-
1
-
-
0036734653
-
Regulation of focal adhesion kinase by a novel protein inhibitor FIP200
-
Abbi S., Ueda H., Zheng C., Cooper L.A., Zhao J., Christopher R., et al. Regulation of focal adhesion kinase by a novel protein inhibitor FIP200. Mol. Biol. Cell 2002, 13:3178-3191.
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 3178-3191
-
-
Abbi, S.1
Ueda, H.2
Zheng, C.3
Cooper, L.A.4
Zhao, J.5
Christopher, R.6
-
2
-
-
0036118284
-
The structural basis of localization and signaling by the focal adhesion targeting domain
-
Arold S.T., Hoellerer M.K., Noble M.E. The structural basis of localization and signaling by the focal adhesion targeting domain. Structure 2002, 10:319-327.
-
(2002)
Structure
, vol.10
, pp. 319-327
-
-
Arold, S.T.1
Hoellerer, M.K.2
Noble, M.E.3
-
3
-
-
46049115251
-
Growth control by intracellular tension and extracellular stiffness
-
Assoian R.K., Klein E.A. Growth control by intracellular tension and extracellular stiffness. Trends Cell Biol. 2008, 18:347-352.
-
(2008)
Trends Cell Biol.
, vol.18
, pp. 347-352
-
-
Assoian, R.K.1
Klein, E.A.2
-
4
-
-
73949157930
-
Neogenin regulates skeletal myofiber size and focal adhesion kinase and extracellular signal-regulated kinase activities in vivo and in vitro
-
Bae G.U., Yang Y.J., Jiang G., Hong M., Lee H.J., Tessier-Lavigne M., et al. Neogenin regulates skeletal myofiber size and focal adhesion kinase and extracellular signal-regulated kinase activities in vivo and in vitro. Mol. Biol. Cell 2009, 20:4920-4931.
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 4920-4931
-
-
Bae, G.U.1
Yang, Y.J.2
Jiang, G.3
Hong, M.4
Lee, H.J.5
Tessier-Lavigne, M.6
-
5
-
-
43049114924
-
Dual focal adhesion kinase/Pyk2 inhibitor has positive effects on bone tumors: implications for bone metastases
-
Bagi C.M., Roberts G.W., Andresen C.J. Dual focal adhesion kinase/Pyk2 inhibitor has positive effects on bone tumors: implications for bone metastases. Cancer 2008, 112:2313-2321.
-
(2008)
Cancer
, vol.112
, pp. 2313-2321
-
-
Bagi, C.M.1
Roberts, G.W.2
Andresen, C.J.3
-
6
-
-
68149170763
-
Sunitinib and PF-562, 271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model
-
Bagi C.M., Christensen J., Cohen D.P., Roberts W.G., Wilkie D., Swanson T., et al. Sunitinib and PF-562, 271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model. Cancer Biol. Ther. 2009, 8:856-865.
-
(2009)
Cancer Biol. Ther.
, vol.8
, pp. 856-865
-
-
Bagi, C.M.1
Christensen, J.2
Cohen, D.P.3
Roberts, W.G.4
Wilkie, D.5
Swanson, T.6
-
7
-
-
33645234372
-
Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer
-
Ballestrem C., Erez N., Kirchner J., Kam Z., Bershadsky A., Geiger B. Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer. J. Cell Sci. 2006, 119:866-875.
-
(2006)
J. Cell Sci.
, vol.119
, pp. 866-875
-
-
Ballestrem, C.1
Erez, N.2
Kirchner, J.3
Kam, Z.4
Bershadsky, A.5
Geiger, B.6
-
8
-
-
77957986990
-
Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate
-
Beinke S., Phee H., Clingan J.M., Schlessinger J., Matloubian M., Weiss A. Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate. Proc. Natl. Acad. Sci. USA 2010, 107:16234-16239.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 16234-16239
-
-
Beinke, S.1
Phee, H.2
Clingan, J.M.3
Schlessinger, J.4
Matloubian, M.5
Weiss, A.6
-
9
-
-
0033679292
-
Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition
-
Beneken J., Tu J.C., Xiao B., Nuriya M., Yuan J.P., Worley P.F., et al. Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron 2000, 26:143-154.
-
(2000)
Neuron
, vol.26
, pp. 143-154
-
-
Beneken, J.1
Tu, J.C.2
Xiao, B.3
Nuriya, M.4
Yuan, J.P.5
Worley, P.F.6
-
10
-
-
14144252115
-
Structural features of the focal adhesion kinase-paxillin complex give insight into the dynamics of focal adhesion assembly
-
Bertolucci C.M., Guibao C.D., Zheng J. Structural features of the focal adhesion kinase-paxillin complex give insight into the dynamics of focal adhesion assembly. Protein Sci. 2005, 14:644-652.
-
(2005)
Protein Sci.
, vol.14
, pp. 644-652
-
-
Bertolucci, C.M.1
Guibao, C.D.2
Zheng, J.3
-
11
-
-
27444431517
-
Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration
-
Bianchi M., De Lucchini S., Marin O., Turner D.L., Hanks S.K., Villa-Moruzzi E. Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration. Biochem. J. 2005, 391:359-370.
-
(2005)
Biochem. J.
, vol.391
, pp. 359-370
-
-
Bianchi, M.1
De Lucchini, S.2
Marin, O.3
Turner, D.L.4
Hanks, S.K.5
Villa-Moruzzi, E.6
-
12
-
-
29944436856
-
Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation
-
Braren R., Hu H., Kim Y.H., Beggs H.E., Reichardt L.F., Wang R. Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J. Cell Biol. 2006, 172:151-162.
-
(2006)
J. Cell Biol.
, vol.172
, pp. 151-162
-
-
Braren, R.1
Hu, H.2
Kim, Y.H.3
Beggs, H.E.4
Reichardt, L.F.5
Wang, R.6
-
13
-
-
0031822185
-
Paxillin LD motifs may define a new family of protein recognition domains
-
Brown M.C., Curtis M.S., Turner C.E. Paxillin LD motifs may define a new family of protein recognition domains. Nat. Struct. Biol. 1998, 5:677-678.
-
(1998)
Nat. Struct. Biol.
, vol.5
, pp. 677-678
-
-
Brown, M.C.1
Curtis, M.S.2
Turner, C.E.3
-
14
-
-
34547453984
-
Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis
-
Buckbinder L., Crawford D.T., Qi H., Ke H.Z., Olson L.M., Long K.R., et al. Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc. Natl. Acad. Sci. USA 2007, 104:10619-10624.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 10619-10624
-
-
Buckbinder, L.1
Crawford, D.T.2
Qi, H.3
Ke, H.Z.4
Olson, L.M.5
Long, K.R.6
-
15
-
-
0030725406
-
Alternatively spliced focal adhesion kinase in rat brain with increased autophosphorylation activity
-
Burgaya F., Toutant M., Studler J.M., Costa A., Le Bert M., Gelman M., et al. Alternatively spliced focal adhesion kinase in rat brain with increased autophosphorylation activity. J. Biol. Chem. 1997, 272:28720-28725.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 28720-28725
-
-
Burgaya, F.1
Toutant, M.2
Studler, J.M.3
Costa, A.4
Le Bert, M.5
Gelman, M.6
-
16
-
-
37549060016
-
Spatial and temporal regulation of focal adhesion kinase activity in living cells
-
Cai X., Lietha D., Ceccarelli D.F., Karginov A.V., Rajfur Z., Jacobson K., et al. Spatial and temporal regulation of focal adhesion kinase activity in living cells. Mol. Cell. Biol. 2008, 28:201-214.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 201-214
-
-
Cai, X.1
Lietha, D.2
Ceccarelli, D.F.3
Karginov, A.V.4
Rajfur, Z.5
Jacobson, K.6
-
17
-
-
0028877919
-
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases
-
Calalb M.B., Polte T.R., Hanks S.K. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol. Cell. Biol. 1995, 15:954-963.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 954-963
-
-
Calalb, M.B.1
Polte, T.R.2
Hanks, S.K.3
-
18
-
-
33644863663
-
Crystal structure of the FERM domain of focal adhesion kinase
-
Ceccarelli D.F., Song H.K., Poy F., Schaller M.D., Eck M.J. Crystal structure of the FERM domain of focal adhesion kinase. J. Biol. Chem. 2006, 281:252-259.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 252-259
-
-
Ceccarelli, D.F.1
Song, H.K.2
Poy, F.3
Schaller, M.D.4
Eck, M.J.5
-
19
-
-
33846064194
-
FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX
-
Chang F., Lemmon C.A., Park D., Romer L.H. FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX. Mol. Biol. Cell 2007, 18:253-264.
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 253-264
-
-
Chang, F.1
Lemmon, C.A.2
Park, D.3
Romer, L.H.4
-
20
-
-
33745468872
-
Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion
-
Chen S.Y., Chen H.C. Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion. Mol. Cell. Biol. 2006, 26:5155-5167.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 5155-5167
-
-
Chen, S.Y.1
Chen, H.C.2
-
21
-
-
0035003136
-
Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain
-
Chen R.Y., Kim O., Li M., Xiong X.S., Guan J.L., Kung H.J., et al. Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. Nat. Cell Biol. 2001, 3:439-444.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 439-444
-
-
Chen, R.Y.1
Kim, O.2
Li, M.3
Xiong, X.S.4
Guan, J.L.5
Kung, H.J.6
-
22
-
-
0031683065
-
The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane
-
Chishti A.H., Kim A.C., Marfatia S.M., Lutchman M., Hanspal M., Jindal H., et al. The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem. Sci. 1998, 23:281-282.
