Chronotherapy with low-dose aspirin for prevention of complications in pregnancy

Chronobiology International

Volumn 30, Issue 1-2, 2013, Pages 260-279

  Ayala, Diana E ^a   Ucieda, Rafael ^b   Hermida, Ramón C ^a  

^a UNIVERSITY OF VIGO   (Spain)

^b Instituto de Salud Carlos III   (Spain)

Author keywords

Ambulatory blood pressure monitoring; Aspirin; Gestational hypertension; Intrauterine growth retardation; Preeclampsia; Preterm delivery

Indexed keywords

EID: 84874164702     PISSN: 07420528     EISSN: 15256073     Source Type: Journal    
DOI: 10.3109/07420528.2012.717455     Document Type: Article

References (177)

1. Angeli A, Gatti G, Masera R. (1992). Chronobiology of the hypothalamic-pituitary-adrenal and renin-angiotensin-aldosterone systems. In Touitou Y, Haus E (Eds.). Biologic rhythms in clinical and laboratory medicine. Berlin: Springer-Verlag, 292-314.
2. Antiplatelet Trialists' Collaboration. (1994). Collaborative overview of randomised trials of antiplatelet therapy. I. Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 308:81-106.
3. Antithrombotic Trialists' Collaboration. (2002). Collaborative metaanalysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 324:71-86.
4. Askie LM, Duley L, Henderson-Smart DJ, Stewart LA, PARIS Collaborative Group. (2007). Antiplatelet agents for prevention of preeclampsia: A meta-analysis of individual patient data. Lancet 369:1791e-1798e.
5. Ayala DE, Hermida RC. (2001). Influence of parity and age on ambulatory monitored blood pressure during pregnancy. Hypertension 38:753-758.
6. Ayala DE, Hermida RC. (2010). Sex differences in the administrationtime- dependent effects of low-dose aspirin on ambulatory blood pressure in hypertensive subjects. Chronobiol. Int. 27:345-362.
7. Ayala DE, Hermida RC. (2012). Ambulatory blood pressure monitoring for the early identification of hypertension in pregnancy. Chronobiol. Int. 29: 233-259.
8. Ayala DE, Hermida RC, Mojón A, Fernández JR, Iglesias M. (1997). Circadian blood pressure variability in healthy and complicated pregnancies. Hypertension 30:603-610. (Pubitemid 27444239)
9. Ayala DE, Hermida RC, Mojón A, Fernández JR, Silva I, Ucieda R, Iglesias M. (1997b). Blood pressure variability during gestation in healthy and complicated pregnancies. Hypertension 30:611-618. (Pubitemid 27444240)
10. Ayala DE, Hermida RC, Mojón A, Fernández Jr. (2013a). Cardiovascular risk of resistant hypertension: Dependence on treatment-time regimen of blood pressure-lowering medications. Chronobiol. Int. 30:340-352.
11. Ayala DE, Moyá A, Crespo JJ, Castiñeira C, Domínguez-Sardiña M, Gomara S, Sineiro E, Mojón A, Fontao MJ, Hermida RC, on behalf of the Hygia Project Investigators. (2013b). Circadian pattern of ambulatory blood pressure in hypertensive patients with and without type 2 diabetes. Chronobiol. Int. 30:99-115.
12. Barth W. (1998). Low-dose aspirin for preeclampsia. The unresolved question. N. Engl. J. Med. 338:756-757. (Pubitemid 28115095)
13. Bartter FC, Chan JCM, Simpson HW. (1979). Chronobiological aspect of plasma renin activity, plasma aldosterone and urinary electrolytes. In Krieger DT (Ed.). Endocrine rhythms. New York: Raven, 49-132.
14. Beaufils M, Uzan S, Donsimoni R, Colau JC. (1985). Prevention of preeclampsia by early antiplatelet therapy. Lancet 1:840-842. (Pubitemid 15115117)
15. Benedetto C, Zonca M, Marozio L, Dolco C, Carandente F, Massobrio M. (1996). Blood pressure patterns in normal pregnancy and in pregnancy-induced hypertension, preeclampsia, and chronic hypertension. Obstet. Gynecol. 88:503-510. (Pubitemid 26326007)
16. BinghamC, Arbogast B, Cornélissen G, Lee JK, Halberg F. (1982). Inferential statistical methods for estimating and comparing cosinor parameters. Chronobiologia 9:397-439. (Pubitemid 13122417)
17. Brown MA, Lindheimer MD, de Swiet M, Van Assche A, Moutquin JM. (2001). The classification and diagnosis of the hypertensive disorders of pregnancy: Statement from The International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens. Pregnancy 20:ix-xiv.
18. Buchbinder A, Sibai BM, Caritis S, Macpherson C, Hauth J, Lindheimer MD, Klebanoff M, Vandorsten P, Landon M, Paul R, Miodovnik M, Meis P, Thurnau G, National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. 002). Adverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild pre-eclampsia. Am. J. Obstet. Gynecol. 186:66-71. (Pubitemid 34093742)
19. Bujold E, Morency AM, Roberge S, Lacasse Y, Forest JC, Giguère Y. (2009). Acetylsalicylic acid for the prevention of preeclampsia and intra-uterine growth restriction in women with abnormal uterine artery Doppler: A systematic review and meta-analysis. J. Obstet. Gynaecol. Can. 31:818-826.
20. Bujold E, Roberge S, Lacasse Y, Bureau M, Audibert F, Marcoux S, Forest JC, Giguère Y. (2010). Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: A meta-analysis. Obstet. Gynecol. 116:402-414.
