Pharmacological characterization of a simple behavioral response mediated selectively by central adenosine A1 receptors, using in vivo and in vitro techniques

Journal of Pharmacology and Experimental Therapeutics

Volumn 285, Issue 3, 1998, Pages 1023-1030

  Marston, Hugh M ^a   Finlayson, Keith ^a   Maemoto, Takuya ^a   Olverman, Henry J ^a   Akahane, Atsushi ^b   Sharkey, John ^a   Butcher, Steven P ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 (2 PHENYLPYRAZOLO[1,5 A]PYRIDIN 3 YL)ACRYLOYL]PIPERIDIN 2 YL ACETIC ACID; 1 BENZYL 1,2,3,4 TETRAHYDRO 6 (4 METHOXYPHENYL) 3 PROPYL 5H IMIDAZO[2',1':5,1]PYRAZOLO[3,4 D]PYRIMIDINE 2,4 DIONE; 1,3 DIPROPYL 8 (4 SULFOPHENYL)XANTHINE; 2 (2 HYDROXYETHYL) 1 [3 (2 PHENYLPYRAZOLO[1,5 A]PYRIDIN 3 YL)ACRYLOYL]PIPERIDINE; 2 [(2 AMINOETHYLAMINO)CARBONYLETHYLPHENYLETHYLAMINO] 5' ETHYLCARBOXAMIDOADENOSINE; 6 N CYCLOPENTYLADENOSINE; 8 (1 PHENYLPROPYL) 1,3 DIPROPYLXANTHINE; 8 (2 NOR 1 ADAMANTYL) 1,3 DIPROPYLXANTHINE; 8 (3,4 DIMETHOXYSTYRYL) 7 METHYL 1,3 DIPROPYLXANTHINE; 8 (4 SULFOPHENYL) 1,3 DIMETHYLXANTHINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING SITE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR OCCUPANCY;

ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ANIMALS; BEHAVIOR, ANIMAL; BLOOD-BRAIN BARRIER; MALE; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; REGRESSION ANALYSIS; VASODILATOR AGENTS; XANTHINES;

