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Volumn 3, Issue , 2014, Pages 6-14

Mineralocorticoid receptor antagonist in heart failure: Past, present and future perspectives

Author keywords

Aldosterone; Guidelines; Heart failure; Mineralocorticoid receptor antagonists; Prognosis

Indexed keywords

ALDOSTERONE; ALDOSTERONE RECEPTOR; ALDOSTERONE SYNTHASE INHIBITOR; ANGIOTENSIN II; APOPTOSIS SIGNAL REGULATING KINASE 1; CANRENONE; COLLAGEN; CORTICOTROPIN; CYTOCHROME P450 3A4; ELASTIN; EPITHELIAL GROWTH FACTOR RECEPTOR; EPLERENONE; EXTRACELLULARSIGNAL REGULATED KINASE 1; EXTRACELLULARSIGNAL REGULATED KINASE 2; FAD 286; FK 506 BINDING PROTEIN; HYDROCORTISONE; INTERSTITIAL COLLAGENASE; LCI 699; MATRIX METALLOPROTEINASE; MINERALOCORTICOID ANTAGONIST; MINERALOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR ANTAGONIST; PATIROMER; PROCOLLAGEN TYPE 3 AMINOPROPEPTIDE; PROTEIN KINASE; RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SM 368229; SPIRONOLACTONE; SPP 2745; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ALDOSTERONE ANTAGONIST; ALDOSTERONE SYNTHASE; ANGIOTENSIN 1 RECEPTOR; CLARITHROMYCIN; FAD286; ITRACONAZOLE; KETOCONAZOLE; LCI699; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SPP2745;

EID: 84901284184     PISSN: 22147632     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijchv.2014.03.005     Document Type: Review
Times cited : (27)

References (102)
  • 1
    • 0035818917 scopus 로고    scopus 로고
    • Aldosterone in congestive heart failure
    • Weber K.T. Aldosterone in congestive heart failure. N Engl J Med 2001, 345:1689-1697.
    • (2001) N Engl J Med , vol.345 , pp. 1689-1697
    • Weber, K.T.1
  • 2
    • 0038179527 scopus 로고    scopus 로고
    • Eplerenone: cardiovascular protection
    • Brown N.J. Eplerenone: cardiovascular protection. Circulation 2003, 107:2512-2518.
    • (2003) Circulation , vol.107 , pp. 2512-2518
    • Brown, N.J.1
  • 3
    • 4043184149 scopus 로고    scopus 로고
    • The clinical implications of aldosterone escape in congestive heart failure
    • Struthers A.D. The clinical implications of aldosterone escape in congestive heart failure. Eur J Heart Fail 2004, 6:539-545.
    • (2004) Eur J Heart Fail , vol.6 , pp. 539-545
    • Struthers, A.D.1
  • 4
    • 77955172275 scopus 로고    scopus 로고
    • Mineralocorticoid accelerates transition to heart failure with preserved ejection fraction via "nongenomic effects"
    • Mohammed S.F., Ohtani T., Korinek J., Lam C.S., Larsen K., Simari R.D., et al. Mineralocorticoid accelerates transition to heart failure with preserved ejection fraction via "nongenomic effects". Circulation 2010, 122:370-378.
    • (2010) Circulation , vol.122 , pp. 370-378
    • Mohammed, S.F.1    Ohtani, T.2    Korinek, J.3    Lam, C.S.4    Larsen, K.5    Simari, R.D.6
  • 5
    • 0028275578 scopus 로고
    • Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone
    • Brilla C.G., Zhou G., Matsubara L., Weber K.T. Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone. J Mol Cell Cardiol 1994, 26:809-820.
    • (1994) J Mol Cell Cardiol , vol.26 , pp. 809-820
    • Brilla, C.G.1    Zhou, G.2    Matsubara, L.3    Weber, K.T.4
  • 7
    • 0033935122 scopus 로고    scopus 로고
    • Aldosterone and myocardial fibrosis in heart failure
    • Brilla C.G. Aldosterone and myocardial fibrosis in heart failure. Herz 2000, 25:299-306.
    • (2000) Herz , vol.25 , pp. 299-306
    • Brilla, C.G.1
  • 8
    • 0033840926 scopus 로고    scopus 로고
    • Induction of cardiac fibrosis by aldosterone
    • Lijnen P., Petrov V. Induction of cardiac fibrosis by aldosterone. J Mol Cell Cardiol 2000, 32:865-879.
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 865-879
    • Lijnen, P.1    Petrov, V.2
  • 9
    • 70349235614 scopus 로고    scopus 로고
    • Critical role of apoptosis signal-regulating kinase 1 in aldosterone/salt-induced cardiac inflammation and fibrosis
    • Nakamura T., Kataoka K., Fukuda M., Nako H., Tokutomi Y., Dong Y.F., et al. Critical role of apoptosis signal-regulating kinase 1 in aldosterone/salt-induced cardiac inflammation and fibrosis. Hypertension 2009, 54:544-551.
    • (2009) Hypertension , vol.54 , pp. 544-551
    • Nakamura, T.1    Kataoka, K.2    Fukuda, M.3    Nako, H.4    Tokutomi, Y.5    Dong, Y.F.6
  • 10
    • 55349133352 scopus 로고    scopus 로고
    • Present and future drug treatments for chronic kidney diseases: evolving targets in renoprotection
    • Perico N., Benigni A., Remuzzi G. Present and future drug treatments for chronic kidney diseases: evolving targets in renoprotection. Nat Rev Drug Discov 2008, 7:936-953.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 936-953
    • Perico, N.1    Benigni, A.2    Remuzzi, G.3
  • 11
    • 33750946166 scopus 로고    scopus 로고
    • Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy
    • Assomull R.G., Prasad S.K., Lyne J., Smith G., Burman E.D., Khan M., et al. Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy. J Am Coll Cardiol 2006, 48:1977-1985.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 1977-1985
    • Assomull, R.G.1    Prasad, S.K.2    Lyne, J.3    Smith, G.4    Burman, E.D.5    Khan, M.6
  • 12
    • 79851476269 scopus 로고    scopus 로고
    • Myocardial fibrosis predicts appropriate device therapy in patients with implantable cardioverter-defibrillators for primary prevention of sudden cardiac death
    • Iles L., Pfluger H., Lefkovits L., Butler M.J., Kistler P.M., Kaye D.M., et al. Myocardial fibrosis predicts appropriate device therapy in patients with implantable cardioverter-defibrillators for primary prevention of sudden cardiac death. J Am Coll Cardiol 2011, 57:821-828.
