Modulation of adenosinergic system and its application for the treatment of epilepsy

Pharmacological Reports

Volumn 66, Issue 3, 2014, Pages 335-342

  Świa̧der, Mariusz J ^a   Kotowski, Jacek ^a   Łuszczki, Jarogniew J ^a,b  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

Author keywords

Adenosine; Antiepileptic drugs; Seizures

Indexed keywords

2 CHLORO 6 N CYCLOPENTYLADENOSINE; 2 CHLOROADENOSINE; 2 DEOXY 6 N CYCLOPENTYLADENOSINE; 6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; 6 N 2 (4 AMINOPHENYL)ETHYL ADENOSINE; 6 N CYCLOPENTYLADENOSINE; 8 BUTYLAMINO 6 N CYCLOPENTYLADENOSINE; ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; CARBAMAZEPINE; CLONAZEPAM; CYCLOHEXYLADENOSINE; DIAZEPAM; PHENOBARBITAL; PHENYLISOPROPYLADENOSINE; PHENYTOIN; TALAMPANEL; UNCLASSIFIED DRUG; VALPROIC ACID; ANTICONVULSIVE AGENT;

ADENOSINERGIC SYSTEM; ANTICONVULSANT ACTIVITY; AUDIOGENIC SEIZURE; AUTONOMIC NERVOUS SYSTEM; BICUCULLINE INDUCED SEIZURE; BRAIN LEVEL; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG SAFETY; ELECTROSHOCK SEIZURE; EPILEPSY; EPILEPTIC STATE; EXPERIMENTAL SEIZURE; FEEDBACK SYSTEM; HUMAN; KINDLING; NEUROMODULATION; NEUROPROTECTION; NMDA INDUCED SEIZURE; NONHUMAN; ORGANOPHOSPHATE INDUCED SEIZURE; PENTYLENETETRAZOLE-INDUCED SEIZURE; PILOCARPINE INDUCED SEIZURE; PURINE METABOLISM; RECEPTOR UPREGULATION; REVIEW; SEIZURE; SEIZURE SUSCEPTIBILITY; SIGNAL TRANSDUCTION; TEMPORAL LOBE EPILEPSY; TONIC CLONIC SEIZURE; ANIMAL; ANTAGONISTS AND INHIBITORS; METABOLISM;

ADENOSINE; ANIMALS; ANTICONVULSANTS; EPILEPSY; HUMANS; PURINERGIC P1 RECEPTOR AGONISTS;

EID: 84901443140     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/j.pharep.2013.10.005     Document Type: Review

References (89)

