Mechanosomes carry a loaded message

Science Signaling

Volumn 3, Issue 153, 2010, Pages

  Bidwell, Joseph P ^a   Pavalko, Fredrick M ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BETA3 INTEGRIN; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; LYMPHOID ENHANCER FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; MULTIPROTEIN COMPLEX; NITRIC OXIDE; NUCLEAR MATRIX PROTEIN; NUCLEAR PROTEIN; PROTEIN C FOS; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; TRANSCRIPTION FACTOR DELTA FOSB; TRANSCRIPTION FACTOR FRA 1; TRANSCRIPTION FACTOR FRA 2; CELL ADHESION MOLECULE; TRANSCRIPTION FACTOR;

BONE CELL; CELL ACTIVATION; CELL MEMBRANE; DNA CONFORMATION; GENE EXPRESSION; GENE TARGETING; MECHANOTRANSDUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; ARTICLE; BIOLOGICAL MODEL; BIOMECHANICS; BONE; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; PHYSIOLOGY;

MAMMALIA;

BIOMECHANICS; BONE AND BONES; CELL ADHESION MOLECULES; CELL MEMBRANE; GENE EXPRESSION REGULATION; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; TRANSCRIPTION FACTORS;

EID: 78650672384     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.3153pe51     Document Type: Review

References (34)

