Fab'-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis

Journal of Controlled Release

Volumn 186, Issue , 2014, Pages 41-53

  Laroui, Hamed ^b   Viennois, Emilie ^a,b,c   Xiao, Bo ^a,b   Canup, Brandon S B ^b   Geem, Duke ^a,b   Denning, Timothy L ^a,b   Merlin, Didier ^a,b,c  

^a Institute for Biomedical Sciences   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

^c ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

DSS induced colitis; Ligand mediated targeting; Targeted siRNA release; TNF secretion

Indexed keywords

DISEASES; DRUG INTERACTIONS; MACROPHAGES; MAMMALS; MOLECULAR BIOLOGY; NANOPARTICLES; PATIENT TREATMENT; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES;

DSS INDUCED COLITIS; INFLAMMATORY BOWEL DISEASE; LIGAND-MEDIATED TARGETING; NANOPARTICLE (NPS); TARGETED SIRNA RELEASE; THERAPEUTIC EFFECTS; THERAPEUTIC MOLECULES; TNF SECRETION;

GENE THERAPY;

CHITOSAN; COPOLYMER; DEXTRAN SULFATE; DOCUSATE SODIUM; I KAPPA B; IMMUNOGLOBULIN F(AB) FRAGMENT; MACROGOL; MALEIMIDE; MYELOPEROXIDASE; NANOPARTICLE; POLYLACTIC ACID; SMALL INTERFERING RNA; THIOL; TUMOR NECROSIS FACTOR ALPHA; ANTIBODY; DIFFERENTIATION ANTIGEN; MACROGOL DERIVATIVE; MONOCYTE-MACROPHAGE DIFFERENTIATION ANTIGEN; MONOMETHOXYPOLYETHYLENEGLYCOL-POLYLACTIDE BLOCK COPOLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LINE; CHEMICAL BINDING; CONTROLLED STUDY; DRUG FORMULATION; DRUG RELEASE; ENCAPSULATION; ENDOCYTOSIS; EXPERIMENTAL COLITIS; FLOW CYTOMETRY; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; KINETICS; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WEIGHT REDUCTION; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; COLITIS; COLON; DRUG EFFECTS; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY;

ANIMALS; ANTIBODIES; ANTIGENS, DIFFERENTIATION; CELL LINE; COLITIS; COLON; DEXTRAN SULFATE; IMMUNOGLOBULIN FAB FRAGMENTS; MACROPHAGES; MICE; NANOPARTICLES; POLYETHYLENE GLYCOLS; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84901307815     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.04.046     Document Type: Article

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