-
2
-
-
34247278567
-
Combinatorial RNAi: A winning strategy for the race against evolving targets?
-
Grimm D, Kay MA.Combinatorial RNAi: a winning strategy for the race against evolving targets? Mol Ther 2007; 15: 878-888.
-
(2007)
Mol Ther
, vol.15
, pp. 878-888
-
-
Grimm, D.1
Kay, M.A.2
-
3
-
-
13844280638
-
Synthetic shRNAs as potent RNAi triggers
-
Siolas D, Lerner C, Burchard J, Ge W, Linsley PS, Paddison PJ et al. Synthetic shRNAs as potent RNAi triggers. Nat Biotechnol 2005; 23: 227-231.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 227-231
-
-
Siolas, D.1
Lerner, C.2
Burchard, J.3
Ge, W.4
Linsley, P.S.5
Paddison, P.J.6
-
4
-
-
15444369907
-
Simple and efficient DNA vector-based RNAi systems in mammalian cells
-
Wu MT, Wu RH, Hung CF, Cheng TL, Tsai WH, Chang WT.Simple and efficient DNA vector-based RNAi systems in mammalian cells. Biochem Biophys Res Commun 2005; 330: 53-59.
-
(2005)
Biochem Biophys Res Commun
, vol.330
, pp. 53-59
-
-
Wu, M.T.1
Wu, R.H.2
Hung, C.F.3
Cheng, T.L.4
Tsai, W.H.5
Chang, W.T.6
-
5
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA.The hallmarks of cancer. Cell 2000; 100: 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
7
-
-
33645804365
-
Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155
-
Chung KH, Hart CC, Al-Bassam S, Avery A, Taylor J, Patel PD et al. Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155. Nucleic Acids Res 2006; 34: e53.
-
(2006)
Nucleic Acids Res
, vol.34
-
-
Chung, K.H.1
Hart, C.C.2
Al-Bassam, S.3
Avery, A.4
Taylor, J.5
Patel, P.D.6
-
8
-
-
33947576051
-
Multi-gene engineering: Simultaneous expression and knockdown of six genes off a single platform
-
Greber D, Fussenegger M.Multi-gene engineering: simultaneous expression and knockdown of six genes off a single platform. Biotechnol Bioeng 2007; 96: 821-834.
-
(2007)
Biotechnol Bioeng
, vol.96
, pp. 821-834
-
-
Greber, D.1
Fussenegger, M.2
-
9
-
-
26444497548
-
Single small-interfering RNA expression vector for silencing multiple transforming growth factor-beta pathway components
-
Jazag A, Kanai F, Ijichi H, Tateishi K, Ikenoue T, Tanaka Y et al. Single small-interfering RNA expression vector for silencing multiple transforming growth factor-beta pathway components. Nucleic Acids Res 2005; 33: e131.
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Jazag, A.1
Kanai, F.2
Ijichi, H.3
Tateishi, K.4
Ikenoue, T.5
Tanaka, Y.6
-
10
-
-
27644590850
-
Combining RNA interference and kinase inhibitors against cell signalling components involved in cancer
-
O'Grady M, Raha D, Hanson BJ, Bunting M, Han son GT. Combining RNA interference and kinase inhibitors against cell signalling components involved in cancer. BMC Cancer 2005; 5: 125.
-
(2005)
BMC Cancer
, vol.5
, pp. 125
-
-
O'Grady, M.1
Raha, D.2
Hanson, B.J.3
Bunting, M.4
Han son, G.T.5
-
11
-
-
33747603277
-
MultimiRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown
-
Sun D, Melegari M, Sridhar S, Rogler CE, Zhu L.MultimiRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown. Biotechniques 2006; 41: 59-63.
-
(2006)
Biotechniques
, vol.41
, pp. 59-63
-
-
Sun, D.1
Melegari, M.2
Sridhar, S.3
Rogler, C.E.4
Zhu, L.5
-
12
-
-
33846906043
-
Development and validation of vectors containing multiple siRNA expression cassettes for maximizing the efficiency of gene silencing
-
Wang S, Shi Z, Liu W, Jules J, Feng X.Development and validation of vectors containing multiple siRNA expression cassettes for maximizing the efficiency of gene silencing. BMC Biotechnol 2006; 6: 50.
