메뉴 건너뛰기




Volumn 68, Issue 17-18, 2005, Pages 1567-1579

A histochemical and pathological study on the interrelationship between TCDD-induced AhR expression, AhR activation, and hepatotoxicity in mice

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A2;

EID: 26044452642     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390590967513     Document Type: Article
Times cited : (29)

References (34)
  • 1
    • 0037764668 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells
    • Abdelrahim, M., Smith, R, and 3rd, and Safe, S. 2003. Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells. Mol. Pharmacol. 63:1373-1381.
    • (2003) Mol. Pharmacol. , vol.63 , pp. 1373-1381
    • Abdelrahim, M.1    Smith III, R.2    Safe, S.3
  • 2
    • 0034044159 scopus 로고    scopus 로고
    • Non-carcinogenic effects of TCDD in animals
    • Birnbaum, L. S., and Tuomisto, J. 2000. Non-carcinogenic effects of TCDD in animals. Food Addit. Contam. 17:275-288.
    • (2000) Food Addit. Contam. , vol.17 , pp. 275-288
    • Birnbaum, L.S.1    Tuomisto, J.2
  • 3
    • 0021940487 scopus 로고
    • Dose-related effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J and DBA/2J mice
    • Chapman, D. E., and Schiller, C. M. 1985. Dose-related effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J and DBA/2J mice. Toxicol. Appl. Pharmacol. 78:147-157.
    • (1985) Toxicol. Appl. Pharmacol. , vol.78 , pp. 147-157
    • Chapman, D.E.1    Schiller, C.M.2
  • 4
    • 0034046390 scopus 로고    scopus 로고
    • Animal studies addressing the carcinogenicity of TCDD (or related compounds) with an emphasis on tumour promotion
    • Dragan, Y. P., and Schrenk, D. 2000. Animal studies addressing the carcinogenicity of TCDD (or related compounds) with an emphasis on tumour promotion. Food. Addit. Contam. 17:289-302.
    • (2000) Food. Addit. Contam. , vol.17 , pp. 289-302
    • Dragan, Y.P.1    Schrenk, D.2
  • 5
    • 0030245635 scopus 로고    scopus 로고
    • Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity
    • Fernandez-Salguero, P. M., Hilbert, D. M., Rudikoff, S., Ward, J. M., and Gonzalez, F. J. 1996. Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicol. Appl. Pharmacol. 140:173-179.
    • (1996) Toxicol. Appl. Pharmacol. , vol.140 , pp. 173-179
    • Fernandez-Salguero, P.M.1    Hilbert, D.M.2    Rudikoff, S.3    Ward, J.M.4    Gonzalez, F.J.5
  • 6
    • 0031018740 scopus 로고    scopus 로고
    • Coexpression of Ah receptor and CYP1A1 in hepatocytes of C57BL/6J and DBA/2J mice
    • Forkert, P. G. 1997. Coexpression of Ah receptor and CYP1A1 in hepatocytes of C57BL/6J and DBA/2J mice. Toxicol. Appl. Pharmacol. 142:69-78.
    • (1997) Toxicol. Appl. Pharmacol. , vol.142 , pp. 69-78
    • Forkert, P.G.1
  • 7
    • 0035880885 scopus 로고    scopus 로고
    • Persistent, low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: Effect on aryl hydrocarbon receptor expression in a dioxin-resistance model
    • Franc, M. A., Pohjanvirta, R., Tuomisto, J., and Okey, A. B. 2001a. Persistent, low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: Effect on aryl hydrocarbon receptor expression in a dioxin-resistance model. Toxicol. Appl. Pharmacol. 175:43-53.
    • (2001) Toxicol. Appl. Pharmacol. , vol.175 , pp. 43-53
    • Franc, M.A.1    Pohjanvirta, R.2    Tuomisto, J.3    Okey, A.B.4
  • 8
    • 0035894283 scopus 로고    scopus 로고
    • In vivo up-regulation of aryl hydrocarbon receptor expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a dioxin-resistant rat model
    • Franc, M. A., Pohjanvirta, R., Tuomisto, J., and Okey, A. B. 2001b. In vivo up-regulation of aryl hydrocarbon receptor expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a dioxin-resistant rat model. Biochem. Pharmacol. 62:1565-1578.
    • (2001) Biochem. Pharmacol. , vol.62 , pp. 1565-1578
    • Franc, M.A.1    Pohjanvirta, R.2    Tuomisto, J.3    Okey, A.B.4
  • 9
    • 0030995904 scopus 로고    scopus 로고
    • Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction of cytochrome P4501a in vascular endothelium with toxicity in early life stages of lake trout
    • Guiney, P. D., Smolowitz, R. M., Peterson, R. E., and Stegeman, J. J. 1997. Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction of cytochrome P4501a in vascular endothelium with toxicity in early life stages of lake trout. Toxicol. Appl. Pharmacol. 143:256-273.