    • (2011) J Am Coll Cardiol , vol.57 , pp. 821-828
    • Iles, L.1    Pfluger, H.2    Lefkovits, L.3    Butler, M.J.4    Kistler, P.M.5    Kaye, D.M.6
  • 13
    • 0032949682 scopus 로고    scopus 로고
    • Molecular mechanisms of myocardial remodeling
    • Swynghedauw B. Molecular mechanisms of myocardial remodeling. Physiol Rev 1999, 79:215-262.
    • (1999) Physiol Rev , vol.79 , pp. 215-262
    • Swynghedauw, B.1
  • 14
    • 66549118329 scopus 로고    scopus 로고
    • Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins
    • Gómez A.M., Rueda A., Sainte-Marie Y., Pereira L., Zissimopoulos S., Zhu X., et al. Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins. Circulation 2009, 119:2179-2187.
    • (2009) Circulation , vol.119 , pp. 2179-2187
    • Gómez, A.M.1    Rueda, A.2    Sainte-Marie, Y.3    Pereira, L.4    Zissimopoulos, S.5    Zhu, X.6
  • 16
    • 28544447015 scopus 로고    scopus 로고
    • Aldosterone receptor antagonists in the medical management of chronic heart failure
    • Tang W.H., Parameswaran A.C., Maroo A.P., Francis G.S. Aldosterone receptor antagonists in the medical management of chronic heart failure. Mayo Clin Proc 2005, 80:1623-1630.
    • (2005) Mayo Clin Proc , vol.80 , pp. 1623-1630
    • Tang, W.H.1    Parameswaran, A.C.2    Maroo, A.P.3    Francis, G.S.4
  • 17
    • 0037869353 scopus 로고    scopus 로고
    • Aldosterone receptor blockade improves left ventricular remodeling and increases ventricular fibrillation threshold in experimental heart failure
    • Cittadini A., Monti M.G., Isgaard J., Casaburi C., Strömer H., Di Gianni A., et al. Aldosterone receptor blockade improves left ventricular remodeling and increases ventricular fibrillation threshold in experimental heart failure. Cardiovasc Res 2003, 58:555-564.
    • (2003) Cardiovasc Res , vol.58 , pp. 555-564
    • Cittadini, A.1    Monti, M.G.2    Isgaard, J.3    Casaburi, C.4    Strömer, H.5    Di Gianni, A.6
  • 18
    • 0038206805 scopus 로고    scopus 로고
    • Addition of the selective aldosterone receptor antagonist eplerenone to ACE inhibition in heart failure: effect on endothelial dysfunction
    • Schafer A., Fraccarollo D., Hildemann S.K., Tas P., Ertl G., Bauersachs J. Addition of the selective aldosterone receptor antagonist eplerenone to ACE inhibition in heart failure: effect on endothelial dysfunction. Cardiovasc Res 2003, 58:655-662.
    • (2003) Cardiovasc Res , vol.58 , pp. 655-662
    • Schafer, A.1    Fraccarollo, D.2    Hildemann, S.K.3    Tas, P.4    Ertl, G.5    Bauersachs, J.6
  • 19
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
    • Pitt B., Zannad F., Remme W.J., Cody R., Castaigne A., Perez A., et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999, 341:709-717.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3    Cody, R.4    Castaigne, A.5    Perez, A.6
  • 20
    • 62449296975 scopus 로고    scopus 로고
    • Anti-remodelling effect of canrenone in patients with mild chronic heart failure (AREA IN-CHF study): final results
    • Boccanelli A., Mureddu G.F., Cacciatore G., Clemenza F., Di Lenarda A., Gavazzi A., et al. Anti-remodelling effect of canrenone in patients with mild chronic heart failure (AREA IN-CHF study): final results. Eur J Heart Fail 2009, 11:68-76.
    • (2009) Eur J Heart Fail , vol.11 , pp. 68-76
    • Boccanelli, A.1    Mureddu, G.F.2    Cacciatore, G.3    Clemenza, F.4    Di Lenarda, A.5    Gavazzi, A.6
  • 21
    • 0035168937 scopus 로고    scopus 로고
    • Aldosterone inhibition limits collagen synthesis and progressive left ventricular enlargement after anterior myocardial infarction
    • Modena M.G., Aveta P., Menozzi A., Rossi R. Aldosterone inhibition limits collagen synthesis and progressive left ventricular enlargement after anterior myocardial infarction. Am Heart J 2001, 141:41-46.
    • (2001) Am Heart J , vol.141 , pp. 41-46
    • Modena, M.G.1    Aveta, P.2    Menozzi, A.3    Rossi, R.4
  • 23
    • 79953720277 scopus 로고    scopus 로고
    • Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) trial
    • PEARL-HF Investigators
    • Pitt B., Anker S.D., Bushinsky D.A., Kitzman D.W., Zannad F., Huang I.Z., PEARL-HF Investigators Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) trial. Eur Heart J 2011, 32:820-828.
    • (2011) Eur Heart J , vol.32 , pp. 820-828
    • Pitt, B.1    Anker, S.D.2    Bushinsky, D.A.3    Kitzman, D.W.4    Zannad, F.5    Huang, I.Z.6
  • 25
    • 84555190258 scopus 로고    scopus 로고
    • Emerging drugs which target the renin-angiotensin-aldosterone system
    • Steckelings U.M., Paulis L., Unger T., Bader M. Emerging drugs which target the renin-angiotensin-aldosterone system. Expert Opin Emerg Drugs 2011, 16:619-630.
