Pre-eclampsia: Risk factors and causal models

Best Practice and Research: Clinical Obstetrics and Gynaecology

Volumn 25, Issue 3, 2011, Pages 329-342

  Trogstad, Lill ^a   Magnus, Per ^a   Stoltenberg, Camilla ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

Author keywords

abortion; causality; pre eclampsia; recurrence; risk factors; risk infertility

Indexed keywords

ANGIOGENIC FACTOR; PHOSPHOLIPID ANTIBODY;

AUTOIMMUNE DISEASE; BODY MASS; DIABETES MELLITUS; DISEASE ASSOCIATION; ENDOTHELIUM LESION; ENVIRONMENTAL FACTOR; ETHNICITY; HUMAN; INDUCED ABORTION; KIDNEY DISEASE; MATERNAL AGE; MATERNAL HYPERTENSION; MATERNAL SMOKING; MULTIPLE PREGNANCY; PLACENTA; PREECLAMPSIA; PRIMIPARA; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SPONTANEOUS ABORTION;

EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; PRE-ECLAMPSIA; PREGNANCY; RISK FACTORS;

EID: 79955798754     PISSN: 15216934     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpobgyn.2011.01.007     Document Type: Review

References (113)

1. Lain KY & Roberts JM. Contemporary concepts of the pathogenesis and management of preeclampsia. JAMA 2002; 287: 3183-3186. (Pubitemid 34686089)
2. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 2000; 183: S1-S22.
3. Chappell L, Poulton L, Halligan A et al. Lack of consistency in research papers over the definition of pre-eclampsia. Br J Obstet Gynaecol 1999; 106: 983-985. (Pubitemid 29415633)
4. von Dadelszen P, Magee LA & Roberts JM. Subclassification of preeclampsia. Hyperten Pregn 2003; 22: 143-148. (Pubitemid 37521365)
5. Valensise H, Vasapollo B, Gagliardi G et al. Early and late preeclampsia: two different maternal hemodynamic states in the latent phase of the disease. Hypertension 2008; 52: 873-880.
6. Lachmeijer AM, Arngrímsson R, Nastiaans EJ et al. A genome-wide scan for preeclampsia in the Netherlands. Eur J Hum Genet 2001; 9: 758-764. (Pubitemid 33014588)
7. Pijnenborg R, Bland JM, Robertson WB et al. The pattern of interstitial trophoblastic invasion of the myometrium in early human pregnancy. Placenta 1981; 2: 303-316. (Pubitemid 11022999)
8. Redman CW & Sargent IL. Latest advances in understanding preeclampsia. Science 2005; 308: 1592-1594. (Pubitemid 40807500)
9. Fitzgerald JS, Germeyer A, Huppertz B et al. Governing the invasive trophoblast: current aspects on intra- and extracellular regulation. Am J Reprod Immunol 2010; 63: 492-505.
10. Kaufman P, Black S & Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod 2003; 69: 1-7. (Pubitemid 36806800)
11. Brosens JJ, Pijnenborg R & Brosens IA. The myometrial junctional one spiral arteries in normal and abnormal pregnancies. Am J Obstet Gynecol 2002; 187: 416-1423.
12. Sargent IL, Germain SJ, Sacks GP et al. Trophoblast deportation and the maternal inflammatory response in preeclampsia. J Reprod Immunol 2003; 59: 153-160. (Pubitemid 36945233)
13. Walsh SW, Vaughan JE, Wang Y et al. Placental isoprostane is significantly increased in preeclampsia. FASEB J 2000; 14: 1289-1296. (Pubitemid 30439737)
14. Staff AC, Braekke K, Harsem NK et al. Circulating concentrations of sFltl (soluble fms-like tyrosine kinase l) in fetal and maternal serum during pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 2005; 122: 33-39. (Pubitemid 41265677)
