Altered function of the SCN1A voltage-gated sodium channel leads to γ-aminobutyric acid-ergic (GABAergic) interneuron abnormalities

Journal of Biological Chemistry

Volumn 285, Issue 13, 2010, Pages 9823-9834

  Martin, Melinda S ^a   Dutt, Karoni ^b   Papale, Ligia A ^a,c   Dubé, Céline M ^b   Dutton, Stacey B ^a   De Haan, Georgius ^d   Shankar, Anupama ^a   Tufik, Sergio ^c   Meisler, Miriam H ^d   Baram, Tallie Z ^b   Goldin, Alan L ^b   Escayg, Andrew ^a,e  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e Whitehead Bldg ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIALS; AMINOBUTYRIC ACIDS; FAMILIAL HEMIPLEGIC MIGRAINES; GABAERGIC; GAIN INSIGHT; INITIATION AND PROPAGATION; PREMATURE DEATH; PYRAMIDAL NEURON; SODIUM CHANNEL; WILD-TYPE CELLS;

AMINO ACIDS; NEURONS; SODIUM;

TOXIC MATERIALS;

4 AMINOBUTYRIC ACID; ARGININE; FLUROTHYL; HISTIDINE; SODIUM CHANNEL NAV1.1; NERVE PROTEIN; SODIUM CHANNEL; SODIUM CHANNEL, VOLTAGE GATED, TYPE I, ALPHA PROTEIN; SODIUM CHANNEL, VOLTAGE-GATED, TYPE I, ALPHA PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; FEBRILE CONVULSION; FEMALE; GABAERGIC SYSTEM; GENE INSERTION; GENE MUTATION; GENERALIZED EPILEPSY; HETEROLOGOUS EXPRESSION; HETEROZYGOSITY; HOMOZYGOSITY; MALE; MOUSE; NERVE CELL EXCITABILITY; NONHUMAN; ORTHOLOGY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SEIZURE THRESHOLD; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; C57BL MOUSE; GENE EXPRESSION REGULATION; GENETICS; HOMOZYGOTE; INTERNEURON; METABOLISM; MUTATION; NERVE CELL; SEIZURE;

MUS;

ANIMALS; FEMALE; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION REGULATION; HOMOZYGOTE; INTERNEURONS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; NEURONS; SEIZURES; SODIUM CHANNELS;

EID: 77951248599     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.078568     Document Type: Article

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