Surrogate antibodies that specifically bind and neutralize CCL17 but not CCL22

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

Volumn 32, Issue 3, 2013, Pages 162-171

  Santulli Marotto, Sandra ^a   Fisher, Jamie ^a   Petley, Theodore ^a   Boakye, Ken ^a   Panavas, Tadas ^a   Luongo, Jennifer ^a   Kavalkovich, Karl ^a   Rycyzyn, Michael ^a   Wu, Bingyuan ^a   Gutshall, Lester ^a   Coelho, Ana ^b   Hogaboam, Cory M ^b   Ryan, Mary ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN; CALCIUM; CHIMERIC ANTIBODY; MACROPHAGE DERIVED CHEMOKINE; NEUTRALIZING ANTIBODY; THYMUS AND ACTIVATION REGULATED CHEMOKINE;

ANIMAL EXPERIMENT; ANTIBODY COMBINING SITE; ANTIBODY SCREENING; ANTIGEN EXPRESSION; ARTICLE; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL INCLUSION; CHEMOTAXIS; ESCHERICHIA COLI; HYBRIDOMA; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODY AFFINITY; ARRESTINS; CELL LINE; CHEMOKINE CCL17; CHEMOKINE CCL22; CHEMOTAXIS; HUMANS; RATS; RECEPTORS, CCR4;

EID: 84881601731     PISSN: None     EISSN: 21679436     Source Type: Journal    
DOI: 10.1089/mab.2012.0112     Document Type: Article

References (26)

1. Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, and Gray PW: Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. J Biol Chem 1998;273: 1764-1768.
2. Allen SJ, Crown SE, and Handel TM: Chemokine: receptor structure, interactions, and antagonism. Annu Rev Immunol 2007;25: 787-820.
3. Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, and Yoshie O: The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J Biol Chem 1997;272: 15036-15042.
4. D'Ambrosio D, Albanesi C, Lang R, Girolomoni G, Sinigaglia F, and Laudanna C: Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion. J Immunol 2002;169: 2303-2312.
5. Mariani M, Lang R, Binda E, Panina-Bordignon P, and D'Ambrosio D: Dominance of CCL22 over CCL17 in induction of chemokine receptor CCR4 desensitization and internalization on human Th2 cells. Eur J Immunol 2004;34: 231-240.
6. Baatar D, Olkhanud P, Newton D, Sumitomo K, and Biragyn A: CCR4-expressing T cell tumors can be specifically controlled via delivery of toxins to chemokine receptors. J Immunol 2007;179: 1996-2004.
7. Matsukawa A, Hogaboam CM, Lukacs NW, Lincoln PM, Evanoff HL, and Kunkel SL: Pivotal role of the CC chemokine, macrophage-derived chemokine, in the innate immune response. J Immunol 2000;164: 5362-5368.
8. Carpenter KJ, and Hogaboam CM: Immunosuppressive effects of CCL17 on pulmonary antifungal responses during pulmonary invasive aspergillosis. Infect Immun 2005;73: 7198-7207.
9. Weber C, Meiler S, Doring Y, Koch M, Drechsler M, Megens RT, Rowinska Z, Bidzhekov K, Fecher C, Ribechini E, van Zandvoort MA, Binder CJ, Jelinek I, Hristov M, Boon L, Jung S, Korn T, Lutz MB, Forster I, Zenke M, Hieronymus T, Junt T, and Zernecke A: CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest 2011;121: 2898-2910.
10. Heiseke AF, Faul AC, Lehr HA, Forster I, Schmid RM, Krug AB, and Reindl W: CCL17 promotes intestinal inflammation in mice and counteracts regulatory T cell-mediated protection from colitis. Gastroenterology 2012;142: 335-345.
11. Alferink J, Lieberam I, Reindl W, Behrens A, Weiss S, Huser N, Gerauer K, Ross R, Reske-Kunz AB, Ahmad-Nejad P, Wagner H, and Forster I: Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen. J Exp Med 2003;197: 585-599.
12. Conroy DM, Jopling LA, Lloyd CM, Hodge MR, Andrew DP, Williams TJ, Pease JE, and Sabroe I: CCR4 blockade does not inhibit allergic airways inflammation. J Leukoc Biol 2003;74: 558-563.
13. Perros F, Hoogsteden HC, Coyle AJ, Lambrecht BN, and Hammad H: Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC-derived CCL17 and CCL22 in attracting Th2 cells and inducing airway inflammation. Allergy 2009;64: 995-1002.
14. Abi-Younes S, Si-Tahar M, and Luster AD: The CC chemokines MDC and TARC induce platelet activation via CCR4. Thromb Res 2001;101: 279-289.
15. Nakagami Y, Kawashima K, Yonekubo K, Etori M, Jojima T, Miyazaki S, Sawamura R, Hirahara K, Nara F, and Yamashita M: Novel CC chemokine receptor 4 antagonist RS-1154 inhibits ovalbumin-induced ear swelling in mice. Eur J Pharmacol 2009;624: 38-44.
16. de St Groth SF, and Scheidegger D: Production of monoclonal antibodies: strategy and tactics. J Immunol Methods 1980;35: 1-21.
17. Schaniel C, Sallusto F, Ruedl C, Sideras P, Melchers F, and Rolink AG: Three chemokines with potential functions in T lymphocyte-independent and -dependent B lymphocyte stimulation. Eur J Immunol 1999;9: 934-947.
18. Imai T, Nagira M, Takagi S, Kakizaki M, Nishimura M, Wang J, Gray PW, Matsushima K, and Yoshie O: Selective recruitment of CCR4-bearing Th2 cells toward antigenpresenting cells by the CC chemokines thymus and activationregulated chemokine and macrophage-derived chemokine. Intl Immunol 1999;11: 81-88.
19. Cronshaw D: Activation of phosphoinositide 3-kinases by the CCR4 ligand macrophage-derived chemokine is a dispensable signal for T lymphocyte chemotaxis. J Immunol 2004;172.
20. Moroi Y, Yu B, Urabe K, Koga T, Nakahara T, Dainichi T, Uchi H, and Furue M: Effects of MAPK inhibitors on CCR4-mediated chemotaxis against thymus and activation-regulated chemokine (TARC/CCL17). J Dermatol Sci 2004;36: 186-188.
21. Schuh JM, Power CA, Proudfoot AE, Kunkel SL, Lukacs NW, and Hogaboam CM: Airway hyperresponsiveness, but not airway remodeling, is attenuated during chronic pulmonary allergic responses to Aspergillus in CCR4-/- mice. FASEB J 2002;16: 1313-1315.
22. Asojo OA, Boulegue C, Hoover DM, Lu W, and Lubkowski J: Structures of thymus and activation-regulated chemokine (TARC). Acta Crystallogr D Biol Crystallogr 2003;59: 1165-1173.
23. Wu M-T, Fang H, and Hwant ST: Cutting edge: CCR4 mediates antigen-primed T cell binding to activated dendritic cells. J Immunol 2001;167: 4791-4795.
24. Imai T, Yoshida T, Baba M, Nishimura M, Kakizaki M, and Yoshie O: Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector. J Biol Chem 1996;271: 21514-21521.
25. Saeki H, and Tamaki K: Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases. J Dermatol Sci 2006;43: 75-84.
26. Berin MC, Eckmann L, Broide DH, and Kagnoff MF: Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts. Am J Respir Cell Mol Biol 2001;24: 382-389.