15. Venkatesha S, Toporsian M, Lam C et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 2006; 12: 642-649. (Pubitemid 43865232)
16. Ness RB & Roberts JM. Heterogeneous causes constituting the single syndrome of preeclampsia, a hypothesis and its implications. Am J Obstet Gynecol 1996; 175: 1365-1370. (Pubitemid 26399006)
17. Redman CWG. Immunological aspects of pre-eclampsia. Baillieres Clin Obstet Gynaecol 1992; 6: 601-615.
18. Libby P. Inflammation in atherosclerosis. Nature 2002; 420: 868-874. (Pubitemid 36019640)
19. Gitto E, Reiter RJ, Karbownik M et al. Causes of oxidative stress in the pre- and perinatal period. Biol Neonate 2002; 81: 146-157. (Pubitemid 34293652)
20. Raijmakers MT, Dechend R & Poston L. Oxidative stress and preeclampsia. Rationale for antioxidant clinical trials. Hypertension 2004; 44: 374-380.
21. Staff AC, Halvorsen B, Ranheim T et al. Elevated levels of free 8-isoprostaglandine F2alpha in the decidua basalis of women with preeclampsia. Am J Obstet Gynecol 1999; 181: 1211-1215.
22. Hubel CA. Oxidative stress in the pathogenesis of preeclampsia. Proc Soc Exp Biol Med 1999; 222: 222-235.
23. Harsem NK, Braekke K & Staff AC. Augmented oxidative stress as well as antioxidant capacity in maternal circulation in preeclampsia. Eur Obstet Gynecol Reprod Biol 2006; 128: 209-215. (Pubitemid 44311326)
24. Tjoa ML, Levine RJ & Karumanchi SA. Angiogenic factors and preeclampsia. Front Biosci 2007; 12: 2395-2402.
25. Maynard SE, Min JY, Merchan J et al. Excess placental soluble fms-like tyrosine-kinase 1 (sFLT1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111: 649-658. (Pubitemid 36278583)
26. Dekker GA. Risk factors for preeclampsia. Clin Obstet Gynecol 1999; 42: 422-435. (Pubitemid 30017267)
27. Mauriceau F. Traite des Maladies des Femmes Grosses, et celles Qui sont Accouchees, Einseignant la Bonne et Veritable Methode pour Bien Aider, etc. Paris 1694: d'Houry, bkII, chap 28.
28. In: Lindheimer MD, Cunningham FG, Roberts JM, editors. Chesley's Hypertensive disorders in pregnancy. 2nd ed. Stamford, Connecticut, 1999.
29. Johns R. Observations of puerperal convulsions. Dublin J Med Sci 1843; 24: 101-115.
30. Luo Z-C, An N, Xu H-R et al. The effects and mechanisms of primiparity on the risk of pre-eclampsia: a systematic review. Paediatr Perinat Epidemiol 2007; 21(suppl. 1): 36-45.
31. Ødegård R, Vatten LJ, Nilsen ST et al. Risk factors and clinical manifestations of pre-eclampsia. BJOG 2000; 107: 1410-1416.
32. Wolf M, Shah A, Lam C et al. Circulating levels of the angiogenic marker sFlt-1 are increased in first versus second pregnancies. Am J Obstet Gynecol 2005; 193: 16-22. (Pubitemid 40991821)
33. Trogstad LIS, Eskild A, Magnus P et al. Changing paternity and time since last pregnancy; the impact on pre-eclampsia risk. A study of 547,238 women with and without previous pre-eclampsia. Int J Epidemiol 2001; 30: 1317-1322. (Pubitemid 34134282)
34. Duckitt K & Harrington D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ 2005; 330: 565.
35. Mostello D, Kallogjeri D, Tungsiripat R et al. Recurrence of preeclampsia: effects of gestational age at delivery of the first pregnancy, body mass index, paternity, and interval between births. Am J Obstet Gynecol 2008; 199: e1-e7.