21. Bujold E, Tapp S, Audibert F, Ferreira E, Forest JC, Rey E, Fraser WD, Chaillet N, Giguère Y. (2011). Prevention of adverse pregnancy outcomes with low-dose ASA in early pregnancy: New perspectives for future randomized trials. J. Obstet. Gynaecol. Can. 33:480-483.
22. Bussolino F, Benedetto C, Massobrio M, Camussi G. (1980). Maternal vascular prostacyclin activity in pre-eclampsia. Lancet 2:702.
23. Caritis S, Sibai B, Hauth J, Lindheimer MD, Klebanoff M, Thom E, Van-Dorsten P, Landon M, Paul R, Miodovnik M, Meis P, Thurnau G. (1998). Low-dose aspirin to prevent preeclampsia in women at high risk. N. Engl. J. Med. 338:701-705. (Pubitemid 28115087)
24. CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group. (1994). CLASP: A randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. Lancet 343:619-629.
25. Cornélissen G, Halberg F, Prikryl P, Dankova E, Siegelova J, Dusek J, International Womb-To-Tomb Chronome Study Group. (1991). Prophylactic aspirin treatment: The merits of timing. JAMA 266:3128-3129.
26. Cugini P, Manconi E, Serdoz N, Mancini A, Meucci R, Scavo D. (1980). Rhythm characteristics of plasma renin, aldosterone and cortisol in five types of mesor-hypertension. J. Endocrinol. Invest. 3:143-149.
27. Cugini P, Letizia C, Scavo D. (1988). The circadian rhythmicity of serum angiotensin converting enzyme: its phasic relation with the circadian cycle of plasma renin and aldosterone. Chronobiologia 15:229-232. (Pubitemid 18268693)
28. Dekker GA, Sibai BM. (1993). Low-dose aspirin in the prevention of preeclampsia and fetal growth retardation: rationale, mechanisms, and clinical trials. Am. J. Obstet. Gynecol. 168:214-227. (Pubitemid 23047644)
29. Delemarre FM, Didden MA, de Jong PA. (1996). Diurnal variation in angiotensin sensitivity in pregnancy. Am. J. Obstet. Gynecol. 174:259-261. (Pubitemid 26037720)
30. Duguay D, Cermakian N. (2009). The crosstalk between physiology and circadian clock proteins. Chronobiol. Int. 26:1479-1513.
31. Duley L. (2009). The global impact of pre-eclampsia and eclampsia. Semin. Perinatol. 33:130-137.
32. Dumont A, Flahault A, Beaufils M, Verdy E, Uzan S. (1999). Effect of aspirin in pregnant women is dependent on increase in bleeding time. Am. J. Obstet. Gynecol. 180:135-140. (Pubitemid 29088403)
33. ECPPA (Estudo Colaborativo para Prevençao da Pré-eclampsia com Aspirina) Collaborative Group. (1996). ECPPA: A randomised trial of low dose aspirin for the prevention of maternal and fetal complications in high risk pregnant women. Br. J. Obstet. Gynaecol. 103:39-47.
34. Fabbian F, Smolensky MH, Tiseo R, Pala M, Manfredini R, Portaluppi F. (2013). Dipper and non-dipper blood pressure 24-hour patterns: circadian rhythm-dependent physiologic and pathophysiologic mechanisms. Chronobiol. Int. 30:17-30.
35. Fernández JR, Hermida RC. (1998). Inferential statistical method for analysis of nonsinusoidal hybrid time series with unequidistant observations. Chronobiol. Int. 15:191-204. (Pubitemid 28189681)
36. Fernández JR, Mojón A, Hermida RC, Alonso I. (2003). Methods for comparison of parameters from longitudinal rhythmometric models with multiple components. Chronobiol. Int. 20:495-513. (Pubitemid 36828482)
37. Friedman SA. (1988). Preeclampsia: A review of the role of prostaglandins. Obstet. Gynecol. 71:122-137. (Pubitemid 18025090)
38. Fuster V, Dyken ML, Vokonas PS, Hennekens C. (1993). Aspirin as a therapeutic agent in cardiovascular disease. Circulation 87:659-675. (Pubitemid 23040943)
39. Gallerani M, Portaluppi F, Grandi E, Manfredini R. (1997). Circadian rhythmicity in the occurrence of spontaneous acute dissection and rupture of thoracic aorta. J. Thorac. Cardiovasc. Surg. 113:603-604. (Pubitemid 27149145)
40. Golding J. A randomised trial of low dose aspirin for primiparae in pregnancy. (1998). Br. J. Obstet. Gynaecol. 105:293-299.
41. Gordon RD,Wolfe LK, Island DP, Liddle GW. (1966). A diurnal rhythm in plasma renin activity in man. J. Clin. Invest. 45:1587-1592.
42. Grosser N, Schroder H. (2003). Aspirin protects endothelial cells from oxidant damage via the nitric-oxide-cGMP pathway. Arterioscler. Thromb. Vasc. Biol. 23:1345-1351. (Pubitemid 36994520)
43. Haus E, Cusulos M, Sackett-Lundeen L, Swoyer J. (1990). Circadian variations in platelet functions and blood coagulation parameters. In Reinberg A, Smolensky M, Labrecque G (Eds.). Annual review of chronopharmacology, Vol. 7. Oxford, UK: Pergamon Press, pp. 153-156. (Pubitemid 20363763)
44. Hayden M, Pignone M, Phillips C, Mulrow C. (2002). Aspirin for the primary prevention of cardiovascular events: A summary of the evidence for the U.S. Preventive Services Task Force. Ann. Intern. Med. 136:161-171.