EID: 0031838227     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Barraco RA, Coffin VL, Altman HJ and Phillis JW (1983) Central effects of adenosine analogs on locomotor activity in mice and antagonism of caffeine. Brain Res 272:392-395.
2. Baumgold J, Nikodijevic O and Jacobson KA (1992) Penetration of adenosine antagonists into mouse brain as determined by ex vivo binding. Biochem Pharm 43:889-894.
3. Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilising the principle of protein-dye binding. Anal Biol 72:248-254.
4. 2 adenosine receptor subtypes in locomotor activity and place conditioning in rats. Behav Pharmacol 7:373-383.
5. 2 receptor regulates apomorphine-induced turning in rats with unilateral dopamine denervation. Psychopharmacology 103:78-82.
6. 1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes. Naunyn-Schmiedeberg Arch Pharmacol 335:59-63.
7. Daly JW (1982) Adenosine receptors: Targets for future drugs. J Med Chem 25:197-207.
8. 2 adenosine receptor antagonist 8FB-PTP, an 8-substituted pyrazolotriazolo-pyrimidine, on in vitro functional models. Br J Pharmacol 112:659-665.
9. Durcan MJ and Morgan PF (1989a) NECA-induced hypomotility in mice: evidence for a predominantly central site of action. Pharmacol Biochem Behav 32:487-490.
10. 1 receptor involvement in the hypomobility effects of adenosine analogues in mice. Eur J Pharmacol 168:285-290.
11. Evoniuk G, von Borstel RW and Wurtman RJ (1987) Antagonism of the cardiovascular effects of adenosine by caffeine or 8-(p-sulphophenyl)theophylline. J Pharmacol Exp Ther 242:428-432.
12. Finlayson K, Butcher SP, Sharkey J and Olverman HJ (1997) Measurement of adenosine receptor antagonists in rat brain using a modified radioreceptor assay. J Neurosci Methods 77:135-142.
13. 3 receptor-mediated hypotensive responses in the rat. Eur J Pharmacol 252:R5-R6.
14. Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P and Williams M (1994) VI. Nomenclature and classification of purinoceptors. Pharmacol Rev 46:143-156.
15. 1-Selective antagonist, DPCPX. Psychopharmacology 103:541-544.
16. Heffner TG, Wiley JN, Williams AE, Bruns RF, Coughenour LL and Downs DA (1989) Comparison of the behavioral effects of adenosine agonists and dopamine antagonists in mice. Psychopharmacology 98:31-37.
17. 1 receptor antagonist MDL 102234 in spatial learning and hippocampal long-term potentiation models. Soc Neurosci Abs 18:362.4.
18. Holtzman SG (1991) CGS 15943, A nonxanthine adenosine receptor antagonist: Effects on locomotor activity of nontolerant and caffeine-tolerant rats. Life Sci 49:1563-1570.
19. 35S]-thio)triphosphate binding to rat cerebral cortical membranes. Br J Pharmacol 116:306P.
20. Jacobson KA, van Galen PJM and Williams M (1992) Adenosine receptors: Pharmacology, structure-activity relationships, and therapeutic potential. J Med Chem 35:407-421.
21. 2-adenosine antagonist in vivo and in vitro. FEBS Lett 323:141-144.
22. 3-adenosine receptors. Mediation of behavioral depressant effects. FBBS Lett 336:57-60.
23. Jacobson KA, Von Lubitz DKJE, Daly JW and Fredholm BB (1996) Adenosine receptor ligands: differences with acute versus chronic treatment. Trends Pharmacol Sci 17:108-113.
24. 3H]DPCPX binding assay. Br J Pharmacol 116:308P.
25. 1 receptors revealed using xanthine and pyrazolopyridine based antagonists. Br J Pharmacol 122, 6:1202-1208.
26. 2-selective adenosine agonist. FEBS Lett 261:67-70.
27. 2-Selective adenosine agonists and antagonists: Evidence for synergism and antagonism. J Pharmacol Exp Ther 259:286-294.
28. Nikodijevic OM, Jacobson KA and Daly JW (1993) Effects of combinations of methylxanthines and adenosine analogs on locomotor activity in control and chronic caffeine-treated mice. Drug Dev Res 30:104-110.
29. 2 receptor antagonist. Eur J Pharmacol 267:335-341.
30. 1 receptors. Brain Res Bull 27:101-104.
31. 1 receptors in the nucleus accumbens impairs inhibitory avoidance memory. Behav Neural Biol 62:163-166.
32. 2 receptor directed drugs using a behavioural index. Br J Pharmacol 113:110P.
33. 2A receptors. Trends Pharmacol Sci 17:364-372.
34. Phillis JW, Barraco RA, DeLong RE and Washington DO (1986) Behavioural characteristics of centrally administered adenosine analogs. Pharmacol Biochem Behav 24:263-270.
35. 1-antagonists for treatment of cognitive deficits. Nucleosides Nucleotides 5:1067-1076.
36. Snyder SH, Katims JJ, Annau A, Bruns RF and Daly JW (1981) Adenosine receptors and behavioral actions of methylxathines. Proc Natl Acad Sci USA 78:5,3260-3264.
37. 6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. J Med Chem 36:2508-2518.
38. 1 receptor antagonist. Eur J Pharmacol 279:217-225.
39. 1 receptor agonist and antagonist on spatial learning and memory. Eur J Pharmacol 249:271-280.
40. 1 selective adenosine radioligand cyclopentyladenosine (CPA), to rat brain tissue. Naunyn-Schmiedeberg Arch Pharmacol 332:179-183.
41. Zarindast MR and Heidari MR (1993) Involvement of adenosine receptors in mouse thermoregulation. J Psychopharmacol 74:365-370.