-
(1998)
Trends Biochem. Sci.
, vol.23
, pp. 281-282
-
-
Chishti, A.H.1
Kim, A.C.2
Marfatia, S.M.3
Lutchman, M.4
Hanspal, M.5
Jindal, H.6
-
23
-
-
0027273886
-
Expression of a gene encoding a unique protein-tyrosine kinase within specific fetal- and adult-derived hematopoietic lineages
-
Choi K., Kennedy M., Keller G. Expression of a gene encoding a unique protein-tyrosine kinase within specific fetal- and adult-derived hematopoietic lineages. Proc. Natl. Acad. Sci. USA 1993, 90:5747-5751.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 5747-5751
-
-
Choi, K.1
Kennedy, M.2
Keller, G.3
-
24
-
-
33645846602
-
Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2
-
Choi H.S., Wang Z., Richmond W., He X., Yang K., Jiang T., et al. Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2. Bioorg. Med. Chem. Lett. 2006, 16:2689-2692.
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 2689-2692
-
-
Choi, H.S.1
Wang, Z.2
Richmond, W.3
He, X.4
Yang, K.5
Jiang, T.6
-
25
-
-
33644798693
-
Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1
-
Choi H.S., Wang Z., Richmond W., He X., Yang K., Jiang T., et al. Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1. Bioorg. Med. Chem. Lett. 2006, 16:2173-2176.
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 2173-2176
-
-
Choi, H.S.1
Wang, Z.2
Richmond, W.3
He, X.4
Yang, K.5
Jiang, T.6
-
26
-
-
0033973360
-
HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cells
-
Cicala C., Arthos J., Rubbert A., Selig S., Wildt K., Cohen O.J., et al. HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cells. Proc. Natl. Acad. Sci. USA 2000, 97:1178-1183.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 1178-1183
-
-
Cicala, C.1
Arthos, J.2
Rubbert, A.3
Selig, S.4
Wildt, K.5
Cohen, O.J.6
-
27
-
-
14844292576
-
Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation
-
Cohen L.A., Guan J.L. Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation. J. Biol. Chem. 2005, 280:8197-8207.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 8197-8207
-
-
Cohen, L.A.1
Guan, J.L.2
-
28
-
-
0242495710
-
Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction
-
Cooper L.A., Shen T.L., Guan J.L. Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction. Mol. Cell. Biol. 2003, 23:8030-8041.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 8030-8041
-
-
Cooper, L.A.1
Shen, T.L.2
Guan, J.L.3
-
29
-
-
33748068089
-
New concepts regarding focal adhesion kinase promotion of cell migration and proliferation
-
Cox B.D., Natarajan M., Stettner M.R., Gladson C.L. New concepts regarding focal adhesion kinase promotion of cell migration and proliferation. J. Cell. Biochem. 2006, 99:35-52.
-
(2006)
J. Cell. Biochem.
, vol.99
, pp. 35-52
-
-
Cox, B.D.1
Natarajan, M.2
Stettner, M.R.3
Gladson, C.L.4
-
31
-
-
0035851104
-
Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus
-
Derkinderen P., Toutant M., Kadare G., Ledent C., Parmentier M., Girault J.A. Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus. J. Biol. Chem. 2001, 276:38289-38296.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38289-38296
-
-
Derkinderen, P.1
Toutant, M.2
Kadare, G.3
Ledent, C.4
Parmentier, M.5
Girault, J.A.6
-
32
-
-
66949126859
-
Transient expression of FRNK reveals stage-specific requirement for focal adhesion kinase activity in cardiac growth
-
DiMichele L.A., Hakim Z.S., Sayers R.L., Rojas M., Schwartz R.J., Mack C.P., et al. Transient expression of FRNK reveals stage-specific requirement for focal adhesion kinase activity in cardiac growth. Circ. Res. 2009, 104:1201-1208.
-
(2009)
Circ. Res.
, vol.104
, pp. 1201-1208
-
-
DiMichele, L.A.1
Hakim, Z.S.2
Sayers, R.L.3
Rojas, M.4
Schwartz, R.J.5
Mack, C.P.6
-
33
-
-
33748313080
-
Membrane and juxtamembrane targeting by PH and PTB domains
-
DiNitto J.P., Lambright D.G. Membrane and juxtamembrane targeting by PH and PTB domains. Biochim. Biophys. Acta 2006, 1761:850-867.
-
(2006)
Biochim. Biophys. Acta
, vol.1761
, pp. 850-867
-
-
DiNitto, J.P.1
Lambright, D.G.2
-
34
-
-
9944258521
-
New insights into FAK signaling and localization based on detection of a FAT domain folding intermediate
-
Dixon R.D., Chen Y., Ding F., Khare S.D., Prutzman K.C., Schaller M.D., et al. New insights into FAK signaling and localization based on detection of a FAT domain folding intermediate. Structure 2004, 12:2161-2171.
-
(2004)
Structure
, vol.12
, pp. 2161-2171
-
-
Dixon, R.D.1
Chen, Y.2
Ding, F.3
Khare, S.D.4
Prutzman, K.C.5
Schaller, M.D.6
-
35
-
-
77956302465
-
Focal adhesion kinase is essential for cardiac looping and multichamber heart formation
-
Doherty J.T., Conlon F.L., Mack C.P., Taylor J.M. Focal adhesion kinase is essential for cardiac looping and multichamber heart formation. Genesis 2010, 48:492-504.
-
(2010)
Genesis
, vol.48
, pp. 492-504
-
-
Doherty, J.T.1
Conlon, F.L.2
Mack, C.P.3
Taylor, J.M.4
-
36
-
-
2942596543
-
FERM domain interaction promotes FAK signaling
-
Dunty J.M., Gabarra-Niecko V., King M.L., Ceccarelli D.F., Eck M.J., Schaller M.D. FERM domain interaction promotes FAK signaling. Mol. Cell. Biol. 2004, 24:5353-5368.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 5353-5368
-
-
Dunty, J.M.1
Gabarra-Niecko, V.2
King, M.L.3
Ceccarelli, D.F.4
Eck, M.J.5
Schaller, M.D.6
-
37
-
-
20444370219
-
Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase
-
Ezratty E.J., Partridge M.A., Gundersen G.G. Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Nat. Cell Biol. 2005, 7:581-590.
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 581-590
-
-
Ezratty, E.J.1
Partridge, M.A.2
Gundersen, G.G.3
-
38
-
-
66149144863
-
Focal adhesion kinase (FAK): a regulator of CNS myelination
-
Forrest A.D., Beggs H.E., Reichardt L.F., Dupree J.L., Colello R.J., Fuss B. Focal adhesion kinase (FAK): a regulator of CNS myelination. J. Neurosci. Res. 2009, 87:3456-3464.
-
(2009)
J. Neurosci. Res.
, vol.87
, pp. 3456-3464
-
-
Forrest, A.D.1
Beggs, H.E.2
Reichardt, L.F.3
Dupree, J.L.4
Colello, R.J.5
Fuss, B.6
-
39
-
-
0036137934
-
Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells
-
Freitas F., Jeschke M., Majstorovic I., Mueller D.R., Schindler P., Voshol H., et al. Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells. Bone 2002, 30:99-108.
-
(2002)
Bone
, vol.30
, pp. 99-108
-
-
Freitas, F.1
Jeschke, M.2
Majstorovic, I.3
Mueller, D.R.4
Schindler, P.5
Voshol, H.6
-
40
-
-
0028783271
-
Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK
-
Furuta Y., Ilic D., Kanazawa S., Takeda N., Yamamoto T., Aizawa S. Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. Oncogene 1995, 11:1989-1995.
-
(1995)
Oncogene
, vol.11
, pp. 1989-1995
-
-
Furuta, Y.1
Ilic, D.2
Kanazawa, S.3
Takeda, N.4
Yamamoto, T.5
Aizawa, S.6
-
41
-
-
0036682924
-
Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'
-
Gabarra-Niecko V., Keely P.J., Schaller M.D. Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'. Biochem. J. 2002, 365:591-603.
-
(2002)
Biochem. J.
, vol.365
, pp. 591-603
-
-
Gabarra-Niecko, V.1
Keely, P.J.2
Schaller, M.D.3
-
42
-
-
1542289014
-
NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding model
-
Gao G., Prutzman K.C., King M.L., Scheswohl D.M., DeRose E.F., London R.E., et al. NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding model. J. Biol. Chem. 2004, 279:8441-8451.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 8441-8451
-
-
Gao, G.1
Prutzman, K.C.2
King, M.L.3
Scheswohl, D.M.4
DeRose, E.F.5
London, R.E.6
-
43
-
-
32944475609
-
Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells
-
Garces C.A., Kurenova E.V., Golubovskaya V.M., Cance W.G. Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells. Cancer Res. 2006, 66:1446-1454.