45. Hermida RC. (1999). Time-qualified reference values for 24 h ambulatory blood pressure monitoring. Blood Press. Monit. 4:137-147.
46. Hermida RC, Ayala DE. (1997). Diagnosing gestational hypertension and preeclampsia with the 24-hour mean of blood pressure. Hypertension 30:1531-1537. (Pubitemid 27528100)
47. Hermida RC, Ayala DE. (2001). Evaluation of the blood pressure load in the diagnosis of hypertension in pregnancy. Hypertension 38:723-729.
48. Hermida RC, Ayala DE. (2002). Prognostic value of office and ambulatory blood pressure measurements in pregnancy. Hypertension 40:298-303. (Pubitemid 35006714)
49. Hermida RC, Ayala DE. (2003). Sampling requirements for ambulatory blood pressure monitoring in the diagnosis of hypertension in pregnancy. Hypertension 42:619-624. (Pubitemid 37237363)
50. Hermida RC, Ayala DE. (2004). Prognostic value of ambulatory blood pressure measurements for the diagnosis of hypertension in pregnancy. Expert Rev. Cardiovasc. Ther. 2:89-105.
51. Hermida RC, Ayala DE. (2005a). Reference thresholds for 24-hour, diurnal, and nocturnal blood pressure mean values in pregnancy. Blood Press. Monit. 10:33-41. (Pubitemid 40316150)
52. Hermida RC, Ayala DE. (2005b). Circadian blood pressure variability in normotensive pregnant women as a function of parity, maternal age, and stage of gestation. Chronobiol. Int. 22:321-341. (Pubitemid 40967235)
53. Hermida RC, Ayala DE. (2009). Chronotherapy with the angiotensinconverting enzyme inhibitor ramipril in essential hypertension: improved blood pressure control with bedtime dosing. Hypertension 54:40-46.
54. Hermida RC, Fernández Jr. (1996). Computation of time-specified tolerance intervals for ambulatorily monitored blood pressure. Biomed. Instrum. Technol. 30:257-266. (Pubitemid 26161490)
55. Hermida RC, Smolensky MH. (2004). Chronotherapy of hypertension. Curr. Opin. Nephrol. Hypertens. 13:501-505. (Pubitemid 39150075)
56. Hermida RC, Mojón A, Fernández JR, Ayala DE. (1996). Computerbased medical system for the computation of blood pressure excess in the diagnosis of hypertension. Biomed. Instrum. Technol. 30:267-283. (Pubitemid 26161491)
57. Hermida RC, Ayala DE, Iglesias M, Mojón A, Silva I, Ucieda R, Fernández Jr. (1997a). Time-dependent effects of low-dose aspirin administration on blood pressure in pregnant women. Hypertension 30:589-595. (Pubitemid 27444237)
58. Hermida RC, Fernández JR, Ayala DE, Mojón A, Iglesias M. (1997). Influence of aspirin usage on blood pressure. Dose and administration time-dependencies. Chronobiol. Int. 14:619-637. (Pubitemid 27502168)
59. Hermida RC, Mojón A, Fernández JR, Ayala DE. (1997c). The tolerance-hyperbaric test for hypertension diagnosis. Biomed. Instrum. Technol. 31:499-510.
60. Hermida RC, Ayala DE, Mojón A, Fernández JR, Silva I, Ucieda R, Iglesias M. (1998). Blood pressure excess for the early identification of gestational hypertension and preeclampsia. Hypertension 31:83-89. (Pubitemid 28124697)
61. Hermida RC, Ayala DE, Fernández JR, Mojón A, Alonso I, Silva I, Ucieda R, Codesido J, Iglesias M. (1999). Administration timedependent effects of aspirin in women at differing risk for preeclampsia. Hypertension 34:1016-1023. (Pubitemid 29501340)
62. Hermida RC, Ayala DE, Mojón A, Fernández JR, Alonso I, Silva I, Ucieda R, Iglesias M. (2000a). Blood pressure patterns in normal pregnancy, gestational hypertension and preeclampsia. Hypertension 36:149-158. (Pubitemid 30626981)
63. Hermida RC, Fernández JR, Mojón A, Ayala DE. (2000b). Reproducibility of the hyperbaric index as a measure of blood pressure excess. Hypertension 35:118-125. (Pubitemid 30054247)
64. Hermida RC, Ayala DE, Iglesias M. (2001a). Predictable blood pressure variability in healthy and complicated pregnancies. Hypertension 38:736-741.
65. Hermida RC, Ayala DE, Mojón A, Fernández Jr. (2001b). Time-qualified reference values for ambulatory blood pressure monitoring in pregnancy. Hypertension 38:746-752.
