Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: A systematic evidence review for the u.s. preventive services task force

Annals of Internal Medicine

Volumn 160, Issue 10, 2014, Pages 695-703

  Henderson, Jillian T ^a   Whitlock, Evelyn P ^a   O'Connor, Elizabeth ^a   Senger, Caitlyn A ^a   Thompson, Jamie H ^a   Rowland, Maya G ^a  

^a CENTER FOR HEALTH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID;

COHORT ANALYSIS; DATA BASE; FOLLOW UP; HIGH RISK PATIENT; HUMAN; INTRAUTERINE GROWTH RETARDATION; LOW DRUG DOSE; MEDLINE; MORBIDITY; MORTALITY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PREECLAMPSIA; PREMATURE LABOR; PRENATAL GROWTH; PRIORITY JOURNAL; QUALITY CONTROL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REGISTER; REVIEW; RISK; RISK REDUCTION; SYSTEMATIC REVIEW; UNITED STATES;

ADVISORY COMMITTEES; ASPIRIN; FEMALE; FETAL GROWTH RETARDATION; HUMANS; PRE-ECLAMPSIA; PREGNANCY; PREMATURE BIRTH; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84901285197     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/M13-2844     Document Type: Review

References (82)

1. Huppertz B. Placental origins of preeclampsia: challenging the current hypothesis. Hypertension. 2008;51:970-5. [PMID: 18259009]
2. Ghulmiyyah L, Sibai B. Maternal mortality from preeclampsia/eclampsia. Semin Perinatol. 2012;36:56-9. [PMID: 22280867]
3. Ananth CV, Keyes KM, Wapner RJ. Pre-eclampsia rates in the United States, 1980-2010: age-period-cohort analysis. BMJ. 2013;347:f6564. [PMID: 24201165]
4. Basso O, Rasmussen S, Weinberg CR, Wilcox AJ, Irgens LM, Skjaerven R. Trends in fetal and infant survival following preeclampsia. JAMA. 2006;296: 1357-62. [PMID: 16985227]
5. Berg CJ, Callaghan WM, Syverson C, Henderson Z. Pregnancy-related mortality in the United States, 1998 to 2005. Obstet Gynecol. 2010;116:1302-9. [PMID: 21099595]
6. Waterstone M, Bewley S, Wolfe C. Incidence and predictors of severe obstetric morbidity: case-control study. BMJ. 2001;322:1089-93. [PMID: 11337436]
7. Lain KY, Roberts JM. Contemporary concepts of the pathogenesis and management of preeclampsia. JAMA. 2002;287:3183-6. [PMID: 12076198]
8. ACOG Committee on Practice Bulletins-Obstetrics. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. Obstet Gynecol. 2002;99:159-67. [PMID: 16175681]
9. American Congress of Obstetricians and Gynecologists. Hypertension in Pregnancy. Washington, DC: American Congress of Obstetricians and Gynecologists; 2013.