36. Hnat MD, Sibai BM, Caritis S et al. Perinatal outcome in women with recurrent preeclampsia compared with women who develop preeclampsia as nulliparas. Am J Obstet Gynecol 2002; 186: 422-426. (Pubitemid 34234151)
37. Bodnar LM, Ness RB, Harger GF & Roberts JM. Inflammation and triglycerides partially mediate the effect of preregnancy body mass index on the risk of preeclampsia. Am J Epidemiol 2005; 162: 1198-1206. (Pubitemid 41785914)
38. Svensson E, Reas DL, Sandanger I & Nygård JF. Urban-rural differences in BMI, overweight and obesity in Norway (1990 and 2001). Scand J Public Health 2007; 35: 555-558.
39. Yeh J & Shelton JA. Increasing prepregnancy body mass index: analysis of trends and contributing variables. Am J Obstet Gynecol 2005; 193: 1994-1998. (Pubitemid 41737624)
40. Sibai BM. Risk factors, pregnancy complications, and prevention of hypertensive disorders in women with pregravid diabetes mellitus. J Matern Fetal Med 2000; 9: 62-65. (Pubitemid 30176215)
41. Chappell LC, Enye S, Seed P et al. Adverse perinatal outcomes and risk factors for preeclampsia in women with chronic hypertension. A prospective study. Hypertension 2008; 51: 1002-1009. (Pubitemid 351398985)
42. Thadhani R, Stampfer MJ, Hunter DJ et al. High body mass index and hypercholesterolemia: risk of hypertensive disorders of pregnancy. Obstet Gynecol 1999; 94: 543-550. (Pubitemid 29460937)
43. Sibai BM, Gordon T, Thom E et al. Risk factors in healthy nulliparous women: a prospective multicenter study. Am J Obstet Gynecol 1995; 172: 642-648.
44. Condé-Agudelo A, Althabe F, Belizán JM et al. Cigarette smoking during pregnancy and risk of pre-eclampsia: a systematic review. Am J Obstet Gynecol 1999; 181: 1026-1035. (Pubitemid 29503633)
45. England L & Zhang J. Smoking and risk of preeclampsia: a systematic review. Front Bioscience 2007; 12: 2471-2483.
46. Cnattingius S, Mills JL, Yuen J et al. The paradoxical effect of smoking in preeclamptic pregnancies: smoking reduces the incidence but increases the rates of perinatal mortality, abruption placentae, and intrauterine growth restriction. Am J Obstet Gynecol 1997; 177: 156-161. (Pubitemid 27327328)
47. Pipkin FB, & on behalf of The Genetics of Preeclampsia Consortium. Smoking in moderate/severe preeclampsia worsens pregnancy outcome, but smoking cessation limits the damage. Hypertension 2008; 51: 1042-1046.
48. England LJ, Levine RJ, Qian C et al. Smoking before pregnancy and risk of gestational hypertension and preeclampsia. Am J Obstet Gynecol 2002; 186: 103-540.
49. Cnattingius S & Lambe M. Trends in smoking and overweight during pregnancy: prevalence, risks of pregnancy complications, and adverse pregnancy outcomes. Semin Perinatol 2002; 26: 286-295. (Pubitemid 34913129)
50. MBRN: smoking in pregnancy The Medical Birth Registry of Norway:1999-2006, http//mfr-nesstar.uib.no/mfr/
51. Sibai BM, Hauth J, Caritis S et al. Hypertensive disorders in twin versus singleton pregnancies. Am J Obstet Gynecol 2000; 182: 938-942. (Pubitemid 30228471)
52. Ros HS, Cnattingius S & Lipworth L. Comparison of risk factors for preeclampsia and gestational hypertension in a population-based cohort study. Am J Epidemiol 1998; 147: 1062-1070.
53. Prasannan-Nair C, Reynolds SF & Budden G. Partial molar pregnancy with severe pre-eclampsia at 19 weeks' gestation. J Obstet Gynaecol 2006; 8: 817. (Pubitemid 44871078)