1. P. Kwan, and M.J. Brodie Early identification of refractory epilepsy N Engl J Med 342 2000 314 319 (Pubitemid 30075244)
2. P. Kwan, and M.J. Brodie Epilepsy after the first drug fails: substitution or add-on? Seizure 9 2000 464 468
3. N. Jette, and S. Wiebe Update on the surgical treatment of epilepsy Curr Opin Neurol 26 2013 201 207
4. J.M. Brundege, L. Diao, W.R. Proctor, and T.V. Dunwiddie The role of cyclic AMP as a precursor of extracellular adenosine in the rat hippocampus Neuropharmacology 36 1997 1201 1210 (Pubitemid 27465608)
5. D.G. Rainnie, H.C. Grunze, R.W. McCarley, and R.W. Greene Adenosine inhibition of mesopontine cholinergic neurons: implications for EEG arousal Science 263 1994 689 692 (Pubitemid 24076298)
6. J.H. Benington, S.K. Kodali, and H.C. Heller Stimulation of A1 adenosine receptors mimics the electroencephalographic effects of sleep deprivation Brain Res 692 1995 79 85
7. R.A. Barraco, V.L. Coffin, H.J. Altman, and J.W. Phillis Central effects of adenosine analogs on locomotor activity in mice and antagonism of caffeine Brain Res 272 1983 392 395 (Pubitemid 13025184)
8. H.M. Marston, K. Finlayson, T. Maemoto, H.J. Olverman, A. Akahane, and J. Sharkey et al. Pharmacological characterization of a simple behavioral response mediated selectively by central adenosine A1 receptors, using in vivo and in vitro techniques J Pharmacol Exp Ther 285 1998 1023 1030 (Pubitemid 28277900)
9. T.V. Dunwiddie, and T. Worth Sedative and anticonvulsant effects of adenosine analogs in mouse and rat J Pharmacol Exp Ther 220 1982 70 76 (Pubitemid 12219290)
10. T.V. Dunwiddie, and S.A. Masino The role and regulation of adenosine in the central nervous system Annu Rev Neurosci 2001 31 55 (Pubitemid 32695222)
11. M.E. Johnston, and J.D. Geiger Adenosine transport systems on dissociated brain cells from mouse, guinea-pig, and rat Neurochem Res 15 1990 911 915 (Pubitemid 20368931)
12. C.G. Boissard, and V.K. Gribkoff The effects of the adenosine reuptake inhibitor soluflazine on synaptic potentials and population hypoxic depolarizations in area CA1 of rat hippocampus in vitro Neuropharmacology 32 1993 149 155 (Pubitemid 23053326)
13. F.L. Eldridge, D. Paydarfar, S.C. Scott, and R.T. Dowell Role of endogenous adenosine in recurrent generalized seizures Exp Neurol 103 1989 179 185 (Pubitemid 19047247)
14. R.A. Gonzales, and S.W. Leslie [3H]adenosine uptake and release from synaptosomes, Alterations by barbiturates Biochem Pharmacol 34 1985 1619 1625 (Pubitemid 15097859)
15. H.L. Haas, and O. Selbach Functions of neuronal adenosine receptors Naunyn Schmiedebergs Arch Pharmacol 362 2000 375 381
16. S.Z. Langer, and S. Arbilla Presynaptic receptors and modulation of the release of noradrenaline, dopamine and GABA Postgrad Med J 57 Suppl 1 1981 18 29 (Pubitemid 11033441)
17. I. von Kügelgen, K. Kurz, R. Bültmann, B. Driessen, and K. Starke Presynaptic modulation of the release of the co-transmitters noradrenaline and ATP Fundam Clin Pharmacol 8 1994 207 213 (Pubitemid 24182384)
18. C.V. Gomes, M.P. Kaster, A.R. Tome, P.M. Agostinho, and R.A. Cunha Adenosine receptors and brain diseases: neuroprotection and neurodegeneration Biochim Biophys Acta 1808 2011 1380 1399
19. B. Johansson, L. Halldner, T.V. Dunwiddie, S.A. Masino, W. Poelchen, and L. Gimenez-Llort et al. Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor Proc Natl Acad Sci U S A 98 2001 9407 9412 (Pubitemid 32743930)
20. M. Klinger, M. Freissmuth, and C. Nanoff Adenosine receptors: G protein-mediated signalling and the role of accessory proteins Cell Signal 14 2002 99 108 (Pubitemid 34056581)
21. A.K. Dixon, A.K. Gubitz, D.J. Sirinathsinghji, P.J. Richardson, and T.C. Freeman Tissue distribution of adenosine receptor mRNAs in the rat Br J Pharmacol 118 1996 1461 1468 (Pubitemid 26248800)
22. J. Fastbom, A. Pazos, and J.M. Palacios The distribution of adenosine A1 receptors and 5'-nucleotidase in the brain of some commonly used experimental animals Neuroscience 22 1987 813 826
23. E. Ongini, and B.B. Fredholm Pharmacology of adenosine A2A receptors Trends Pharmacol Sci 17 1996 364 372