66. Hermida RC, Ayala DE, Fernández JR, Mojón A, Alonso I, Calvo C. (2002a). Modeling the circadian variability of ambulatorily monitored blood pressure by multiple-component analysis. Chronobiol. Int. 19:461-481. (Pubitemid 34478039)
67. Hermida RC, Calvo C, Ayala DE, Fernández JR, Ruilope LM, López JE. (2002b). Evaluation of the extent and duration of the "ABPM effect" in hypertensive patients. J. Am. Coll. Cardiol. 40:710-717. (Pubitemid 34925618)
68. Hermida RC, Calvo C, Ayala DE, Mojón A, López JE. (2002c). Relationship between physical activity and blood pressure in dipper and nondipper hypertensive patients. J. Hypertens. 20:1097-1104. (Pubitemid 34913627)
69. Hermida RC, Mojón A, Fernández JR, Alonso I, Ayala DE. (2002d). The tolerance-hyperbaric test: A chronobiologic approach for improved diagnosis of hypertension. Chronobiol. Int. 19:1183-1211. (Pubitemid 36008225)
70. Hermida RC, Ayala DE, Calvo C, López JE, Fernández JR, Mojón A, Domínguez MJ, Covelo M. (2003a). Administration-time dependent effects of aspirin on blood pressure in untreated hypertensive patients. Hypertension 41:1259-1267. (Pubitemid 36706075)
71. Hermida RC, Ayala DE, Iglesias M. (2003b). Circadian rhythm of blood pressure challengues office values as the "gold standard" in the diagnosis of gestational hypertension. Chronobiol. Int. 20:135-156. (Pubitemid 36288278)
72. Hermida RC, Ayala DE, Iglesias M. (2003c). Administration-time dependent influence of aspirin on blood pressure in pregnant women. Hypertension 41:651-656. (Pubitemid 36314569)
73. Hermida RC, Ayala DE, Mojón A, Fernández JR, Alonso I, Aguilar MF, Ucieda R, Iglesias M. (2003d). Differences in circadian blood pressure variability during gestation between healthy and complicated pregnancies. Am. J. Hypertens. 16:200-208. (Pubitemid 36293064)
74. Hermida RC, Calvo C, Ayala DE, Domínguez MJ, Covelo M, Fernández JR, Mojón A, López JE. (2003e). Administration-time-dependent effects of valsartan on ambulatory blood pressure in hypertensive subjects. Hypertension 42:283-290. (Pubitemid 37093474)
75. Hermida RC, Ayala DE, Iglesias M. (2004a). Differences in circadian pattern of ambulatory pulse pressure between healthy and complicated pregnancies. Hypertension 44:316-321. (Pubitemid 39167229)
76. Hermida RC, Ayala DE, Iglesias M. (2004b). Circadian blood pressure variability as a function of parity in normotensive pregnant women. J. Clin. Hypertens. 6:126-133.
77. Hermida RC, Ayala DE, Fernández JR, Mojón A, Iglesias M. (2004). Reproducibility of the tolerance-hyperbaric test for diagnosing hypertension in pregnancy. J. Hypertens. 22:565-572. (Pubitemid 38368491)
78. Hermida RC, Calvo C, Ayala DE, Domínguez MJ, Covelo M, Fernández JR, Fontao MJ, López JE. (2004d). Administration-time- dependent effects of doxazosin GITS on ambulatory blood pressure of hypertensive subjects. Chronobiol. Int. 21:277-296. (Pubitemid 39014625)
79. Hermida RC, Fernández JR, Ayala DE, Mojón A, Alonso I, Calvo C. (2004e). Circadian time-qualified tolerance intervals for ambulatory blood pressure monitoring in the diagnosis of hypertension. Chronobiol. Int. 21:149-170.
80. Hermida RC, Ayala DE, Calvo C, López JE. (2005a). Aspirin administered at bedtime, but not on awakening, has an effect on ambulatory blood pressure in hypertensive patients. J. Am. Coll. Cardiol. 46:975-983. (Pubitemid 41316502)
81. Hermida RC, Ayala DE, Calvo C, López JE, Mojón A, Rodríguez M, Fernández Jr. (2005b). Differing administration time-dependent effects of aspirin on blood pressure in dipper and non-dipper hypertensives. Hypertension 46:1060-1068.
82. Hermida RC, Ayala DE, Fernández JR, Calvo C. (2007a). Comparison of the efficacy of morning versus evening administration of telmisartan in essential hypertension. Hypertension 50:715-722. (Pubitemid 47442736)
83. Hermida RC, Ayala DE. Fernandez JR, Mojón A, Calvo C. (2007). Influence of measurement duration and frequency on ambulatory blood pressure monitoring. Rev. Esp. Cardiol. 60:131-138. (Pubitemid 46566967)
84. Hermida RC, Ayala DE, Portaluppi F. (2007c). Circadian variation of blood pressure: The basis for the chronotherapy of hypertension. Adv. Drug Deliv. Rev. 59:904-922. (Pubitemid 47534216)
85. Hermida RC, Ayala DE, Calvo C, Portaluppi F, Smolensky MH. (2007). Chronotherapy of hypertension: administration-time dependent effects of treatment on the circadian pattern of blood pressure. Adv. Drug Deliv. Rev. 59:923-939. (Pubitemid 47531897)
86. Hermida RC, Ayala DE, Chayán L, Mojón A, Fernández Jr. (2009). Administration-time-dependent effects of olmesartan on the ambulatory blood pressure of essential hypertension patients. Chronobiol. Int. 26:61-79.
87. Hermida RC, Ayala DE, Mojón A, Fernández Jr. (2009b). Ambulatory blood pressure control with bedtime aspirin administration in subjects with prehypertension. Am. J. Hypertens. 22:896-903.
88. Hermida RC, Ayala DE, Fontao MJ, Mojón A, Alonso I, Fernández Jr. (2010a). Administration-time-dependent effects of spirapril on ambulatory blood pressure in uncomplicated essential hypertension. Chronobiol. Int. 27:560-574.