-
(2006)
Cancer Res.
, vol.66
, pp. 1446-1454
-
-
Garces, C.A.1
Kurenova, E.V.2
Golubovskaya, V.M.3
Cance, W.G.4
-
44
-
-
37549055113
-
Structural basis for the interaction between focal adhesion kinase and CD4
-
Garron M.L., Arthos J., Guichou J.F., McNally J., Cicala C., Arold S.T. Structural basis for the interaction between focal adhesion kinase and CD4. J. Mol. Biol. 2008, 375:1320-1328.
-
(2008)
J. Mol. Biol.
, vol.375
, pp. 1320-1328
-
-
Garron, M.L.1
Arthos, J.2
Guichou, J.F.3
McNally, J.4
Cicala, C.5
Arold, S.T.6
-
45
-
-
34548845081
-
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice
-
Gil-Henn H., Destaing O., Sims N.A., Aoki K., Alles N., Neff L., et al. Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. J. Cell Biol. 2007, 178:1053-1064.
-
(2007)
J. Cell Biol.
, vol.178
, pp. 1053-1064
-
-
Gil-Henn, H.1
Destaing, O.2
Sims, N.A.3
Aoki, K.4
Alles, N.5
Neff, L.6
-
46
-
-
0029741102
-
Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation
-
Gilmore A.P., Romer L.H. Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol. Biol. Cell 1996, 7:1209-1224.
-
(1996)
Mol. Biol. Cell
, vol.7
, pp. 1209-1224
-
-
Gilmore, A.P.1
Romer, L.H.2
-
47
-
-
70349329549
-
How adhesion signals reach a mitochondrial conclusion-ECM regulation of apoptosis
-
Gilmore A.P., Owens T.W., Foster F.M., Lindsay J. How adhesion signals reach a mitochondrial conclusion-ECM regulation of apoptosis. Curr. Opin. Cell Biol. 2009, 21:654-661.
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 654-661
-
-
Gilmore, A.P.1
Owens, T.W.2
Foster, F.M.3
Lindsay, J.4
-
48
-
-
0033071270
-
The N-termini of FAK and JAKs contain divergent band 4.1 domains
-
Girault J.A., Labesse G., Mornon J.P., Callebaut I. The N-termini of FAK and JAKs contain divergent band 4.1 domains. Trends Biochem. Sci. 1999, 24:54-57.
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 54-57
-
-
Girault, J.A.1
Labesse, G.2
Mornon, J.P.3
Callebaut, I.4
-
49
-
-
21644466387
-
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53
-
Golubovskaya V.M., Finch R., Cance W.G. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. J. Biol. Chem. 2005, 280:25008-25021.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 25008-25021
-
-
Golubovskaya, V.M.1
Finch, R.2
Cance, W.G.3
-
50
-
-
41649107660
-
The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning
-
Golubovskaya V.M., Finch R., Zheng M., Kurenova E.V., Cance W.G. The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning. Biochem. J. 2008, 411:151-160.
-
(2008)
Biochem. J.
, vol.411
, pp. 151-160
-
-
Golubovskaya, V.M.1
Finch, R.2
Zheng, M.3
Kurenova, E.V.4
Cance, W.G.5
-
51
-
-
57349153946
-
A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth
-
Golubovskaya V.M., Nyberg C., Zheng M., Kweh F., Magis A., Ostrov D., et al. A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. J. Med. Chem. 2008, 51:7405-7416.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 7405-7416
-
-
Golubovskaya, V.M.1
Nyberg, C.2
Zheng, M.3
Kweh, F.4
Magis, A.5
Ostrov, D.6
-
53
-
-
77951096447
-
Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer
-
Guan J.L. Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer. IUBMB Life 2010, 62:268-276.
-
(2010)
IUBMB Life
, vol.62
, pp. 268-276
-
-
Guan, J.L.1
-
54
-
-
0034232062
-
Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response
-
Guinamard R., Okigaki M., Schlessinger J., Ravetch J.V. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat. Immunol. 2000, 1:31-36.
-
(2000)
Nat. Immunol.
, vol.1
, pp. 31-36
-
-
Guinamard, R.1
Okigaki, M.2
Schlessinger, J.3
Ravetch, J.V.4
-
55
-
-
34547146412
-
Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment
-
Hakim Z.S., DiMichele L.A., Doherty J.T., Homeister J.W., Beggs H.E., Reichardt L.F., et al. Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment. Mol. Cell. Biol. 2007, 27:5352-5364.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 5352-5364
-
-
Hakim, Z.S.1
DiMichele, L.A.2
Doherty, J.T.3
Homeister, J.W.4
Beggs, H.E.5
Reichardt, L.F.6
-
56
-
-
33748364149
-
Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy
-
Halder J., Kamat A.A., Landen C.N., Han L.Y., Lutgendorf S.K., Lin Y.G., et al. Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy. Clin. Cancer Res. 2006, 12:4916-4924.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 4916-4924
-
-
Halder, J.1
Kamat, A.A.2
Landen, C.N.3
Han, L.Y.4
Lutgendorf, S.K.5
Lin, Y.G.6
-
57
-
-
36348933509
-
Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma
-
Halder J., Lin Y.G., Merritt W.M., Spannuth W.A., Nick A.M., Honda T., et al. Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma. Cancer Res. 2007, 67:10976-10983.
-
(2007)
Cancer Res.
, vol.67
, pp. 10976-10983
-
-
Halder, J.1
Lin, Y.G.2
Merritt, W.M.3
Spannuth, W.A.4
Nick, A.M.5
Honda, T.6
-
58
-
-
65749105992
-
Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design
-
Han S., Mistry A., Chang J.S., Cunningham D., Griffor M., Bonnette P.C., et al. Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J. Biol. Chem. 2009, 284:13193-13201.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 13193-13201
-
-
Han, S.1
Mistry, A.2
Chang, J.S.3
Cunningham, D.4
Griffor, M.5
Bonnette, P.C.6
-
59
-
-
0026674919
-
Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin
-
Hanks S.K., Calalb M.B., Harper M.C., Patel S.K. Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc. Natl. Acad. Sci. USA 1992, 89:8487-8491.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 8487-8491
-
-
Hanks, S.K.1
Calalb, M.B.2
Harper, M.C.3
Patel, S.K.4
-
60
-
-
0142141199
-
Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility
-
Hanks S.K., Ryzhova L., Shin N.Y., Brabek J. Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. Front Biosci. 2003, 8:d982-d996.
-
(2003)
Front Biosci.
, vol.8
-
-
Hanks, S.K.1
Ryzhova, L.2
Shin, N.Y.3
Brabek, J.4
-
61
-
-
33750520546
-
Ca2+ lightning conveys cell-cell contact information inside the cells
-
Hashido M., Hayashi K., Hirose K., Iino M. Ca2+ lightning conveys cell-cell contact information inside the cells. EMBO Rep. 2006, 7:1117-1123.
-
(2006)
EMBO Rep.
, vol.7
, pp. 1117-1123
-
-
Hashido, M.1
Hayashi, K.2
Hirose, K.3
Iino, M.4
-
62
-
-
0036172186
-
The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin
-
Hayashi I., Vuori K., Liddington R.C. The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin. Nat. Struct. Biol. 2002, 9:101-106.
-
(2002)
Nat. Struct. Biol.
, vol.9
, pp. 101-106
-
-
Hayashi, I.1
Vuori, K.2
Liddington, R.C.3
-
63
-
-
3142520112
-
The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation
-
He H., Hirokawa Y., Gazit A., Yamashita Y., Mano H., Kawakami Y., et al. The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation. Cancer Biol. Ther. 2004, 3:96-101.
-
(2004)
Cancer Biol. Ther.
, vol.3
, pp. 96-101
-
-
He, H.1
Hirokawa, Y.2
Gazit, A.3
Yamashita, Y.4
Mano, H.5
Kawakami, Y.6
-
64
-
-
0027428367
-
Identification of sequences required for the efficient localization of the focal adhesion kinase, pp 125FAK, to cellular focal adhesions
-
Hildebrand J.D., Schaller M.D., Parsons J.T. Identification of sequences required for the efficient localization of the focal adhesion kinase, pp 125FAK, to cellular focal adhesions. J. Cell Biol. 1993, 123:993-1005.
-
(1993)
J. Cell Biol.
, vol.123
, pp. 993-1005
-
-
Hildebrand, J.D.1
Schaller, M.D.2
Parsons, J.T.3
-
65
-
-
4143135453
-
Radixin: cytoskeletal adopter and signaling protein
-
Hoeflich K.P., Ikura M. Radixin: cytoskeletal adopter and signaling protein. Int. J. Biochem. Cell Biol. 2004, 36:2131-2136.
-
(2004)
Int. J. Biochem. Cell Biol.
, vol.36
, pp. 2131-2136
-
-
Hoeflich, K.P.1
Ikura, M.2
-
66
-
-
0141483200
-
Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain
-
Hoellerer M.K., Noble M.E., Labesse G., Campbell I.D., Werner J.M., Arold S.T. Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain. Structure 2003, 11:1207-1217.