24. J.L. Moreau, and G. Huber Central adenosine A(2A) receptors: an overview Brain Res Brain Res Rev 31 1999 65 82 (Pubitemid 30009614)
25. T.V. Dunwiddie The physiological role of adenosine in the central nervous system Int Rev Neurobiol 27 1985 63 139
26. M.J. During, and D.D. Spencer Adenosine: a potential mediator of seizure arrest and postictal refractoriness Ann Neurol 32 1992 618 624
27. R.F. Berman, B.B. Fredholm, U. Aden, and W.T. O'Connor Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats Brain Res 872 2000 44 53 (Pubitemid 30618885)
28. A.E. Kline, S. Montanez, H.A. Bradley, C.J. Millar, and T.D. Hernandez Distinctive amygdala kindled seizures differentially affect neurobehavioral recovery and lesion-induced basic fibroblast growth factor (bFGF) expression Brain Res 880 2000 38 50
29. A. Huber, V. Padrun, N. Deglon, P. Aebischer, H. Mohler, and D. Boison Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy Proc Natl Acad Sci U S A 98 2001 7611 7616 (Pubitemid 32567996)
30. M. Guttinger, V. Padrun, W.F. Pralong, and D. Boison Seizure suppression and lack of adenosine A1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts Exp Neurol 193 2005 53 64 (Pubitemid 40463267)
31. M. Guttinger, D. Fedele, P. Koch, V. Padrun, W.F. Pralong, and O. Brustle et al. Suppression of kindled seizures by paracrine adenosine release from stem cell-derived brain implants Epilepsia 46 2005 1162 1169 (Pubitemid 41647752)
32. D. Boison, L. Scheurer, J.L. Tseng, P. Aebischer, and H. Mohler Seizure suppression in kindled rats by intraventricular grafting of an adenosine releasing synthetic polymer Exp Neurol 160 1999 164 174
33. T.V. Dunwiddie Endogenously released adenosine regulates excitability in the in vitro hippocampus Epilepsia 21 1980 541 548 (Pubitemid 11232057)
34. G. Kostopoulos, C. Drapeau, M. Avoli, A. Olivier, and J.G. Villemeure Endogenous adenosine can reduce epileptiform activity in the human epileptogenic cortex maintained in vitro Neurosci Lett 106 1989 119 124 (Pubitemid 19285973)
35. Y. Fujiwara-Tsukamoto, Y. Isomura, A. Nambu, and M. Takada Excitatory GABA input directly drives seizure-like rhythmic synchronization in mature hippocampal CA1 pyramidal cells Neuroscience 119 2003 265 275 (Pubitemid 36577429)
36. + channel activation J Neurosci 29 2009 11237 11245
37. B.B. Fredholm, J.F. Chen, R.A. Cunha, P. Svenningsson, and J.M. Vaugeois Adenosine and brain function Int Rev Neurobiol 63 2005 191 270 (Pubitemid 43631262)
38. H. Hosseinzadeh, and T.W. Stone Tolbutamide blocks postsynaptic but not presynaptic effects of adenosine on hippocampal CA1 neurones J Neural Transm 105 1998 161 172 (Pubitemid 28243223)
39. A. Ilie, J.V. Raimondo, and C.J. Akerman Adenosine release during seizures attenuates GABAA receptor-mediated depolarization J Neurosci 32 2012 5321 5332
40. Y. Fujiwara-Tsukamoto, Y. Isomura, M. Imanishi, T. Fukai, and M. Takada Distinct types of ionic modulation of GABA actions in pyramidal cells and interneurons during electrical induction of hippocampal seizure-like network activity Eur J Neurosci 25 2007 2713 2725 (Pubitemid 46888854)
41. Y. Fujiwara-Tsukamoto, Y. Isomura, M. Imanishi, T. Ninomiya, M. Tsukada, and Y. Yanagawa et al. Prototypic seizure activity driven by mature hippocampal fast-spiking interneurons J Neurosci 30 2010 13679 13689
42. 2+ conditions J Neurophysiol 95 2006 2013 2019
43. T.H. Han, S.H. Jang, S.Y. Lee, and P.D. Ryu Adenosine reduces GABAergic IPSC frequency via presynaptic A(1) receptors in hypothalamic paraventricular neurons projecting to rostral ventrolateral medulla Neurosci Lett 490 2011 63 67
44. I. Kruglikov, and B. Rudy Perisomatic GABA release and thalamocortical integration onto neocortical excitatory cells are regulated by neuromodulators Neuron 58 2008 911 924 (Pubitemid 351842749)
45. S.M. Thompson, M. Capogna, and M. Scanziani Presynaptic inhibition in the hippocampus Trends Neurosci 16 1993 222 227 (Pubitemid 23139186)
46. S.M. Thompson, H.L. Haas, and B.H. Gahwiler Comparison of the actions of adenosine at pre- and postsynaptic receptors in the rat hippocampus in vitro J Physiol 451 1992 347 363