89. Hermida RC, Ayala DE, Fontao MJ, Mojón A, Fernández Jr. (2010). Chronotherapy with valsartan/amlodipine combination in essential hypertension: improved blood pressure control with bedtime dosing. Chronobiol. Int. 27:1287-1303.
90. Hermida RC, Ayala DE, Mojón A, Fernández Jr. (2010c). Influence of circadian time of hypertension treatment on cardiovascular risk: results of the MAPEC study. Chronobiol. Int. 27:1629-1651.
91. Hermida RC, Ayala DE, Fernández JR, Portaluppi F, Fabbian F, Smolensky MH. (2011a). Circadian rhythms in blood pressure regulation and optimization of hypertension treatment with ACE inhibitor and ARB medications. Am. J. Hypertens. 24:383-391.
92. Hermida RC, Ayala DE, Mojón A, Fernández Jr. (2011b). Decreasing sleep-time blood pressure determined by ambulatory monitoring reduces cardiovascular risk. J. Am. Coll. Cardiol. 58:1165-1173.
93. Hermida RC, Ayala DE, Mojón A, Fernández Jr. (2011c). Influence of time of day of blood pressure-lowering treatment on cardiovascular risk in hypertensive patients with type 2 diabetes. Diabetes Care 34:1270-1276.
94. Hermida RC, Ayala DE, Mojón A, Fernández Jr. (2011d). Bedtime dosing of antihypertensive medications reduces cardiovascular risk in CKD. J. Am. Soc. Nephrol. 22:2313-2321.
95. Hermida RC, Ayala DE, Mojón A, Fontao MJ, Fernández Jr. (2011). Chronotherapy with valsartan/hydrochlorothiazide combination in essential hypertension: improved sleep-time blood pressure control with bedtime dosing. Chronobiol. Int. 28:601-610.
96. Hermida RC, Ayala DE, Mojón A, Fernández Jr. (2012a). Sleep-time blood pressure and the prognostic value of isolated-office and masked hypertension. Am. J. Hypertens. 25:297-305.
97. Hermida RC, Ayala DE, Mojón A, Fernández Jr. (2012b). Sleep-time blood pressure as a therapeutic target for cardiovascular risk reduction in type 2 diabetes. Am. J. Hypertens. 25:325-334.
98. Hermida RC, Ayala DE, Fernández JR, Mojón A. (2013a). Sleeptime blood pressure: prognostic value and relevance as a therapeutic target for cardiovascular risk reduction. Chronobiol. Int. 30:68-86.
99. Hermida RC, Ayala DE, Fernández JR, Mojón A, Smolensky MH, Fabbian F, Portaluppi F. (2013b). Administration-time differences in effects of hypertension medications on ambulatory blood pressure regulation. Chronobiol. Int. 30:280-314.
100. Hermida RC, Ayala DE, Fontao MJ, Mojón A, Fernández Jr. (2013). Ambulatory blood pressure monitoring: importance of sampling rate and duration - 48 versus 24 hours - on the accurate assessment of cardiovascular risk. Chronobiol. Int. 30:55-67.
101. Hermida RC, Ayala DE, Mojón A, Fernández Jr. (2013d). Blunted sleep-time relative blood pressure decline increases cardiovascular risk independent of blood pressure level - the "normotensive non-dipper" paradox. Chronobiol Int. 30:87-98.
102. Hermida RC, Ayala DE, Mojón A, Fernández Jr. (2013e). Cardiovascular risk of essential hypertension: influence of class, number, and treatment-time regimen of hypertension medications. Chronobiol. Int. 30:315-327.
103. Hernández-Díaz S, Toh S, Cnattingius S. (2009). Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study. BMJ 338:b2255.
104. Higashi Y, Nakagawa K, Kimura M, Noma K, Hara K, Sasaki S, Goto C, Oshima T, Chayama K, Yoshizumi M. (2002). Circadian variation of blood pressure and endothelial function in patients with essential hypertension: A comparison of dippers and non-dippers. J. Am. Coll. Cardiol. 40:2039-2043. (Pubitemid 35425374)
105. Imperiale TF, Petrulis A. (1991). A meta-analysis of low-dose aspirin for the prevention of pregnancy-induced hypertensive disease. JAMA 266:261-265.
106. Italian Study of Aspirin in Pregnancy. (1993). Low-dose aspirin in prevention and treatment of intrauterine growth retardation and pregnancy-induced hypertension. Lancet 341:396-400.
107. Janes SL, Kyle PM, Redman C, Goodall AH. (1995). Flow cytometric detection of activated platelets in pregnant women prior to the development of pre-eclampsia. Thromb. Haemost. 74:1059-1063.
108. Johnson AG, Nguyen TV, Day RO. (1994). Do nonsteroidal anti-inflammatory drugs affect blood pressure? A meta-analysis. Ann. Intern. Med. 121:289-300.
109. Kanabrocki EL, George M, Hermida RC, Messmore HL, Ryan MD, Ayala DE, Hoppensteadt DA, Fareed J, Bremmer FW, Third JLHC, Shirazi P, Nemchausky BA. (2001). Day-night variations in blood levels of nitric oxide, T-TFPI and E-selectin. Clin. Appl. Thromb. Hemostasis 7:339-345. (Pubitemid 32988902)
110. Kanzik I, Cakici I, Ersoy S, Ark M, Abacioglu N, Zengil H. (1992). Effects of cyclooxygenase and lipoxygenase inhibitors on digoxin-induced arrhythmias and haemodynamics in guinea-pigs. Pharmacol. Res. 26:305-316.
