-
1
-
-
65649131585
-
Multitarget drugs: The present and the future of cancer therapy
-
Petrelli, A. and Valabrega, G. (2009) Multitarget drugs: The present and the future of cancer therapy. Expert Opin. Pharmacother., 10, 589-600.
-
(2009)
Expert Opin. Pharmacother.
, vol.10
, pp. 589-600
-
-
Petrelli, A.1
Valabrega, G.2
-
2
-
-
9244221653
-
Targeting multiple signaling pathways as a strategy for managing prostate cancer: Multifocal signal modulation therapy
-
McCarty, M.F. (2004) Targeting multiple signaling pathways as a strategy for managing prostate cancer: Multifocal signal modulation therapy. Integr. Cancer Ther., 3, 349-380.
-
(2004)
Integr. Cancer Ther.
, vol.3
, pp. 349-380
-
-
McCarty, M.F.1
-
3
-
-
84893581794
-
Interest resparks in RNAi
-
Sinha, G. (2012) Interest resparks in RNAi. Nat. Biotechnol., 30, 1012.
-
(2012)
Nat. Biotechnol.
, vol.30
, pp. 1012
-
-
Sinha, G.1
-
4
-
-
77951132901
-
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
-
Davis, M.E., Zuckerman, J.E., Choi, C.H.J., Seligson, D., Tolcher, A., Alabi, C.A., Yen, Y., Heidel, J.D. and Ribas, A. (2010) Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature, 464, 1067-1070.
-
(2010)
Nature
, vol.464
, pp. 1067-1070
-
-
Davis, M.E.1
Zuckerman, J.E.2
Choi, C.H.J.3
Seligson, D.4
Tolcher, A.5
Alabi, C.A.6
Yen, Y.7
Heidel, J.D.8
Ribas, A.9
-
5
-
-
65749088084
-
SiRNA vs shRNA: Similarities and differences
-
Rao, D.D., Vorhies, J.S., Senzer, N. and Nemunaitis, J. (2009) siRNA vs. shRNA: Similarities and differences. Adv. Drug Deliv. Rev., 61, 746-759.
-
(2009)
Adv. Drug Deliv. Rev.
, vol.61
, pp. 746-759
-
-
Rao, D.D.1
Vorhies, J.S.2
Senzer, N.3
Nemunaitis, J.4
-
6
-
-
79954580272
-
Current prospects for RNA interference-based therapies
-
Davidson, B.L. and McCray, P.B. (2011) Current prospects for RNA interference-based therapies. Nat. Rev. Genet., 12, 329-340.
-
(2011)
Nat. Rev. Genet.
, vol.12
, pp. 329-340
-
-
Davidson, B.L.1
McCray, P.B.2
-
7
-
-
66149150498
-
Multitarget therapy of malignant cancers by the head-To-Tail tandem array multiple shRNAs expression system
-
Cheng, T.L., Teng, C.F., Tsai, W.H., Yeh, C.W., Wu, M.P., Hsu, H.C., Hung, C.F. and Chang, W.T. (2009) Multitarget therapy of malignant cancers by the head-To-Tail tandem array multiple shRNAs expression system. Cancer Gene Ther., 16, 516-531.
-
(2009)
Cancer Gene Ther.
, vol.16
, pp. 516-531
-
-
Cheng, T.L.1
Teng, C.F.2
Tsai, W.H.3
Yeh, C.W.4
Wu, M.P.5
Hsu, H.C.6
Hung, C.F.7
Chang, W.T.8
-
8
-
-
33751001588
-
Silencing of HIV-1 with RNA interference: A multiple shRNA approach
-
ter Brake, O., Konstantinova, P., Ceylan, M. and Berkhout, B. (2006) Silencing of HIV-1 with RNA interference: A multiple shRNA approach. Mol. Ther., 14, 883-892.
-
(2006)
Mol. Ther.
, vol.14
, pp. 883-892
-
-
Ter Brake, O.1
Konstantinova, P.2
Ceylan, M.3
Berkhout, B.4
-
9
-
-
77952725116
-
Dual-Targeting siRNAs
-
Tiemann, K., Hohn, B., Ehsani, A., Forman, S.J., Rossi, J.J. and Saetrom, P. (2010) Dual-Targeting siRNAs. RNA, 16, 1275-1284.
