Adenosine reduces GABAergic IPSC frequency via presynaptic A1 receptors in hypothalamic paraventricular neurons projecting to rostral ventrolateral medulla

Neuroscience Letters

Volumn 490, Issue 1, 2011, Pages 63-67

  Han, Tae Hee ^a   Jang, Soo Hwa ^a   Lee, So Yeong ^a   Ryu, Pan Dong ^a  

^a Seoul National University   (South Korea)

Author keywords

Neurotransmission; Presympathetic neuron; Purinergic receptor; Sympathetic nervous system

Indexed keywords

3,7 DIMETHYL 1 PROPARGYLXANTHINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR; CYCLOHEXYLADENOSINE; PRESYNAPTIC RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GABAERGIC TRANSMISSION; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; INHIBITORY POSTSYNAPTIC CURRENT; MALE; MEDULLA OBLONGATA; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SYNAPTIC POTENTIAL; SYNAPTIC TRANSMISSION;

ADENOSINE; ADENOSINE A1 RECEPTOR AGONISTS; ADENOSINE A1 RECEPTOR ANTAGONISTS; ADENOSINE A2 RECEPTOR ANTAGONISTS; AFFERENT PATHWAYS; ANIMALS; BIOPHYSICS; ELECTRIC STIMULATION; GAMMA-AMINOBUTYRIC ACID; INHIBITORY POSTSYNAPTIC POTENTIALS; MALE; MEDULLA OBLONGATA; NEURAL INHIBITION; NEURONS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A1; THEOBROMINE; XANTHINES;

EID: 78751706681     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.12.026     Document Type: Article

References (30)

