6-Trifluoromethyl-2-thiouracil possesses anti-Toxoplasma gondii effect in vitro and in vivo with low hepatotoxicity

Experimental Parasitology

Volumn 143, Issue 1, 2014, Pages 24-29

  Choi, Hwa Jung ^a,d   Yu, Seung Taek ^a   Lee, Kee In ^b   Choi, Joong Kwon ^b   Chang, Bo Yoon ^c   Kim, Sung Yeon ^c   Ko, Mi Hwa ^c   Song, Hyun Ok ^a   Park, Hyun ^a  

^a Wonkwang University School of Medicine   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Wonkwang University   (South Korea)

^d Kwangju Women University   (South Korea)

Author keywords

Anti Toxoplasma gondii activity; KH 0562; Toxoplasmosis

Indexed keywords

3 [[2 (FURAN 2 YLMETHYLENE)HYDRAZINYL]METHYLENE] 1,3 DIHYDRO INDOL 2 ONE; 6 TRIFLUOROMETHYL 2 THIOURACIL; ALANINE AMINOTRANSFERASE; ANTIPROTOZOAL AGENT; ASPARTATE AMINOTRANSFERASE; ATT 5126; GLUTATHIONE; KH 0562; PYRIMETHAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; ASCITES; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; LIVER LEVEL; LIVER TOXICITY; LIVER WEIGHT; MOUSE; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; SPLEEN WEIGHT; TACHYZOITE; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANTI-TOXOPLASMA GONDII ACTIVITY; KH-0562; TOXOPLASMOSIS;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; COCCIDIOSTATS; FEMALE; GLUTATHIONE; HELA CELLS; HUMANS; LIPID PEROXIDATION; LIVER; MICE; MICE, INBRED ICR; ORGAN SIZE; SPLEEN; THIOURACIL; TOXOPLASMA; TOXOPLASMOSIS;

EID: 84901355343     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2014.05.002     Document Type: Article

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