Issue.SUPPL. 1
-
-
Heise, T.1
Nosek, L.2
Arbit, E.3
Beckett, P.4
Gelfand, R.5
Porter, K.M.6
Goldberg, M.7
Kapitza, C.8
-
14
-
-
38049013137
-
Improved glycemic control with oral recombinant human insulin in patients with type 2 diabetes (T2DM) inadequately controlled on metformin
-
Goldberg M, Dinh S, Castelli C, Majuru S, Arbit E. Improved glycemic control with oral recombinant human insulin in patients with type 2 diabetes (T2DM) inadequately controlled on metformin. Diabetes. 2007;56(Suppl 2):A121.
-
(2007)
Diabetes
, vol.56
, Issue.SUPPL. 2
-
-
Goldberg, M.1
Dinh, S.2
Castelli, C.3
Majuru, S.4
Arbit, E.5
-
15
-
-
0036379293
-
Oral insulin product hexyl-insulin monoconjugate 2 (HIM2) in type 1 diabetes mellitus: The glucose stabilization effects of HIM2
-
Clement S, Still JG, Kosutic G, McAllister RG. Oral insulin product hexyl-insulin monoconjugate 2 (HIM2) in type 1 diabetes mellitus: the glucose stabilization effects of HIM2. Diabetes Technol Ther. 2002;4(4):459-66.
-
(2002)
Diabetes Technol Ther
, vol.4
, Issue.4
, pp. 459-466
-
-
Clement, S.1
Still, J.G.2
Kosutic, G.3
McAllister, R.G.4
-
16
-
-
0038390434
-
Control of postprandial plasma glucose by an oral insulin product (HIM2) in patients with type 2 diabetes
-
Kipnes M, Dandona P, Tripathy D, Still JG, Kosutic G. Control of postprandial plasma glucose by an oral insulin product (HIM2) in patients with type 2 diabetes. Diabetes Care. 2003;26(2):421-6.
-
(2003)
Diabetes Care
, vol.26
, Issue.2
, pp. 421-426
-
-
Kipnes, M.1
Dandona, P.2
Tripathy, D.3
Still, J.G.4
Kosutic, G.5
-
17
-
-
9444230519
-
Dose-response effect of a single administration of oral hexyl-insulin monoconjugate 2 in healthy nondiabetic subjects
-
Wajcberg E, Miyazaki Y, Triplitt C, Cersosimo E, DeFronzo RA. Dose-response effect of a single administration of oral hexyl-insulin monoconjugate 2 in healthy nondiabetic subjects. Diabetes Care. 2004;27(12):2868-73.
-
(2004)
Diabetes Care
, vol.27
, Issue.12
, pp. 2868-2873
-
-
Wajcberg, E.1
Miyazaki, Y.2
Triplitt, C.3
Cersosimo, E.4
DeFronzo, R.A.5
-
18
-
-
38049085549
-
Early evaluation of a novel oral insulin delivery system in healthy volunteers
-
Phillips J, Russel-Jones DL, Wright J, Brackenridge A, New R, Bansal G. Early evaluation of a novel oral insulin delivery system in healthy volunteers. Diabetes. 2004;53(Suppl 2):A113.
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 2
-
-
Phillips, J.1
Russel-Jones, D.L.2
Wright, J.3
Brackenridge, A.4
New, R.5
Bansal, G.6
-
19
-
-
38049032166
-
Comparison of an oral insulin (Capsulin) and Actrapid during an isoglycemic clamp study in persons with type 2 diabetes
-
Luzio S, Dunseath G, Lockett A, Broke-Smith TP, New RR, Owens D. Comparison of an oral insulin (Capsulin) and Actrapid during an isoglycemic clamp study in persons with type 2 diabetes. Diabetes. 2008;56(Suppl 1):A10.