1. Cham J.L., Badoer E. Exposure to a hot environment can activate rostral ventrolateral medulla-projecting neurones in the hypothalamic paraventricular nucleus in conscious rats. Exp. Physiol. 2008, 93:64-74.
2. Chen G., van den Pol A.N. Adenosine modulation of calcium currents and presynaptic inhibition of GABA release in suprachiasmatic and arcuate nucleus neurons. J. Neurophysiol. 1997, 77:3035-3047.
3. Daly J.W., Fredholm B.B. Caffeine - an atypical drug of dependence. Drug Alcohol Depend. 1998, 51:199-206.
4. Dampney R.A., Horiuchi J., Killinger S., Sheriff M.J., Tan P.S., McDowall L.M. Long-term regulation of arterial blood pressure by hypothalamic nuclei: some critical questions. Clin. Exp. Pharmacol. Physiol. 2005, 32:419-425.
5. Deckert J., Bisserbe J., Klein E., Marangos P. Adenosine uptake sites in brain: regional distribution of putative subtypes in relationship to adenosine A1-receptors. J. Neurosci. 1988, 8:2338-2349.
6. Dixon A.K., Gubitz A.K., Sirinathsinghji D.J., Richardson P.J., Freeman T.C. Tissue distribution of adenosine receptor mRNAs in the rat. Br. J. Pharmacol. 1996, 118:1461-1468.
7. Dunwiddie T.V., Fredholm B.B. Adenosine A1 receptors inhibit adenylate cyclase activity and neurotransmitter release and hyperpolarize pyramidal neurons in rat hippocampus. J. Pharmacol. Exp. Ther. 1989, 249:31-37.
8. Fastbom J., Pazos A., Palacios J.M. The distribution of adenosine a1 receptors and 5'-nucleotidase in the brain of some commonly used experimental animals. Neuroscience 1987, 22:813-826.
9. Fredholm B.B., IJzerman A.P., Jacobson K.A., Klotz K.-N., Linden J. International union of pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol. Rev. 2001, 53:527-552.
10. Han S.K., Chong W., Li L.H., Lee I.S., Murase K., Ryu P.D. Noradrenaline excites and inhibits GABAergic transmission in parvocellular neurons of rat hypothalamic paraventricular nucleus. J. Neurophysiol. 2002, 87:2287-2296.
11. Han T.H., Lee K., Park J.B., Ahn D., Park J.-H., Kim D.-Y., Stern J.E., Lee S.Y., Ryu P.D. Reduction in synaptic GABA release contributes to target-selective elevation of PVN neuronal activity in rats with myocardial infarction. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2010, 299:R129-139.
12. Jensen K., Mody I. L-type Ca2+ channel-mediated short-term plasticity of GABAergic synapses. Nat. Neurosci. 2001, 4:975-976.
13. Jeong H.-J., Jang I.-S., Nabekura J., Akaike N. Adenosine A1 receptor-mediated presynaptic inhibition of GABAergic transmission in immature rat hippocampal CA1 neurons. J. Neurophysiol. 2003, 89:1214-1222.
14. Lashgari R., Motamedi F., Noorbakhsh S.-M., Zahedi-Asl S., Komaki A., Shahidi S., Haghparast A. Assessing the long-term role of L-type voltage dependent calcium channel blocker verapamil on short-term presynaptic plasticity at dentate gyrus of hippocampus. Neurosci. Lett. 2007, 415:174-178.
15. Li D.P., Chen S.R., Pan H.L. Adenosine inhibits paraventricular pre-sympathetic neurons through ATP-dependent potassium channels. J. Neurochem. 2010, 113:530-542.
16. Li D.P., Pan H.L. Angiotensin II attenuates synaptic GABA release and excites paraventricular-rostral ventrolateral medulla output neurons. J. Pharmacol. Exp. Ther. 2005, 313:1035-1045.
17. Okada M., Nutt D.J., Murakami T., Zhu G., Kamata A., Kawata Y., Kaneko S. Adenosine receptor subtypes modulate two major functional pathways for hippocampal serotonin release. J. Neurosci. 2001, 21:628-640.
18. Oliet S.H.R., Poulain D.A. Adenosine-induced presynaptic inhibition of IPSCs and EPSCs in rat hypothalamic supraoptic nucleus neurones. J. Physiol. 1999, 520:815-825.
19. Porkka-Heiskanen T., Strecker R.E., McCarley R.W. Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study. Neuroscience 2000, 99:507-517.
20. Pyner S., Coote J.H. Identification of branching paraventricular neurons of the hypothalamus that project to the rostroventrolateral medulla and spinal cord. Neuroscience 2000, 100:549-556.
21. Sperlagh B., Vizi S.E. Neuronal synthesis, storage and release of ATP. Semin. Neurosci. 1996, 8:175-186.
22. Stehle J.H, Rivkees S.A., Lee J.J., Weaver D.R., Deeds J.D., Reppert S.M. Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype. Mol. Endocrinol. 1992, 6:384-393.
23. Stella L., Berrino L., Maione S., de Novellis V., Rossi F. Cardiovascular effects of adenosine and its analogs in anaesthetized rats. Life Sci. 1993, 53:755-763.
24. Stocker S.D., Cunningham J.T., Toney G.M. Water deprivation increases Fos immunoreactivity in PVN autonomic neurons with projections to the spinal cord and rostral ventrolateral medulla. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004, 287:R1172-R1183.
25. Sun X., Barnes S., Baldridge W.H. Adenosine inhibits calcium channel currents via A1 receptors on salamander retinal ganglion cells in a mini-slice preparation. J. Neurochem. 2002, 81:550-556.
26. Swanson L.W., Sawchenko P.E. Paraventricular nucleus: a site for the integration of neuroendocrine and autonomic mechanism. Neuroendocrinology 1980, 31:410-417.
27. Trincavelli M.L., Daniele S., Martini C. Adenosine receptors: what we know and what we are learning. Curr. Top. Med. Chem. 2010, 10:860-877.
28. Wu L.-G., Saggau P. Adenosine inhibits evoked synaptic transmission primarily by reducing presynaptic calcium influx in area CA1 of hippocampus. Neuron 1994, 12:1139-1148.
29. Wu L.-G., Saggau P. Presynaptic inhibition of elicited neurotransmitter release. Trends Neurosci. 1997, 20:204-212.
30. Zucker R.S. Short-term synaptic plasticity. Annu. Rev. Neurosci. 1989, 12:13-31.