Effects of β-hydroxy-β-methylbutyrate free acid and cold water immersion on post-exercise markers of muscle damage

Amino Acids

Volumn 46, Issue 6, 2014, Pages 1501-1511

  Gonzalez, Adam M ^a   Stout, Jeffrey R ^a   Jajtner, Adam R ^a   Townsend, Jeremy R ^a   Wells, Adam J ^a   Beyer, Kyle S ^a   Boone, Carleigh H ^a   Pruna, Gabriel J ^a   Mangine, Gerald T ^a   Scanlon, Tyler M ^a   Bohner, Jonathan D ^a   Oliveira, Leonardo P ^a   Fragala, Maren S ^a   Hoffman, Jay R ^a  

^a UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

C reactive protein; Cryotherapy; Cytokines; HMB; Myoglobin; Recovery

Indexed keywords

BETA HYDROXY BETA METHYLBUTYRATE FREE ACID; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CHEMICAL COMPOUND; CREATINE KINASE; INTERLEUKIN 10; INTERLEUKIN 6; MYOGLOBIN; UNCLASSIFIED DRUG; BETA-HYDROXYISOVALERIC ACID; VALERIC ACID DERIVATIVE; WATER;

ADULT; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; DIET SUPPLEMENTATION; DIETARY INTAKE; EXERCISE; HUMAN; LEG EDEMA; LEG PAIN; MALE; MUSCLE INJURY; PLASMA VOLUME; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESISTANCE TRAINING; WATER IMMERSION; BLOOD; COLD; METABOLISM; PHYSIOLOGY; SKELETAL MUSCLE; YOUNG ADULT;

C-REACTIVE PROTEIN; COLD TEMPERATURE; EXERCISE; HUMANS; MALE; MUSCLE, SKELETAL; MYOGLOBIN; VALERATES; WATER; YOUNG ADULT;

EID: 84901393621     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-014-1722-2     Document Type: Article

References (40)