    • (2011) Expert Opin Emerg Drugs , vol.16 , pp. 619-630
    • Steckelings, U.M.1    Paulis, L.2    Unger, T.3    Bader, M.4
  • 26
    • 77955012886 scopus 로고    scopus 로고
    • Novel therapeutic targets for hypertension
    • Paulis L., Unger T. Novel therapeutic targets for hypertension. Nat Rev Cardiol 2010, 7:431-441.
    • (2010) Nat Rev Cardiol , vol.7 , pp. 431-441
    • Paulis, L.1    Unger, T.2
  • 28
    • 64949189157 scopus 로고    scopus 로고
    • Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt
    • Lea W.B., Kwak E.S., Luther J.M., Fowler S.M., Wang Z., Ma J., et al. Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt. Kidney Int 2009, 75:936-944.
    • (2009) Kidney Int , vol.75 , pp. 936-944
    • Lea, W.B.1    Kwak, E.S.2    Luther, J.M.3    Fowler, S.M.4    Wang, Z.5    Ma, J.6
  • 29
    • 50849123772 scopus 로고    scopus 로고
    • Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone
    • Mulder P., Mellin V., Favre J., Vercauteren M., Remy-Jouet I., Monteil C., et al. Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone. Eur Heart J 2008, 29:2171-2179.
    • (2008) Eur Heart J , vol.29 , pp. 2171-2179
    • Mulder, P.1    Mellin, V.2    Favre, J.3    Vercauteren, M.4    Remy-Jouet, I.5    Monteil, C.6
  • 30
    • 78149238346 scopus 로고    scopus 로고
    • Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism
    • Amar L., Azizi M., Menard J., Peyrard S., Watson C., Plouin P.F. Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism. Hypertension 2010, 56:831-838.
    • (2010) Hypertension , vol.56 , pp. 831-838
    • Amar, L.1    Azizi, M.2    Menard, J.3    Peyrard, S.4    Watson, C.5    Plouin, P.F.6
  • 31
    • 21244485815 scopus 로고    scopus 로고
    • Mineralocorticoid receptors: distribution and activation
    • Funder J.W. Mineralocorticoid receptors: distribution and activation. Heart Fail Rev 2005, 10:15-22.
    • (2005) Heart Fail Rev , vol.10 , pp. 15-22
    • Funder, J.W.1
  • 32
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    • Pitt B., Remme W., Zannad F., Neaton J., Martinez F., Roniker B., et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003, 348:1309-1321.
    • (2003) N Engl J Med , vol.348 , pp. 1309-1321
    • Pitt, B.1    Remme, W.2    Zannad, F.3    Neaton, J.4    Martinez, F.5    Roniker, B.6
  • 34
    • 0034727695 scopus 로고    scopus 로고
    • Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales Investigators
    • Zannad F., Alla F., Dousset B., Perez A., Pitt B. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales Investigators. Circulation 2000, 102:2700-2706.
    • (2000) Circulation , vol.102 , pp. 2700-2706
    • Zannad, F.1    Alla, F.2    Dousset, B.3    Perez, A.4    Pitt, B.5
  • 35
    • 0038526268 scopus 로고    scopus 로고
    • Immediate administration of mineralocorticoid receptor antagonist spironolactone prevents post-infarct left ventricular remodeling associated with suppression of a marker of myocardial collagen synthesis in patients with first anterior acute myocardial infarction
    • Hayashi M., Tsutamoto T., Wada A., Tsutsui T., Ishii C., Ohno K., et al. Immediate administration of mineralocorticoid receptor antagonist spironolactone prevents post-infarct left ventricular remodeling associated with suppression of a marker of myocardial collagen synthesis in patients with first anterior acute myocardial infarction. Circulation 2003, 107:2559-2565.
    • (2003) Circulation , vol.107 , pp. 2559-2565
    • Hayashi, M.1    Tsutamoto, T.2    Wada, A.3    Tsutsui, T.4    Ishii, C.5    Ohno, K.6
  • 36
    • 54149092408 scopus 로고    scopus 로고
    • Plasma aldosterone levels during hospitalization are predictive of survival post-myocardial infarction
    • Palmer B.R., Pilbrow A.P., Frampton C.M., Yandle T.G., Skelton L., Nicholls M.G., et al. Plasma aldosterone levels during hospitalization are predictive of survival post-myocardial infarction. Eur Heart J 2008, 29:2489-2496.
    • (2008) Eur Heart J , vol.29 , pp. 2489-2496
    • Palmer, B.R.1    Pilbrow, A.P.2    Frampton, C.M.3    Yandle, T.G.4    Skelton, L.5    Nicholls, M.G.6
  • 37
  • 39
    • 84868597662 scopus 로고    scopus 로고
    • Eplerenone in patients with systolic heart failure and mild symptoms: analysis of repeat hospitalizations
    • Rogers J.K., McMurray J.J., Pocock S.J., Zannad F., Krum H., van Veldhuisen D.J., et al. Eplerenone in patients with systolic heart failure and mild symptoms: analysis of repeat hospitalizations. Circulation 2012, 126:2317-2323.
    • (2012) Circulation , vol.126 , pp. 2317-2323
    • Rogers, J.K.1    McMurray, J.J.2    Pocock, S.J.3    Zannad, F.4    Krum, H.5    van Veldhuisen, D.J.6
  • 40
    • 84884644195 scopus 로고    scopus 로고
    • Clinical benefit of eplerenone in patients with mild symptoms of systolic heart failure already receiving optimal best practice background drug therapy: analysis of the EMPHASIS-HF study
    • Krum H., Shi H., Pitt B., McMurray J., Swedberg K., van Veldhuisen D.J., et al. Clinical benefit of eplerenone in patients with mild symptoms of systolic heart failure already receiving optimal best practice background drug therapy: analysis of the EMPHASIS-HF study. Circ Heart Fail 2013, 6:711-718.
