Defective Tibetan PHD2 binding to p23 links high altitude Adaption to altered oxygen sensing

Journal of Biological Chemistry

Volumn 289, Issue 21, 2014, Pages 14656-14665

  Song, Daisheng ^a   Li, Lin Sheng ^a   Arsenault, Patrick R ^a   Tan, Qiulin ^a   Bigham, Abigail W ^b   Heaton Johnson, Katherine J ^a   Master, Stephen R ^a   Lee, Frank S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS;

CHRONIC HYPOXIAS; CODING REGION; HAPLOTYPES; HYPOXIA-INDUCIBLE FACTORS; OXYGEN-SENSING; PROLYL HYDROXYLASE DOMAINS; TIBETANS; ZINC FINGER;

OXYGEN SENSORS;

GLUTATHIONE TRANSFERASE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MEMBRANE PROTEIN; PROLYL HYDROXYLASE DOMAIN PROTEIN 2; PROTEIN P23; UNCLASSIFIED DRUG;

ALTITUDE ACCLIMATIZATION; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BACULOVIRUS; BINDING SITE; CONTROLLED STUDY; DOWN REGULATION; GENE FREQUENCY; HAPLOTYPE; HUMAN; HUMAN CELL; HYDROXYLATION; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; OXYGEN SENSING; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TIBETAN (PEOPLE);

EGLN1; EVOLUTION; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR; HYPOXIA-INDUCIBLE FACTOR (HIF); MUTANT; PHD2;

ADAPTATION, PHYSIOLOGICAL; ALTITUDE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CELL HYPOXIA; CELLS, CULTURED; EMBRYO, MAMMALIAN; FIBROBLASTS; HAPLOTYPES; HEK293 CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASES; INTRAMOLECULAR OXIDOREDUCTASES; MICE; MICE, KNOCKOUT; OXYGEN; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN BINDING; TIBET;

EID: 84901459613     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.541227     Document Type: Article

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