111. Katz F, Romfh P, Smith JA. (1975). Diurnal variation of plasma aldosterone, cortisol and renin activity in supine man. J. Clin. Endocrinol. Metab. 40:125-134.
112. Khan KS, Wojdyla D, Say L, Gulmezoglu Am, Van Look PF. (2006). WHO analysis of causes of maternal death: A systematic review. Lancet 367:1066-1074.
113. Klemmensen AK, Olsen SF, Osterdal ML, Tabor A. (2007). Validity of pre-eclampsia-related diagnoses recorded in a national hospital registry and in a postpartum interview of the women. Am. J. Epidemiol. 166:117-124. (Pubitemid 47227297)
114. Labrecque G, Reinberg A. (1989). Chronopharmacology of nonsteroid anti-inflammatory drugs. In Lemmer B (Ed.). Chronopharmacology: cellular and biochemical interactions. New York: Marcel Dekker, 545-579.
115. Lawler J, Osman M, Shelton JA, Yeh J. (2007). Population-based analysis of hypertensive disorders in pregnancy. Hypertens. Pregnancy 26:67-76. (Pubitemid 46649348)
116. Leitich H, Egarter C, Husslein P, Kaider A, Schemper M. (1997). A meta-analysis of low dose aspirin for the prevention of intrauterine growth retardation. Br. J. Obstet. Gynecol. 104:450-459. (Pubitemid 27189685)
117. Manfredini R, Gallerani M, Portaluppi F, Fersini C. (1996). Relationships of the circadian rhythms of thrombotic, ischemic, hemorrhagic, and arrhythmic events to blood pressure rhythms. Ann. N. Y. Acad. Sci. 783:141-158. (Pubitemid 26372087)
118. Manson JE, Stampfer MJ, Colditz GA, Willet WC, Rosner B, Speizer FE, Hennekens CH. (1991). A prospective study of aspirin use and primary prevention of cardiovascular disease in women. JAMA 266:521-527.
119. Marín R, Gorostidi M, Portal CG, Sánchez M, Sánchez E, Alvarez J. (2000). Long-term prognosis of hypertension in pregnancy. Hypertens. Pregnancy 19:199-209. (Pubitemid 30436487)
120. Markiewicz A, Semenowicz K. (1979). Time dependent changes in the pharmacokinetics of aspirin. Int. J. Clin. Pharmacol. Biopharm. 17:409-411. (Pubitemid 10225509)
121. Masotti G, Galanti G, Poggesi L, Abbate R, Neri Serneri GG. (1979). Differential inhibition of prostacyclin production and platelet aggregation by aspirin. Lancet 2:1213-1217.
122. Miyamoto S, Shimokawa H, Sumioki H, Touno A, Nakano H. (1998). Circadian rhythm of plasma atrial natriuretic peptide, aldosterone, and blood pressure during the third trimester in normal and preeclamptic pregnancy. Am. J. Obstet. Gynecol. 158:393-399.
123. Moore JG, Goo RH. (1987). Day and night aspirin-induced gastric mucosal damage and protection by ranitidine in man. Chronobiol. Int. 4:111-116. (Pubitemid 17096308)
124. Page NM. (2002). The endocrinology of preeclampsia. Clin. Endocrinol. 57:413-423.
125. Panza JA, Epstein SE, Quyyumi AA. (1991). Circadian variation in vascular tone and its relation to alpha-sympathetic vasoconstrictor activity. N. Engl. J. Med. 325:986-990.
126. Patrono C, Ciabattoni G, Patrignani P, Pugliese F, Filabozzi P, Catella F, Dave G, Forni L. (1985). Clinical pharmacology of platelet cyclooxygenase inhibition. Circulation 72:1177-1184. (Pubitemid 16126796)
127. Pinotti M, Bertolucci C, Portaluppi F, Colognesi I, Frigato E, Foa A, Bernardi F. (2005). Daily and circadian rhythms of tissue factor pathway inhibitor and factor VII activity. Arterioscler. Thromb. Vasc. Biol. 25:646-649. (Pubitemid 40315692)
128. Pope JE, Anderson JJ, Felson DT. (1993). A meta-analysis of the effects of nonsteroidal anti-inflammatory drugs on blood pressure. Arch. Intern. Med. 153:477-484. (Pubitemid 23064991)
129. Portaluppi F, Smolensky MH. (2007). Circadian rhythm and environmental determinants of blood pressure regulation in normal and hypertensive conditions. In White WB (Ed.). Blood pressure monitoring in cardiovascular medicine and therapeutics. Totowa, NJ: Humana Press, 135-158.
130. Portaluppi F, Smolensky MH. (2010). Perspectives on the chronotherapy of hypertension based on the results of the MAPEC study. Chronobiol. Int. 27:1652-1667.
131. Portaluppi F, Montanari L, Ferlini M, Gilli P. (1990). Altered circadian rhythms of blood pressure and heart rate in non-hemodialysis chronic renal failure. Chronobiol. Int. 7:321-327.
132. Portaluppi F, Trasforini G, Margutti A, Vergnani L, Ambrosio MR, Rossi R, Bagni B, Pansini R, degli Uberti EC. (1992). Circadian rhythm of calcitonin gene-related peptide in uncomplicated essential hypertension. J. Hypertens. 10:1227-1234.