54. Wong LFA, Stuart B & Gleeson N. Triploidy partial mole and proteinuric hypertension. J Obstet Gynaecol 2007; 4: 424-425. (Pubitemid 47124329)
55. Bdolah Y, Lam C, Rajakumar A et al. Twin pregnancy and the risk of preeclampsia: bigger placenta or relative ischemia? Am J Obstet Gynecol 2008; 198: 428.e1-428.e6.
56. Hernández-Díaz S, Werler MM et al. Gestational hypertension in pregnancies supported by infertility treatments: role of infertility, treatments, and multiple gestations. Fertil Steril 2007; 88: 438-445. (Pubitemid 47212142)
57. Salha O, Sharma V, Dada T et al. The influence of donated gametes on the incidence of hypertensive disorders of pregnancy. Hum Reprod 1999; 14: 2268-2273. (Pubitemid 29425412)
58. Sibai BM, Ewell M, Levine RJ et al. Risk factors associated with preeclampsia in healthy nulliparous women. Am J Obstet Gynecol 1997; 177: 1003-1010. (Pubitemid 27525346)
59. Dempsey JC, Williams MA, Luthy DA et al. Weight at birth and subsequent risk of preeclampsia as an adult. Am J Obstet Gynecol 2003; 189: 494-500.
60. Knuist M, Bonsel GJ, Zondervan HA et al. Risk factors for preeclampsia in nulliparous women in distinct ethnic groups: a prospective cohort study. Obstet Gynecol 1998; 92: 174-178.
61. Eskenazi B, Fenster L & Sidney S. A multivariate analysis of risk factors for preeclampsia. JAMA 1991; 266: 237-241.
62. Campbell DM, MacGillivray I & Carr-Hill R. Pre-eclampsia in second pregnancy. Clin Exp Hypertens B 1983; 2: 303-306.
63. Seidman DS, Ever-Hadani P, Stevenson DK & Gale R. The effect of abortion on the incidence of pre-eclampsia. Eur J Obstet Gynecol Repr Biol 1989; 33: 109-114.
64. Strickland DM, Guzic DS, Cox K et al. The relationship between abortion in the first pregnancy and development of pregnancy induced hypertension in the subsequent pregnancy. Am J Obstet Gynecol 1986; 54: 146-148. (Pubitemid 16106669)
65. Eras JL, Saftlas AF, Triche E et al. Abortion and its effect on risk of preeclampsia and transient hypertension. Epidemiology 2000; 11: 36-43. (Pubitemid 30005149)
66. Xiong X, Fraser WD & Demianczuk NN. History of abortion, preterm, term birth, and risk of preeclampsia: A population-based study. Am J Obstet Gynecol 2002; 187: 1013-1018. (Pubitemid 35178404)
67. Magnus P, Irgens LM, Haug K et al. Cohort profile: the Norwegian Mother and Child Cohort Study (MoBa). Int J Epidemiol 2006; 35: 1146-1150. (Pubitemid 44605528)
68. Trogstad L, Magnus P, Skjærven R et al. Previous abortions and the risk of pre-eclampsia. Int J Epidemiol 2008; 37: 1333-1340.
69. Trogstad L, Magnus P, Moffett A et al. The effect of recurrent miscarriage and infertility on the risk of preeclampsia. BJOG 2009; 116: 108-113.
70. Hiby SE, Walker JJ, O'Shaughnessy KM et al. Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med 2004; 200: 957-965. (Pubitemid 39431121)
71. Hiby SE, Regan L, Farrell L et al. Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage. Hum Reprod 2008; 23: 972-976.
72. Adams MM, Gaudino JA, Berg CJ et al. Preeclampsia and paternity. Paediatr Perinat Epidemiol 1996; 10: A21-A22 [abstract].
73. Li DK & Wi S. Changing paternity and the risk of preeclampsia/ eclampsia in the subsequent pregnancy. Am J Epidemiol 2000; 151: 57-62. (Pubitemid 30470395)