1. Banfi G, Lombardi G, Colombini A, Melegati G (2010) Whole-body cryotherapy in athletes. Sports Med 40(6):509-517
2. Black S, Kushner I, Samols D (2004) C-reactive protein. J Biol Chem 279(47):48487-48490 (Pubitemid 39625721)
3. Brzycki M (1993) Strength testing - predicting a one-rep max from reps-to-fatigue. J Phys Educ Recreat Dance 64(1):88-90
4. Buford TW, Cooke MB, Willoughby DS (2009) Resistance exercise-induced changes of inflammatory gene expression within human skeletal muscle. Eur J Appl Physiol 107(4):463-471
5. Calle MC, Fernandez ML (2010) Effects of resistance training on the inflammatory response. Nutr Res Pract 4(4):259-269
6. Croisier JL, Camus G, Venneman I, Deby-Dupont G, Juchmès-Ferir A, Lamy M, Crielaard JM, Deby C, Duchateau J (1999) Effects of training on exercise-induced muscle damage and interleukin 6 production. Muscle Nerve 22(2):208-212 (Pubitemid 29070394)
7. Dill D, Costill DL (1974) Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 37:247
8. Eley HL, Russell ST, Baxter JH, Mukerji P, Tisdale MJ (2007) Signaling pathways initiated by β-hydroxy-β-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli. Am J Physiol Endocrinol Metab 293(4):E923-E931 (Pubitemid 47535823)
9. Eston R, Peters D (1999) Effects of cold water immersion on the symptoms of exercise-induced muscle damage. J Sports Sci 17(3):231-238 (Pubitemid 29231913)
10. Fuller JC, Sharp RL, Angus HF, Baier SM, Rathmacher JA (2011) Free acid gel form of β-hydroxy-β-methylbutyrate (HMB) improves HMBclearance from plasma in human subjects compared with the calcium HMB salt. Br J Nutr 105(03):367-372
11. Hirose L, Nosaka K, Newton M, Laveder A, Kano M, Peake J, SuzukiK (2004) Changes in inflammatory mediators following eccentric exercise of the elbow flexors. Exerc Immunol Rev 10(75-90):20
12. Hoffman J (2006) Norms for fitness, performance, and health. Human Kinetics Publishers, Champaign, IL
13. Hoffman JR, Cooper J, Wendell M, Im J, Kang J (2004) Effects of [beta]-hydroxy [beta]-methylbutyrate on power performance and indices of muscle damage and stress during high-intensity training. J Strength Cond Res 18(4):747-752 (Pubitemid 39627313)
14. Hoffman JR, Ratamess NA, Tranchina CP, Rashti SL, Kang J, Faigenbaum AD (2010) Effect of a proprietary protein supplement on recovery indices following resistance exercise in strength/power athletes. Amino Acids 38(3):771-778
15. Ingram J, Dawson B, Goodman C, Wallman K, Beilby J (2009) Effect of water immersion methods on post-exercise recovery from simulated team sport exercise. J Sci Med Sport 12(3):417-421
16. Kenttä G, Hassmen P, Kellmann M (2002) Underrecovery and overtraining: a conceptual model. Enhancing recovery: preventing underperformance in athletes. Human Kinetics Publishers, Champaign, IL
17. Kones R (2009) The Jupiter study, CRP screening, and aggressive statin therapy-implications for the primary prevention of cardiovascular disease. Ther Adv Cardiovasc Dis 3(4):309-315
18. Lee KA, Hicks G, Nino-Murcia G (1991) Validity and reliability of a scale to assess fatigue. Psychiatry Res 36(3):291-298
19. Leeder J, Gissane C, van Someren K, Gregson W, Howatson G (2012) Cold water immersion and recovery from strenuous exercise: a meta-analysis. Br J Sports Med 46(4):233-240
20. MacIntyre DL, Sorichter S, Mair J, Berg A, McKenzie DC (2001) Markers of inflammation and myofibrillar proteins following eccentric exercise in humans. Eur J Appl Physiol 84(3):180-186 (Pubitemid 32229391)
21. Meyer T, Gabriel HH, Ratz M, Muller H, Kindermann W (2001) Anaerobic exercise induces moderate acute phase response. Med Sci Sports Exerc 33(4):549-555 (Pubitemid 32274145)
22. Nissen S, Van Koevering M, Webb D (1990) Analysis of β-hydroxy- β-methyl butyrate in plasma by gas chromatography and mass spectrometry. Anal Biochem 188(1):17-19 (Pubitemid 20215869)
23. Peake J, Nosaka KK, Muthalib M, Suzuki K (2006) Systemic inflammatory responses to maximal versus submaximal lengthening contractions of the elbow flexors. Exerc Immunol Rev 12:72-85
24. Pedersen BK, Steensberg A, Fischer C, Keller C, Ostrowski K, Schjerling P (2001) Exercise and cytokines with particular focus on muscle-derived IL-6. Exerc Immunol Rev 7:18
25. Petersen AMW, Pedersen BK (2005) The anti-inflammatory effect of exercise. J Appl Physiol 98(4):1154-1162 (Pubitemid 40396484)
26. Phillips MD, Mitchell JB, Currie-Elolf LM, Yellott RC, Hubing KA (2010) Influence of commonly employed resistance exercise protocols on circulating IL-6 and indices of insulin sensitivity. J Strength Cond Res 24(4):1091
27. Pue CA, Mortensen RF, Marsh CB, Pope HA, Wewers MD (1996) Acute phase levels of C-reactive protein enhance IL-1 beta and IL-1ra production by human blood monocytes but inhibit IL-1 beta and IL-1ra production by alveolar macrophages. J Immunol 156(4):1594-1600 (Pubitemid 26065872)
28. Ransone J, Neighbors K, Lefavi R, Chromiak J (2003) The effect of beta-hydroxy beta-methylbutyrate on muscular strength and body composition in collegiate football players. J Strength Cond Res/Natl Strength Cond Assoc 17(1):34-39
29. Ratamess NA, Kraemer WJ, Volek JS, Rubin MR, Gomez AL, French DN, Sharman MJ, McGuigan MM, Scheett T, HÄKKINEN K (2003) The effects of amino acid supplementation on muscular performance during resistance training overreaching. J Strength Cond Res 17(2):250-258 (Pubitemid 36745488)
30. Smith L, Anwar A, Fragen M, Rananto C, Johnson R, Holbert D (2000) Cytokines and cell adhesion molecules associated with high-intensity eccentric exercise. Eur J Appl Physiol 82(1-2):61-67 (Pubitemid 30312845)
31. Smith HJ, Mukerji P, Tisdale MJ (2005) Attenuation of proteasomeinduced proteolysis in skeletal muscle by β-hydroxy-β-methylbutyrate in cancer-induced muscle loss. Cancer Res 65(1):277-283 (Pubitemid 40070819)
32. Swenson C, Swärd L, Karlsson J (1996) Cryotherapy in sports medicine. Scand J Med Sci Sports 6(4):193-200 (Pubitemid 126479173)
33. Tseng C, Lee J, Tsai Y, Lee S, Kao C, Liu T, Lai C, Harris M, Kuo C (2012) Topical cooling (icing) delays recovery from eccentric exercise-induced muscle damage. J Strength Cond Res 27(5):1354-1361
34. Uchida MC, Nosaka K, Ugrinowitsch C, Yamashita A, Martins E Jr, Moriscot AS, Aoki MS (2009) Effect of bench press exercise intensity on muscle soreness and inflammatory mediators. J Sports Sci 27(5):499-507
35. Van Someren KA, Edwards AJ, Howatson G (2005) Supplementation with [beta]-hydroxy-[beta]-methylbutyrate (HMB) and [alpha]-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man. Int J Sport Nutr Exerc Metab 15(4):413-424 (Pubitemid 41283877)
36. Versey NG, Halson SL, Dawson BT (2013) Water immersion recovery for athletes: effect on exercise performance and practical recommendations. Sports Med 43(11):1101-1130
37. Wilkinson DJ, Hossain T, Hill DS, Phillips BE, Crossland H, Williams J, Loughna P, Churchward-Venne TA, Breen L, Phillips SM (2013) Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism. J Physiol 591(11):2911-2923
38. Wilson JM, Kim J, Lee S, Rathmacher JA, Dalmau B, Kingsley JD, Koch H, Manninen AH, Saadat R, Panton LB (2009) Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage. Nutr Metab 6(6):1-8
39. Wilson JM, Fitschen PJ, Campbell B, Wilson GJ, Zanchi N, Taylor L, Wilborn C, Kalman DS, Stout JR, Hoffman JR (2013a) International Society of Sports Nutrition Position Stand: beta-hydroxy- beta-methylbutyrate (HMB). J Int Soc Sports Nutr 10(1):1-14
40. Wilson JM, Lowery RP, Joy JM, Walters JA, Baier SM, Fuller JC, Stout JR, Norton LE, Sikorski EM, Wilson S (2013b) β-Hydroxy-β-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resis-tance- trained men. Br J Nutr 1(1):1-7