133. Portaluppi F, Cortelli P, Avoni P, Vergnani L, Contin E, Maltoni P, Pavani A, Sforza E, degli Uberti EC, Gambetti P, Lugaresi E. (1994). Diurnal blood pressure variation and hormonal correlates in fatal familial insomnia. Hypertension 23:569-576. (Pubitemid 24129349)
134. Portaluppi F, Vergnani L, Manfredini R, Fersini C. (1996). Endocrine mechanisms of blood pressure rhythms. Ann. N. Y. Acad. Sci. 783:113-131. (Pubitemid 26372085)
135. Portaluppi F, Boari B, Manfredini R. (2004). Oxidative stress in essential hypertension. Curr. Pharm. Des. 10:1695-1698. (Pubitemid 38559779)
136. Portaluppi F, Smolensky MH, Touitou Y. (2010). Ethics and methods for biological rhythm research on animals and human beings. Chronobiol. Int. 27:1911-1929.
137. Portaluppi F, Tiseo R, Smolensky MH, Hermida RC, Ayala DE, Fabbian F. (2012). Circadian rhythms and cardiovascular health. Sleep Med. Rev. 16:151-166.
138. Redman CW, Bonnar J, Beilin L. (1978). Early platelet consumption in pre-eclampsia. BMJ 1:467-469. (Pubitemid 8318838)
139. Redman CW, Sargent IL. (2003). Pre-eclampsia, the placenta and the maternal systemic inflammatory response - a review. Placenta 24: S21-s27. (Pubitemid 37184731)
140. Redman CW, Sargent IL. (2005). Latest advances in understanding preeclampsia. Science 308:1592-1594. (Pubitemid 40807500)
141. Roberge S, Giguère Y, Villa P, Nicolaides K, Vainio M, Forest JC, von Dadelzen P, Vaiman D, Tapp S, Bujold E. (2012a). Early administration of low-dose aspirin for the prevention of severe and mild preeclampsia: A systematic review and meta-analysis. Am. J. Perinatol. 29:551-556.
142. Roberge S, Villa P, Nicolaides K, Giguère Y, Vainio M, Bakthi A, Ebrashy A, Bujold E. (2012b). Early administration of low-dose aspirin for the prevention of preterm and term preeclampsia: A systematic review and meta-analysis. Fetal Diagn. Ther. 31:141-146.
143. Roberts CL, Algert CS, Morris JM, Ford JB, Henderson-Smart DJ. (2005). Hypertensive disorders in pregnancy: A population-based study. Med. J. Aust. 182:332-335. (Pubitemid 40514929)
144. Roberts CL, Bell JC, Ford JB, Hadfield RM, Algert CS, Morris JM. (2008). The accuracy of reporting of the hypertensive disorders of pregnancy in population health data. Hypertens. Pregnancy 27:285-297.
145. Roberts CL, Ford JB, Algert CS, Antonsen S, Chalmers J, Cnattingius S, Gokhale M, Kotelchuck M, Melve KK, Langridge A, Morris C, Morris JM, Nassar N, Norman JE, Norrie J, Sorensen HT, Walker R, Weir CJ. (2011). Population-based trends in pregnancy hypertension and pre-eclampsia: an international comparative study. BMJ Open 1:e000101.
146. Rotchell YE, Cruickshank JK, Phillips Gay M, Griffiths J, Stewart A, Farrell B, Ayers S, Hennis A, Grant A, Duley L, Collins R. (1998). Barbados Low Dose Aspirin Study in Pregnancy (BLASP): A randomised trial for the prevention of pre-eclampsia and its complications. Br. J. Obstet. Gynaecol. 105:286-292. (Pubitemid 28123577)
147. Ros HS, Cnattingius S, Lipworth L. (1998). Comparison of risk factors for pre-eclampsia and gestational hypertension in a populationbased cohort study. Am. J. Epidemiol. 147:1062-1070.
148. Ruano R, Fontes RS, Zugaib M. (2005). Prevention of preeclampsia with low-dose aspirin - a systematic review and meta-analysis of the main randomized controlled trials. Clinics (Sao Paulo) 60:407-414.
149. Shennan AH, Kissane J, De Swiet M. (1993). Validation of the Space-Labs 90207 ambulatory blood pressure monitor for use in pregnancy. Br. J. Obstet. Gynaecol. 100:904-908. (Pubitemid 23308273)
150. Sibai BM, Caritis SN, Thom E, Klebanoff M, McNellis D, Rocco L, Paul RH, Romero R, Witter F, Rosen M, Depp R, and the National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. (1993). Prevention of preeclampsia with low-dose aspirin in healthy, nulliparous pregnant women. N. Engl. J. Med. 329:1213-1218. (Pubitemid 23306321)
151. Sibai BM, Caritis S, Hauth J. (2003). What we have learned about preeclampsia. Semin. Perinatol. 27:239-246. (Pubitemid 36828961)
152. Smolensky MH, Haus E. (2001). Circadian rhythms in clinical medicine with applications to hypertension. Am. J. Hypertens. 14(9 Pt 2):280S-290S. (Pubitemid 32868544)
153. Smolensky MH, Portaluppi F. (1999). Chronopharmacology and chronotherapy of cardiovascular medications: relevance to prevention and treatment of coronary heart disease. Am. Heart J. 137(4 Pt 2):S14-S24. (Pubitemid 29162888)
154. Smolensky MH, Hermida RC, Castriotta RJ, Portaluppi F. (2007). Role of sleep-wake cycle on blood pressure circadian rhythms and hypertension. Sleep Med. 8:668-680. (Pubitemid 47192885)
155. Smolensky MH, Hermida RC, Ayala DE, Tiseo R, Portaluppi F. (2010). Administration-time-dependent effect of blood pressure-lowering medications: basis for the chronotherapy of hypertension. Blood Press. Monit. 15:173-180.