74. Skjærven R, Wilcox AJ & Lie RT. The interval between pregnancies and the risk of preeclampsia. N Engl J Med 2002; 346: 33-38. (Pubitemid 34438917)
75. Basso O, Christensen K & Olsen J. Higher risk of pre-eclampsia after change of partner. An effect of longer interpregnancy intervals? Epidemiology 2001; 12: 624-629.
76. Mogren I, Hogberg U, Winkvist A et al. Familial occurrence of preeclampsia. Epidemiology 1999; 10: 518-522. (Pubitemid 29398907)
77. Cincotta RB & Brennecke SP. Family history of pre-eclampsia as a predictor for pre-eclampsia in primigravidas. Int J Gynaec Obstet 1998; 60: 23-27. (Pubitemid 28055272)
78. Arngrimsson R, Bjørnsson S, Geirsson RT et al. Genetic and familial predisposition to eclampsia and pre-eclampsia in a defined population. Br J Obstet Gynaecol 1990; 97: 762-769. (Pubitemid 20283312)
79. Chesley LC & Cooper DW. Genetics of hypertension in pregnancy: possible single gene control of pre-eclampsia and eclampsia in the descendants of eclamptic women. Br J Obstet Gynaecol 1996; 93: 898-908.
80. Chesley LC, Annitto JD & Cosgrove RA. The familial factor in toxemia of pregnancy. Obstet Gynecol 1968; 32: 303-311.
81. Chesley LC, Cosgrove RA & Annitto JE. Pregnancies in the sisters and daughters of eclamptic Women. Obstet Gynecol 1962; 20: 39-46.
82. Lie RT, Brunborg H, Gjessing HK et al. Fetal and maternal contributions to risk of pre-eclampsia: population-based study. BMJ 1998; 316: 1343-1347. (Pubitemid 28195872)
83. Esplin MS, Fausett MB, Fraser A et al. Paternal and maternal components of the predisposition to preeclampsia. N Engl J Med 2001; 344: 867-872. (Pubitemid 32224394)
84. Arngrímsson R, Purandare S, Connor M et al. Angiotensinogen: a candidate gene involved in preeclampsia? Nature Genet 1993; 4: 114-115.
85. Lachmeijer AMA, Arngrimsson R, Bastiaans EJ et al. Mutations in the gene for methylenetetrahydrofolate reductase, homocysteine levels, and vitamin status in women with a history of preeclampsia. Am J Obstet Gynecol 2001; 184: 394-402. (Pubitemid 32206990)
86. Currie L, Peek M, McNiven M et al. Is there an increased maternal-infant prevalence of Factor V Leiden in association with severe pre-eclampsia? BJOG 2002; 109: 191-196.
87. Livingston JC, Park V, Barton JR et al. Lack of association of severe preeclampsia with maternal and fetal mutant alleles for tumor necrosis factor α and lymphotoxin α genes and plasma tumor necrosis factor a levels. Am J Obstet Gynecol 2001; 184: 1273-1277. (Pubitemid 32434286)
88. The GOPEC Consortium. Disentangling fetal and maternal susceptibility for pre-eclampsia: a British multicentre candidate-gene study. Am J Hum Gen 2005; 77: 127-131.
89. Arngrímsson R, SigurCardóttir S, Frigge ML et al. A genome-wide scan reveals a maternal susceptibility locus for preeclampsia on chromosome 2p13. Hum Mol Genet 1999; 8: 1799-1805. (Pubitemid 29423892)
90. Moses EK, Lade JA, Guo G et al. A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for pre-eclampsia, on chromosome 2. Am J Hum Genet 2000; 67: 1581-1585.
91. Laivuori H, Lahermo P, Ollikainen V et al. Susceptibility loci for preeclampsia on chromosomes 2p25 and 9p13 in Finnish families. Am J Hum Genet 2003; 72: 168-177. (Pubitemid 36056853)
92. Ros HS, Lichtenstein P, Lipworth L et al. Genetic effects on the liability of developing pre-eclampsia and gestational hypertension. Am J Med Gen 2000; 91: 256-260. (Pubitemid 30191247)