    • (1997) Toxicol. Appl. Pharmacol. , vol.143 , pp. 256-273
    • Guiney, P.D.1    Smolowitz, R.M.2    Peterson, R.E.3    Stegeman, J.J.4
  • 10
    • 0019518958 scopus 로고
    • Effects of 2,3,7,8-tetrachlorodibenzo-dioxin (TCDD) on early life stages of rainbow trout (salmo gairdneri, Richardson)
    • Helder, T. 1981. Effects of 2,3,7,8-tetrachlorodibenzo-dioxin (TCDD) on early life stages of rainbow trout (salmo gairdneri, Richardson). Toxicology 19:101-112.
    • (1981) Toxicology , vol.19 , pp. 101-112
    • Helder, T.1
  • 11
    • 0034101110 scopus 로고    scopus 로고
    • Studies of cancer in humans
    • Kogevinas, M. 2000. Studies of cancer in humans. Food Addit. Contam. 17:317-324.
    • (2000) Food Addit. Contam. , vol.17 , pp. 317-324
    • Kogevinas, M.1
  • 13
    • 0000829737 scopus 로고    scopus 로고
    • Exposure of populations to dioxins and related compounds
    • Liem, A. K., Furst, P., and Rappe, C. 2000. Exposure of populations to dioxins and related compounds. Food Addit. Contam. 17:241-259.
    • (2000) Food Addit. Contam. , vol.17 , pp. 241-259
    • Liem, A.K.1    Furst, P.2    Rappe, C.3
  • 16
    • 0026674759 scopus 로고
    • The potentiation of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity by tamoxifen in female CD1 mice
    • MacKenzie, S. A., Thomas, T., Umbreit, T. H., and Gallo, M. A. 1992. The potentiation of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity by tamoxifen in female CD1 mice. Toxicol. Appl. Pharmacol. 116:101-109.
    • (1992) Toxicol. Appl. Pharmacol. , vol.116 , pp. 101-109
    • MacKenzie, S.A.1    Thomas, T.2    Umbreit, T.H.3    Gallo, M.A.4
  • 17
    • 0024829409 scopus 로고
    • The Ah locus: Genetic differences in toxicity, cancer, mutation, and birth defects
    • Nebert, D. W. 1989. The Ah locus: Genetic differences in toxicity, cancer, mutation, and birth defects. Crit. Rev. Toxicol. 20:153-174.
    • (1989) Crit. Rev. Toxicol. , vol.20 , pp. 153-174
    • Nebert, D.W.1
  • 18
    • 0031972732 scopus 로고    scopus 로고
    • Zonation of hepatic cytochrome P-450 expression and regulation
    • Oinonen, T., and Lindros, K. O. 1998. Zonation of hepatic cytochrome P-450 expression and regulation. Biochem. J. 329:17-35.
    • (1998) Biochem. J. , vol.329 , pp. 17-35
    • Oinonen, T.1    Lindros, K.O.2
  • 19
    • 0028104347 scopus 로고
    • Pretranslational induction of cytochrome P4501a enzymes by beta-naphthoflavone and 3-methylcholanthrene occurs in different liver zones
    • Oinonen, T., Saarikoski, S., Husgafvel-Pursiainen, K., Hirvonen, A., and Lindros, K. O. 1994. Pretranslational induction of cytochrome P4501a enzymes by beta-naphthoflavone and 3-methylcholanthrene occurs in different liver zones. Biochem. Pharmacol. 48:2189-2197.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 2189-2197
    • Oinonen, T.1    Saarikoski, S.2    Husgafvel-Pursiainen, K.3    Hirvonen, A.4    Lindros, K.O.5
  • 20
    • 0028588925 scopus 로고
    • Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals: Effects, mechanisms, and animal models
    • Pohjanvirta, R., and Tuomisto, J. 1994. Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals: Effects, mechanisms, and animal models. Pharmacol. Rev. 46:483-549.
    • (1994) Pharmacol. Rev. , vol.46 , pp. 483-549
    • Pohjanvirta, R.1    Tuomisto, J.2
  • 21
    • 0020010617 scopus 로고
    • 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity
    • Poland, A., and Knutson, J. C. 1982. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22:517-554.
    • (1982) Annu. Rev. Pharmacol. Toxicol. , vol.22 , pp. 517-554
    • Poland, A.1    Knutson, J.C.2
  • 22
    • 0037145007 scopus 로고    scopus 로고
    • The mechanism of Ah receptor protein down-regulation (degradation) and its impact on Ah receptor-mediated gene regulation
    • Pollenz, R. S. 2002. The mechanism of Ah receptor protein down-regulation (degradation) and its impact on Ah receptor-mediated gene regulation. Chem. Biol. Interact. 141:41-61.
    • (2002) Chem. Biol. Interact. , vol.141 , pp. 41-61
    • Pollenz, R.S.1
  • 23
    • 0026000191 scopus 로고
    • Downregulation of the Ah receptor in mouse hepatoma cells treated in culture with 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • Prokipcak, R. D., and Okey, A. B. 1991. Downregulation of the Ah receptor in mouse hepatoma cells treated in culture with 2,3,7,8-tetrachlorodibenzo-p- dioxin. Can. J. Physiol. Pharmacol. 69:1204-1210.