    • (2013) Circ Heart Fail , vol.6 , pp. 711-718
    • Krum, H.1    Shi, H.2    Pitt, B.3    McMurray, J.4    Swedberg, K.5    van Veldhuisen, D.J.6
  • 41
    • 84884890413 scopus 로고    scopus 로고
    • The impact of eplerenone at different levels of risk in patients with systolic heart failure and mild symptoms: insight from a novel risk score for prognosis derived from the EMPHASIS-HF trial
    • Collier T.J., Pocock S.J., McMurray J.J., Zannad F., Krum H., van Veldhuisen D.J., et al. The impact of eplerenone at different levels of risk in patients with systolic heart failure and mild symptoms: insight from a novel risk score for prognosis derived from the EMPHASIS-HF trial. Eur Heart J 2013, 34:2823-2829.
    • (2013) Eur Heart J , vol.34 , pp. 2823-2829
    • Collier, T.J.1    Pocock, S.J.2    McMurray, J.J.3    Zannad, F.4    Krum, H.5    van Veldhuisen, D.J.6
  • 42
    • 84885845957 scopus 로고    scopus 로고
    • ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
    • Writing Committee Members
    • Writing Committee Members, Yancy C.W., Jessup M., Bozkurt B., Butler J., Casey D.E., Drazner M.H., et al. ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2013, 128:e240-e319.
    • (2013) Circulation , vol.128
    • Yancy, C.W.1    Jessup, M.2    Bozkurt, B.3    Butler, J.4    Casey, D.E.5    Drazner, M.H.6
  • 43
    • 84864493727 scopus 로고    scopus 로고
    • ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC
    • McMurray J.J., Adamopoulos S., Anker S.D., Auricchio A., Böhm M., Dickstein K., et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 2012, 33:1787-1847.
    • (2012) Eur Heart J , vol.33 , pp. 1787-1847
    • McMurray, J.J.1    Adamopoulos, S.2    Anker, S.D.3    Auricchio, A.4    Böhm, M.5    Dickstein, K.6
  • 44
    • 84866732231 scopus 로고    scopus 로고
    • ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation
    • Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC)
    • Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC), Steg P.G., James S.K., Atar D., Badano L.P., Blömstrom-Lundqvist C., Borger M.A., et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 2012, 33:2569-2619.
    • (2012) Eur Heart J , vol.33 , pp. 2569-2619
    • Steg, P.G.1    James, S.K.2    Atar, D.3    Badano, L.P.4    Blömstrom-Lundqvist, C.5    Borger, M.A.6
  • 45
    • 78049243363 scopus 로고    scopus 로고
    • Effect of spironolactone on left ventricular ejection fraction and volumes in patients with class I or II heart failure
    • Vizzardi E., D'Aloia A., Giubbini R., Bordonali T., Bugatti S., Pezzali N., et al. Effect of spironolactone on left ventricular ejection fraction and volumes in patients with class I or II heart failure. Am J Cardiol 2010, 106:1292-1296.
    • (2010) Am J Cardiol , vol.106 , pp. 1292-1296
    • Vizzardi, E.1    D'Aloia, A.2    Giubbini, R.3    Bordonali, T.4    Bugatti, S.5    Pezzali, N.6
  • 46
    • 77954739690 scopus 로고    scopus 로고
    • Randomized, double-blind, multicenter, placebo-controlled study evaluating the effect of aldosterone antagonism with eplerenone on ventricular remodeling in patients with mild-to-moderate heart failure and left ventricular systolic dysfunction
    • Udelson J.E., Feldman A.M., Greenberg B., Pitt B., Mukherjee R., Solomon H.A., et al. Randomized, double-blind, multicenter, placebo-controlled study evaluating the effect of aldosterone antagonism with eplerenone on ventricular remodeling in patients with mild-to-moderate heart failure and left ventricular systolic dysfunction. Circ Heart Fail 2010, 3:347-353.
    • (2010) Circ Heart Fail , vol.3 , pp. 347-353
    • Udelson, J.E.1    Feldman, A.M.2    Greenberg, B.3    Pitt, B.4    Mukherjee, R.5    Solomon, H.A.6
  • 47
    • 34547555364 scopus 로고    scopus 로고
    • Aldosterone receptor antagonism induces reverse remodeling when added to angiotensin receptor blockade in chronic heart failure
    • Chan A.K., Sanderson J.E., Wang T., Lam W., Yip G., Wang M., et al. Aldosterone receptor antagonism induces reverse remodeling when added to angiotensin receptor blockade in chronic heart failure. J Am Coll Cardiol 2007, 50:591-596.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 591-596
    • Chan, A.K.1    Sanderson, J.E.2    Wang, T.3    Lam, W.4    Yip, G.5    Wang, M.6
  • 48
    • 84897116317 scopus 로고    scopus 로고
    • Effects of spironolactone on long-term mortality and morbidity in patients with heart failure and mild or no symptoms
    • Vizzardi E., Nodari S., Caretta G., et al. Effects of spironolactone on long-term mortality and morbidity in patients with heart failure and mild or no symptoms. Am J Med Sci 2014, 347(4):271-276.
    • (2014) Am J Med Sci , vol.347 , Issue.4 , pp. 271-276
    • Vizzardi, E.1    Nodari, S.2    Caretta, G.3
  • 49
    • 84880118241 scopus 로고    scopus 로고
    • The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis
    • Meta-analysis Global Group in Chronic Heart F
    • Meta-analysis Global Group in Chronic Heart F The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis. Eur Heart J 2012, 33:1750-1757.
    • (2012) Eur Heart J , vol.33 , pp. 1750-1757
  • 50
    • 79952829685 scopus 로고    scopus 로고
    • Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment
    • Borlaug B.A., Paulus W.J. Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment. Eur Heart J 2011, 32:670-679.