156. Smolensky MH, Siegel RA, Haus E, Hermida R, Portaluppi F. (2012). Biological rhythms, drug delivery, and chronotherapeutics. In Siepmann J, Siegel RA, Rathbone MJ (Eds.). Fundamentals and applications of controlled release drug delivery. Heidelberg, Germany: Springer-Verlag, 359-443.
157. Snoep JD, Hovens MMC, Pasha SM, Frölich M, Pijl H, Tamsma JT, Huisman MV. (2009). Time-dependent effects of low-dose aspirin on plasma renin activity, aldosterone, cortisol, and catecholamines. Hypertension 54:1136-1142.
158. Sothern RB, VeselyDL, Kanabrocki EL,Hermida RC, Bremner FW, Third JLHC, Boles MA, Nemchausky BM, Olwin JH, Scheving LE. (1995). Temporal (circadian) and functional relationship between atrial natriuretic peptides and blood pressure. Chronobiol. Int. 12:106-120.
159. Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. (2010). Preeclampsia. Lancet 376:631-644.
160. Svensson A, L Sigström, B Andersch, L Hansson. (1983). Maternal hypertension during pregnancy and high blood pressure in children. Clin. Exp. Hypertens. B Hypertens. Pregnancy 2:203-209. (Pubitemid 14144147)
161. Taubert D, Berkels R, Grosser N, Schroder H, Grundemann D, Schomig E. (2004). Aspirin induces nitric oxide release fromvascular endothelium: A novel mechanism of action. Br. J. Pharmacol. 143:159-165. (Pubitemid 39280035)
162. Trasforini G, Margutti A, Portaluppi F, Menegatti M, Ambrosio MR, Bagni B, Pansini R, degli Uberti EC. (1991). Circadian profile of plasma calcitonin gene-related peptide in healthy man. J. Clin. Endocrinol. Metab. 73:945-951. (Pubitemid 21901129)
163. Trivedi NA. (2011). A meta-analysis of low-dose aspirin for prevention of preeclampsia. J. Postgrad. Med. 57:91-95.
164. Varani K, Gessi S, Caiazza A, Rastelli G, Portaluppi F, Borea PA. (1999a). Platelet alpha2-adrenoceptor alterations in patients with essential hypertension. Br. J. Clin. Pharmacol. 47:167-172. (Pubitemid 29078015)
165. Varani K, Portaluppi F, Merighi S, Ongini E, Belardinelli L, Borea PA. (1999b). Caffeine alters A2A adenosine receptors and their function in human platelets. Circulation 99:2499-2502. (Pubitemid 29228278)
166. Varani K, Portaluppi F, Gessi S, Merighi S, Ongini E, Belardinelli L, Borea PA. (2000). Dose and time effects of caffeine intake on human platelet adenosine A(2A) receptors: functional and biochemical aspects. Circulation 102:285-289. (Pubitemid 30457577)
167. Walker RL, Hemmelgarn B, Quan H. (2009). Incidence of gestational hypertension in the Calgary Health Region from 1995 to 2004. Can. J. Cardiol. 25:e284-e287.
168. Wallis AB, Saftlas AF, Hsia J, Atrash HK. (2008). Secular trends in the rates of pre-eclampsia, eclampsia, and gestational hypertension, United States, 1987-2004. Am. J. Hypertens. 21:521-526. (Pubitemid 351589674)
169. Walsh SW. (1985). Preeclampsia: an imbalance in placental prostacyclin and thromboxane production. Am. J. Obstet. Gynecol. 152:335-340. (Pubitemid 15049763)
170. Walsh SW, Wang Y. (1998). Maternal perfusion with low-dose aspirin preferentially inhibits placental thromboxane while sparing prostacyclin. Hypertens. Pregnancy 17:203-215. (Pubitemid 28383048)
171. Walsh SW, Wang Y, Kay HH, McCoy MC. (1992). Low-dose aspirin inhibits lipid peroxides and thromboxane but not prostacyclin in pregnant women. Am. J. Obstet. Gynecol. 167:926-930.
172. Wang JL, Cheng HF, Harris RC. (1999). Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular hypertension. Hypertension 34:96-101. (Pubitemid 29325725)
173. Willard JE, Lange RA, Hillis LD. (1992). The use of aspirin in ischemic heart disease. N. Engl. J. Med. 327:175-181.
174. Winters CJ, Sallman AL, Vesely DL. (1988). Circadian rhythm of prohormone atrial natriuretic peptides 1-30, 31-67 and 99-126 in man. Chronobiol. Int. 5:403-409. (Pubitemid 19019152)
175. Witte K, Lemmer B. (2003).Rhythms and pharmacodynamics. In Redfern P (Ed.). Chronotherapeutics. London: Pharmaceutical Press, 111-126.
176. Wu R, Lamontagne D, de Champlain J. (2002). Antioxidative properties of acetylsalicylic acid on vascular tissues from normotensive and spontaneously hypertensive rats. Circulation 105:387-392. (Pubitemid 34106190)
177. Wu R, Laplante MA, de Champlain J. (2004). Prevention of angiotensin II-induced hypertension, cardiovascular hypertrophy and oxidative stress by acetylsalicylic acid in rats. J. Hypertens. 22:793-801. (Pubitemid 38543572)