47. K.W. Yoon, and S.M. Rothman Adenosine inhibits excitatory but not inhibitory synaptic transmission in the hippocampus J Neurosci 11 1991 1375 1380
48. T.E. Albertson, L.G. Stark, R.M. Joy, and J.F. Bowyer Aminophylline and kindled seizures Exp Neurol 81 1983 703 713 (Pubitemid 13002234)
49. M. Dragunow, G.V. Goddard, and R. Laverty Is adenosine an endogenous anticonvulsant? Epilepsia 26 1985 480 487 (Pubitemid 16226450)
50. M. Dragunow, and G.V. Goddard Adenosine modulation of amygdala kindling Exp Neurol 84 1984 654 665 (Pubitemid 14120153)
51. M. Dragunow Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline Pharmacol Biochem Behav 36 1990 751 755 (Pubitemid 20272288)
52. A. Handforth, and D.M. Treiman Effect of an adenosine antagonist and an adenosine agonist on status entry and severity in a model of limbic status epilepticus Epilepsy Res 18 1994 29 42 (Pubitemid 24159588)
53. W.A. Turski, E.A. Cavalheiro, C. Ikonomidou, L.E. Mello, Z.A. Bortolotto, and L. Turski Effects of aminophylline and 2-chloroadenosine on seizures produced by pilocarpine in rats: morphological and electroencephalographic correlates Brain Res 361 1985 309 323 (Pubitemid 16185367)
54. G. De Sarro, A. De Sarr, E.D. Di Paola, and R. Bertorelli Effects of adenosine receptor agonists and antagonists on audiogenic seizure-sensible DBA/2 mice Eur J Pharmacol 371 1999 137 145 (Pubitemid 29216995)
55. T.F. Murray, D. Sylvester, C.S. Schultz, and P. Szot Purinergic modulation of the seizure threshold for pentylenetetrazol in the rat Neuropharmacology 24 1985 761 766 (Pubitemid 15239051)
56. W. Löscher, and D. Schmidt Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations Epilepsy Res 2 1988 145 181
57. K.K. Borowicz, J. Łuszczki, and S.J. Czuczwar 2-Chloroadenosine, a preferential agonist of adenosine A1 receptors, enhances the anticonvulsant activity of carbamazepine and clonazepam in mice Eur Neuropsychopharmacol 12 2002 173 179 (Pubitemid 34168483)
58. G. De Sarro, A. De Sarro, and B.S. Meldrum Anticonvulsant action of 2-chloroadenosine injected focally into the inferior colliculus and substantia nigra Eur J Pharmacol 194 1991 145 152
59. M. Adami, R. Bertorelli, N. Ferri, M.C. Foddi, and E. Ongini Effects of repeated administration of selective adenosine A1 and A2A receptor agonists on pentylenetetrazole-induced convulsions in the rat Eur J Pharmacol 294 1995 383 389 (Pubitemid 26014845)
60. J.A. Tintos-Hernandez, and I.P. Davalos-Rodriguez Deficiency of adenosine desaminase (ADA): clinical, biochemical, molecular and treatment aspects Rev Invest Clin 63 2011 75 83
61. N. Ates, G. Ilbay, and D. Sahin Suppression of generalized seizures activity by intrathalamic 2-chloroadenosine application Exp Biol Med (Maywood) 230 2005 501 505 (Pubitemid 40923428)
62. E.A. Cavalheiro, L.S. Calderazzo Filho, Z.A. Bortolotto, L. Mello, and L. Turski Anticonvulsant role of adenosine Pol J Pharmacol Pharm 39 1987 537 543
63. G.M. Khan, I. Smolders, G. Ebinger, and Y. Michotte Anticonvulsant effect and neurotransmitter modulation of focal and systemic 2-chloroadenosine against the development of pilocarpine-induced seizures Neuropharmacology 39 2000 2418 2432 (Pubitemid 30642785)
64. R.A. Barraco, T.H. Swanson, J.W. Phillis, and R.F. Berman Anticonvulsant effects of adenosine analogues on amygdaloid-kindled seizures in rats Neurosci Lett 46 1984 317 322 (Pubitemid 14105555)
65. J.B. Rosen, and R.F. Berman Differential effects of adenosine analogs on amygdala, hippocampus, and caudate nucleus kindled seizures Epilepsia 28 1987 658 666 (Pubitemid 18021804)
66. D. Young, and M. Dragunow Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms Neuroscience 58 1994 245 261 (Pubitemid 24037236)
67. D.K. von Lubitz, I.A. Paul, M. Carter, and K.A. Jacobson Effects of N6-cyclopentyl adenosine and 8-cyclopentyl-1,3-dipropylxanthine on N-methyl-d-aspartate induced seizures in mice Eur J Pharmacol 249 1993 265 270
68. D.K. von Lubitz, I.A. Paul, X.D. Ji, M. Carter, and K.A. Jacobson Chronic adenosine A1 receptor agonist and antagonist: effect on receptor density and N-methyl-d-aspartate induced seizures in mice Eur J Pharmacol 253 1994 95 99