-
(2003)
Structure
, vol.11
, pp. 1207-1217
-
-
Hoellerer, M.K.1
Noble, M.E.2
Labesse, G.3
Campbell, I.D.4
Werner, J.M.5
Arold, S.T.6
-
67
-
-
0032547796
-
Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis
-
Ilic D., Almeida E.A., Schlaepfer D.D., Dazin P., Aizawa S., Damsky C.H. Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. J. Cell Biol. 1998, 143:547-560.
-
(1998)
J. Cell Biol.
, vol.143
, pp. 547-560
-
-
Ilic, D.1
Almeida, E.A.2
Schlaepfer, D.D.3
Dazin, P.4
Aizawa, S.5
Damsky, C.H.6
-
68
-
-
23044467828
-
A truncated FAK lacking the FERM domain displays high catalytic activity but retains responsiveness to adhesion-mediated signals
-
Jacamo R.O., Rozengurt E. A truncated FAK lacking the FERM domain displays high catalytic activity but retains responsiveness to adhesion-mediated signals. Biochem. Biophys. Res. Commun. 2005, 334:1299-1304.
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.334
, pp. 1299-1304
-
-
Jacamo, R.O.1
Rozengurt, E.2
-
69
-
-
33646339916
-
RNA interference reveals a differential role of FAK and Pyk2 in cell migration, leading edge formation and increase in focal adhesions induced by LPA in intestinal epithelial cells
-
Jiang X., Jacamo R., Zhukova E., Sinnett-Smith J., Rozengurt E. RNA interference reveals a differential role of FAK and Pyk2 in cell migration, leading edge formation and increase in focal adhesions induced by LPA in intestinal epithelial cells. J. Cell. Physiol. 2006, 207:816-828.
-
(2006)
J. Cell. Physiol.
, vol.207
, pp. 816-828
-
-
Jiang, X.1
Jacamo, R.2
Zhukova, E.3
Sinnett-Smith, J.4
Rozengurt, E.5
-
70
-
-
0346220294
-
PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation
-
Kadare G., Toutant M., Formstecher E., Corvol J.C., Carnaud M., Boutterin M.C., et al. PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation. J. Biol. Chem. 2003, 278:47434-47440.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 47434-47440
-
-
Kadare, G.1
Toutant, M.2
Formstecher, E.3
Corvol, J.C.4
Carnaud, M.5
Boutterin, M.C.6
-
71
-
-
0037030464
-
The focal adhesion kinase (P125FAK) is constitutively active in human malignant melanoma
-
Kahana O., Micksche M., Witz I.P., Yron I. The focal adhesion kinase (P125FAK) is constitutively active in human malignant melanoma. Oncogene 2002, 21:3969-3977.
-
(2002)
Oncogene
, vol.21
, pp. 3969-3977
-
-
Kahana, O.1
Micksche, M.2
Witz, I.P.3
Yron, I.4
-
72
-
-
76049123040
-
Receptor-interacting protein shuttles between cell death and survival signaling pathways
-
Kamarajan P., Bunek J., Lin Y., Nunez G., Kapila Y.L. Receptor-interacting protein shuttles between cell death and survival signaling pathways. Mol. Biol. Cell 2010, 21:481-488.
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 481-488
-
-
Kamarajan, P.1
Bunek, J.2
Lin, Y.3
Nunez, G.4
Kapila, Y.L.5
-
73
-
-
41149130736
-
Protein-tyrosine kinase CAKbeta/PYK2 is activated by binding Ca2+/calmodulin to FERM F2 alpha2 helix and thus forming its dimer
-
Kohno T., Matsuda E., Sasaki H., Sasaki T. Protein-tyrosine kinase CAKbeta/PYK2 is activated by binding Ca2+/calmodulin to FERM F2 alpha2 helix and thus forming its dimer. Biochem. J. 2008, 410:513-523.
-
(2008)
Biochem. J.
, vol.410
, pp. 513-523
-
-
Kohno, T.1
Matsuda, E.2
Sasaki, H.3
Sasaki, T.4
-
74
-
-
0031034574
-
Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
-
Kulik G., Klippel A., Weber M.J. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol. 1997, 17:1595-1606.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1595-1606
-
-
Kulik, G.1
Klippel, A.2
Weber, M.J.3
-
75
-
-
2942531163
-
Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein
-
Kurenova E., Xu L.H., Yang X., Baldwin A.S., Craven R.J., Hanks S.K., et al. Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Mol. Cell. Biol. 2004, 24:4361-4371.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 4361-4371
-
-
Kurenova, E.1
Xu, L.H.2
Yang, X.3
Baldwin, A.S.4
Craven, R.J.5
Hanks, S.K.6
-
76
-
-
68549120961
-
Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo
-
Kurenova E.V., Hunt D.L., He D., Magis A.T., Ostrov D.A., Cance W.G. Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo. J. Med. Chem. 2009, 52:4716-4724.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 4716-4724
-
-
Kurenova, E.V.1
Hunt, D.L.2
He, D.3
Magis, A.T.4
Ostrov, D.A.5
Cance, W.G.6
-
77
-
-
38049098089
-
Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression
-
Lahlou H., Sanguin-Gendreau V., Zuo D., Cardiff R.D., McLean G.W., Frame M.C., et al. Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Proc. Natl. Acad. Sci. USA 2007, 104:20302-20307.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 20302-20307
-
-
Lahlou, H.1
Sanguin-Gendreau, V.2
Zuo, D.3
Cardiff, R.D.4
McLean, G.W.5
Frame, M.C.6
-
78
-
-
0029154733
-
Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions
-
Lev S., Moreno H., Martinez R., Canoll P., Peles E., Musacchio J.M., et al. Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature 1995, 376:737-745.
-
(1995)
Nature
, vol.376
, pp. 737-745
-
-
Lev, S.1
Moreno, H.2
Martinez, R.3
Canoll, P.4
Peles, E.5
Musacchio, J.M.6
-
79
-
-
7044260519
-
Activation of FAK and Src are receptor-proximal events required for netrin signaling
-
Li W., Lee J., Vikis H.G., Lee S.H., Liu G., Aurandt J., et al. Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat. Neurosci. 2004, 7:1213-1221.
-
(2004)
Nat. Neurosci.
, vol.7
, pp. 1213-1221
-
-
Li, W.1
Lee, J.2
Vikis, H.G.3
Lee, S.H.4
Liu, G.5
Aurandt, J.6
-
80
-
-
57049091187
-
Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation
-
Lietha D., Eck M.J. Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation. PLoS One 2008, 3:e3800.
-
(2008)
PLoS One
, vol.3
-
-
Lietha, D.1
Eck, M.J.2
-
81
-
-
34250026140
-
Structural basis for the autoinhibition of focal adhesion kinase
-
Lietha D., Cai X., Ceccarelli D.F., Li Y., Schaller M.D., Eck M.J. Structural basis for the autoinhibition of focal adhesion kinase. Cell 2007, 129:1177-1187.
-
(2007)
Cell
, vol.129
, pp. 1177-1187
-
-
Lietha, D.1
Cai, X.2
Ceccarelli, D.F.3
Li, Y.4
Schaller, M.D.5
Eck, M.J.6
-
82
-
-
38149070791
-
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation
-
Lim S.T., Chen X.L., Lim Y., Hanson D.A., Vo T.T., Howerton K., et al. Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol. Cell 2008, 29:9-22.
-
(2008)
Mol. Cell
, vol.29
, pp. 9-22
-
-
Lim, S.T.1
Chen, X.L.2
Lim, Y.3
Hanson, D.A.4
Vo, T.T.5
Howerton, K.6
-
83
-
-
48849089827
-
FERM control of FAK function: implications for cancer therapy
-
Lim S.T., Mikolon D., Stupack D.G., Schlaepfer D.D. FERM control of FAK function: implications for cancer therapy. Cell Cycle 2008, 7:2306-2314.
-
(2008)
Cell Cycle
, vol.7
, pp. 2306-2314
-
-
Lim, S.T.1
Mikolon, D.2
Stupack, D.G.3
Schlaepfer, D.D.4
-
84
-
-
38349058006
-
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility
-
Lim Y., Lim S.T., Tomar A., Gardel M., Bernard-Trifilo J.A., Chen X.L., et al. PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. J. Cell Biol. 2008, 180:187-203.
-
(2008)
J. Cell Biol.
, vol.180
, pp. 187-203
-
-
Lim, Y.1
Lim, S.T.2
Tomar, A.3
Gardel, M.4
Bernard-Trifilo, J.A.5
Chen, X.L.6
-
85
-
-
0036197382
-
Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase
-
Liu G., Guibao C.D., Zheng J. Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase. Mol. Cell. Biol. 2002, 22:2751-2760.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 2751-2760
-
-
Liu, G.1
Guibao, C.D.2
Zheng, J.3
-
86
-
-
7044254701
-
Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction
-
Liu G., Beggs H., Jurgensen C., Park H.T., Tang H., Gorski J., et al. Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction. Nat. Neurosci. 2004, 7:1222-1232.
-
(2004)
Nat. Neurosci.
, vol.7
, pp. 1222-1232
-
-
Liu, G.1
Beggs, H.2
Jurgensen, C.3
Park, H.T.4
Tang, H.5
Gorski, J.6
-
87
-
-
34248136479
-
Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo
-
Liu T.J., LaFortune T., Honda T., Ohmori O., Hatakeyama S., Meyer T., et al. Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol. Cancer Ther. 2007, 6:1357-1367.