10. Hutcheon JA, Lisonkova S, Joseph KS. Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy. Best Pract Res Clin Obstet Gynaecol. 2011;25:391-403. [PMID: 21333604]
11. Trogstad L, Magnus P, Stoltenberg C. Pre-eclampsia: Risk factors and causal models. Best Pract Res Clin Obstet Gynaecol. 2011;25:329-42. [PMID: 21349772]
12. Roberts JM, Bell MJ. If we know so much about preeclampsia, why haven't we cured the disease? J Reprod Immunol. 2013;99:1-9. [PMID: 23890710]
13. Stepan H, Unversucht A, Wessel N, Faber R. Predictive value of maternal angiogenic factors in second trimester pregnancies with abnormal uterine perfusion. Hypertension. 2007;49:818-24. [PMID: 17261644]
14. Thangaratinam S, Rogozinska E, Jolly K, Glinkowski S, Roseboom T, Tomlinson JW, et al. Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-Analysis of randomised evidence. BMJ. 2012;344: e2088. [PMID: 22596383]
15. Grill S, Rusterholz C, Zanetti-Dallenbach R, Tercanli S, Holzgreve W, Hahn S, et al. Potential markers of preeclampsia-A review. Reprod Biol Endocrinol. 2009;7:70. [PMID: 19602262]
16. Duckitt K, Harrington D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ. 2005;330:565. [PMID: 15743856]
17. Adeney KL, Williams MA. Migraine headaches and preeclampsia: an epidemiologic review. Headache. 2006;46:794-803. [PMID: 16643583]
18. Facchinetti F, Allais G, Nappi RE, D'Amico R, Marozio L, Bertozzi L, et al. Migraine is a risk factor for hypertensive disorders in pregnancy: a prospective cohort study. Cephalalgia. 2009;29:286-92. [PMID: 19220309]
19. Dombrowski MP. Asthma and pregnancy. Obstet Gynecol. 2006;108:667-81. [PMID: 16946229]
20. Mendola P, Laughon SK, Mannisto TI, Leishear K, Reddy UM, Chen Z, et al. Obstetric complications among US women with asthma. Am J Obstet Gynecol. 2013;208:127.e1-8. [PMID: 23159695]
21. Czerwinski S, Gollero J, Qiu C, Sorensen TK, Williams MA. Migraineasthma comorbidity and risk of hypertensive disorders of pregnancy. J Pregnancy. 2012;2012:858097. [PMID: 22934185]
22. Bushnell CD, Jamison M, James AH. Migraines during pregnancy linked to stroke and vascular diseases: US population based case-control study. BMJ. 2009; 338:b664. [PMID: 19278973]
23. Poon LC, Kametas NA, Chelemen T, Leal A, Nicolaides KH. Maternal risk factors for hypertensive disorders in pregnancy: a multivariate approach. J Hum Hypertens. 2010;24:104-10. [PMID: 19516271]
24. Audibert F, Boucoiran I, An N, Aleksandrov N, Delvin E, Bujold E, et al. Screening for preeclampsia using first-trimester serum markers and uterine artery Doppler in nulliparous women. Am J Obstet Gynecol. 2010;203:383.e1-8. [PMID: 20691410]
25. Cetin I, Huppertz B, Burton G, Cuckle H, Gonen R, Lapaire O, et al. Pregenesys pre-eclampsia markers consensus meeting: What do we require from markers, risk assessment and model systems to tailor preventive strategies? Placenta. 2011;32 Suppl:S4-16. [PMID: 21185077]
26. Duley L, Henderson-Smart DJ, Meher S, King JF. Antiplatelet agents for preventing pre-eclampsia and its complications. Cochrane Database Syst Rev. 2007:CD004659. [PMID: 17443552]
27. Askie LM, Duley L, Henderson-Smart DJ, Stewart LA; PARIS Collaborative Group. Antiplatelet agents for prevention of pre-eclampsia: a meta-Analysis of individual patient data. Lancet. 2007;369:1791-8. [PMID: 17512048]
28. Henderson J, Whitlock E, O'Connor E, Senger C, Thompson J, Rowland M. Low-dose aspirin for the prevention of morbidity and mortality from preeclampsia: a systematic review for the U.S. Preventive Services Task Force. Rockville, MD: Agency for Healthcare Research and Quality; 2014. [Forthcoming].
29. U.S. Preventive Services Task Force. U.S. Preventive Services Task Force Procedure Manual. Rockville, MD: Agency for Healthcare Research and Quality; 2008.
30. National Institute for Health and Care Excellence. The Guidelines Manual. London: National Institute for Health and Care Excellence; 2006.
31. Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-Analyses. Ottawa, Ontario, Canada: Ottawa Hospital Research Institute; 2013. Accessed at www.ohri.ca/programs/clinicalepidemiology/oxford.asp on 2 December 2013.
32. Bradburn MJ, Deeks JJ, Altman DG. metan-A command for meta-Analysis in Stata. In: Sterne JAC, ed. Meta-Analysis in Stata: An Updated Collection from the Stata Journal. College Station, TX: Stata Pr; 1998:3-28.