69. P.H. Franklin, G. Zhang, E.D. Tripp, and T.F. Murray Adenosine A1 receptor activation mediates suppression of (-) bicuculline methiodide-induced seizures in rat prepiriform cortex J Pharmacol Exp Ther 251 1989 1229 1236 (Pubitemid 20024949)
70. P.K. Harrison, T.J. Bueters, A.P. Ijzerman, H.P. van Helden, and J.E. Tattersall Partial adenosine A(1) receptor agonists inhibit sarin-induced epileptiform activity in the hippocampal slice Eur J Pharmacol 471 2003 97 104 (Pubitemid 36724922)
71. B. Zuchora, W.A. Turski, M. Wielosz, and E.M. Urbanska Protective effect of adenosine receptor agonists in a new model of epilepsy - seizures evoked by mitochondrial toxin, 3-nitropropionic acid, in mice Neurosci Lett 305 2001 91 94 (Pubitemid 33762773)
72. B.B. Fredholm, A.P. Ijzerman, K.A. Jacobson, K.N. Klotz, and J. Linden International Union of Pharmacology, XXV. Nomenclature and classification of adenosine receptors Pharmacol Rev 53 2001 527 552 (Pubitemid 33136237)
73. R.A. Cunha, and J.A. Ribeiro Adenosine A2A receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation Neurosci Lett 289 2000 127 130 (Pubitemid 30440642)
74. A.M. Sebastiao, and J.A. Ribeiro Adenosine A2 receptor-mediated excitatory actions on the nervous system Prog Neurobiol 48 1996 167 189 (Pubitemid 26161859)
75. J. Malhotra, and Y.K. Gupta Effect of adenosine receptor modulation on pentylenetetrazole-induced seizures in rats Br J Pharmacol 120 1997 282 288 (Pubitemid 27039278)
76. T.V. Dunwiddie Adenosine and suppression of seizures Adv Neurol 79 1999 1001 1010
77. T.V. Dunwiddie, L. Diao, H.O. Kim, J.L. Jiang, and K.A. Jacobson Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus J Neurosci 17 1997 607 614 (Pubitemid 27024573)
78. L.A. Etherington, and B.G. Frenguelli Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner Eur J Neurosci 19 2004 2539 2550 (Pubitemid 38621851)
79. K.K. Borowicz, M. Świa̧der, R. Kamiński, H. Kuźniar, Z. Kleinrok, and S.J. Czuczwar Two essential amino acids, l-lysine and l-histidine, in five types of experimental seizures Pol J Pharmacol 52 2000 345 352
80. K.K. Borowicz, M. Świa̧der, M. Wielosz, and S.J. Czuczwar Influence of the combined treatment of LY 300164 (an AMPA/kainate receptor antagonist) with adenosine receptor agonists on the electroconvulsive threshold in mice Eur Neuropsychopharmacol 14 2004 407 412 (Pubitemid 39141683)
81. D.K. von Lubitz, M.F. Carter, S.I. Deutsch, R.C. Lin, J. Mastropaolo, and Y. Meshulam et al. The effects of adenosine A3 receptor stimulation on seizures in mice Eur J Pharmacol 275 1995 23 29
82. T. Noji, A. Karasawa, and H. Kusaka Adenosine uptake inhibitors Eur J Pharmacol 495 2004 1 16 (Pubitemid 38829385)
83. B.G. Ugarkar, A.J. Castellino, J.M. DaRe, J.J. Kopcho, J.B. Wiesner, and J.M. Schanzer et al. Adenosine kinase inhibitors. 2. Synthesis, enzyme inhibition, and antiseizure activity of diaryltubercidin analogues J Med Chem 43 2000 2894 2905 (Pubitemid 30599647)
84. J.B. Wiesner, B.G. Ugarkar, A.J. Castellino, J. Barankiewicz, D.P. Dumas, and H.E. Gruber et al. Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy J Pharmacol Exp Ther 289 1999 1669 1677 (Pubitemid 29246705)
85. S. McGaraughty, M. Cowart, and M.F. Jarvis Recent developments in the discovery of novel adenosine kinase inhibitors: mechanism of action and therapeutic potential CNS Drug Rev 7 2001 415 432 (Pubitemid 34263875)
86. E.A. Kowaluk, and M.F. Jarvis Therapeutic potential of adenosine kinase inhibitors Expert Opin Investig Drugs 9 2000 551 564 (Pubitemid 30119693)
87. S.J. Czuczwar, B. Szczepanik, A. Wamil, W. Janusz, and Z. Kleinrok Differential effects of agents enhancing purinergic transmission upon the antielectroshock efficacy of carbamazepine, diphenylhydantoin, diazepam, phenobarbital, and valproate in mice J Neural Transm Gen Sect 81 1990 153 166 (Pubitemid 20175070)
88. 2+ channel inhibitors in mice Pharmacol Biochem Behav 56 1997 629 635 (Pubitemid 27189746)
89. M. Dragunow, and H.A. Robertson 8-Cyclopentyl 1,3-dimethylxanthine prolongs epileptic seizures in rats Brain Res 417 1987 377 379 (Pubitemid 17158869)