    • (2011) Eur Heart J , vol.32 , pp. 670-679
    • Borlaug, B.A.1    Paulus, W.J.2
  • 51
    • 70349312455 scopus 로고    scopus 로고
    • Central aortic stiffness is increased in patients with heart failure and preserved ejection fraction
    • Desai A.S., Mitchell G.F., Fang J.C., Creager M.A. Central aortic stiffness is increased in patients with heart failure and preserved ejection fraction. J Card Fail 2009, 15:658-664.
    • (2009) J Card Fail , vol.15 , pp. 658-664
    • Desai, A.S.1    Mitchell, G.F.2    Fang, J.C.3    Creager, M.A.4
  • 52
    • 3543099842 scopus 로고    scopus 로고
    • Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure
    • Mottram P.M., Haluska B., Leano R., Cowley D., Stowasser M., Marwick T.H. Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure. Circulation 2004, 110:558-565.
    • (2004) Circulation , vol.110 , pp. 558-565
    • Mottram, P.M.1    Haluska, B.2    Leano, R.3    Cowley, D.4    Stowasser, M.5    Marwick, T.H.6
  • 53
    • 85047687352 scopus 로고    scopus 로고
    • Impact of mineralocorticoid receptor antagonists on changes in cardiac structure and function of left ventricular dysfunction: a meta-analysis of randomized controlled trials
    • Li X., Qi Y., Li Y., et al. Impact of mineralocorticoid receptor antagonists on changes in cardiac structure and function of left ventricular dysfunction: a meta-analysis of randomized controlled trials. Circ Heart Fail 2013, 6:156-165.
    • (2013) Circ Heart Fail , vol.6 , pp. 156-165
    • Li, X.1    Qi, Y.2    Li, Y.3
  • 54
    • 0036841840 scopus 로고    scopus 로고
    • Aldosterone antagonist improves diastolic function in essential hypertension
    • Grandi A.M., Imperiale D., Santillo R., et al. Aldosterone antagonist improves diastolic function in essential hypertension. Hypertension 2002, 40:647-652.
    • (2002) Hypertension , vol.40 , pp. 647-652
    • Grandi, A.M.1    Imperiale, D.2    Santillo, R.3
  • 55
    • 84874367056 scopus 로고    scopus 로고
    • Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial
    • Edelmann F., Wachter R., Schmidt A.G., et al. Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial. JAMA 2013, 309:781-791.
    • (2013) JAMA , vol.309 , pp. 781-791
    • Edelmann, F.1    Wachter, R.2    Schmidt, A.G.3
  • 56
    • 84877259591 scopus 로고    scopus 로고
    • Baseline characteristics of patients in the treatment of preserved cardiac function heart failure with an aldosterone antagonist trial
    • Shah S.J., Heitner J.F., Sweitzer N.K., et al. Baseline characteristics of patients in the treatment of preserved cardiac function heart failure with an aldosterone antagonist trial. Circ Heart Fail 2013, 6:184-192.
    • (2013) Circ Heart Fail , vol.6 , pp. 184-192
    • Shah, S.J.1    Heitner, J.F.2    Sweitzer, N.K.3
  • 58
    • 0035131479 scopus 로고    scopus 로고
    • Prevention of aortic and cardiac fibrosis by spironolactone in old normotensive rats
    • Lacolley P., Safar M.E., Lucet B., Ledudal K., Labat C., Benetos A. Prevention of aortic and cardiac fibrosis by spironolactone in old normotensive rats. J Am Coll Cardiol 2001, 37:662-667.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 662-667
    • Lacolley, P.1    Safar, M.E.2    Lucet, B.3    Ledudal, K.4    Labat, C.5    Benetos, A.6
  • 59
    • 0026638123 scopus 로고
    • Reactive and reparative myocardial fibrosis in arterial hypertension in the rat
    • Brilla C.G., Weber K.T. Reactive and reparative myocardial fibrosis in arterial hypertension in the rat. Cardiovasc Res 1992, 26:671-677.
    • (1992) Cardiovasc Res , vol.26 , pp. 671-677
    • Brilla, C.G.1    Weber, K.T.2
  • 60
    • 0025266820 scopus 로고
    • Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications
    • Pfeffer M.A., Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation 1990, 81:1161-1172.
    • (1990) Circulation , vol.81 , pp. 1161-1172
    • Pfeffer, M.A.1    Braunwald, E.2
  • 61
    • 57749186656 scopus 로고    scopus 로고
    • Relations of biomarkers representing distinct biological pathways to left ventricular geometry
    • [5p following 8]
    • Velagaleti R.S., Gona P., Levy D., Velagaleti R.S., Gona P., Levy D., et al. Relations of biomarkers representing distinct biological pathways to left ventricular geometry. Circulation 2008, 118:2252-2258. [5p following 8].
    • (2008) Circulation , vol.118 , pp. 2252-2258
    • Velagaleti, R.S.1    Gona, P.2    Levy, D.3    Velagaleti, R.S.4    Gona, P.5    Levy, D.6
  • 62
    • 80155151956 scopus 로고    scopus 로고
    • Aldosterone, mineralocorticoid receptor activation, and cardiovascular remodeling
    • Leopold J.A. Aldosterone, mineralocorticoid receptor activation, and cardiovascular remodeling. Circulation 2011, 124:e466-e468.
    • (2011) Circulation , vol.124
    • Leopold, J.A.1
  • 63
    • 0035726137 scopus 로고    scopus 로고
    • Biochemical assessment of myocardial fibrosis in hypertensive heart disease
    • Lopez B., Gonzalez A., Varo N., Laviades C., Querejeta R., Diez J. Biochemical assessment of myocardial fibrosis in hypertensive heart disease. Hypertension 2001, 38:1222-1226.