-
(2006)
BMC Biotechnol
, vol.6
, pp. 50
-
-
Wang, S.1
Shi, Z.2
Liu, W.3
Jules, J.4
Feng, X.5
-
13
-
-
33747587442
-
Multiple shRNAs expressed by an inducible pol II promoter can knock down the expression of multiple target genes
-
Xia XG, Zhou H, Xu Z.Multiple shRNAs expressed by an inducible pol II promoter can knock down the expression of multiple target genes. Biotechniques 2006; 41: 64-68.
-
(2006)
Biotechniques
, vol.41
, pp. 64-68
-
-
Xia, X.G.1
Zhou, H.2
Xu, Z.3
-
14
-
-
0037380598
-
Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells
-
Jiang M, Milner J.Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells. Genes Dev 2003; 17: 832-837.
-
(2003)
Genes Dev
, vol.17
, pp. 832-837
-
-
Jiang, M.1
Milner, J.2
-
15
-
-
0042170180
-
Survivin is required for stable checkpoint activation in taxol-treated HeLa cells
-
Carvalho A, Carmena M, Sambade C, Earnshaw WC, Wheatley SP.Survivin is required for stable checkpoint activation in taxol-treated HeLa cells. J Cell Sci 2003; 116: 2987-2998.
-
(2003)
J Cell Sci
, vol.116
, pp. 2987-2998
-
-
Carvalho, A.1
Carmena, M.2
Sambade, C.3
Earnshaw, W.C.4
Wheatley, S.P.5
-
16
-
-
0041845231
-
Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions
-
Katome T, Obata T, Matsushima R, Masuyama N, Cantley LC, Gotoh Y et al. Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions. J Biol Chem 2003; 278: 28312-28323.
-
(2003)
J Biol Chem
, vol.278
, pp. 28312-28323
-
-
Katome, T.1
Obata, T.2
Matsushima, R.3
Masuyama, N.4
Cantley, L.C.5
Gotoh, Y.6
-
17
-
-
1242272924
-
The MAP kinase pathway is required for entry into mitosis and cell survival
-
Liu X, Yan S, Zhou T, Terada Y, Erikson RL.The MAP kinase pathway is required for entry into mitosis and cell survival. Oncogene 2004; 23: 763-776.
-
(2004)
Oncogene
, vol.23
, pp. 763-776
-
-
Liu, X.1
Yan, S.2
Zhou, T.3
Terada, Y.4
Erikson, R.L.5
-
18
-
-
0042173218
-
SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth
-
Filleur S, Courtin A, Ait-Si-Ali S, Guglielmi J, Merle C, Harel-Bellan A et al. SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth. Cancer Res 2003; 63: 3919-3922.
-
(2003)
Cancer Res
, vol.63
, pp. 3919-3922
-
-
Filleur, S.1
Courtin, A.2
Ait-Si-Ali, S.3
Guglielmi, J.4
Merle, C.5
Harel-Bellan, A.6
-
19
-
-
2542449068
-
Enhanced chemosensitivity to irinotecan by RNA interference-mediated down-regulation of the nuclear factor-kappaB p65 subunit
-
Guo J, Verma UN, Gaynor RB, Frenkel EP, Becerra CR.Enhanced chemosensitivity to irinotecan by RNA interference-mediated down-regulation of the nuclear factor-kappaB p65 subunit. Clin Cancer Res 2004; 10: 3333-3341.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3333-3341
-
-
Guo, J.1
Verma, U.N.2
Gaynor, R.B.3
Frenkel, E.P.4
Becerra, C.R.5
-
20
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp TR, Bernards R, Agami R.A system for stable expression of short interfering RNAs in mammalian cells. Science 2002; 296: 550-553.
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
21
-
-
14444279883
-
Fas-mediated apoptosis in human prostatic carcinoma cell lines
-
Rokhlin OW, Bishop GA, Hostager BS, Waldschmidt TJ, Sidorenko SP, Pavloff N et al. Fas-mediated apoptosis in human prostatic carcinoma cell lines. Cancer Res 1997; 57: 1758-1768.