-
(2010)
RNA
, vol.16
, pp. 1275-1284
-
-
Tiemann, K.1
Hohn, B.2
Ehsani, A.3
Forman, S.J.4
Rossi, J.J.5
Saetrom, P.6
-
10
-
-
67650648483
-
Interfering ribonucleic acids that suppress expression of multiple unrelated genes
-
Passioura, T., Gozar, M.M., Goodchild, A., King, A., Arndt, G.M., Poidinger, M., Birkett, D.J. and Rivory, L.P. (2009) Interfering ribonucleic acids that suppress expression of multiple unrelated genes. BMC Biotechnol., 9, 57.
-
(2009)
BMC Biotechnol.
, vol.9
, pp. 57
-
-
Passioura, T.1
Gozar, M.M.2
Goodchild, A.3
King, A.4
Arndt, G.M.5
Poidinger, M.6
Birkett, D.J.7
Rivory, L.P.8
-
11
-
-
58249088751
-
MicroRNAs: Target recognition and regulatory functions
-
Bartel, D.P. (2009) MicroRNAs: Target recognition and regulatory functions. Cell, 136, 215-233.
-
(2009)
Cell
, vol.136
, pp. 215-233
-
-
Bartel, D.P.1
-
12
-
-
84856533765
-
MiR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222
-
Acunzo, M., Visone, R., Romano, G., Veronese, A., Lovat, F., Palmieri, D., Bottoni, A., Garofalo, M., Gasparini, P., Condorelli, G. et al. (2012) miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222. Oncogene, 31, 634-642.
-
(2012)
Oncogene
, vol.31
, pp. 634-642
-
-
Acunzo, M.1
Visone, R.2
Romano, G.3
Veronese, A.4
Lovat, F.5
Palmieri, D.6
Bottoni, A.7
Garofalo, M.8
Gasparini, P.9
Condorelli, G.10
-
13
-
-
84878133983
-
Cross-Talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2
-
Acunzo, M., Romano, G., Palmieri, D., Laganá, A., Garofalo, M., Balatti, V., Drusco, A., Chiariello, M., Nana-Sinkam, P. and Croce, C.M. (2013) Cross-Talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2. Proc. Natl. Acad. Sci. U. S. A., 110, 8573-8578.
-
(2013)
Proc. Natl. Acad. Sci. U. S.A.
, vol.110
, pp. 8573-8578
-
-
Acunzo, M.1
Romano, G.2
Palmieri, D.3
Laganá, A.4
Garofalo, M.5
Balatti, V.6
Drusco, A.7
Chiariello, M.8
Nana-Sinkam, P.9
Croce, C.M.10
-
14
-
-
77957766910
-
Desperately seeking microRNA targets
-
Thomas, M., Lieberman, J. and Lal, A. (2010) Desperately seeking microRNA targets. Nat. Struct. Mol. Biol., 17, 1169-1174.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 1169-1174
-
-
Thomas, M.1
Lieberman, J.2
Lal, A.3
-
15
-
-
34250805982
-
MicroRNA targeting specificity in mammals: Determinants beyond seed pairing
-
Grimson, A., Farh, K.K-H., Johnston, W.K., Garrett-Engele, P., Lim, L.P. and Bartel, D.P. (2007) MicroRNA targeting specificity in mammals: Determinants beyond seed pairing. Mol. Cell, 27, 91-105.
-
(2007)
Mol. Cell
, vol.27
, pp. 91-105
-
-
Grimson, A.1
Farh, K.K.-H.2
Johnston, W.K.3
Garrett-Engele, P.4
Lim, L.P.5
Bartel, D.P.6
-
16
-
-
84891768855
-
Expression Atlas update-A database of gene and transcript expression from microarray-And sequencing-based functional genomics experiments
-
doi:10.1093/nar/gkt1270
-
Petryszak, R., Burdett, T., Fiorelli, B., Fonseca, N.A., Gonzalez-Porta, M., Hastings, E., Huber, W., Jupp, S., Keays, M., Kryvych, N. et al. (2013) Expression Atlas update-A database of gene and transcript expression from microarray-And sequencing-based functional genomics experiments. Nucleic Acids Res., doi:10.1093/nar/gkt1270.