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 1357-1367
-
-
Liu, T.J.1
LaFortune, T.2
Honda, T.3
Ohmori, O.4
Hatakeyama, S.5
Meyer, T.6
-
88
-
-
46949105858
-
FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells
-
Liu W., Bloom D.A., Cance W.G., Kurenova E.V., Golubovskaya V.M., Hochwald S.N. FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis 2008, 29:1096-1107.
-
(2008)
Carcinogenesis
, vol.29
, pp. 1096-1107
-
-
Liu, W.1
Bloom, D.A.2
Cance, W.G.3
Kurenova, E.V.4
Golubovskaya, V.M.5
Hochwald, S.N.6
-
89
-
-
75949092766
-
SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration
-
Long W., Yi P., Amazit L., LaMarca H.L., Ashcroft F., Kumar R., et al. SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration. Mol. Cell 2010, 37:321-332.
-
(2010)
Mol. Cell
, vol.37
, pp. 321-332
-
-
Long, W.1
Yi, P.2
Amazit, L.3
LaMarca, H.L.4
Ashcroft, F.5
Kumar, R.6
-
90
-
-
67349236641
-
Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2
-
Lulo J., Yuzawa S., Schlessinger J. Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2. Biochem. Biophys. Res. Commun. 2009, 383:347-352.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.383
, pp. 347-352
-
-
Lulo, J.1
Yuzawa, S.2
Schlessinger, J.3
-
91
-
-
76849100707
-
Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis
-
Luo M., Guan J.L. Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Lett. 2010, 289:127-139.
-
(2010)
Cancer Lett.
, vol.289
, pp. 127-139
-
-
Luo, M.1
Guan, J.L.2
-
92
-
-
69849090245
-
Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2
-
Luo S.W., Zhang C., Zhang B., Kim C.H., Qiu Y.Z., Du Q.S., et al. Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2. EMBO J. 2009, 28:2568-2582.
-
(2009)
EMBO J.
, vol.28
, pp. 2568-2582
-
-
Luo, S.W.1
Zhang, C.2
Zhang, B.3
Kim, C.H.4
Qiu, Y.Z.5
Du, Q.S.6
-
93
-
-
0039441744
-
Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility
-
Manes S., Mira E., Gomez-Mouton C., Zhao Z.J., Lacalle R.A., Martinez A. Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility. Mol. Cell. Biol. 1999, 19:3125-3135.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 3125-3135
-
-
Manes, S.1
Mira, E.2
Gomez-Mouton, C.3
Zhao, Z.J.4
Lacalle, R.A.5
Martinez, A.6
-
94
-
-
0033955634
-
Activation of a pro-apoptotic amplification loop through inhibition of NF-kappaB-dependent survival signals by caspase-mediated inactivation of RIP
-
Martinon F., Holler N., Richard C., Tschopp J. Activation of a pro-apoptotic amplification loop through inhibition of NF-kappaB-dependent survival signals by caspase-mediated inactivation of RIP. FEBS Lett. 2000, 468:134-136.
-
(2000)
FEBS Lett.
, vol.468
, pp. 134-136
-
-
Martinon, F.1
Holler, N.2
Richard, C.3
Tschopp, J.4
-
95
-
-
0028053831
-
Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells
-
Matsumoto K., Matsumoto K., Nakamura T., Kramer R.H. Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. J. Biol. Chem. 1994, 269:31807-31813.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 31807-31813
-
-
Matsumoto, K.1
Matsumoto, K.2
Nakamura, T.3
Kramer, R.H.4
-
96
-
-
10644280092
-
Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression
-
McLean G.W., Komiyama N.H., Serrels B., Asano H., Reynolds L., Conti F., et al. Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. Genes Dev. 2004, 18:2998-3003.
-
(2004)
Genes Dev.
, vol.18
, pp. 2998-3003
-
-
McLean, G.W.1
Komiyama, N.H.2
Serrels, B.3
Asano, H.4
Reynolds, L.5
Conti, F.6
-
97
-
-
33746481375
-
Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model
-
Mitra S.K., Lim S.T., Chi A., Schlaepfer D.D. Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model. Oncogene 2006, 25:4429-4440.
-
(2006)
Oncogene
, vol.25
, pp. 4429-4440
-
-
Mitra, S.K.1
Lim, S.T.2
Chi, A.3
Schlaepfer, D.D.4
-
98
-
-
33749188459
-
Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors
-
Mitra S.K., Mikolon D., Molina J.E., Hsia D.A., Hanson D.A., Chi A., et al. Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors. Oncogene 2006, 25:5969-5984.
-
(2006)
Oncogene
, vol.25
, pp. 5969-5984
-
-
Mitra, S.K.1
Mikolon, D.2
Molina, J.E.3
Hsia, D.A.4
Hanson, D.A.5
Chi, A.6
-
99
-
-
0041369959
-
FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma
-
Miyazaki T., Kato H., Nakajima M., Sohda M., Fukai Y., Masuda N., et al. FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma. Br. J. Cancer 2003, 89:140-145.
-
(2003)
Br. J. Cancer
, vol.89
, pp. 140-145
-
-
Miyazaki, T.1
Kato, H.2
Nakajima, M.3
Sohda, M.4
Fukai, Y.5
Masuda, N.6
-
100
-
-
35748981202
-
Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland
-
Nagy T., Wei H., Shen T.L., Peng X., Liang C.C., Gan B., et al. Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland. J. Biol. Chem. 2007, 282:31766-31776.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 31766-31776
-
-
Nagy, T.1
Wei, H.2
Shen, T.L.3
Peng, X.4
Liang, C.C.5
Gan, B.6
-
101
-
-
25444530005
-
Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning
-
Nikolopoulos S.N., Giancotti F.G. Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning. Cell Cycle 2005, 4:e131-e135.
-
(2005)
Cell Cycle
, vol.4
-
-
Nikolopoulos, S.N.1
Giancotti, F.G.2
-
102
-
-
0032784060
-
Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase
-
Nolan K., Lacoste J., Parsons J.T. Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase. Mol. Cell. Biol. 1999, 19:6120-6129.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 6120-6129
-
-
Nolan, K.1
Lacoste, J.2
Parsons, J.T.3
-
103
-
-
1842848073
-
Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography
-
Nowakowski J., Cronin C.N., McRee D.E., Knuth M.W., Nelson C.G., Pavletich N.P., et al. Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography. Structure 2002, 10:1659-1667.
-
(2002)
Structure
, vol.10
, pp. 1659-1667
-
-
Nowakowski, J.1
Cronin, C.N.2
McRee, D.E.3
Knuth, M.W.4
Nelson, C.G.5
Pavletich, N.P.6
-
104
-
-
0020554503
-
Mitogen-potentiating action and binding characteristics of insulin and insulin-like growth factors in Chinese hamster fibroblasts
-
Obberghen-Schilling E., Pouyssegur J. Mitogen-potentiating action and binding characteristics of insulin and insulin-like growth factors in Chinese hamster fibroblasts. Exp. Cell Res. 1983, 147:369-378.
-
(1983)
Exp. Cell Res.
, vol.147
, pp. 369-378
-
-
Obberghen-Schilling, E.1
Pouyssegur, J.2
-
105
-
-
0141591532
-
Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration
-
Okigaki M., Davis C., Falasca M., Harroch S., Felsenfeld D.P., Sheetz M.P., et al. Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration. Proc. Natl. Acad. Sci. USA 2003, 100:10740-10745.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 10740-10745
-
-
Okigaki, M.1
Davis, C.2
Falasca, M.3
Harroch, S.4
Felsenfeld, D.P.5
Sheetz, M.P.6
-
106
-
-
66149139873
-
Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility
-
Papusheva E., Mello de Queiroz F., Dalous J., Han Y., Esposito A., Jares-Erijmanxa E.A., et al. Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility. J. Cell Sci. 2009, 122:656-666.
-
(2009)
J. Cell Sci.
, vol.122
, pp. 656-666
-
-
Papusheva, E.1
Mello de Queiroz, F.2
Dalous, J.3
Han, Y.4
Esposito, A.5
Jares-Erijmanxa, E.A.6
-
107
-
-
66149099270
-
Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis
-
Park A.Y., Shen T.L., Chien S., Guan J.L. Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis. J. Biol. Chem. 2009, 284:9418-9425.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 9418-9425
-
-
Park, A.Y.1
Shen, T.L.2
Chien, S.3
Guan, J.L.4
-
108
-
-
27944485709
-
Focal adhesion kinase and Src phosphorylations in HGF-induced proliferation and invasion of human cholangiocarcinoma cell line, HuCCA-1
-
Pongchairerk U., Guan J.L., Leardkamolkarn V. Focal adhesion kinase and Src phosphorylations in HGF-induced proliferation and invasion of human cholangiocarcinoma cell line, HuCCA-1. World J. Gastroenterol. 2005, 11:5845-5852.
-
(2005)
World J. Gastroenterol.