33. DerSimonian R, Laird N. Meta-Analysis in clinical trials. Control Clin Trials. 1986;7:177-88. [PMID: 3802833]
34. Fu R, Gartlehner G, Grant M, Shamliyan T, Sedrakyan A, Wilt TJ, et al. Conducting quantitative synthesis when comparing medical interventions: AHRQ and the Effective Health Care Program. J Clin Epidemiol. 2011;64: 1187-97. [PMID: 21477993]
35. Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Introduction to Meta-Analysis. 1st ed. West Sussex, United Kingdom: J Wiley; 2009.
36. Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions. The Cochrane Collaboration; 2011.
37. Harbord RM, Harris RJ, Sterne JAC. Updated tests for small-study effects in meta-Analysis. Stata J. 2009;9:197-210.
38. Cornell JE, Mulrow CD, Localio R, Stack CB, Meibohm AR, Guallar E, et al. Random-effects meta-Analysis of inconsistent effects: a time for change. Ann Intern Med. 2014;160:267-70.
39. Hermida RC, Ayala DE, Iglesias M, Mojón A, Silva I, Ucieda R, et al. Time-dependent effects of low-dose aspirin administration on blood pressure in pregnant women. Hypertension. 1997;30:589-95. [PMID: 9322987]
40. Gallery EDM, Ross MR, Hawkins M, Leslie G, Gyory AZ. Low-dose aspirin in high-risk pregnancy? Hypertens Pregnancy. 1997;16:229-38.
41. Vainio M, Kujansuu E, Iso-Mustajarvi M, Maenpaa J. Low dose acetylsalicylic acid in prevention of pregnancy-induced hypertension and intrauterine growth retardation in women with bilateral uterine artery notches. BJOG. 2002; 109:161-7. [PMID: 11888098]
42. Hauth JC, Goldenberg RL, Parker CR Jr., Philips JB 3rd, Copper RL, DuBard MB, et al. Low-dose aspirin therapy to prevent preeclampsia. Am J Obstet Gynecol. 1993;168:1083-91. [PMID: 8475955]
43. Sibai BM, Caritis SN, Thom E, Klebanoff M, McNellis D, Rocco L, et al. Prevention of preeclampsia with low-dose aspirin in healthy, nulliparous pregnant women. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. N Engl J Med. 1993;329:1213-8. [PMID: 8413387]
44. Caritis S, Sibai B, Hauth J, Lindheimer MD, Klebanoff M, Thom E, et al. Low-dose aspirin to prevent preeclampsia in women at high risk. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. N Engl J Med. 1998;338:701-5. [PMID: 9494145]
45. Keim SA, Klebanoff MA. Aspirin use and miscarriage risk. Epidemiology. 2006;17:435-9. [PMID: 16755260]
46. Yu CK, Papageorghiou AT, Parra M, Palma Dias R, Nicolaides KH; Fetal Medicine Foundation Second Trimester Screening Group. Randomized controlled trial using low-dose aspirin in the prevention of pre-eclampsia in women with abnormal uterine artery Doppler at 23 weeks' gestation. Ultrasound Obstet Gynecol. 2003;22:233-9. [PMID: 12942493]
47. Schiff E, Peleg E, Goldenberg M, Rosenthal T, Ruppin E, Tamarkin M, et al. The use of aspirin to prevent pregnancy-induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high risk pregnancies. N Engl J Med. 1989;321:351-6. [PMID: 2664522]
48. Davies NJ, Gazvani MR, Farquharson RG, Walkinshaw SA. Low-dose aspirin in the prevention of hypertensive disorders of pregnancy in relatively low-risk nulliparous women. Hypertens Pregnancy. 1995;14:49-55.