-
(2008)
Diabetes
, vol.56
, Issue.SUPPL. 1
-
-
Luzio, S.1
Dunseath, G.2
Lockett, A.3
Broke-Smith, T.P.4
New, R.R.5
Owens, D.6
-
20
-
-
84876549393
-
Repeat-dosing of oral insulin (Capsulin) in persons with type 2 diabetes
-
Broke-Smith TP, Luzio S, Lockett A, New RR, Owens DR. Repeat-dosing of oral insulin (Capsulin) in persons with type 2 diabetes. Diabetologia. 2008;51(Suppl 1):S8.
-
(2008)
Diabetologia
, vol.51
, Issue.SUPPL. 1
-
-
Broke-Smith, T.P.1
Luzio, S.2
Lockett, A.3
New, R.R.4
Owens, D.R.5
-
21
-
-
0034878181
-
The effects of HDV-insulin on carbohydrate metabolism in type 1 diabetic patients
-
Davis SN, Geho B, Tate D, Galassetti P, Lau J, Granner D, Mann S. The effects of HDV-insulin on carbohydrate metabolism in type 1 diabetic patients. J Diabetes Complications. 2001;15(5):227-33.
-
(2001)
J Diabetes Complications
, vol.15
, Issue.5
, pp. 227-233
-
-
Davis, S.N.1
Geho, B.2
Tate, D.3
Galassetti, P.4
Lau, J.5
Granner, D.6
Mann, S.7
-
22
-
-
84876549409
-
Single-blind, placebo-controlled, dose-ranging trial of oral HDV-insulin in patients with type 2 diabetes mellitus
-
Schwartz S, Geho B, Rosenberg L. Single-blind, placebo-controlled, dose-ranging trial of oral HDV-insulin in patients with type 2 diabetes mellitus. Diabetes. 2008;57(Suppl 1):A127.
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Schwartz, S.1
Geho, B.2
Rosenberg, L.3
-
23
-
-
78650259906
-
A 2-week randomized active comparator study of two HDV-Insulin routes (SC and oral) and SC human insulin in patients with type 1 diabetes
-
Schwartz S, Geho B, Rosenberg L, Lau J. A 2-week randomized active comparator study of two HDV-Insulin routes (SC and oral) and SC human insulin in patients with type 1 diabetes. Diabetes. 2008;57(Suppl 1):A124.
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Schwartz, S.1
Geho, B.2
Rosenberg, L.3
Lau, J.4
-
24
-
-
84887203796
-
Pharmacokinetics (PK) and pharmacodynamics (PD) or oral insulin in healthy subjects
-
Kidron M, Raz I, Schruefer C, Showb H, Wolfensberger M. Pharmacokinetics (PK) and pharmacodynamics (PD) or oral insulin in healthy subjects. Diabetes. 2008;57(Suppl 1):A127.
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Kidron, M.1
Raz, I.2
Schruefer, C.3
Showb, H.4
Wolfensberger, M.5
-
25
-
-
57349113888
-
Realität der Insulintherapie bei Typ 2 Diabetes in Deutschland: Daten aus 41 Schwerpunktpraxen
-
Faber-Heinemann G, Hess E, Hess G, von Hübbenet J, Kaltheuner M, Krakow D, Lederle M, Molinski M, Nitzsche G, Reuter HM, Scheper N, Simonsohn M, Heinemann L. Realität der Insulintherapie bei Typ 2 Diabetes in Deutschland: Daten aus 41 Schwerpunktpraxen. Diabetes, Stoffwechsel, und Herz. 2008;5:357-61.
-
(2008)
Diabetes, Stoffwechsel, und Herz
, vol.5
, pp. 357-361
-
-
Faber-Heinemann, G.1
Hess, E.2
Hess, G.3
Von Hübbenet, J.4
Kaltheuner, M.5
Krakow, D.6
Lederle, M.7
Molinski, M.8
Nitzsche, G.9
Reuter, H.M.10
Scheper, N.11
Simonsohn, M.12
Heinemann, L.13
-
26
-
-
0032718171
-
Sublingual human insulin for hyperglycaemia in type I diabetes
-
Al-Waili NS. Sublingual human insulin for hyperglycaemia in type I diabetes. JPMA. 1999;49(7):167-9.