, vol.11
, pp. 5845-5852
-
-
Pongchairerk, U.1
Guan, J.L.2
Leardkamolkarn, V.3
-
109
-
-
0035813119
-
Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion
-
Poullet P., Gautreau A., Kadare G., Girault J.A., Louvard D., Arpin M. Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion. J. Biol. Chem. 2001, 276:37686-37691.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37686-37691
-
-
Poullet, P.1
Gautreau, A.2
Kadare, G.3
Girault, J.A.4
Louvard, D.5
Arpin, M.6
-
110
-
-
70350453823
-
The role of focal adhesion kinase in tumor initiation and progression
-
Provenzano P.P., Keely P.J. The role of focal adhesion kinase in tumor initiation and progression. Cell Adh. Migr. 2009, 3:347-350.
-
(2009)
Cell Adh. Migr.
, vol.3
, pp. 347-350
-
-
Provenzano, P.P.1
Keely, P.J.2
-
111
-
-
55349105491
-
Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer
-
Provenzano P.P., Inman D.R., Eliceiri K.W., Beggs H.E., Keely P.J. Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer. Am. J. Pathol. 2008, 173:1551-1565.
-
(2008)
Am. J. Pathol.
, vol.173
, pp. 1551-1565
-
-
Provenzano, P.P.1
Inman, D.R.2
Eliceiri, K.W.3
Beggs, H.E.4
Keely, P.J.5
-
112
-
-
2342649951
-
The focal adhesion targeting domain of focal adhesion kinase contains a hinge region that modulates tyrosine 926 phosphorylation
-
Prutzman K.C., Gao G., King M.L., Iyer V.V., Mueller G.A., Schaller M.D., et al. The focal adhesion targeting domain of focal adhesion kinase contains a hinge region that modulates tyrosine 926 phosphorylation. Structure 2004, 12:881-891.
-
(2004)
Structure
, vol.12
, pp. 881-891
-
-
Prutzman, K.C.1
Gao, G.2
King, M.L.3
Iyer, V.V.4
Mueller, G.A.5
Schaller, M.D.6
-
113
-
-
61749094852
-
Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling
-
Pylayeva Y., Gillen K.M., Gerald W., Beggs H.E., Reichardt L.F., Giancotti F.G. Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J. Clin. Invest. 2009, 119:252-266.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 252-266
-
-
Pylayeva, Y.1
Gillen, K.M.2
Gerald, W.3
Beggs, H.E.4
Reichardt, L.F.5
Giancotti, F.G.6
-
114
-
-
64549099929
-
Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA
-
Rajasekharan S., Baker K.A., Horn K.E., Jarjour A.A., Antel J.P., Kennedy T.E. Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA. Development 2009, 136:415-426.
-
(2009)
Development
, vol.136
, pp. 415-426
-
-
Rajasekharan, S.1
Baker, K.A.2
Horn, K.E.3
Jarjour, A.A.4
Antel, J.P.5
Kennedy, T.E.6
-
115
-
-
7044269185
-
Focal adhesion kinase in netrin-1 signaling
-
Ren X.R., Ming G.L., Xie Y., Hong Y., Sun D.M., Zhao Z.Q., et al. Focal adhesion kinase in netrin-1 signaling. Nat. Neurosci. 2004, 7:1204-1212.
-
(2004)
Nat. Neurosci.
, vol.7
, pp. 1204-1212
-
-
Ren, X.R.1
Ming, G.L.2
Xie, Y.3
Hong, Y.4
Sun, D.M.5
Zhao, Z.Q.6
-
116
-
-
0029971297
-
A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp 125FAK
-
Richardson A., Parsons T. A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp 125FAK. Nature 1996, 380:538-540.
-
(1996)
Nature
, vol.380
, pp. 538-540
-
-
Richardson, A.1
Parsons, T.2
-
117
-
-
11244328441
-
Control of axonal branching and synapse formation by focal adhesion kinase
-
Rico B., Beggs H.E., Schahin-Reed D., Kimes N., Schmidt A., Reichardt L.F. Control of axonal branching and synapse formation by focal adhesion kinase. Nat. Neurosci. 2004, 7:1059-1069.
-
(2004)
Nat. Neurosci.
, vol.7
, pp. 1059-1069
-
-
Rico, B.1
Beggs, H.E.2
Schahin-Reed, D.3
Kimes, N.4
Schmidt, A.5
Reichardt, L.F.6
-
118
-
-
11244328441
-
Control of axonal branching and synapse formation by focal adhesion kinase
-
Rico B., Beggs H.E., Schahin-Reed D., Kimes N., Schmidt A., Reichardt L.F. Control of axonal branching and synapse formation by focal adhesion kinase. Nat. Neurosci. 2004, 7:1059-1069.
-
(2004)
Nat. Neurosci.
, vol.7
, pp. 1059-1069
-
-
Rico, B.1
Beggs, H.E.2
Schahin-Reed, D.3
Kimes, N.4
Schmidt, A.5
Reichardt, L.F.6
-
119
-
-
77957802351
-
The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation
-
Riggs D., Yang Z., Kloss J., Loftus J.C. The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation. Cell Signal. 2011, 23:288-296.
-
(2011)
Cell Signal.
, vol.23
, pp. 288-296
-
-
Riggs, D.1
Yang, Z.2
Kloss, J.3
Loftus, J.C.4
-
120
-
-
40949152523
-
Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562, 271
-
Roberts W.G., Ung E., Whalen P., Cooper B., Hulford C., Autry C., et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562, 271. Cancer Res. 2008, 68:1935-1944.
-
(2008)
Cancer Res.
, vol.68
, pp. 1935-1944
-
-
Roberts, W.G.1
Ung, E.2
Whalen, P.3
Cooper, B.4
Hulford, C.5
Autry, C.6
-
121
-
-
33847152222
-
Focal adhesion kinase and E-cadherin as markers for nodal metastasis in laryngeal cancer
-
Rodrigo J.P., Dominguez F., Suarez V., Canel M., Secades P., Chiara M.D. Focal adhesion kinase and E-cadherin as markers for nodal metastasis in laryngeal cancer. Arch. Otolaryngol. Head Neck Surg. 2007, 133:145-150.
-
(2007)
Arch. Otolaryngol. Head Neck Surg.
, vol.133
, pp. 145-150
-
-
Rodrigo, J.P.1
Dominguez, F.2
Suarez, V.3
Canel, M.4
Secades, P.5
Chiara, M.D.6
-
122
-
-
0035475321
-
Paxillin: a focal adhesion-associated adaptor protein
-
Schaller M.D. Paxillin: a focal adhesion-associated adaptor protein. Oncogene 2001, 20:6459-6472.
-
(2001)
Oncogene
, vol.20
, pp. 6459-6472
-
-
Schaller, M.D.1
-
123
-
-
77951184829
-
Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions
-
Schaller M.D. Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions. J. Cell Sci. 2010, 123:1007-1013.
-
(2010)
J. Cell Sci.
, vol.123
, pp. 1007-1013
-
-
Schaller, M.D.1
-
124
-
-
0026612521
-
Pp 125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions
-
Schaller M.D., Borgman C.A., Cobb B.S., Vines R.R., Reynolds A.B., Parsons J.T. pp 125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc. Natl. Acad. Sci. USA 1992, 89:5192-5196.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 5192-5196
-
-
Schaller, M.D.1
Borgman, C.A.2
Cobb, B.S.3
Vines, R.R.4
Reynolds, A.B.5
Parsons, J.T.6
-
125
-
-
0027439594
-
Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp 125FAK
-
Schaller M.D., Borgman C.A., Parsons J.T. Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp 125FAK. Mol. Cell. Biol. 1993, 13:785-791.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 785-791
-
-
Schaller, M.D.1
Borgman, C.A.2
Parsons, J.T.3
-
126
-
-
0028350859
-
Autophosphorylation of the focal adhesion kinase, pp 125FAK, directs SH2-dependent binding of pp60src
-
Schaller M.D., Hildebrand J.D., Shannon J.D., Fox J.W., Vines R.R., Parsons J.T. Autophosphorylation of the focal adhesion kinase, pp 125FAK, directs SH2-dependent binding of pp60src. Mol. Cell. Biol. 1994, 14:1680-1688.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 1680-1688
-
-
Schaller, M.D.1
Hildebrand, J.D.2
Shannon, J.D.3
Fox, J.W.4
Vines, R.R.5
Parsons, J.T.6
-
127
-
-
39649086685
-
Multiple paxillin binding sites regulate FAK function
-
Scheswohl D.M., Harrell J.R., Rajfur Z., Gao G., Campbell S.L., Schaller M.D. Multiple paxillin binding sites regulate FAK function. J. Mol. Signal. 2008, 3:1.
-
(2008)
J. Mol. Signal.
, vol.3
, pp. 1
-
-
Scheswohl, D.M.1
Harrell, J.R.2
Rajfur, Z.3
Gao, G.4
Campbell, S.L.5
Schaller, M.D.6
-
128
-
-
0029834447
-
Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases
-
Schlaepfer D.D., Hunter T. Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. Mol. Cell. Biol. 1996, 16:5623-5633.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 5623-5633
-
-
Schlaepfer, D.D.1
Hunter, T.2
-
129
-
-
0028609382
-
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
-
Schlaepfer D.D., Hanks S.K., Hunter T., van der Geer P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 1994, 372:786-791.