93. Thornton JG & Macdonald AM. Twin mothers, pregnancy hypertension and pre-eclampsia. Br J Obstet Gynaecol 1999; 106: 256-260.
94. Treolar S, Cooper DW, Brennecke SP et al. An Australian twin study on the genetic basis of preeclampsia and eclampsia. Am J Obstet Gynecol 2001; 184: 374-381. (Pubitemid 32206987)
95. Haig D. Genetic conflicts in human pregnancy. Q Rev Biol 1993; 68: 495-532. (Pubitemid 2031412)
96. Astin M, Scott JR & Worley RJ. Pre-eclampsia/eclampsia: a fatal father factor. Lancet 1981; 2: 533. (Pubitemid 11051506)
97. Zusterzeel PLM, Visser WHM, Merkus HMWM et al. Polymorphism in the gluthatione S-transferase P1 gene and risk for preeclampsia. Obstet Gynecol 1999; 94: 1033-1038.
98. Zusterzeel PLM, Morsche R te, Raijmakers MTM et al. Paternal contribution to the risk for pre-eclampsia. J Med Genet 2002; 39: 44-45. (Pubitemid 34093605)
99. Sorensen TK, Williams MA, Lee IM et al. Recreational physical activity during pregnancy and risk of preeclampsia. Hypertension 2003; 41: 1273-1280. (Pubitemid 36706077)
100. Saftlas AF, Logsden- Sackett N, Wang W et al. Work, leisure-time physical activity, and risk of preeclampsia and gestational hypertension. Am J Epidemiol 2004; 160: 758-765. (Pubitemid 39362213)
101. Magnus P, Trogstad L, Owe KM et al. Recreational physical activity and the risk of preeclampsia: a prospective cohort of Norwegian women. Am J Epidemiol 2008; 168: 952-957.
102. Østerdal ML, Strøm M, Klemmensen ÅK et al. Does leisure time physical activity in early pregnancy protect against preeclampsia? Prospective cohort in Danish women. BJOG 2008; 116: 98-107.
103. Trogstad L, Eskild A, Bruu AL et al. Is preeclampsia an infectious disease? Acta Obstet Gynecol 2001; 80: 1036-1038.
104. Dadelszen von P, Magee LA, Krajden M et al. Levels of antibodies against cytomegalovirus and Chlamydophila pneumoniae are increased in early onset pre-eclampsia. BJOG 2003; 110: 725-730. (Pubitemid 36936773)
105. Magnus P & Eskild A. Seasonal variation in the occurrence of pre-eclampsia. BJOG 2001; 108: 1116-1119. (Pubitemid 33052472)
106. Immink A, Scherjon S, Wolterbeek R et al. Seasonal influence on the admittance of pre-eclampsia patients in Tygerberg hospital. Acta Obstet Gynecol 2008; 87: 36-42.
107. Haugen M, Brantsæter AL, Trogstad L et al. Vitamin D supplementation in nulliparous pregnant women. Epidemiology 2009; 20: 720-726.
108. Silva LM, Coolman M, Steegers EAP et al. Low socioeconomic status is a risk factor for preeclampsia: the Generation R Study. J Hypertens 2008; 26: 1200-1208. (Pubitemid 351670511)
109. Lawlor DA, Morton SMB, Nitsch D et al. Association between childhood and adulthood socioeconomic position and pregnancy induced hypertension: results from the Aberdeen children of the 1950s cohort study. J Epidemiol Comm Health 2005; 59: 49-55. (Pubitemid 40037086)
110. Rothman K & Greenland S. Causation and causal inference in epidemiology. Am J Publ Health 2005; 95(S1): 144-150.
111. Falconer DS. Introduction to quantitative genetics. 2nd ed. New York: Longman Inc, 1981. pp. 270-280.
112. Carter CO. Polygenic inheritance and common diseases. Lancet 1969; 1: 125-126.
113. Huppertz B. Placental origins of preeclampsia. Challenging the current hypothesis. Hypertension 2008; 51: 970-975.