Barbados Low Dose Aspirin Study in Pregnancy (BLASP): A randomised trial for the prevention of pre-eclampsia and its complications

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 105, Issue 3, 1998, Pages 286-292

  Rotchell, Y E ^a   Cruickshank, J K ^a,b   Phillips Gay, M ^a   Griffiths, J ^a   Stewart, A ^a   Farrell, B ^d   Ayers, S ^c   Hennis, A ^a   Grant, A ^c   Duley, L ^c   Collins, R ^d  

^a UNIVERSITY OF THE WEST INDIES   (Jamaica)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d CLINICAL TRIAL SERVICE UNIT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID;

ADULT; ARTICLE; BARBADOS; CLINICAL TRIAL; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MATERNAL HYPERTENSION; PREECLAMPSIA; PREGNANCY COMPLICATION; PRIORITY JOURNAL; PROPHYLAXIS; PROTEINURIA; RANDOMIZED CONTROLLED TRIAL;

AMERICAS; BARBADOS; CARIBBEAN; CASE CONTROL STUDIES; DEVELOPING COUNTRIES; DISEASES; DRUGS; NORTH AMERICA; PREECLAMPSIA--PREVENTION AND CONTROL; PREGNANCY; PREGNANCY COMPLICATIONS; REPRODUCTION; RESEARCH METHODOLOGY; RESEARCH REPORT; STUDIES; TREATMENT;

ADULT; ASPIRIN; BARBADOS; BIRTH WEIGHT; DELAYED-ACTION PREPARATIONS; FEMALE; FETAL DEATH; GESTATIONAL AGE; HOSPITALIZATION; HUMANS; INFANT; INFANT MORTALITY; INFANT, NEWBORN; PLATELET AGGREGATION INHIBITORS; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY OUTCOME; PRENATAL CARE; TIME FACTORS;

EID: 0031939857     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.1998.tb10088.x     Document Type: Article

References (28)

1. Ashley D, McCaw-Binns A, Foster-Williams K. The perinatal morbidity and mortality survey in Jamaica. Paediatr Perinat Epidemiol 1988; 2: 138–147.
2. Louisy C, Rotchell Y. Maternal mortality in Barbados 1970-1989 [abstract]. West Ind Med J 1990; 39: Suppl 1:16.
3. Presad P, Goopesingh T, Ali J. Hypertensive disease in pregnant women delivering before 34 weeks gestation in Trinidad [abstract]. West Ind Med J 1990; 39 Suppl 1:14.
4. Matadial L, Grell GAC, Walker G, Forrester T. Hypertensive Disease ofPregnancy. West Ind Med J 1985; 34: 225–233.
5. Ibison JM, Swerdlow AJ, Head JA, Marmot M. Maternal mortality in England and Wales 1970-1985: an analysis by country of birth. Br J Obstet Gynaecol 1996; 103: 973–980.
6. Chief Medical Officer of Barbados. Annual Report 1991-1992. Bridgetown, Barbados : Ministry of Health, 1995.
7. Forrester TE, Wilks RJ, Bennett FI et al. Foetal growth and cardiovascular risk factors in Jamaican schoolchildren. BM J 1996; 312:156–160.
8. Barker D, Osmond C, Golding J, Kuh D, Wadsworth M. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BM J 1989; 298: 564–567.
9. Freeman V, Fraser H, Forrester T et al. A comparative study of hypertension prevalence, awareness, treatment and control rates in St. Lucia, Jamaica and Barbados. J Hypertension 1996; 14: 495–501.
10. Foster C, Rotimi C, Fraser H et al. Hypertension, diabetes and obesity in Barbados: findings from a population-based study. Ethnicity and Disease 1993; 3: 404–412.
11. Cruickshank JK. Natural history of blood pressure in black populations in the West Indies, West Africa and the UK. In: Cruickshank JK, Beevers DG, editors. Ethnic Factors in Health and Disease. London : Buttenvorth Heineman, 1989: 268–279.
12. Redman CWG. Platelets and the beginnings of pre-eclampsia. N Engl J Med 1990; 323: 478–480.
13. De Swiet M, Fryers G. The use of aspirin in pregnancy. J Obstet Gynaecol 1990; 10: 467–483.
14. Redman CW, Bonnar J, Beilin L. Early platelet consumption in pre eclampsia. BMJ 1978; 1: 467–469.
15. Dixon HG, Robertson WB. A study of the vessels of the placental bed in hypertensive pregnancy. J Obstet Gynaecol 1958; 65: 803–809.
16. ECPPA Randomized trial of low-dose aspirin for the prevention of maternal and fetal complications in high risk pregnant women in Brazil. Br J Obstet Gynaecol 1996; 103: 39–47.
17. CLASP: a randomised trial of low-dose aspirin for prevention and treatment of pre-eclampsia among 9364 pregnant women. Lancet 1994; 343: 619–629.
18. Italian Study Group. Low-dose aspirin in prevention and treatment of intra-uterine growth retardation and pregnancy induced hypertension. Italian study of aspirin in pregnancy. Lancet 1993; 341: 396–400.
19. Sibai BM, Caritis SN, Thom E et al. Prevention of pre-eclampsia with low-dose aspirin in healthy, nulliparous pregnant women. New Engl J Med 1993; 329: 1213–1218.
20. Hauth JC, Goldenberg RL, Parker CR, Philips JB, Copper RL, DuBard MB, Cutter GR. Low-dose aspirin to prevent pre-eclampsia. Arn J Obsfer Gynecol 1993; 168: 1083–1091.
21. Collins R. Anti-platelet agents for IUGR and pre-eclampsia. In: Keirse MJNC, Renfrew MJ, Neilson JP, Crowther C, editors. Pregnancy and Childbirth Module. In: The Cochrane Collaboration. The Cochrane Pregnancy and Childbirth Database; Issue 2. Oxford Update Software, 1995.
22. Clarke RL, Mayo G, Price P, Fitzgerald GA. Suppression of thromboxane A, but not of systemic prostacyclin by controlled release aspirin. N Engl J Med 1991; 325: 1137–1141.
23. David R, Collins JW. Differing birth weight among infants of US-born Blacks, African-born Blacks and US-born Whites. N Engl J Med 1997; 337: 1209–1214.
24. Dekker GA. The pharmocological prevention of pre-eclampsia [review]. Bailleres Clin Obstet Gynaecol 1995; 9: 509–528.
25. Villar J, Bergsjo P. Scientific basis for the content of routine antenatal care: 1. Philosophy, recent studies, and power to eliminate or alleviate adverse maternal outcomes. Acta Obstet Gynecol Scand 1997; 76: 1–14.
26. Lindheimer MD. Pre-eclampsia-eclampsia 1996: preventable? Have disputes on its treatment been resolved Curr Opin Nephrol Hypertens 1996; 5: 452–458.
27. Grifiths J, Rotchell YE, Cruickshank JK et al. The Barbados low- dose aspirin study in pregnancy (BLASP): a population -based trial in a developing country with excess pre-eclampsia and perinatal mortality [abstract]. In: Proceedings of the 41st Scientific Meeting of the Commonwealth Caribbean Meadical Research Council; 17-20 Apr 1996; Port of Spain, Trinidad. West Ind Med J 1996; 45 Suppl 2: 26.
28. Forrester T, Jones D, McCaw-Binns A et al. Low-dose aspirin in pregnancy; are there any benefits? [abstract]. In: Proceedings of the 41st Scientific Meeting of the Commonwealth Caribbean Meadical Research Council; 17-20 Apr 1996; Port of Spain, Trinidad. West Ind Med J 1996; 45 Suppl 2:26.