Influence of commonly employed resistance exercise protocols on circulating IL-6 and indices of insulin sensitivity

Journal of Strength and Conditioning Research

Volumn 24, Issue 4, 2010, Pages 1091-1101

  Phillips, Melody D ^a   Mitchell, Joel B ^a   Currie Elolf, Lauren M ^a   Yellott, Robert C ^a   Hubing, Kimberly A ^a  

^a TEXAS CHRISTIAN UNIVERSITY   (United States)

Author keywords

Cytokine; Exercise intensity; Glucose tolerance; Weight training

Indexed keywords

INSULIN; INTERLEUKIN 6;

ADULT; ANALYSIS OF VARIANCE; ANTHROPOMETRY; ARTICLE; ATHLETIC PERFORMANCE; BLOOD; CARBOHYDRATE DIET; CASE CONTROL STUDY; COMPARATIVE STUDY; ENDURANCE; ENERGY METABOLISM; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HUMAN; INSULIN RESISTANCE; MALE; METABOLISM; METHODOLOGY; OXYGEN CONSUMPTION; PHYSIOLOGY; PROBABILITY; REFERENCE VALUE; RESISTANCE TRAINING; RISK FACTOR; WEIGHT LIFTING;

ANALYSIS OF VARIANCE; ANTHROPOMETRY; ATHLETIC PERFORMANCE; BLOOD GLUCOSE; CASE-CONTROL STUDIES; DIETARY CARBOHYDRATES; ENERGY METABOLISM; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN RESISTANCE; INTERLEUKIN-6; MALE; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE; PROBABILITY; REFERENCE VALUES; RESISTANCE TRAINING; RISK FACTORS; WEIGHT LIFTING; YOUNG ADULT;

EID: 77950637729     PISSN: 10648011     EISSN: None     Source Type: Journal    
DOI: 10.1519/JSC.0b013e3181cc2212     Document Type: Article

References (44)

