Mesenchymal stem/stromal cells inhibit the NLRP3 Inflammasome by Decreasing Mitochondrial Reactive Oxygen Species

Stem Cells

Volumn 32, Issue 6, 2014, Pages 1553-1563

  Oh, Joo Youn ^a   Ko, Jung Hwa ^a   Lee, Hyun Ju ^a   Yu, Ji Min ^b   Choi, Hosoon ^b   Kim, Mee Kum ^a   Wee, Won Ryang ^a   Prockop, Darwin J ^b  

^a Seoul National University Hospital   (South Korea)

^b SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

Author keywords

Macrophage; Mesenchymal stem stromal cell; NLRP3 inflammasome; Reactive oxygen species

Indexed keywords

CASPASE 3; CRYOPYRIN; HYPOCALCIN; INFLAMMASOME; INTERLEUKIN 1BETA; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; GLYCOPROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; MESSENGER RNA; NLRP3 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MACROPHAGE; MESENCHYMAL STEM CELL; MITOCHONDRION; NONHUMAN; PROTEIN EXPRESSION; REGULATORY MECHANISM; STROMA CELL; ANIMAL; CELL LINE; DNA MICROARRAY; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; MACROPHAGE ACTIVATION; MESENCHYMAL STROMA CELL; METABOLISM; MOUSE; SECRETION (PROCESS);

ADENOSINE TRIPHOSPHATE; ANIMALS; CARRIER PROTEINS; CASPASE 1; CELL LINE; ENZYME ACTIVATION; GENE KNOCKDOWN TECHNIQUES; GLYCOPROTEINS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MESENCHYMAL STROMAL CELLS; MICE; MITOCHONDRIA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC;

EID: 84901418433     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1608     Document Type: Article

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