    • (2001) Hypertension , vol.38 , pp. 1222-1226
    • Lopez, B.1    Gonzalez, A.2    Varo, N.3    Laviades, C.4    Querejeta, R.5    Diez, J.6
  • 64
    • 66549112420 scopus 로고    scopus 로고
    • Extracellular cardiac matrix biomarkers in patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure: insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) study
    • Iraqi W., Rossignol P., Angioi M., et al. Extracellular cardiac matrix biomarkers in patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure: insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) study. Circulation 2009, 119:2471-2479.
    • (2009) Circulation , vol.119 , pp. 2471-2479
    • Iraqi, W.1    Rossignol, P.2    Angioi, M.3
  • 65
    • 70349990209 scopus 로고    scopus 로고
    • Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone
    • Mak G.J., Ledwidge M.T., Watson C.J., et al. Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone. J Am Coll Cardiol 2009, 54:1674-1682.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1674-1682
    • Mak, G.J.1    Ledwidge, M.T.2    Watson, C.J.3
  • 66
    • 78149424364 scopus 로고    scopus 로고
    • Effect of spironolactone on left ventricular systolic and diastolic function in patients with early stage chronic kidney disease
    • Edwards N.C., Ferro C.J., Kirkwood H., et al. Effect of spironolactone on left ventricular systolic and diastolic function in patients with early stage chronic kidney disease. Am J Cardiol 2010, 106:1505-1511.
    • (2010) Am J Cardiol , vol.106 , pp. 1505-1511
    • Edwards, N.C.1    Ferro, C.J.2    Kirkwood, H.3
  • 67
    • 27744459326 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: a pilot study
    • Izawa H., Murohara T., Nagata K., et al. Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: a pilot study. Circulation 2005, 112:2940-2945.
    • (2005) Circulation , vol.112 , pp. 2940-2945
    • Izawa, H.1    Murohara, T.2    Nagata, K.3
  • 68
    • 84874105560 scopus 로고    scopus 로고
    • Fibrosis and cardiac function in obesity: a randomised controlled trial of aldosterone blockade
    • Kosmala W., Przewlocka-Kosmala M., Szczepanik-Osadnik H., Mysiak A., Marwick T.H. Fibrosis and cardiac function in obesity: a randomised controlled trial of aldosterone blockade. Heart 2013, 99:320-326.
    • (2013) Heart , vol.99 , pp. 320-326
    • Kosmala, W.1    Przewlocka-Kosmala, M.2    Szczepanik-Osadnik, H.3    Mysiak, A.4    Marwick, T.H.5
  • 69
    • 0035714567 scopus 로고    scopus 로고
    • Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients
    • Laurent S., Boutouyrie P., Asmar R., et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001, 37:1236-1241.
    • (2001) Hypertension , vol.37 , pp. 1236-1241
    • Laurent, S.1    Boutouyrie, P.2    Asmar, R.3
  • 70
    • 0012666855 scopus 로고    scopus 로고
    • Aortic stiffness is an independent predictor of fatal stroke in essential hypertension
    • Laurent S., Katsahian S., Fassot C., et al. Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke 2003, 34:1203-1206.
    • (2003) Stroke , vol.34 , pp. 1203-1206
    • Laurent, S.1    Katsahian, S.2    Fassot, C.3
  • 71
    • 43049102796 scopus 로고    scopus 로고
    • Arterial stiffness and vascular load in heart failure
    • Ooi H., Chung W., Biolo A. Arterial stiffness and vascular load in heart failure. Congest Heart Fail 2008, 14:31-36.
    • (2008) Congest Heart Fail , vol.14 , pp. 31-36
    • Ooi, H.1    Chung, W.2    Biolo, A.3
  • 72
    • 64749092668 scopus 로고    scopus 로고
    • Proximal aortic stiffness is related to left ventricular function and exercise capacity in patients with dilated cardiomyopathy
    • Patrianakos A.P., Parthenakis F.I., Karakitsos D., Nyktari E., Vardas P.E. Proximal aortic stiffness is related to left ventricular function and exercise capacity in patients with dilated cardiomyopathy. Eur J Echocardiogr 2009, 10:425-432.
    • (2009) Eur J Echocardiogr , vol.10 , pp. 425-432
    • Patrianakos, A.P.1    Parthenakis, F.I.2    Karakitsos, D.3    Nyktari, E.4    Vardas, P.E.5
  • 73
    • 0037381647 scopus 로고    scopus 로고
    • Aortic distensibility independently affects exercise tolerance in patients with dilated cardiomyopathy
    • Bonapace S., Rossi A., Cicoira M., et al. Aortic distensibility independently affects exercise tolerance in patients with dilated cardiomyopathy. Circulation 2003, 107:1603-1608.
    • (2003) Circulation , vol.107 , pp. 1603-1608
    • Bonapace, S.1    Rossi, A.2    Cicoira, M.3
  • 75
    • 0037180412 scopus 로고    scopus 로고
    • Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone
    • Lacolley P., Labat C., Pujol A., Delcayre C., Benetos A., Safar M. Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone. Circulation 2002, 106:2848-2853.
    • (2002) Circulation , vol.106 , pp. 2848-2853
    • Lacolley, P.1    Labat, C.2    Pujol, A.3    Delcayre, C.4    Benetos, A.5    Safar, M.6
  • 76
    • 23644435630 scopus 로고    scopus 로고
    • Spironolactone improves carotid artery fibrosis and distensibility in rat post-ischaemic heart failure
    • Nehme J.A., Lacolley P., Labat C., et al. Spironolactone improves carotid artery fibrosis and distensibility in rat post-ischaemic heart failure. J Mol Cell Cardiol 2005, 39:511-519.
    • (2005) J Mol Cell Cardiol , vol.39 , pp. 511-519
    • Nehme, J.A.1    Lacolley, P.2    Labat, C.3
  • 77
    • 34250321620 scopus 로고    scopus 로고
    • The influence of serum aldosterone and the aldosterone-renin ratio on pulse wave velocity in hypertensive patients
    • Park S., Kim J.B., Shim C.Y., et al. The influence of serum aldosterone and the aldosterone-renin ratio on pulse wave velocity in hypertensive patients. J Hypertens 2007, 25:1279-1283.