1. Abdul-Ghani, MA, Jenkinson, CP, Richardson, DK, Tripathy, D, and DeFronzo, RA. Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance. Results from the veterans administration genetic epidemiology study. Diabetes 55: 1430-1435, 2006.
2. American College of Sports Medicine. Guidelines for Exercise Testing and Prescription (7th ed.). Philadelphia, PA: Lippincott, Williams, & Wilkins, 2005.
3. Bajpeyi, S, Tanner, CH, Slentz, CA, Duscha, BD, McCartney, JS, Hickner, RC, Kraus, WE, and Houmard, JA. Effect of exercise intensity and volume on persistence of insulin sensitivity during training cessation. J Appl Physiol 106: 1079-1085, 2009.
4. Bastard, J-P, Maachi, M, van Nhieu, JT, Jardel, C, Bruckert, E, Grimaldi, A, Robert, J-J, Capeau, J, and Hainque, B. Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J Clin Endorinol Metab 87: 2084-2089, 2002.
5. Borst, SE. The role of TNF-a in insulin resistance. Endocrine 23: 177-182, 2004.
6. Carey, AL, Steinberg, GR, Macaulay, SL, Thomas, WG, Holmes, AG, Ramm, G, Prelovsek, O, Hohnen-Behrens, C, Watt, MJ, James, DE, Kemp, BE, Pedersen, BK, and Febbraio, MA. Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMPK. Diabetes 55: 2688-2697, 2006.
7. Chapman, J, Garvin, AW, Ward, A, and Cartee, GD. Unaltered insulin sensitivity after resistance exercise bout by postmenopausal women. Med Sci Sport Exerc. 34: 936-941, 2002.
8. Febbraio, MA, Hiscock, N, Sacchetti, M, Fischer, CP, and Pedersen, BK. Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes 53: 1643-1648, 2004.
9. Febbraio, MA and Pedersen, BK. Muscle-derived interleukin-6: Mechanisms for activation and possible biological roles. FASEB J. 16: 1335-1347, 2002.
10. Fischer, CP. Interleukin-6 in acute exercise and training: What is the biological relevance? Exercise Immmunol Rev 12: 6-33, 2006.
11. Grundy, SM. Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol 28: 629-636, 2008.
12. Grundy, SM, Brewer, HB Jr, Cleeman, JI, Smith, SC Jr, and Lenfant, C. Definition of metabolic syndrome. Circulation 109: 433-438, 2004.
13. Harada, N, Fukushima, M, Toyoda, K, Mitsui, R, Izuka, T, Taniguchi, A, Nakai, Y, Yamada, Y, Seino, Y, and Inagaki, N. Factors responsible for elevation of 1-h postchallenge plasma glucose levels in Japanese men. Diabetes Res Clin Pract 81: 284-289, 2008.
14. Hayashi, Y, Nagasaka, S, Takahashi, N, Kusaka, I, Ishibashi, S, Numao, S, Lee DJ, Taki, Y, Ogata, H, Tokuyama, K, and Tanaka, K. A single bout of exercise at higher intensity enhances glucose effectiveness in sedentary men. J Clin Endocrinol Metab 90: 4035-4040, 2005.
15. Heath, GW, Gavin, JR III, Hinderliter, JM, Hagberg, JM, Bloomfield, SA, and Holloszy, JO. Effects of exercise and lack of exercise on glucose tolerance and insulin sensitivity. J Appl Phsyiol. 55: 512-517, 1983.
16. Houmard, JA, Tanner, CJ, Slentz, CA, Duscha, BD, McCartney, JS, and Kraus, WE. Effect of the volume and intensity of exercise training on insulin sensitivity. J Appl Physiol 96: 101-106, 2004.
17. Koopman, R, Manders, RJF, Zorenc AHG, Hul, GBJ, Kuipers, H, Keizer, HA, and van Loon, LJC. A single session of resistance exercise enhances insulin sensitivity for at least 24 h in healthy men. Eur J Appl Physiol 94: 180-187, 2005.
18. Kowalska, I, Straczkowski, M, Nikolajuk, A, Adamska, A, Karczewska-Kupczewska, M, Otziomek, E, Kinalska, I, and Gorska, M. Insulin resistance, serum adiponectin, and proinflammatory markers in young subjects with the metabolic syndrome. Metabolism 57: 1539-1544, 2008.
19. Kraemer, WJ, Ratamess, NA, and French, DN. Resistance training for health and performance. Curr Sports Med Rep 1: 165-171, 2002.
20. Li, T-L and Gleeson, M. The effects of carbohydrate supplementation during the second of two prolonged cycling bouts on immunoendocrine responses. Eur J Appl Physiol 95: 391-399, 2005.
21. Luebbers, PE, Potteiger, JA, Warren, BJ, Clore, JN, Jennings, C, and Bond, DS. Glucose uptake after resistance training of different intensities but of equal work volume. J Strength Cond Res 22: 1094-1100, 2008.
22. Matsuda, M and DeFronzo, RA. Insulin sensitivity indices obtained fromoral glucose tolerance testing. Diabetes Care 22: 1462-1470, 1999.
