Mesenchymal stromal cells support the viability and differentiation of follicular lymphoma-infiltrating follicular helper T-cells

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Brady, Michael T ^a   Hilchey, Shannon P ^a   Hyrien, Ollivier ^a   Spence, Stephen A ^a   Bernstein, Steven H ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL FUNCTION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE ACTIVITY; FOLLICULAR LYMPHOMA; HELPER CELL; HUMAN; HUMAN CELL; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTE TRANSFER; LYMPHOCYTIC INFILTRATION; MESENCHYMAL STROMA CELL; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; BIOSYNTHESIS; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; IMMUNOLOGY; LYMPHOPOIESIS; PALATINE TONSIL; PHYSIOLOGY; SECRETION (PROCESS); TUMOR ASSOCIATED LEUKOCYTE;

B-LYMPHOCYTES; CELL SURVIVAL; CELLS, CULTURED; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-6; LYMPHOCYTES, TUMOR-INFILTRATING; LYMPHOMA, FOLLICULAR; LYMPHOPOIESIS; MESENCHYMAL STROMAL CELLS; PALATINE TONSIL; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY;

EID: 84901381731     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097597     Document Type: Article

References (30)

1. Ame-Thomas P, Maby-El Hajjami H, Monvoisin C, Jean R, Monnier D, et al. (2007) Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth: role of stromal cells in follicular lymphoma pathogenesis. Blood 109: 693-702. (Pubitemid 46105971)
2. Lwin T, Crespo LA, Wu A, Dessureault S, Shu HB, et al. (2009) Lymphoma cell adhesion-induced expression of B cell-activating factor of the TNF family in bone marrow stromal cells protects non-Hodgkin's B lymphoma cells from apoptosis. Leukemia 23: 170-177.
3. Chauhan D, Uchiyama H, Akbarali Y, Urashima M, Yamamoto K, et al. (1996) Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. Blood 87: 1104-1112. (Pubitemid 26043538)
4. Medina DJ, Goodell L, Glod J, Gelinas C, Rabson AB, et al. (2012) Mesenchymal stromal cells protect mantle cell lymphoma cells from spontaneous and drug-induced apoptosis through secretion of B-cell activating factor and activation of the canonical and non-canonical nuclear factor kappaB pathways. Haematologica 97: 1255-1263.
5. Zhu W, Xu W, Jiang R, Qian H, Chen M, et al. (2006) Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo. Exp Mol Pathol 80: 267-274.
6. Mayer H, Bertram H, Lindenmaier W, Korff T, Weber H, et al. (2005) Vascular endothelial growth factor (VEGF-A) expression in human mesenchymal stem cells: autocrine and paracrine role on osteoblastic and endothelial differentiation. J Cell Biochem 95: 827-839. (Pubitemid 41420169)
7. Dave SS, Wright G, Tan B, Rosenwald A, Gascoyne RD, et al. (2004) Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med 351: 2159-2169. (Pubitemid 39507628)
8. Hilchey SP, De A, Rimsza LM, Bankert RB, Bernstein SH (2007) Follicular lymphoma intratumoral CD4+ CD25 +GITR+ regulatory T cells potently suppress CD3/CD28-costimulated autologous and allogeneic CD8+CD25-and CD4+CD25- T cells. J Immunol 178: 4051-4061. (Pubitemid 46492353)
9. Di Ianni M, Del Papa B, De Ioanni M, Moretti L, Bonifacio E, et al. (2008) Mesenchymal cells recruit and regulate T regulatory cells. Exp Hematol 36: 309-318. (Pubitemid 351221170)
10. Ame-Thomas P, Le Priol J, Yssel H, Caron G, Pangault C, et al. (2012) Characterization of intratumoral follicular helper T cells in follicular lymphoma: role in the survival of malignant B cells. Leukemia 26: 1053-1063.
11. Hilchey SP, Rosenberg AF, Hyrien O, Secor-Socha S, Cochran MR, et al. (2011) Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation. Blood 118: 3591-3602.
12. Pangault C, Ame-Thomas P, Ruminy P, Rossille D, Caron G, et al. (2010) Follicular lymphoma cell niche: identification of a preeminent IL-4-dependent T(FH)-B cell axis. Leukemia 24: 2080-2089.
13. Fazilleau N, Mark L, McHeyzer-Williams LJ, McHeyzer-Williams MG (2009) Follicular helper T cells: lineage and location. Immunity 30: 324-335.
14. Wollenberg I, Agua-Doce A, Hernandez A, Almeida C, Oliveira VG, et al. (2011) Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells. J Immunol 187: 4553-4560.
15. Chung Y, Tanaka S, Chu F, Nurieva RI, Martinez GJ, et al. (2011) Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med 17: 983-988.
16. Linterman MA, Pierson W, Lee SK, Kallies A, Kawamoto S, et al. (2011) Foxp3+ follicular regulatory T cells control the germinal center response. Nat Med 17: 975-982.
17. Mosna F, Sensebe L, Krampera M (2010) Human bone marrow and adipose tissue mesenchymal stem cells: a user's guide. Stem Cells Dev 19: 1449-1470.
18. Mourcin F, Pangault C, Amin-Ali R, Ame-Thomas P, Tarte K (2012) Stromal cell contribution to human follicular lymphoma pathogenesis. Front Immunol 3: 280.
19. Shinagawa K, Kitadai Y, Tanaka M, Sumida T, Kodama M, et al. (2010) Mesenchymal stem cells enhance growth and metastasis of colon cancer. Int J Cancer 127: 2323-2333.
20. Orimo A, Weinberg RA (2006) Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle 5: 1597-1601. (Pubitemid 44285243)
21. Bhowmick NA, Neilson EG, Moses HL (2004) Stromal fibroblasts in cancer initiation and progression. Nature 432: 332-337. (Pubitemid 39551661)
22. Guilloton F, Caron G, Menard C, Pangault C, Ame-Thomas P, et al. (2012) Mesenchymal stromal cells orchestrate follicular lymphoma cell niche through the CCL2-dependent recruitment and polarization of monocytes. Blood 119: 2556-2567.
23. Aggarwal S, Pittenger MF (2005) Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105: 1815-1822. (Pubitemid 40223708)
24. Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, et al. (2002) Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99: 3838-3843. (Pubitemid 34534559)
25. Akiyama K, Chen C, Wang D, Xu X, Qu C, et al. (2012) Mesenchymal-stem- cell-induced immunoregulation involves FAS-ligand2/FAS-mediated T cell apoptosis. Cell Stem Cell 10: 544-555.
26. Augello A, Tasso R, Negrini SM, Amateis A, Indiveri F, et al. (2005) Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway. Eur J Immunol 35: 1482-1490. (Pubitemid 40691430)
27. Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, et al. (2009) Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325: 1006-1010.
28. Nurieva RI, Chung Y, Martinez GJ, Yang XO, Tanaka S, et al. (2009) Bcl6 mediates the development of T follicular helper cells. Science 325: 1001-1005.
29. Crotty S (2011) Follicular helper CD4 T cells (TFH). Annu Rev Immunol 29: 621-663.
30. Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, et al. (2008) Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29: 138-149.