Interfering ribonucleic acids that suppress expression of multiple unrelated genes

BMC Biotechnology

Volumn 9, Issue , 2009, Pages

  Passioura, Toby ^a   Gozar, Mary M ^a   Goodchild, Amber ^a   King, Andrew ^a   Arndt, Greg M ^a   Poidinger, Michael ^a   Birkett, Donald J ^a   Rivory, Laurent P ^a  

^a JOHNSON AND JOHNSON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL TRIAL; CONCENTRATION OF; DIABETIC RETINOPATHY; GENE SUPPRESSION; INOSINE; MULTIPLE GENES; POSITIVE CORRELATIONS; RESEARCH TOOLS; RIBONUCLEIC ACID; SEQUENCE VARIANTS; SHORT INTERFERING RNA; TARGET GENES; TARGET SEQUENCES; TARGET SITES;

EYE PROTECTION; GENES; NUCLEIC ACIDS; RNA; SUGAR (SUCROSE);

TARGETS;

INOSINE; INTERCELLULAR ADHESION MOLECULE 1; SMALL INTERFERING RNA; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ARTICLE; CELL LINE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GENE REPRESSION; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PLASMID; REPORTER GENE; RNA INTERFERENCE; WESTERN BLOTTING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

CELL LINE; GENE EXPRESSION REGULATION; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; RNA INTERFERENCE; RNA, SMALL INTERFERING; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 67650648483     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-9-57     Document Type: Article

References (25)

1. Schwarz DS Ding H Kennington L Moore JT Schelter J Burchard J Linsley PS Aronin N Xu Z Zamore PD Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide PLoS Genet 2006, 2:9. 1560399 16965178
2. Kloosterman WP Plasterk RH The diverse functions of microRNAs in animal development and disease Dev Cell 2006, 11(4):441-450. 10.1016/ j.devcel.2006.09.009 17011485
3. Khvorova A Reynolds A Jayasena SD Functional siRNAs and miRNAs exhibit strand bias Cell 2003, 115(2):209-216. 10.1016/S0092-8674(03)00801-8 14567918
4. Engels BM Hutvagner G Principles and effects of microRNA-mediated post-transcriptional gene regulation Oncogene 2006, 25(46):6163-6169. 10.1038/sj.onc.1209909 17028595
5. Filipowicz W Jaskiewicz L Kolb FA Pillai RS Post-transcriptional gene silencing by siRNAs and miRNAs Curr Opin Struct Biol 2005, 15(3):331-341. 10.1016/j.sbi.2005.05.006 15925505
6. Schwarz DS Hutvagner G Du T Xu Z Aronin N Zamore PD Asymmetry in the assembly of the RNAi enzyme complex Cell 2003, 115(2):199-208. 10.1016/ S0092-8674(03)00759-1 14567917
7. Martinez J Patkaniowska A Urlaub H Luhrmann R Tuschl T Single-stranded antisense siRNAs guide target RNA cleavage in RNAi Cell 2002, 110(5):563-574. 10.1016/S0092-8674(02)00908-X 12230974
8. Reynolds A Leake D Boese Q Scaringe S Marshall WS Khvorova A Rational siRNA design for RNA interference Nat Biotechnol 2004, 22(3):326-330. 10.1038/nbt936 14758366
9. Brennecke J Stark A Russell RB Cohen SM Principles of microRNA-target recognition PLoS Biol 2005, 3(3):e85. 1043860 15723116 10.1371/ journal.pbio.0030085
10. Doench JG Sharp PA Specificity of microRNA target selection in translational repression Genes Dev 2004, 18(5):504-511. 374233 15014042 10.1101/gad.1184404
11. Grimson A Farh KK Johnston WK Garrett-Engele P Lim LP Bartel DP MicroRNA targeting specificity in mammals: Determinants beyond seed pairing Mol Cell 2007, 27(1):91-105. 10.1016/j.molcel.2007.06.017 17612493
12. Lai EC Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation Nat Genet 2002, 30(4):363-364. 10.1038/ng865 11896390
13. Funatsu H Yamashita H Sakata K Noma H Mimura T Suzuki M Eguchi S Hori S Vitreous levels of vascular endothelial growth factor and intercellular adhesion molecule 1 are related to diabetic macular edema Ophthalmology 2005, 112(5):806-816. 10.1016/j.ophtha.2004.11.045 15878060
14. Hofacker IL Vienna RNA secondary structure server Nucleic Acids Res 2003, 31(13):3429-3431. 169005 12824340 10.1093/nar/gkg599
15. Rehmsmeier M Steffen P Hochsmann M Giegerich R Fast and effective prediction of microRNA/target duplexes Rna 2004, 10(10):1507-1517. 1370637 15383676 10.1261/rna.5248604
16. Marques JT Devosse T Wang D Zamanian-Daryoush M Serbinowski P Hartmann R Fujita T Behlke MA Williams BR A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells Nat Biotechnol 2006, 24(5):559-565. 10.1038/nbt1205 16648842
17. Rivory LRPM Birkett DJ Arndt GM Passioura TJ Multitargeting Interfering RNAs and Methods of their Use and Design International Patent Application: WO2007/056826A1
18. Imming P Sinning C Meyer A Drugs, their targets and the nature and number of drug targets Nat Rev Drug Discov 2006, 5(10):821-834. 10.1038/ nrd2132 17016423
19. Frantz S The trouble with making combination drugs Nat Rev Drug Discov 2006, 5(11):881-882. 10.1038/nrd2189 17117518
20. Morphy R Rankovic Z The physicochemical challenges of designing multiple ligands J Med Chem 2006, 49(16):4961-4970. 10.1021/jm0603015 16884308
21. Meltzer HY An overview of the mechanism of action of clozapine J Clin Psychiatry 1994, 55(Suppl B):47-52. 7961573
22. Pardanani A Tefferi A Imatinib targets other than bcr/abl and their clinical relevance in myeloid disorders Blood 2004, 104(7):1931-1939. 10.1182/blood-2004-01-0246 15166033
23. Jackson AL Burchard J Schelter J Chau BN Cleary M Lim L Linsley PS Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity Rna 2006, 12(7):1179-1187. 1484447 16682560 10.1261/rna.25706
24. Zimmermann TS Lee AC Akinc A Bramlage B Bumcrot D Fedoruk MN Harborth J Heyes JA Jeffs LB John M et al RNAi-mediated gene silencing in non-human primates Nature 2006, 441(7089):111-114. 10.1038/nature04688 16565705
25. Castanotto D, Sakurai K, Lingeman R, Li H, Shively L, Aagaard L, Soifer H, Gatignol A, Riggs A, Rossi JJ: Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC. Nucleic Acids Res 2007, 35(15):5154-5164. 1976469 17660190 10.1093/nar/gkm543