    • (2007) J Hypertens , vol.25 , pp. 1279-1283
    • Park, S.1    Kim, J.B.2    Shim, C.Y.3
  • 78
    • 80053380047 scopus 로고    scopus 로고
    • Long-term use of low-dose spironolactone in spontaneously hypertensive rats: effects on left ventricular hypertrophy and stiffness
    • Baldo M.P., Forechi L., Morra E.A., et al. Long-term use of low-dose spironolactone in spontaneously hypertensive rats: effects on left ventricular hypertrophy and stiffness. Pharmacol Rep 2011, 63:975-982.
    • (2011) Pharmacol Rep , vol.63 , pp. 975-982
    • Baldo, M.P.1    Forechi, L.2    Morra, E.A.3
  • 79
    • 77954324475 scopus 로고    scopus 로고
    • Spironolactone and hydrochlorothiazide decrease vascular stiffness and blood pressure in geriatric hypertension
    • Kithas P.A., Supiano M.A. Spironolactone and hydrochlorothiazide decrease vascular stiffness and blood pressure in geriatric hypertension. J Am Geriatr Soc 2010, 58:1327-1332.
    • (2010) J Am Geriatr Soc , vol.58 , pp. 1327-1332
    • Kithas, P.A.1    Supiano, M.A.2
  • 80
    • 0142085752 scopus 로고    scopus 로고
    • Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study
    • Pitt B., Reichek N., Willenbrock R., et al. Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation 2003, 108:1831-1838.
    • (2003) Circulation , vol.108 , pp. 1831-1838
    • Pitt, B.1    Reichek, N.2    Willenbrock, R.3
  • 81
    • 20544464438 scopus 로고    scopus 로고
    • Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias
    • Ouvrard-Pascaud A., Sainte-Marie Y., Benitah J.P., et al. Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias. Circulation 2005, 111:3025-3033.
    • (2005) Circulation , vol.111 , pp. 3025-3033
    • Ouvrard-Pascaud, A.1    Sainte-Marie, Y.2    Benitah, J.P.3
  • 82
    • 22844437062 scopus 로고    scopus 로고
    • Eplerenone reduces mortality 30days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure
    • Pitt B., White H., Nicolau J., et al. Eplerenone reduces mortality 30days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure. J Am Coll Cardiol 2005, 46:425-431.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 425-431
    • Pitt, B.1    White, H.2    Nicolau, J.3
  • 83
    • 84877245602 scopus 로고    scopus 로고
    • Effects of mineralocorticoid receptor antagonists on the risk of sudden cardiac death in patients with left ventricular systolic dysfunction: a meta-analysis of randomized controlled trials
    • Bapoje S.R., Bahia A., Hokanson J.E., et al. Effects of mineralocorticoid receptor antagonists on the risk of sudden cardiac death in patients with left ventricular systolic dysfunction: a meta-analysis of randomized controlled trials. Circ Heart Fail 2013, 6:166-173.
    • (2013) Circ Heart Fail , vol.6 , pp. 166-173
    • Bapoje, S.R.1    Bahia, A.2    Hokanson, J.E.3
  • 84
    • 4143113285 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonism prevents the electrical remodeling that precedes cellular hypertrophy after myocardial infarction
    • Perrier E., Kerfant B.G., Lalevee N., et al. Mineralocorticoid receptor antagonism prevents the electrical remodeling that precedes cellular hypertrophy after myocardial infarction. Circulation 2004, 110:776-783.
    • (2004) Circulation , vol.110 , pp. 776-783
    • Perrier, E.1    Kerfant, B.G.2    Lalevee, N.3
  • 85
    • 0007731069 scopus 로고
    • The influence of aldosterone on magnesium metabolism
    • Hanna S., Mac I.I. The influence of aldosterone on magnesium metabolism. Lancet 1960, 2:348-350.
    • (1960) Lancet , vol.2 , pp. 348-350
    • Hanna, S.1    Mac, I.I.2
  • 86
    • 34247157767 scopus 로고    scopus 로고
    • Spironolactone reduced arrhythmia and maintained magnesium homeostasis in patients with congestive heart failure
    • Gao X., Peng L., Adhikari C.M., Lin J., Zuo Z. Spironolactone reduced arrhythmia and maintained magnesium homeostasis in patients with congestive heart failure. J Card Fail 2007, 13:170-177.
    • (2007) J Card Fail , vol.13 , pp. 170-177
    • Gao, X.1    Peng, L.2    Adhikari, C.M.3    Lin, J.4    Zuo, Z.5
  • 87
    • 0020348343 scopus 로고
    • The effect of potassium canrenoate (aldactone) on the norepinephrine metabolism and potassium ionic currents of the heart
    • Antaloczy Z., Sebeszta M., Preda I. The effect of potassium canrenoate (aldactone) on the norepinephrine metabolism and potassium ionic currents of the heart. Adv Myocardiol 1982, 3:215-222.
    • (1982) Adv Myocardiol , vol.3 , pp. 215-222
    • Antaloczy, Z.1    Sebeszta, M.2    Preda, I.3
  • 88
    • 0037454044 scopus 로고    scopus 로고
    • Effect of spironolactone on cardiac sympathetic nerve activity and left ventricular remodeling in patients with dilated cardiomyopathy
    • Kasama S., Toyama T., Kumakura H., et al. Effect of spironolactone on cardiac sympathetic nerve activity and left ventricular remodeling in patients with dilated cardiomyopathy. J Am Coll Cardiol 2003, 41:574-581.