-
(1997)
Cancer Res
, vol.57
, pp. 1758-1768
-
-
Rokhlin, O.W.1
Bishop, G.A.2
Hostager, B.S.3
Waldschmidt, T.J.4
Sidorenko, S.P.5
Pavloff, N.6
-
22
-
-
0027255417
-
Specific proteolytic cleavage of poly(ADPribose) polymerase: An early marker of chemotherapyinduced apoptosis
-
Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE, Poirier GG.Specific proteolytic cleavage of poly(ADPribose) polymerase: an early marker of chemotherapyinduced apoptosis. Cancer Res 1993; 53: 3976-3985.
-
(1993)
Cancer Res
, vol.53
, pp. 3976-3985
-
-
Kaufmann, S.H.1
Desnoyers, S.2
Ottaviano, Y.3
Davidson, N.E.4
Poirier, G.G.5
-
23
-
-
0032577703
-
Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis
-
Simbulan-Rosenthal CM, Rosenthal DS, Iyer S, Boulares AH, Smulson ME.Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis. J Biol Chem 1998; 273: 13703-13712.
-
(1998)
J Biol Chem
, vol.273
, pp. 13703-13712
-
-
Simbulan-Rosenthal, C.M.1
Rosenthal, D.S.2
Iyer, S.3
Boulares, A.H.4
Smulson, M.E.5
-
24
-
-
33745200043
-
A novel siRNA validation system for functional screening and identification of effective RNAi probes in mammalian cells
-
Hung CF, Lu KC, Cheng TL, Wu RH, Huang LY, Teng CF et al. A novel siRNA validation system for functional screening and identification of effective RNAi probes in mammalian cells. Biochem Biophys Res Commun 2006; 346: 707-720.
-
(2006)
Biochem Biophys Res Commun
, vol.346
, pp. 707-720
-
-
Hung, C.F.1
Lu, K.C.2
Cheng, T.L.3
Wu, R.H.4
Huang, L.Y.5
Teng, C.F.6
-
25
-
-
33745299723
-
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
-
Grimm D, Streetz KL, Jopling CL, Storm TA, Pandey K, Davis CR et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 2006; 441: 537-541.
-
(2006)
Nature
, vol.441
, pp. 537-541
-
-
Grimm, D.1
Streetz, K.L.2
Jopling, C.L.3
Storm, T.A.4
Pandey, K.5
Davis, C.R.6
-
26
-
-
33751081567
-
Mechanisms of action of novel agents for prostate cancer chemoprevention
-
Singh RP, Agarwal R.Mechanisms of action of novel agents for prostate cancer chemoprevention. Endocr Relat Cancer 2006; 13: 751-778.
-
(2006)
Endocr Relat Cancer
, vol.13
, pp. 751-778
-
-
Singh, R.P.1
Agarwal, R.2
-
27
-
-
13444262170
-
Inhibition of respiratory viruses by nasally administered siRNA
-
Bitko V, Musiyenko A, Shulyayeva O, Barik S.Inhibition of respiratory viruses by nasally administered siRNA. Nat Med 2005; 11: 50-55.
-
(2005)
Nat Med
, vol.11
, pp. 50-55
-
-
Bitko, V.1
Musiyenko, A.2
Shulyayeva, O.3
Barik, S.4
-
28
-
-
0037173613
-
Short interfering RNA confers intracellular antiviral immunity in human cells
-
Gitlin L, Karelsky S, Andino R.Short interfering RNA confers intracellular antiviral immunity in human cells. Nature 2002; 418: 430-434.
-
(2002)
Nature
, vol.418
, pp. 430-434
-
-
Gitlin, L.1
Karelsky, S.2
Andino, R.3
-
29
-
-
24744466699
-
Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque
-
Li BJ, Tang Q, Cheng D, Qin C, Xie FY, Wei Q et al. Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque. Nat Med 2005; 11: 944-951.
-
(2005)
Nat Med
, vol.11
, pp. 944-951
-
-
Li, B.J.1
Tang, Q.2
Cheng, D.3
Qin, C.4
Xie, F.Y.5
Wei, Q.6
-
30
-
-
0036066508
-
siRNA-directed inhibition of HIV-1 infection
-
Novina CD, Murray MF, Dykxhoorn DM, Beresford PJ, Riess J, Lee SK et al. siRNA-directed inhibition of HIV-1 infection. Nat Med 2002; 8: 681-686.