-
(2013)
Nucleic Acids Res.
-
-
Petryszak, R.1
Burdett, T.2
Fiorelli, B.3
Fonseca, N.A.4
Gonzalez-Porta, M.5
Hastings, E.6
Huber, W.7
Jupp, S.8
Keays, M.9
Kryvych, N.10
-
17
-
-
1542336952
-
Rational siRNA design for RNA interference
-
Reynolds, A., Leake, D., Boese, Q., Scaringe, S., Marshall, W.S. and Khvorova, A. (2004) Rational siRNA design for RNA interference. Nat. Biotechnol., 22, 326-330.
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 326-330
-
-
Reynolds, A.1
Leake, D.2
Boese, Q.3
Scaringe, S.4
Marshall, W.S.5
Khvorova, A.6
-
18
-
-
0037686295
-
Killing the messenger: Short RNAs that silence gene expression
-
Dykxhoorn, D.M., Novina, C.D. and Sharp, P.A. (2003) Killing the messenger: Short RNAs that silence gene expression. Nat. Rev. Mol. Cell Biol., 4, 457-467.
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 457-467
-
-
Dykxhoorn, D.M.1
Novina, C.D.2
Sharp, P.A.3
-
19
-
-
77955963884
-
Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites
-
Betel, D., Koppal, A., Agius, P., Sander, C. and Leslie, C. (2010) Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol., 11(8), R90.
-
(2010)
Genome Biol., 11(
, Issue.8
-
-
Betel, D.1
Koppal, A.2
Agius, P.3
Sander, C.4
Leslie, C.5
-
20
-
-
34748833042
-
Effect of target secondary structure on RNAi efficiency
-
DOI 10.1261/rna.546207
-
Shao, Y., Chan, C.Y., Maliyekkel, A., Lawrence, C.E., Roninson, I.B. and Ding, Y. (2007) Effect of target secondary structure on RNAi efficiency. RNA, 13, 1631-1640. (Pubitemid 47481671
-
(2007)
RNA
, vol.13
, Issue.10
, pp. 1631-1640
-
-
Shao, Y.1
Chi, Y.C.2
Maliyekkel, A.3
Lawrence, C.E.4
Roninson, I.B.5
Ding, Y.6
-
21
-
-
34748821761
-
The role of site accessibility in microRNA target recognition
-
Kertesz, M., Iovino, N., Unnerstall, U., Gaul, U. and Segal, E. (2007) The role of site accessibility in microRNA target recognition. Nat. Genet., 39, 1278-1284.
-
(2007)
Nat. Genet.
, vol.39
, pp. 1278-1284
-
-
Kertesz, M.1
Iovino, N.2
Unnerstall, U.3
Gaul, U.4
Segal, E.5
-
22
-
-
75649129058
-
Sequence context outside the target region influences the effectiveness of miR-223 target sites in the RhoB 3'UTR
-
Sun, G., Li, H. and Rossi, J.J. (2010) Sequence context outside the target region influences the effectiveness of miR-223 target sites in the RhoB 3'UTR. Nucleic Acids Res., 38(1), 239-252.
-
(2010)
Nucleic Acids Res.
, vol.38
, Issue.1
, pp. 239-252
-
-
Sun, G.1
Li, H.2
Rossi, J.J.3
-
23
-
-
0001717058
-
Inducing model trees for continuous classes
-
In: Van Someren, M and Widmer, G (eds) Prague, Czech Republic
-
Wang, Y. and Witten, I.H. (1997) Inducing model trees for continuous classes. In: Van Someren, M and Widmer, G (eds). Poster Papers of the 9th European Conference on Machine Learning (ECML 97).Prague, Czech Republic, 128-137.
-
(1997)
Poster Papers of the 9th European Conference on Machine Learning (ECML 97)
, pp. 128-137
-
-
Wang, Y.1
Witten, I.H.2
-
24
-
-
33749677657
-
Unbiased recursive partitioning: A conditional inference framework
-
Hothorn, T., Hornik, K. and Zeileis, A. (2006) Unbiased recursive partitioning: A conditional inference framework. J. Comput. Graph. Stat., 15, 651-674.