-
(1994)
Nature
, vol.372
, pp. 786-791
-
-
Schlaepfer, D.D.1
Hanks, S.K.2
Hunter, T.3
van der Geer, P.4
-
130
-
-
34250656135
-
GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin
-
Schmalzigaug R., Garron M.L., Roseman J.T., Xing Y., Davidson C.E., Arold S.T., et al. GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin. Cell Signal. 2007, 19:1733-1744.
-
(2007)
Cell Signal.
, vol.19
, pp. 1733-1744
-
-
Schmalzigaug, R.1
Garron, M.L.2
Roseman, J.T.3
Xing, Y.4
Davidson, C.E.5
Arold, S.T.6
-
131
-
-
34548316989
-
Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex
-
Serrels B., Serrels A., Brunton V.G., Holt M., McLean G.W., Gray C.H., et al. Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex. Nat. Cell Biol. 2007, 9:1046-1056.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 1046-1056
-
-
Serrels, B.1
Serrels, A.2
Brunton, V.G.3
Holt, M.4
McLean, G.W.5
Gray, C.H.6
-
132
-
-
22344434300
-
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis
-
Shen T.L., Park A.Y., Alcaraz A., Peng X., Jang I., Koni P., et al. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J. Cell Biol. 2005, 169:941-952.
-
(2005)
J. Cell Biol.
, vol.169
, pp. 941-952
-
-
Shen, T.L.1
Park, A.Y.2
Alcaraz, A.3
Peng, X.4
Jang, I.5
Koni, P.6
-
133
-
-
67649321881
-
Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity
-
Shi Y., Pontrello C.G., DeFea K.A., Reichardt L.F., Ethell I.M. Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity. J. Neurosci. 2009, 29:8129-8142.
-
(2009)
J. Neurosci.
, vol.29
, pp. 8129-8142
-
-
Shi, Y.1
Pontrello, C.G.2
DeFea, K.A.3
Reichardt, L.F.4
Ethell, I.M.5
-
134
-
-
0033772308
-
FAK integrates growth-factor and integrin signals to promote cell migration
-
Sieg D.J., Hauck C.R., Ilic D., Klingbeil C.K., Schaefer E., Damsky C.H., et al. FAK integrates growth-factor and integrin signals to promote cell migration. Nat. Cell Biol. 2000, 2:249-256.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 249-256
-
-
Sieg, D.J.1
Hauck, C.R.2
Ilic, D.3
Klingbeil, C.K.4
Schaefer, E.5
Damsky, C.H.6
-
135
-
-
34447538483
-
Cellular characterization of a novel focal adhesion kinase inhibitor
-
Slack-Davis J.K., Martin K.H., Tilghman R.W., Iwanicki M., Ung E.J., Autry C., et al. Cellular characterization of a novel focal adhesion kinase inhibitor. J. Biol. Chem. 2007, 282:14845-14852.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 14845-14852
-
-
Slack-Davis, J.K.1
Martin, K.H.2
Tilghman, R.W.3
Iwanicki, M.4
Ung, E.J.5
Autry, C.6
-
136
-
-
4644315256
-
Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion
-
Sood A.K., Coffin J.E., Schneider G.B., Fletcher M.S., DeYoung B.R., Gruman L.M., et al. Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion. Am. J. Pathol. 2004, 165:1087-1095.
-
(2004)
Am. J. Pathol.
, vol.165
, pp. 1087-1095
-
-
Sood, A.K.1
Coffin, J.E.2
Schneider, G.B.3
Fletcher, M.S.4
DeYoung, B.R.5
Gruman, L.M.6
-
137
-
-
77953709612
-
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments
-
Tanjoni I., Walsh C., Uryu S., Tomar A., Nam J.O., Mielgo A., et al. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol. Ther. 2010, 9:764-777.
-
(2010)
Cancer Biol. Ther.
, vol.9
, pp. 764-777
-
-
Tanjoni, I.1
Walsh, C.2
Uryu, S.3
Tomar, A.4
Nam, J.O.5
Mielgo, A.6
-
138
-
-
0031962265
-
SH2- and SH3-mediated interactions between focal adhesion kinase and Src
-
Thomas J.W., Ellis B., Boerner R.J., Knight W.B., White G.C., Schaller M.D. SH2- and SH3-mediated interactions between focal adhesion kinase and Src. J. Biol. Chem. 1998, 273:577-583.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 577-583
-
-
Thomas, J.W.1
Ellis, B.2
Boerner, R.J.3
Knight, W.B.4
White, G.C.5
Schaller, M.D.6
-
139
-
-
70349332774
-
Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility
-
Tomar A., Schlaepfer D.D. Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr. Opin. Cell Biol. 2009, 21:676-683.
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 676-683
-
-
Tomar, A.1
Schlaepfer, D.D.2
-
140
-
-
0036839636
-
Alternative splicing controls the mechanisms of FAK autophosphorylation
-
Toutant M., Costa A., Studler J.M., Kadare G., Carnaud M., Girault J.A. Alternative splicing controls the mechanisms of FAK autophosphorylation. Mol. Cell. Biol. 2002, 22:7731-7743.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 7731-7743
-
-
Toutant, M.1
Costa, A.2
Studler, J.M.3
Kadare, G.4
Carnaud, M.5
Girault, J.A.6
-
141
-
-
33748912488
-
Netrin-1 signaling regulates de novo protein synthesis of kappa opioid receptor by facilitating polysomal partition of its mRNA
-
Tsai N.P., Bi J., Loh H.H., Wei L.N. Netrin-1 signaling regulates de novo protein synthesis of kappa opioid receptor by facilitating polysomal partition of its mRNA. J. Neurosci. 2006, 26:9743-9749.
-
(2006)
J. Neurosci.
, vol.26
, pp. 9743-9749
-
-
Tsai, N.P.1
Bi, J.2
Loh, H.H.3
Wei, L.N.4
-
142
-
-
33947577607
-
The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation
-
Tsai N.P., Bi J., Wei L.N. The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation. EMBO J. 2007, 26:1522-1531.
-
(2007)
EMBO J.
, vol.26
, pp. 1522-1531
-
-
Tsai, N.P.1
Bi, J.2
Wei, L.N.3
-
143
-
-
0034678330
-
Suppression of Pyk2 kinase and cellular activities by FIP200
-
Ueda H., Abbi S., Zheng C., Guan J.L. Suppression of Pyk2 kinase and cellular activities by FIP200. J. Cell Biol. 2000, 149:423-430.
-
(2000)
J. Cell Biol.
, vol.149
, pp. 423-430
-
-
Ueda, H.1
Abbi, S.2
Zheng, C.3
Guan, J.L.4
-
144
-
-
35649008373
-
Focal adhesion kinase: an essential kinase in the regulation of cardiovascular functions
-
Vadali K., Cai X., Schaller M.D. Focal adhesion kinase: an essential kinase in the regulation of cardiovascular functions. IUBMB Life 2007, 59:709-716.
-
(2007)
IUBMB Life
, vol.59
, pp. 709-716
-
-
Vadali, K.1
Cai, X.2
Schaller, M.D.3
-
145
-
-
68849129918
-
Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development
-
Vallejo-Illarramendi A., Zang K., Reichardt L.F. Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development. J. Clin. Invest. 2009, 119:2218-2230.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 2218-2230
-
-
Vallejo-Illarramendi, A.1
Zang, K.2
Reichardt, L.F.3
-
146
-
-
19644388523
-
Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation
-
van Nimwegen M.J., Verkoeijen S., van Buren L., Burg D., van de Water B. Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation. Cancer Res. 2005, 65:4698-4706.
-
(2005)
Cancer Res.
, vol.65
, pp. 4698-4706
-
-
van Nimwegen, M.J.1
Verkoeijen, S.2
van Buren, L.3
Burg, D.4
van de Water, B.5
-
147
-
-
55549143963
-
Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation
-
Walker D.P., Bi F.C., Kalgutkar A.S., Bauman J.N., Zhao S.X., Soglia J.R., et al. Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation. Bioorg. Med. Chem. Lett. 2008, 18:6071-6077.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 6071-6077
-
-
Walker, D.P.1
Bi, F.C.2
Kalgutkar, A.S.3
Bauman, J.N.4
Zhao, S.X.5
Soglia, J.R.6
-
148
-
-
79960150764
-
Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models
-
Walsh C., Tanjoni I., Uryu S., Tomar A., Nam J.O., Luo H., et al. Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. Cancer Biol. Ther. 2010, 9:778-790.
-
(2010)
Cancer Biol. Ther.
, vol.9
, pp. 778-790
-
-
Walsh, C.1
Tanjoni, I.2
Uryu, S.3
Tomar, A.4
Nam, J.O.5
Luo, H.6
-
149
-
-
0037450657
-
Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin
-
Wang Q., Xie Y., Du Q.S., Wu X.J., Feng X., Mei L., et al. Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin. J. Cell Biol. 2003, 160:565-575.