49. McParland P, Pearce JM, Chamberlain GV. Doppler ultrasound and aspirin in recognition and prevention of pregnancy-induced hypertension. Lancet. 1990; 335:1552-5. [PMID: 1972487]
50. Villa PM, Kajantie E, Raikkonen K, Pesonen AK, Hamalainen E, Vainio M, et al; PREDO Study group. Aspirin in the prevention of pre-eclampsia in high-risk women: a randomised placebo-controlled PREDO Trial and a metaanalysis of randomised trials. BJOG. 2013;120:64-74. [PMID: 23126307]
51. Subtil D, Goeusse P, Puech F, Lequien P, Biausque S, Breart G, et al; Essai Régional Aspirine Mere-Enfant (ERASME) Collaborative Group. Aspirin (100 mg) used for prevention of pre-eclampsia in nulliparous women: the Essai Ré-gional Aspirine Mere-Enfant study (Part 1). BJOG. 2003;110:475-84. [PMID: 12742332]
52. Benigni A, Gregorini G, Frusca T, Chiabrando C, Ballerini S, Valcamonico A, et al. Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension. N Engl J Med. 1989;321:357-62. [PMID: 2664523]
53. CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group. Lancet. 1994;343: 619-29. [PMID: 7906809]
54. Wallenburg HC, Dekker GA, Makovitz JW, Rotmans P. Low-dose aspirin prevents pregnancy-induced hypertension and pre-eclampsia in angiotensinsensitive primigravidae. Lancet. 1986;1:1-3. [PMID: 2867260]
55. Ayala DE, Ucieda R, Hermida RC. Chronotherapy with low-dose aspirin for prevention of complications in pregnancy. Chronobiol Int. 2013;30:260-79. [PMID: 23004922]
56. Caspi E, Raziel A, Sherman D, Arieli S, Bukovski I, Weinraub Z. Prevention of pregnancy-induced hypertension in twins by early administration of lowdose aspirin: a preliminary report. Am J Reprod Immunol. 1994;31:19-24. [PMID: 8166943]
57. Grab D, Paulus WE, Erdmann M, Terinde R, Oberhoffer R, Lang D, et al. Effects of low-dose aspirin on uterine and fetal blood flow during pregnancy: results of a randomized, placebo-controlled, double-blind trial. Ultrasound Obstet Gynecol. 2000;15:19-27. [PMID: 10776008]
58. Viinikka L, Hartikainen-Sorri AL, Lumme R, Hiilesmaa V, Ylikorkala O. Low dose aspirin in hypertensive pregnant women: effect on pregnancy outcome and prostacyclin-thromboxane balance in mother and newborn. Br J Obstet Gynaecol. 1993;100:809-15. [PMID: 8217999]
59. Rotchell YE, Cruickshank JK, Gay MP, Griffiths J, Stewart A, Farrell B, et al. Barbados Low Dose Aspirin Study in Pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications. Br J Obstet Gynaecol. 1998;105:286-92. [PMID: 9532988]
60. Newnham JP, Godfrey M, Walters BJ, Phillips J, Evans SF. Low dose aspirin for the treatment of fetal growth restriction: a randomized controlled trial. Aust N Z J Obstet Gynaecol. 1995;35:370-4. [PMID: 8717556]
61. Jensen MS, Rebordosa C, Thulstrup AM, Toft G, Sørensen HT, Bonde JP, et al. Maternal use of acetaminophen, ibuprofen, and acetylsalicylic acid during pregnancy and risk of cryptorchidism. Epidemiology. 2010;21:779-85. [PMID: 20805751]
62. Bower SJ, Harrington KF, Schuchter K, McGirr C, Campbell S. Prediction of pre-eclampsia by abnormal uterine Doppler ultrasound and modification by aspirin. Br J Obstet Gynaecol. 1996;103:625-9. [PMID: 8688387]
63. Trivedi NA. A meta-Analysis of low-dose aspirin for prevention of preeclampsia. J Postgrad Med. 2011;57:91-5. [PMID: 21654128]
