Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Hum, Julia M ^a   Day, Richard N ^a   Bidwell, Joseph P ^a   Wang, Yingxiao ^b   Pavalko, Fredrick M ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; DNA; FOCAL ADHESION KINASE 2; METHYL CPG BINDING PROTEIN 2; OSTEOCALCIN; OSTEOPONTIN; PROTEIN TYROSINE KINASE; ANOV COMPOUND; ANTHRACENE DERIVATIVE; DNA BINDING PROTEIN; MBD2 PROTEIN, MOUSE; MULTIPROTEIN COMPLEX; PRIMER DNA; PTK2B PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BONE MASS; CELL NUCLEUS; COMPLEX FORMATION; DNA METHYLATION; GENE DELETION; GENE EXPRESSION REGULATION; MOLECULAR MECHANICS; MOUSE; NEWBORN; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCYTE; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SHEAR STRESS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; BIOSYNTHESIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; MECHANICAL STRESS; MECHANOTRANSDUCTION; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SHEAR STRENGTH; WESTERN BLOTTING;

ANIMALS; ANTHRACENES; BLOTTING, WESTERN; DNA METHYLATION; DNA PRIMERS; DNA-BINDING PROTEINS; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT ANTIBODY TECHNIQUE; FOCAL ADHESION KINASE 2; GENE EXPRESSION REGULATION; MECHANOTRANSDUCTION, CELLULAR; MICE; MULTIPROTEIN COMPLEXES; OSTEOCYTES; REAL-TIME POLYMERASE CHAIN REACTION; SHEAR STRENGTH; SRC-FAMILY KINASES; STRESS, MECHANICAL;

EID: 84901315642     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097942     Document Type: Article

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