-
(2002)
Nat Med
, vol.8
, pp. 681-686
-
-
Novina, C.D.1
Murray, M.F.2
Dykxhoorn, D.M.3
Beresford, P.J.4
Riess, J.5
Lee, S.K.6
-
31
-
-
30144434185
-
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
-
Palliser D, Chowdhury D, Wang QY, Lee SJ, Bronson RT, Knipe DM et al. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature 2006; 439: 89-94.
-
(2006)
Nature
, vol.439
, pp. 89-94
-
-
Palliser, D.1
Chowdhury, D.2
Wang, Q.Y.3
Lee, S.J.4
Bronson, R.T.5
Knipe, D.M.6
-
32
-
-
0142124143
-
Human immunodeficiency virus type 1 escape from RNA interference
-
Boden D, Pusch O, Lee F, Tucker L, Ramratnam B.Human immunodeficiency virus type 1 escape from RNA interference. J Virol 2003; 77: 11531-11535.
-
(2003)
J Virol
, vol.77
, pp. 11531-11535
-
-
Boden, D.1
Pusch, O.2
Lee, F.3
Tucker, L.4
Ramratnam, B.5
-
33
-
-
11144239376
-
Poliovirus escape from RNA interference: Short interfering RNA-target recognition and implications for therapeutic approaches
-
Gitlin L, Stone JK, Andino R.Poliovirus escape from RNA interference: short interfering RNA-target recognition and implications for therapeutic approaches. J Virol 2005; 79: 1027-1035.
-
(2005)
J Virol
, vol.79
, pp. 1027-1035
-
-
Gitlin, L.1
Stone, J.K.2
Andino, R.3
-
34
-
-
15744372307
-
RNA interference-mediated control of hepatitis B virus and emergence of resistant mutant
-
Wu HL, Huang LR, Huang CC, Lai HL, Liu CJ, Huang YT et al. RNA interference-mediated control of hepatitis B virus and emergence of resistant mutant. Gastroenterology 2005; 128: 708-716.
-
(2005)
Gastroenterology
, vol.128
, pp. 708-716
-
-
Wu, H.L.1
Huang, L.R.2
Huang, C.C.3
Lai, H.L.4
Liu, C.J.5
Huang, Y.T.6
-
35
-
-
22744451729
-
Lentiviral siRNAs targeting multiple highly conserved RNA sequences of human immunodeficiency virus type 1
-
Chang LJ, Liu X, He J.Lentiviral siRNAs targeting multiple highly conserved RNA sequences of human immunodeficiency virus type 1. Gene Therapy 2005; 12: 1133-1144.
-
(2005)
Gene Therapy
, vol.12
, pp. 1133-1144
-
-
Chang, L.J.1
Liu, X.2
He, J.3
-
36
-
-
33748081146
-
Simultaneous targeting of HCV replication and viral binding with a single lentiviral vector containing multiple RNA interference expression cassettes
-
Henry SD, van der Wegen P, Metselaar HJ, Tilanus HW, Scholte BJ, van der Laan LJ.Simultaneous targeting of HCV replication and viral binding with a single lentiviral vector containing multiple RNA interference expression cassettes. Mol Ther 2006; 14: 485-493.
-
(2006)
Mol Ther
, vol.14
, pp. 485-493
-
-
Henry, S.D.1
van der Wegen, P.2
Metselaar, H.J.3
Tilanus, H.W.4
Scholte, B.J.5
van der Laan, L.J.6
-
37
-
-
33751001588
-
Silencing of HIV-1 with RNA interference: A multiple shRNA approach
-
ter Brake O, Konstantinova P, Ceylan M, Berkhout B. Silencing of HIV-1 with RNA interference: a multiple shRNA approach. Mol Ther 2006; 14: 883-892.
-
(2006)
Mol Ther
, vol.14
, pp. 883-892
-
-
ter Brake, O.1
Konstantinova, P.2
Ceylan, M.3
Berkhout, B.4
-
38
-
-
33947255461
-
Simultaneously inhibition of HIV and HBV replication through a dual small interfering RNA expression system
-
Wu K, Mu Y, Hu J, Lu L, Zhang X, Yang Y et al. Simultaneously inhibition of HIV and HBV replication through a dual small interfering RNA expression system. Antiviral Res 2007; 74: 142-149.
-
(2007)
Antiviral Res
, vol.74
, pp. 142-149
-
-
Wu, K.1
Mu, Y.2
Hu, J.3
Lu, L.4
Zhang, X.5
Yang, Y.6
|