-
(2006)
J. Comput. Graph. Stat.
, vol.15
, pp. 651-674
-
-
Hothorn, T.1
Hornik, K.2
Zeileis, A.3
-
25
-
-
78651266827
-
MiRTarBase: A database curates experimentally validated microRNA-Target interactions
-
Hsu, S.D., Lin, F.M., Wu, W.Y., Liang, C., Huang, W.C., Chan, W.L., Tsai, W.T., Chen, G.Z., Lee, C.J., Chiu, C.M. et al. (2010) miRTarBase: A database curates experimentally validated microRNA-Target interactions. Nucleic Acids Res., 39, D163-D169.
-
(2010)
Nucleic Acids Res.
, vol.39
-
-
Hsu, S.D.1
Lin, F.M.2
Wu, W.Y.3
Liang, C.4
Huang, W.C.5
Chan, W.L.6
Tsai, W.T.7
Chen, G.Z.8
Lee, C.J.9
Chiu, C.M.10
-
26
-
-
84860511174
-
Conversion from the oncogene addiction to "drug addiction" by intensive inhibition of the EGFR and MET in lung cancer with activating EGFR mutation
-
doi:10.1016/j.lungcan.2011.11.007
-
Suda, K., Tomizawa, K., Osada, H., Maehara, Y., Yatabe, Y., Sekido, Y. and Mitsudomi, T. (2011) Conversion from the "oncogene addiction" to "drug addiction" by intensive inhibition of the EGFR and MET in lung cancer with activating EGFR mutation. Lung Cancer, doi:10.1016/j.lungcan.2011. 11.007.
-
(2011)
Lung Cancer
-
-
Suda, K.1
Tomizawa, K.2
Osada, H.3
Maehara, Y.4
Yatabe, Y.5
Sekido, Y.6
Mitsudomi, T.7
-
27
-
-
84863471303
-
MicroRNA-mediated regulation of gene expression is affected by disease-Associated SNPs within the 3'-UTR via altered RNA structure
-
Haas, U., Sczakiel, G. and Laufer, S.D. (2012) MicroRNA-mediated regulation of gene expression is affected by disease-Associated SNPs within the 3'-UTR via altered RNA structure. RNA Biol., 9, 924-937.
-
(2012)
RNA Biol.
, vol.9
, pp. 924-937
-
-
Haas, U.1
Sczakiel, G.2
Laufer, S.D.3
-
28
-
-
33847665108
-
Human polymorphism at microRNAs and microRNA target sites
-
Saunders, M.A., Liang, H. and Li, W.-H. (2007) Human polymorphism at microRNAs and microRNA target sites. Proc. Natl. Acad. Sci. U. S. A., 104, 3300-3305.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 3300-3305
-
-
Saunders, M.A.1
Liang, H.2
Li, W.-H.3
-
29
-
-
14544280255
-
The silent revolution: RNA interference as basic biology research tool, and therapeutic
-
Dykxhoorn, D.M. and Lieberman, J. (2005) The silent revolution: RNA interference as basic biology, research tool, and therapeutic. Annu. Rev. Med., 56, 401-423.
-
(2005)
Annu. Rev. Med.
, vol.56
, pp. 401-423
-
-
Dykxhoorn, D.M.1
Lieberman, J.2
-
30
-
-
84882253822
-
RNA interference and personalized cancer therapy
-
Rao, D.D., Wang, Z., Senzer, N. and Nemunaitis, J. (2013) RNA interference and personalized cancer therapy. Discov. Med., 15, 101-110.
-
(2013)
Discov. Med.
, vol.15
, pp. 101-110
-
-
Rao, D.D.1
Wang, Z.2
Senzer, N.3
Nemunaitis, J.4
-
31
-
-
84867642276
-
RNAi-based nanomedicines for targeted personalized therapy
-
Daka, A. and Peer, D. (2012) RNAi-based nanomedicines for targeted personalized therapy. Adv. Drug Deliv. Rev., 64, 1508-1521.
-
(2012)
Adv. Drug Deliv. Rev.
, vol.64
, pp. 1508-1521
-
-
Daka, A.1
Peer, D.2
-
32
-
-
84864324577
-
A review of nanocarriers for the delivery of small interfering RNA
-
Kesharwani, P., Gajbhiye, V. and Jain, N.K. (2012) A review of nanocarriers for the delivery of small interfering RNA. Biomaterials, 33, 7138-7150.