-
(1999)
JPMA
, vol.49
, Issue.7
, pp. 167-169
-
-
Al-Waili, N.S.1
-
27
-
-
54049114336
-
Delivery of insulin to the buccal mucosa utilizing the RapidMist system
-
Bernstein G. Delivery of insulin to the buccal mucosa utilizing the RapidMist system. Expert Opin Drug Deliv. 2008;5(9):1047-55.
-
(2008)
Expert Opin Drug Deliv
, vol.5
, Issue.9
, pp. 1047-1055
-
-
Bernstein, G.1
-
28
-
-
0035898002
-
Inhaled insulin in type 1 diabetes
-
Cavallo MG, Coppolino G, Romero S, Pozzilli P. Inhaled insulin in type 1 diabetes. Lancet. 2001;357(9272):1980.
-
(2001)
Lancet
, vol.357
, Issue.9272
, pp. 1980
-
-
Cavallo, M.G.1
Coppolino, G.2
Romero, S.3
Pozzilli, P.4
-
29
-
-
0036103168
-
The evolving role of oral insulin in the treatment of diabetes using a novel RapidMist System
-
Modi P, Mihic M, Lewin A. The evolving role of oral insulin in the treatment of diabetes using a novel RapidMist System. Diabetes Metab Res Rev. 2002;18 Suppl 1:S38-42.
-
(2002)
Diabetes Metab Res Rev
, vol.18
, Issue.SUPPL. 1
-
-
Modi, P.1
Mihic, M.2
Lewin, A.3
-
30
-
-
11144254615
-
Oral spray insulin in treatment of type 2 diabetes: A comparison of efficacy of the oral spray insulin (Oralin) with subcutaneous (SC) insulin injection, a proof of concept study
-
Guevara-Aguirre J, Guevara M, Saavedra J, Mihic M, Modi P. Oral spray insulin in treatment of type 2 diabetes: a comparison of efficacy of the oral spray insulin (Oralin) with subcutaneous (SC) insulin injection, a proof of concept study. Diabetes Metab Res Rev. 2004;20(6):472-8.
-
(2004)
Diabetes Metab Res Rev
, vol.20
, Issue.6
, pp. 472-478
-
-
Guevara-Aguirre, J.1
Guevara, M.2
Saavedra, J.3
Mihic, M.4
Modi, P.5
-
31
-
-
1242276363
-
Beneficial effects of addition of oral spray insulin (Oralin) on insulin secretion and metabolic control in subjects with type 2 diabetes mellitus suboptimally controlled on oral hypoglycemic agents
-
Guevara-Aguirre J, Guevara M, Saavedra J, Mihic M, Modi P. Beneficial effects of addition of oral spray insulin (Oralin) on insulin secretion and metabolic control in subjects with type 2 diabetes mellitus suboptimally controlled on oral hypoglycemic agents. Diabetes Technol Ther. 2004;6(1):1-8.
-
(2004)
Diabetes Technol Ther
, vol.6
, Issue.1
, pp. 1-8
-
-
Guevara-Aguirre, J.1
Guevara, M.2
Saavedra, J.3
Mihic, M.4
Modi, P.5
-
32
-
-
14844357794
-
Comparison of pharmacokinetic and pharmacodynamic properties of single-dose oral insulin spray and subcutaneous insulin injection in healthy subjects using the euglycemic clamp technique
-
Cernea S, Kidron M, Wohlgelernter J, Modi P, Raz I. Comparison of pharmacokinetic and pharmacodynamic properties of single-dose oral insulin spray and subcutaneous insulin injection in healthy subjects using the euglycemic clamp technique. Clin Ther. 2004;26(12):2084-91.
-
(2004)
Clin Ther
, vol.26
, Issue.12
, pp. 2084-2091
-
-
Cernea, S.1
Kidron, M.2
Wohlgelernter, J.3
Modi, P.4
Raz, I.5
-
33
-
-
19944400122
-
Dose-response relationship of oral insulin spray in healthy subjects
-
Cernea S, Kidron M, Wohlgelernter J, Modi P, Raz I. Dose-response relationship of oral insulin spray in healthy subjects. Diabetes Care. 2005;28(6):1353-7.