-
(2003)
J. Cell Biol.
, vol.160
, pp. 565-575
-
-
Wang, Q.1
Xie, Y.2
Du, Q.S.3
Wu, X.J.4
Feng, X.5
Mei, L.6
-
150
-
-
41849098553
-
Focal adhesion kinase signaling controls cyclic tensile strain enhanced collagen I-induced osteogenic differentiation of human mesenchymal stem cells
-
Ward D.F., Williams W.A., Schapiro N.E., Weber G.L., Christy S.R., Salt M., et al. Focal adhesion kinase signaling controls cyclic tensile strain enhanced collagen I-induced osteogenic differentiation of human mesenchymal stem cells. Mol. Cell Biomech. 2007, 4:177-188.
-
(2007)
Mol. Cell Biomech.
, vol.4
, pp. 177-188
-
-
Ward, D.F.1
Williams, W.A.2
Schapiro, N.E.3
Weber, G.L.4
Christy, S.R.5
Salt, M.6
-
151
-
-
63449115157
-
Requirement of focal adhesion kinase in branching tubulogenesis
-
Wei W.C., Kopec A.K., Tang M.J. Requirement of focal adhesion kinase in branching tubulogenesis. J. Biomed. Sci. 2009, 16:5.
-
(2009)
J. Biomed. Sci.
, vol.16
, pp. 5
-
-
Wei, W.C.1
Kopec, A.K.2
Tang, M.J.3
-
152
-
-
0027448821
-
Expression of focal adhesion kinase gene and invasive cancer
-
Weiner T.M., Liu E.T., Craven R.J., Cance W.G. Expression of focal adhesion kinase gene and invasive cancer. Lancet 1993, 342:1024-1025.
-
(1993)
Lancet
, vol.342
, pp. 1024-1025
-
-
Weiner, T.M.1
Liu, E.T.2
Craven, R.J.3
Cance, W.G.4
-
153
-
-
0029883092
-
Expression and herbimycin A-sensitive localization of pp 125FAK in retinal growth cones
-
Worley T.L., Holt C.E. Expression and herbimycin A-sensitive localization of pp 125FAK in retinal growth cones. Neuroreport 1996, 7:1133-1137.
-
(1996)
Neuroreport
, vol.7
, pp. 1133-1137
-
-
Worley, T.L.1
Holt, C.E.2
-
154
-
-
1542304700
-
Focal adhesion kinase regulation of N-WASP subcellular localization and function
-
Wu X., Suetsugu S., Cooper L.A., Takenawa T., Guan J.L. Focal adhesion kinase regulation of N-WASP subcellular localization and function. J. Biol. Chem. 2004, 279:9565-9576.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 9565-9576
-
-
Wu, X.1
Suetsugu, S.2
Cooper, L.A.3
Takenawa, T.4
Guan, J.L.5
-
155
-
-
33747837804
-
Antisense oligonucleodes targeting the focal adhesion kinase inhibit proliferation, induce apoptosis and cooperate with cytotoxic drugs in human glioma cells
-
Wu Z.M., Yuan X.H., Jiang P.C., Li Z.Q., Wu T. Antisense oligonucleodes targeting the focal adhesion kinase inhibit proliferation, induce apoptosis and cooperate with cytotoxic drugs in human glioma cells. J. Neurooncol. 2006, 77:117-123.
-
(2006)
J. Neurooncol.
, vol.77
, pp. 117-123
-
-
Wu, Z.M.1
Yuan, X.H.2
Jiang, P.C.3
Li, Z.Q.4
Wu, T.5
-
156
-
-
3843063704
-
Cdk5 phosphorylation of FAK regulates centrosome-associated miocrotubules and neuronal migration
-
Xie Z., Tsai L.H. Cdk5 phosphorylation of FAK regulates centrosome-associated miocrotubules and neuronal migration. Cell Cycle 2004, 3:108-110.
-
(2004)
Cell Cycle
, vol.3
, pp. 108-110
-
-
Xie, Z.1
Tsai, L.H.2
-
157
-
-
0035378669
-
Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion
-
Xie B., Zhao J., Kitagawa M., Durbin J., Madri J.A., Guan J.L., et al. Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion. J. Biol. Chem. 2001, 276:19512-19523.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 19512-19523
-
-
Xie, B.1
Zhao, J.2
Kitagawa, M.3
Durbin, J.4
Madri, J.A.5
Guan, J.L.6
-
158
-
-
0042329506
-
Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration
-
Xie Z., Sanada K., Samuels B.A., Shih H., Tsai L.H. Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. Cell 2003, 114:469-482.
-
(2003)
Cell
, vol.114
, pp. 469-482
-
-
Xie, Z.1
Sanada, K.2
Samuels, B.A.3
Shih, H.4
Tsai, L.H.5
-
159
-
-
0031846188
-
Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein
-
Xiong W.C., Macklem M., Parsons J.T. Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein. J. Cell Sci. 1998, 111(Pt 14):1981-1991.
-
(1998)
J. Cell Sci.
, vol.111
, Issue.PART 14
, pp. 1981-1991
-
-
Xiong, W.C.1
Macklem, M.2
Parsons, J.T.3
-
160
-
-
23044510550
-
Role of PYK2 in the development of obesity and insulin resistance
-
Yu Y., Ross S.A., Halseth A.E., Hollenbach P.W., Hill R.J., Gulve E.A., et al. Role of PYK2 in the development of obesity and insulin resistance. Biochem. Biophys. Res. Commun. 2005, 334:1085-1091.
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.334
, pp. 1085-1091
-
-
Yu, Y.1
Ross, S.A.2
Halseth, A.E.3
Hollenbach, P.W.4
Hill, R.J.5
Gulve, E.A.6
-
161
-
-
73949141711
-
Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration
-
Yu J.A., Deakin N.O., Turner C.E. Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration. Mol. Biol. Cell 2009, 20:4706-4719.
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 4706-4719
-
-
Yu, J.A.1
Deakin, N.O.2
Turner, C.E.3
-
162
-
-
0042090404
-
Direct interaction of focal adhesion kinase with p190RhoGEF
-
Zhai J., Lin H., Nie Z., Wu J., Canete-Soler R., Schlaepfer W.W., et al. Direct interaction of focal adhesion kinase with p190RhoGEF. J. Biol. Chem. 2003, 278:24865-24873.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 24865-24873
-
-
Zhai, J.1
Lin, H.2
Nie, Z.3
Wu, J.4
Canete-Soler, R.5
Schlaepfer, W.W.6
-
163
-
-
25844465843
-
Multiple signaling pathways are activated during insulin-like growth factor-I (IGF-I) stimulated breast cancer cell migration
-
Zhang X., Lin M., van Golen K.L., Yoshioka K., Itoh K., Yee D. Multiple signaling pathways are activated during insulin-like growth factor-I (IGF-I) stimulated breast cancer cell migration. Breast Cancer Res. Treat. 2005, 93:159-168.
-
(2005)
Breast Cancer Res. Treat.
, vol.93
, pp. 159-168
-
-
Zhang, X.1
Lin, M.2
van Golen, K.L.3
Yoshioka, K.4
Itoh, K.5
Yee, D.6
-
164
-
-
67651085772
-
Signal transduction by focal adhesion kinase in cancer
-
Zhao J., Guan J.L. Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev. 2009, 28:35-49.
-
(2009)
Cancer Metastasis Rev.
, vol.28
, pp. 35-49
-
-
Zhao, J.1
Guan, J.L.2
-
165
-
-
69249217669
-
Targeting of the protein interaction site between FAK and IGF-1R
-
Zheng D., Kurenova E., Ucar D., Golubovskaya V., Magis A., Ostrov D., et al. Targeting of the protein interaction site between FAK and IGF-1R. Biochem. Biophys. Res. Commun. 2009, 388:301-305.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.388
, pp. 301-305
-
-
Zheng, D.1
Kurenova, E.2
Ucar, D.3
Golubovskaya, V.4
Magis, A.5
Ostrov, D.6
-
166
-
-
0028860968
-
Structure and ligand recognition of the phosphotyrosine binding domain of Shc
-
Zhou M.M., Ravichandran K.S., Olejniczak E.F., Petros A.M., Meadows R.P., Sattler M., et al. Structure and ligand recognition of the phosphotyrosine binding domain of Shc. Nature 1995, 378:584-592.
-
(1995)
Nature
, vol.378
, pp. 584-592
-
-
Zhou, M.M.1
Ravichandran, K.S.2
Olejniczak, E.F.3
Petros, A.M.4
Meadows, R.P.5
Sattler, M.6
-
167
-
-
33749025025
-
Detection of a hidden folding intermediate in the focal adhesion target domain: implications for its function and folding
-
Zhou Z., Feng H., Bai Y. Detection of a hidden folding intermediate in the focal adhesion target domain: implications for its function and folding. Proteins 2006, 65:259-265.
-
(2006)
Proteins
, vol.65
, pp. 259-265
-
-
Zhou, Z.1
Feng, H.2
Bai, Y.3
-
168
-
-
0028028202
-
Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis
-
Zhu H., Naujokas M.A., Fixman E.D., Torossian K., Park M. Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis. J. Biol. Chem. 1994, 269:29943-29948.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 29943-29948
-
-
Zhu, H.1
Naujokas, M.A.2
Fixman, E.D.3
Torossian, K.4
Park, M.5
|