Insulin and IGFs enhance hepatocyte differentiation from human embryonic stem cells via the PI3K/AKT Pathway

Stem Cells

Volumn 31, Issue 10, 2013, Pages 2095-2103

  Magner, Nataly L ^a   Jung, Yunjoon ^a   Wu, Jian ^b   Nolta, Jan A ^a   Zern, Mark A ^b   Zhou, Ping ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Embryonic stem cells; Hepatocyte differentiation; Insulin like growth factor; Signal transduction

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 1; HEPATOCYTE NUCLEAR FACTOR 4; INSULIN; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SHORT HAIRPIN RNA; SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DEFINITIVE ENDODERM; EMBRYONIC STEM CELL; ENDODERM; ENZYME ACTIVATION; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; LIVER CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RECEPTOR BLOCKING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION;

EMBRYONIC STEM CELLS; HEPATOCYTE DIFFERENTIATION; INSULIN-LIKE GROWTH FACTOR; SIGNAL TRANSDUCTION;

ANTIGENS, DIFFERENTIATION; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; EMBRYONIC STEM CELLS; HEPATOCYTES; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTOME;

EID: 84887929544     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1478     Document Type: Article

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