Isolation and optimization for affinity and biophysical characteristics of anti-CCL17 antibodies from the VH1-69 germline gene

Protein Engineering, Design and Selection

Volumn 27, Issue 6, 2014, Pages 199-206

  Kehoe, John W ^a   Whitaker, Brian ^a   Bethea, Deidra ^a   Lacy, Eilyn R ^a   Boakye, Ken ^a   Santulli Marotto, Sandra ^a   Ryan, Mary H ^a   Feng, Yiqing ^b   Wheeler, John C ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

affinity maturation; antibody; phage display; protein engineering; solubility

Indexed keywords

BINDING ENERGY; CHAINS; DISPLAY DEVICES; GENES; HYDROPHOBICITY; SOLUBILITY;

AFFINITY MATURATION; BIOPHYSICAL CHARACTERISTICS; HYDROPHOBIC POCKETS; INFLAMMATORY DISEASE; PHAGE DISPLAY; PHAGE DISPLAY LIBRARIES; PROTEIN ENGINEERING; PROTEIN-PROTEIN INTERACTIONS;

ANTIBODIES;

ANTIBODY; CCL17 ANTIBODY; EPITOPE; THYMUS AND ACTIVATION REGULATED CHEMOKINE; UNCLASSIFIED DRUG; CCL17 PROTEIN, HUMAN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; PEPTIDE LIBRARY; PROTEIN BINDING;

ANTIBODY AFFINITY; ANTIBODY ISOLATION; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BIOPANNING; CALCIUM TRANSPORT; CHROMATOGRAPHY; CONTROLLED STUDY; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GLYCOSYLATION; HEAVY CHAIN; HUMAN; HYDROPHOBICITY; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; ANIMAL; CALCIUM SIGNALING; CELL LINE; CHEMISTRY; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; MACACA FASCICULARIS; PEPTIDE LIBRARY; PROTEIN ENGINEERING;

ANIMALS; ANTIBODY AFFINITY; CALCIUM SIGNALING; CELL LINE; CHEMOKINE CCL17; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; MACACA FASCICULARIS; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN ENGINEERING;

EID: 84901400423     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzu012     Document Type: Article

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