23. Miller, AD, Ruby, BC, Laskin, JJ, and Gaskill, SE. Effects of high intensity/low volume and low intensity/high volume isokinetic resistance exercise on postexercise glucose tolerance. J Strength Cond Res 21: 330-335, 2007.
24. Mitchell, JB, Phillips, MD, Yellott, RC, Currie, LM, and Hubing, KA. Resistance and aerobic exercise: the influence of mode on the relationship between IL-6 and glucose uptake in obese young men. In review.
25. Nielsen, AR and Pedersen, BK. The biological roles of exerciseinduced cytokine: IL-6, IL-8, and IL-15. Appl Physiol Nutri Metab 32: 833-839, 2007.
26. Nieman, DC, Davis, JM, Brown, VA, Henson, DA, Dumke, CL, Utter, AC, Vinci, DM, Downs, MF, Smith, JC, Carson, J, Brown, A, McAnulty, SR, and McAnulty, LS. Influence of carbohydrate ingestion on immune changes after 2 h of intensive resistance training. J Appl Physiol 96: 1292-1298, 2004.
27. Nieman, DC, Davis, JM, Henson, DA, Gross, SJ, Dumke, CL, Utter, AC, Vinci, DM, Carson, JA, Brown, A, McAnulty, SR, McAnulty, LS, and Triplett, NT. Muscle cytokine mRNA changes after 2.5 h of cycling: influence of carbohydrate. Med Sci Sports Exerc 37: 1283-1290, 2005.
28. Nieman, DC, Henson, D, Gojanovich, G, Davis, JM, Dumke, CL, Utter, AC, Murphy, A, Pearce, S, McAnulty, SR, and McAnulty, LS. Immune changes: 2 h of continuous vs intermittent cycling. Int J Sports Med 28: 625-630, 2007.
29. Ostrowski, K, Schjerling, P, and Pedersen, BK. Physical activity and plasma interleukin-6 in humans: effect of intensity of exercise. Eur J Appl Physiol 83: 512-515, 2000.
30. Pedersen, BK. The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control. Biochem Soc Essays Biochem 42: 105-117, 2006.
31. Pedersen, BK and Febbraio, MA. Muscle as an endocrine organ: Focus on muscle-derived IL-6. Physiol Rev 88: 1379-1406, 2008.
32. Phillips, MD, Flynn, MG, McFarlin, BK, Stewart, LK, and Timmerman, KL. Resistance training at 80% 1RM reduces the inflammatory milieu in elderly women. Med Sci Sports Exerc 42: 314-325, 2010.
33. Phillips, MD, Flynn, MG, McFarlin, BK, Stewart, LK, Timmerman, KL, and Ji, H. Resistive exercise blunts LPS-stimulated TNF-a and IL-1b. Int J Sports Med 29: 102-109, 2008.
34. Pontiroli, AE, Pizzocir, P, Caumo, A, Perseghin, G, and Luzi, L. Evaluation of insulin release and insulin sensitivity through oral glucose tolerance test: Differences between NGT, IFG, IGT, and type 2 diabetes mellitus. A cross-sectional and follow-up study. Acta Diabetol 41: 70-76, 2004.
35. Rotter, V, Nagaev, I, and Smith, U. Interleukin-6 induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-a, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 278: 45777-45784, 2003.
36. Siri, WE. Body composition from fluid spaces and density: Analysis of methods. Nutrition 9: 480-491, 1993.
37. Starkie, R, Ostrowski, SR, Jauffred, S, Febbraio, M, and Pedersen, BK. TNF-a production in humans. FASEB 17: 884-886, 2003.
38. Steensberg, A, Febbraio, MA, Osada, T, Schjerling, P, van Hall, G, Saltin, B, and Pedersen, BK. Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content. J Physiol 537: 633-639, 2001.
39. Steensberg, A, van Hall, G, Osada, T, Sacchetti, M, Saltin, B, and Pedersen, BK. Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol 529: 237-242, 2000.
40. Thyfault, JP. Setting the Stage: possible mechanisms by which acute contraction restores insulin sensitivity in muscle. Am J Physiol Regul Integr Comp Physiol 294: R1103-R1110, 2008.
41. van Hall, G, Steensberg, A. Sacchetti, M. Fischer, C. Keller, C, Schjerling, P. Hiscock, N, Moller, K, Saltin, B, Febbraio, MA, and Pedersen, BK. Interleukin-6 stimulates lipolysis and fat oxidation in humans. J Clin Endocrinol Metab 88: 3005-3010, 2003.
42. Weigert, C, Hennige, AM, Lehmann, R, Brodbeck, K, Baumgartner, F, Schäuble, M, Häring, HU, and Schleicher, ED. Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells. J Biol Chem 281: 7060-7067, 2006.
43. Yang, SC, Chen, CY, Liao, YH, Lin, FC, Lee, WC, Cho, YM, Chen, MT, Chous, CH, and Kuo, CH. Interactive effect of an acute bout of resistance exercise and dehydroepiandrosterone administration on glucose tolerance and serum lipids in middle-aged women. Chin J Physiol 48: 23-29, 2005.
44. Zhou, W, Gu, Y, Li, H, and Luo, M. Assessing 1-h plasma glucose and shape of the glucose curve during oral glucose tolerance test. Eur J Endocrin 155: 191-197, 2006.