64. Bujold E, Roberge S, Lacasse Y, Bureau M, Audibert F, Marcoux S, et al. Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-Analysis. Obstet Gynecol. 2010;116:402-14. [PMID: 20664402]
65. Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre-eclampsia. Lancet. 2010;376:631-44. [PMID: 20598363]
66. Wen SW, Smith G, Yang Q, Walker M. Epidemiology of preterm birth and neonatal outcome. Semin Fetal Neonatal Med. 2004;9:429-35. [PMID: 15691780]
67. Saigal S, Doyle LW. An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet. 2008;371:261-9. [PMID: 18207020]
68. McIntire DD, Bloom SL, Casey BM, Leveno KJ. Birth weight in relation to morbidity and mortality among newborn infants. N Engl J Med. 1999;340: 1234-8. [PMID: 10210706]
69. Sterne JA, Egger M, Smith GD. Systematic reviews in health care: investigating and dealing with publication and other biases in meta-Analysis. BMJ. 2001;323:101-5. [PMID: 11451790]
70. Malacrida C, Boulton T. The best laid plans? Women's choices, expectations and experiences in childbirth. Health (London). 2014;18:41-59. [PMID: 23426792]
71. Soet JE, Brack GA, DiIorio C. Prevalence and predictors of women's experience of psychological trauma during childbirth. Birth. 2003;30:36-46. [PMID: 12581038]
72. Tatano Beck C, Gable RK, Sakala C, Declercq ER. Postpartum depressive symptomatology: results from a two-stage US national survey. J Midwifery Womens Health. 2011;56:427-35. [PMID: 23181639]
73. Rowe-Murray HJ, Fisher Jr. Operative intervention in delivery is associated with compromised early mother-infant interaction. BJOG. 2001;108:1068-75. [PMID: 11702839]
74. Hoedjes M, Berks D, Vogel I, Franx A, Duvekot JJ, Steegers EA, et al. Poor health-related quality of life after severe preeclampsia. Birth. 2011;38:246-55. [PMID: 21884233]
75. Rep A, Ganzevoort W, Bonsel GJ, Wolf H, de Vries JI. Psychosocial impact of early-onset hypertensive disorders and related complications in pregnancy. Am J Obstet Gynecol. 2007;197:158.e1-6. [PMID: 17689633]
76. Engelhard IM, van Rij M, Boullart I, Ekhart TH, Spaanderman ME, van den Hout MA, et al. Posttraumatic stress disorder after pre-eclampsia: an exploratory study. Gen Hosp Psychiatry. 2002;24:260-4. [PMID: 12100837]
77. Gaugler-Senden IP, Duivenvoorden HJ, Filius A, De Groot CJ, Steegers EA, Passchier J. Maternal psychosocial outcome after early onset preeclampsia and preterm birth. J Matern Fetal Neonatal Med. 2012;25:272-6. [PMID: 21557690]
78. Davis EF, Lazdam M, Lewandowski AJ, Worton SA, Kelly B, Kenworthy Y, et al. Cardiovascular risk factors in children and young adults born to preeclamptic pregnancies: a systematic review. Pediatrics. 2012;129:e1552-61. [PMID: 22614768]
79. Valdiviezo C, Garovic VD, Ouyang P. Preeclampsia and hypertensive disease in pregnancy: their contributions to cardiovascular risk. Clin Cardiol. 2012;35: 160-5. [PMID: 22389120]
80. Bellamy L, Casas JP, Hingorani AD, Williams DJ. Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-Analysis. BMJ. 2007;335:974. [PMID: 17975258]
81. Lykke JA, Langhoff-Roos J, Sibai BM, Funai EF, Triche EW, Paidas MJ. Hypertensive pregnancy disorders and subsequent cardiovascular morbidity and type 2 diabetes mellitus in the mother. Hypertension. 2009;53:944-51. [PMID: 19433776]
82. American Congress of Obstetricians and Gynecologists. Intrauterine Growth Restriction. ACOG Practice Bulletin no. 12. Washington, DC: American Congress of Obstetricians and Gynecologists; 2000.