1. F. M. Pavalko, S. M. Norvell, D. B. Burr, C. H. Turner, R. L. Duncan, J. P. Bidwell, A model for mechanotransduction in bone cells: The load-bearing mechanosomes. J. Cell. Biochem. 88, 104-112 (2003).
2. P. Childress, A. G. Robling, J. P. Bidwell, Nmp4/ CIZ: Road block at the intersection of PTH and load. Bone 46, 259-266 (2010).
3. S. M. Norvell, M. Alvarez, J. P. Bidwell, F. M. Pavalko, Fluid shear stress induces beta-catenin signaling in osteoblasts. Calcif. Tissue Int. 75, 396-404 (2004).
4. J. A. Robinson, M. Chatterjee-Kishore, P. J. Yaworsky, D. M. Cullen, W. Zhao, C. Li, Y. Kharode, L. Sauter, P. Babij, E. L. Brown, A. A. Hill, M. P. Akhter, M. L. Johnson, R. R. Recker, B. S. Komm, F. J. Bex, Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone. J. Biol. Chem. 281, 31720-31728 (2006).
5. N. Case, J. Rubin, Beta-catenin-A supporting role in the skeleton. J. Cell. Biochem. 110, 545- 553 (2010).
6. A. G. Robling, P. Childress, J. Yu, J. Cotte, A. Heller, B. K. Philip, J. P. Bidwell, Nmp4/CIZ suppresses parathyroid hormone-induced increases in trabecular bone. J. Cell. Physiol. 219, 734-743 (2009).
7. Z. Yang, J. P. Bidwell, S. R. Young, R. Gerard- O'Riley, H. Wang, F. M. Pavalko, Nmp4/CIZ inhibits mechanically induced beta-catenin signaling activity in osteoblasts. J. Cell. Physiol. 223, 435-441 (2010).
8. H. Rangaswami, R. Schwappacher, N. Marathe, S. Zhuang, D. E. Casteel, B. Haas, Y. Chen, A. Pfeifer, H. Kato, S. Shattil, G. R. Boss, R. B. Pilz, Cyclic GMP Protein kinase G control a Src-containing mechanosome in osteoblasts. Sci. Signal. 3, 91 (2010).
9. H. Rangaswami, N. Marathe, S. Zhuang, Y. Chen, J. C. Yeh, J. A. Frangos, G. R. Boss, R. B. Pilz, Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction. J. Biol. Chem. 284, 14796-14808 (2009).
10. Y. Tamamura, T. Otani, N. Kanatani, E. Koyama, J. Kitagaki, T. Komori, Y. Yamada, F. Costantini, S. Wakisaka, M. Pacifi ci, M. Iwamoto, M. Enomoto- Iwamoto, Developmental regulation of Wnt/ beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossifi cation. J. Biol. Chem. 280, 19185-19195 (2005).
11. I. Kramer, C. Halleux, H. Keller, M. Pegurri, J. H. Gooi, P. B. Weber, J. Q. Feng, L. F. Bonewald, M. Kneissel, Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis. Mol. Cell. Biol. 30, 3071-3085 (2010).
12. T. Nakamoto, T. Yamagata, R. Sakai, S. Ogawa, H. Honda, H. Ueno, N. Hirano, Y. Yazaki, H. Hirai, CIZ, a zinc fi nger protein that interacts with p130(cas) and activates the expression of matrix metalloproteinases. Mol. Cell. Biol. 20, 1649-1658 (2000).
13. M. Alvarez, P. Thunyakitpisal, P. Morrison, J. Onyia, J. Hock, J. P. Bidwell, PTH-responsive osteoblast nuclear matrix architectural transcription factor binds to the rat type I collagen promoter. J. Cell. Biochem. 69, 336-352 (1998).
14. P. Thunyakitpisal, M. Alvarez, K. Tokunaga, J. E. Onyia, J. Hock, N. Ohashi, H. Feister, S. J. Rhodes, J. P. Bidwell, Cloning and functional analysis of a family of nuclear matrix transcription factors (NP/NMP4) that regulate type I collagen expression in osteoblasts. J. Bone Miner. Res. 16, 10-23 (2001).
15. Y. Nojima, N. Morino, T. Mimura, K. Hamasaki, H. Furuya, R. Sakai, T. Sato, K. Tachibana, C. Morimoto, Y. Yazaki, H. Hirai, Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs. J. Biol. Chem. 270, 15398-15402 (1995).
16. K. Vuori, E. Ruoslahti, Tyrosine phosphorylation of p130Cas and cortactin accompanies integrinmediated cell adhesion to extracellular matrix. J. Biol. Chem. 270, 22259-22262 (1995).
17. T. R. Polte, S. K. Hanks, Interaction between focal adhesion kinase and Crk-Associated tyrosine kinase substrate p130Cas. Proc. Natl. Acad. Sci. U.S.A. 92, 10678-10682 (1995).
18. Y. Sawada, M. Tamada, B. J. Dubin-Thaler, O. Cherniavskaya, R. Sakai, S. Tanaka, M. P. Sheetz, Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell 127, 1015-1026 (2006).
19. R. Sakai, A. Iwamatsu, N. Hirano, S. Ogawa, T. Tanaka, H. Mano, Y. Yazaki, H. Hirai, A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation- dependent manner. EMBO J. 13, 3748-3756 (1994).
20. K. Charoonpatrapong-Panyayong, R. Shah, J. Yang, M. Alvarez, F. M. Pavalko, R. Gerard- O'Riley, A. G. Robling, E. Templeton, J. P. Bidwell, Nmp4/CIZ contributes to fluid shear stress induced MMP-13 gene induction in osteoblasts. J. Cell. Biochem. 102, 1202-1213 (2007).
21. W. Kim, S. Kook, D. J. Kim, C. Teodorof, W. K. Song, The 31-kDa caspase-generated cleavage product of p130cas functions as a transcriptional repressor of E2A in apoptotic cells. J. Biol. Chem. 279, 8333-8342 (2004).
22. J. P. Bidwell, F. M. Pavalko, The load-bearing mechanosome revisited. Clin. Rev. Bone Miner. Metab., published online 11 November 2010 (10.1007/s12018-010-9075-1).
23. A. G. Robling, F. M. Hinant, D. B. Burr, C. H. Turner, Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts. J. Bone Miner. Res. 17, 1545-1554 (2002).
24. N. S. Datta, T. A. Samra, C. D. Mahalingam, T. Datta, A. B. Abou-Samra, Role of PTH1R internalization in osteoblasts and bone mass using a phosphorylation-defi cient knock-in mouse model. J. Endocrinol. 207, 355-365 (2010).
25. J. L. Guan, Role of focal adhesion kinase in integrin signaling. Int. J. Biochem. Cell Biol. 29, 1085-1096 (1997).
26. J. T. Parsons, K. H. Martin, J. K. Slack, J. M. Taylor, S. A. Weed, Focal adhesion kinase: A regulator of focal adhesion dynamics and cell movement. Oncogene 19, 5606-5613 (2000).
27. S. Li, M. Kim, Y. L. Hu, S. Jalali, D. D. Schlaepfer, T. Hunter, S. Chien, J. Y. Shyy, Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-Activated protein kinases. J. Biol. Chem. 272, 30455-30462 (1997).
28. M. Takahashi, T. Ishida, O. Traub, M. A. Corson, B. C. Berk, Mechanotransduction in endothelial cells: Temporal signaling events in response to shear stress. J. Vasc. Res. 34, 212-219 (1997).
29. J. B. Kim, P. Leucht, C. A. Luppen, Y. J. Park, H. E. Beggs, C. H. Damsky, J. A. Helms, Reconciling the roles of FAK in osteoblast differentiation, osteoclast remodeling, and bone regeneration. Bone 41, 39-51 (2007).
30. S. R. Young, R. Gerard-O'Riley, J. B. Kim, F. M. Pavalko, Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts. J. Bone Miner. Res. 24, 411-424 (2009).
31. S. R. Young, R. Gerard-O'Riley, M. Harrington, F. M. Pavalko, Activation of NF-kappaB by fluid shear stress, but not TNF-Alpha, requires focal adhesion kinase in osteoblasts. Bone 47, 74-82 (2010).
32. S. T. Lim, X. L. Chen, Y. Lim, D. A. Hanson, T. T. Vo, K. Howerton, N. Larocque, S. J. Fisher, D. D. Schlaepfer, D. Ilic, Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol. Cell 29, 9-22 (2008).
33. S. W. Luo, C. Zhang, B. Zhang, C. H. Kim, Y. Z. Qiu, Q. S. Du, L. Mei, W. C. Xiong, Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2. EMBO J. 28, 2568-2582 (2009).
34. Funding:Supported by NIH R01AR052682 to F.M.P. and DK053796 to J.P.B.