-
(2005)
Diabetes Care
, vol.28
, Issue.6
, pp. 1353-1357
-
-
Cernea, S.1
Kidron, M.2
Wohlgelernter, J.3
Modi, P.4
Raz, I.5
-
34
-
-
28444480623
-
Dose-response relationship of an oral insulin spray in six patients with type 1 diabetes: A single-center, randomized, single-blind, 5-way crossover study
-
Cernea S, Kidron M, Wohlgelernter J, Raz I. Dose-response relationship of an oral insulin spray in six patients with type 1 diabetes: a single-center, randomized, single-blind, 5-way crossover study. Clin Ther. 2005;27(10):1562-70.
-
(2005)
Clin Ther
, vol.27
, Issue.10
, pp. 1562-1570
-
-
Cernea, S.1
Kidron, M.2
Wohlgelernter, J.3
Raz, I.4
-
35
-
-
20144370838
-
Glucose evaluation trial for remission (GETREM) in type 1 diabetes: A European multicentre study
-
IMDIAB Group
-
Pozzilli P, Manfrini S, Buzzetti R, Lampeter E, Leeuw ID, Iafusco D, Prisco M, Ionescu-Tirgoviste C, Kolouskovà S, Linn T, Ludvigsson J, Madàcsy L, Mrozikiewicz AS, Mrozikiewicz PM, Podar T, Vavrinec J, Vialettes B, Visalli N, Yilmaz T, Browne PD, IMDIAB Group. Glucose evaluation trial for remission (GETREM) in type 1 diabetes: a European multicentre study. Diabetes Res Clin Pract. 2005;68(3):258-64.
-
(2005)
Diabetes Res Clin Pract
, vol.68
, Issue.3
, pp. 258-264
-
-
Pozzilli, P.1
Manfrini, S.2
Buzzetti, R.3
Lampeter, E.4
Leeuw, I.D.5
Iafusco, D.6
Prisco, M.7
Ionescu-Tirgoviste, C.8
Kolouskovà, S.9
Linn, T.10
Ludvigsson, J.11
Madàcsy, L.12
Mrozikiewicz, A.S.13
Mrozikiewicz, P.M.14
Podar, T.15
Vavrinec, J.16
Vialettes, B.17
Visalli, N.18
Yilmaz, T.19
Browne, P.D.20
more..
-
36
-
-
34548331327
-
Comparison of oral insulin spray and subcutaneous regular insulin at mealtime in type 1 diabetes
-
Guevara-Aguirre J, Guevara-Aguirre M, Saavedra J, Bernstein G, Rosenbloom AL. Comparison of oral insulin spray and subcutaneous regular insulin at mealtime in type 1 diabetes. Diabetes Technol Ther. 2007;9(4):372-6.
-
(2007)
Diabetes Technol Ther
, vol.9
, Issue.4
, pp. 372-376
-
-
Guevara-Aguirre, J.1
Guevara-Aguirre, M.2
Saavedra, J.3
Bernstein, G.4
Rosenbloom, A.L.5
-
37
-
-
0036410334
-
Variability of insulin absorption and insulin action
-
Heinemann L. Variability of insulin absorption and insulin action. Diabetes Technol Ther. 2002;4(5):673-82.
-
(2002)
Diabetes Technol Ther
, vol.4
, Issue.5
, pp. 673-682
-
-
Heinemann, L.1
-
38
-
-
0035132416
-
Factors and strategies for improving buccal absorption of peptides
-
Veuillez F, Kalia YN, Jacques Y, Deshusses J, Buri P. Factors and strategies for improving buccal absorption of peptides. Eur J Pharm Biopharm. 2001;51(2):93-109.
-
(2001)
Eur J Pharm Biopharm
, vol.51
, Issue.2
, pp. 93-109
-
-
Veuillez, F.1
Kalia, Y.N.2
Jacques, Y.3
Deshusses, J.4
Buri, P.5
|