    • (1991) Can. J. Physiol. Pharmacol. , vol.69 , pp. 1204-1210
    • Prokipcak, R.D.1    Okey, A.B.2
  • 24
    • 0026648792 scopus 로고
    • Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1
    • Puga, A., Nebert, D. W., and Carrier, F. 1992. Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1. DNA Cell Biol. 11:269-281.
    • (1992) DNA Cell Biol. , vol.11 , pp. 269-281
    • Puga, A.1    Nebert, D.W.2    Carrier, F.3
  • 27
    • 0025811022 scopus 로고
    • Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated hepatotoxicity in C57BL/6J and DBA/2J mice
    • Shen, E. S., Gutman, S. I., and Olson, J. R. 1991. Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated hepatotoxicity in C57BL/6J and DBA/2J mice. J. Toxicol. Environ. Health 32:367-381.
    • (1991) J. Toxicol. Environ. Health , vol.32 , pp. 367-381
    • Shen, E.S.1    Gutman, S.I.2    Olson, J.R.3
  • 28
    • 0031913632 scopus 로고    scopus 로고
    • Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p- dioxin in mice with variants of the Ahr gene: A hepatic oxidative mechanism
    • Smith, A. G., Clothier, B., Robinson, S., Scullion, M. J., Carthew, P., Edwards, R., Luo, J., Lim, C. K., and Toledano, M. 1998. Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: A hepatic oxidative mechanism. Mol. Pharmacol. 53:52-61.
    • (1998) Mol. Pharmacol. , vol.53 , pp. 52-61
    • Smith, A.G.1    Clothier, B.2    Robinson, S.3    Scullion, M.J.4    Carthew, P.5    Edwards, R.6    Luo, J.7    Lim, C.K.8    Toledano, M.9
  • 29
    • 0035370158 scopus 로고    scopus 로고
    • Protection of the cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • Smith, A. G., Clothier, B., Carthew, P., Childs, N. L., Sinclair, P. R., Nebert, D. W., and Dalton, T. P. 2001. Protection of the cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 173:89-98.
    • (2001) Toxicol. Appl. Pharmacol. , vol.173 , pp. 89-98
    • Smith, A.G.1    Clothier, B.2    Carthew, P.3    Childs, N.L.4    Sinclair, P.R.5    Nebert, D.W.6    Dalton, T.P.7
  • 30
    • 0036783736 scopus 로고    scopus 로고
    • Ligand-dependent and independent modulation of aryl hydrocarbon receptor localization, degradation, and gene regulation
    • Song, Z., and Pollenz, R. S. 2002. ligand-dependent and independent modulation of aryl hydrocarbon receptor localization, degradation, and gene regulation. Mol. Pharmacol. 62:806-816.
    • (2002) Mol. Pharmacol. , vol.62 , pp. 806-816
    • Song, Z.1    Pollenz, R.S.2
  • 31
    • 0023829259 scopus 로고
    • Morphologic lesions and acute toxicity in rainbow trout (salmo gairdneri) treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • Spitsbergen, J. M., Kleeman, J. M., and Peterson, R. E. 1988. Morphologic lesions and acute toxicity in rainbow trout (salmo gairdneri) treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Toxicol. Environ. Health. 23:333-358.
    • (1988) J. Toxicol. Environ. Health. , vol.23 , pp. 333-358
    • Spitsbergen, J.M.1    Kleeman, J.M.2    Peterson, R.E.3
  • 32
    • 0034125821 scopus 로고    scopus 로고
    • Human health effects after exposure to 2,3,7,8-TCDD
    • Sweeney, M. H., and Mocarelli, P. 2000. Human health effects after exposure to 2,3,7,8-TCDD. Food Addit. Contam. 17:303-316.
    • (2000) Food Addit. Contam. , vol.17 , pp. 303-316
    • Sweeney, M.H.1    Mocarelli, P.2
  • 33
    • 0033168528 scopus 로고    scopus 로고
    • A chimeric aryl hydrocarbon receptor knockout mouse model indicates that aryl hydrocarbon receptor activation in hematopoietic cells contributes to the hepatic lesions induced by 2,3,7, 8-tetrachlorodibenzo-p-dioxin
    • Thurmond, T. S., Silverstone, A. E., Baggs, R. B., Quimby, F. W., Staples, J. E., and Gasiewicz, T. A. 1999. A chimeric aryl hydrocarbon receptor knockout mouse model indicates that aryl hydrocarbon receptor activation in hematopoietic cells contributes to the hepatic lesions induced by 2,3,7, 8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 158:33-40.
    • (1999) Toxicol. Appl. Pharmacol. , vol.158 , pp. 33-40
    • Thurmond, T.S.1    Silverstone, A.E.2    Baggs, R.B.3    Quimby, F.W.4    Staples, J.E.5    Gasiewicz, T.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.