-
(2012)
Biomaterials
, vol.33
, pp. 7138-7150
-
-
Kesharwani, P.1
Gajbhiye, V.2
Jain, N.K.3
-
33
-
-
80052406557
-
Intravenous delivery of a multi-mechanistic cancer-Targeted oncolytic poxvirus in humans
-
Breitbach, C.J., Burke, J., Jonker, D., Stephenson, J., Haas, A.R., Chow, L.Q.M., Nieva, J., Hwang, T.-H., Moon, A., Patt, R. et al. (2011) Intravenous delivery of a multi-mechanistic cancer-Targeted oncolytic poxvirus in humans. Nature, 477, 99-102.
-
(2011)
Nature
, vol.477
, pp. 99-102
-
-
Breitbach, C.J.1
Burke, J.2
Jonker, D.3
Stephenson, J.4
Haas, A.R.5
Chow, L.Q.M.6
Nieva, J.7
Hwang, T.-H.8
Moon, A.9
Patt, R.10
-
34
-
-
70349784215
-
Oral delivery of siRNA and antisense oligonucleotides
-
Akhtar, S. (2009) Oral delivery of siRNA and antisense oligonucleotides. J Drug Target., 17, 491-495.
-
(2009)
J Drug Target.
, vol.17
, pp. 491-495
-
-
Akhtar, S.1
-
35
-
-
65949106130
-
Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
-
Aouadi, M., Tesz, G.J., Nicoloro, S.M., Wang, M., Chouinard, M., Soto, E., Ostroff, G.R. and Czech, M.P. (2009) Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature, 458, 1180-1184.
-
(2009)
Nature
, vol.458
, pp. 1180-1184
-
-
Aouadi, M.1
Tesz, G.J.2
Nicoloro, S.M.3
Wang, M.4
Chouinard, M.5
Soto, E.6
Ostroff, G.R.7
Czech, M.P.8
-
36
-
-
84855502918
-
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: Evidence of cross-kingdom regulation by microRNA
-
Zhang, L., Hou, D., Chen, X., Li, D., Zhu, L., Zhang, Y., Li, J., Bian, Z., Liang, X., Cai, X. et al. (2012) Exogenous plant MIR168a specifically targets mammalian LDLRAP1: Evidence of cross-kingdom regulation by microRNA. Cell Res., 22, 107-126.
-
(2012)
Cell Res.
, Issue.22
, pp. 107-126
-
-
Zhang, L.1
Hou, D.2
Chen, X.3
Li, D.4
Zhu, L.5
Zhang, Y.6
Li, J.7
Bian, Z.8
Liang, X.9
Cai, X.10
-
37
-
-
33745612464
-
Widespread siRNA off-Target' transcript silencing mediated by seed region sequence complementarity
-
Jackson, A.L., Burchard, J., Schelter, J., Chau, B.N., Cleary, M., Lim, L. and Linsley, P.S. (2006) Widespread siRNA off-Target' transcript silencing mediated by seed region sequence complementarity. RNA, 12, 1179-1187.
-
(2006)
RNA
, vol.12
, pp. 1179-1187
-
-
Jackson, A.L.1
Burchard, J.2
Schelter, J.3
Chau, B.N.4
Cleary, M.5
Lim, L.6
Linsley, P.S.7
-
38
-
-
33646188259
-
3-UTR seed matches, but not overall identity, are associated with RNAi off-Targets
-
Birmingham, A., Anderson, E.M., Reynolds, A., Ilsley-Tyree, D., Leake, D., Fedorov, Y., Baskerville, S., Maksimova, E., Robinson, K., Karpilow, J. et al. (2006) 3-UTR seed matches, but not overall identity, are associated with RNAi off-Targets. Nat. Methods, 3, 199-204.
-
(2006)
Nat. Methods
, vol.3
, pp. 199-204
-
-
Birmingham, A.1
Anderson, E.M.2
Reynolds, A.3
Ilsley-Tyree, D.4
Leake, D.5
Fedorov, Y.6
Baskerville, S.7
Maksimova, E.8
Robinson, K.9
Karpilow, J.10
|