    • (2003) J Am Coll Cardiol , vol.41 , pp. 574-581
    • Kasama, S.1    Toyama, T.2    Kumakura, H.3
  • 89
    • 26044461618 scopus 로고    scopus 로고
    • Spironolactone reduces fibrosis of dilated atria during heart failure in rats with myocardial infarction
    • Milliez P., Deangelis N., Rucker-Martin C., et al. Spironolactone reduces fibrosis of dilated atria during heart failure in rats with myocardial infarction. Eur Heart J 2005, 26:2193-2199.
    • (2005) Eur Heart J , vol.26 , pp. 2193-2199
    • Milliez, P.1    Deangelis, N.2    Rucker-Martin, C.3
  • 91
    • 20344396863 scopus 로고    scopus 로고
    • Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis
    • Healey J.S., Baranchuk A., Crystal E., et al. Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis. J Am Coll Cardiol 2005, 45:1832-1839.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1832-1839
    • Healey, J.S.1    Baranchuk, A.2    Crystal, E.3
  • 93
    • 84860309326 scopus 로고    scopus 로고
    • Eplerenone and atrial fibrillation in mild systolic heart failure: results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) study
    • Swedberg K., Zannad F., McMurray J.J., et al. Eplerenone and atrial fibrillation in mild systolic heart failure: results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) study. J Am Coll Cardiol 2012, 59:1598-1603.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 1598-1603
    • Swedberg, K.1    Zannad, F.2    McMurray, J.J.3
  • 94
    • 34250329441 scopus 로고    scopus 로고
    • Added benefit of mineralocorticoid receptor blockade in the primary prevention of sudden cardiac death
    • [discussion 82]
    • Pitt B., Pitt G.S. Added benefit of mineralocorticoid receptor blockade in the primary prevention of sudden cardiac death. Circulation 2007, 115:2976-2982. [discussion 82].
    • (2007) Circulation , vol.115 , pp. 2976-2982
    • Pitt, B.1    Pitt, G.S.2
  • 95
    • 0028860490 scopus 로고
    • Effects of adding spironolactone to an angiotensin-converting enzyme inhibitor in chronic congestive heart failure secondary to coronary artery disease
    • Barr C.S., Lang C.C., Hanson J., Arnott M., Kennedy N., Struthers A.D. Effects of adding spironolactone to an angiotensin-converting enzyme inhibitor in chronic congestive heart failure secondary to coronary artery disease. Am J Cardiol 1995, 76:1259-1265.
    • (1995) Am J Cardiol , vol.76 , pp. 1259-1265
    • Barr, C.S.1    Lang, C.C.2    Hanson, J.3    Arnott, M.4    Kennedy, N.5    Struthers, A.D.6
  • 96
    • 0035312341 scopus 로고    scopus 로고
    • Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure
    • Tsutamoto T., Wada A., Maeda K., et al. Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure. J Am Coll Cardiol 2001, 37:1228-1233.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 1228-1233
    • Tsutamoto, T.1    Wada, A.2    Maeda, K.3
  • 97
    • 0037125404 scopus 로고    scopus 로고
    • Long-term, dose-dependent effects of spironolactone on left ventricular function and exercise tolerance in patients with chronic heart failure
    • Cicoira M., Zanolla L., Rossi A., et al. Long-term, dose-dependent effects of spironolactone on left ventricular function and exercise tolerance in patients with chronic heart failure. J Am Coll Cardiol 2002, 40:304-310.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 304-310
    • Cicoira, M.1    Zanolla, L.2    Rossi, A.3
  • 98
    • 2542418105 scopus 로고    scopus 로고
    • Effects of spironolactone and metoprolol on QT dispersion in heart failure
    • Akbulut M., Ozbay Y., Ilkay E., Karaca I., Arslan N. Effects of spironolactone and metoprolol on QT dispersion in heart failure. Jpn Heart J 2003, 44:681-692.
    • (2003) Jpn Heart J , vol.44 , pp. 681-692
    • Akbulut, M.1    Ozbay, Y.2    Ilkay, E.3    Karaca, I.4    Arslan, N.5
  • 99
    • 41749096636 scopus 로고    scopus 로고
    • Probrain natriuretic peptide for assessment of efficacy in heart failure treatment
    • Ozkara A., Turgut F., Selcoki Y., et al. Probrain natriuretic peptide for assessment of efficacy in heart failure treatment. Adv Ther 2007, 24:1233-1239.
    • (2007) Adv Ther , vol.24 , pp. 1233-1239
    • Ozkara, A.1    Turgut, F.2    Selcoki, Y.3
  • 100
    • 36849009582 scopus 로고    scopus 로고
    • Additive effects of spironolactone and candesartan on cardiac sympathetic nerve activity and left ventricular remodeling in patients with congestive heart failure
    • Kasama S., Toyama T., Sumino H., et al. Additive effects of spironolactone and candesartan on cardiac sympathetic nerve activity and left ventricular remodeling in patients with congestive heart failure. J Nucl Med 2007, 48:1993-2000.
    • (2007) J Nucl Med , vol.48 , pp. 1993-2000
    • Kasama, S.1    Toyama, T.2    Sumino, H.3
  • 101
    • 67649770575 scopus 로고    scopus 로고
    • Spironolactone in chronic hemodialysis patients improves cardiac function
    • Taheri S., Mortazavi M., Shahidi S., et al. Spironolactone in chronic hemodialysis patients improves cardiac function. Saudi J Kidney Dis Transpl 2009, 20:392-397.
    • (2009) Saudi J Kidney Dis Transpl , vol.20 , pp. 392-397
    • Taheri, S.1    Mortazavi, M.2    Shahidi, S.3
  • 102
    • 79951951967 scopus 로고    scopus 로고
    • Effects of mineralocorticoid receptor antagonist spironolactone on atrial conduction and remodeling in patients with heart failure
    • Kimura M., Ogawa H., Wakeyama T., et al. Effects of mineralocorticoid receptor antagonist spironolactone on atrial conduction and remodeling in patients with heart failure. J Cardiol 2011, 57:208-214.
    • (2011) J Cardiol , vol.57 , pp. 208-214
    • Kimura, M.1    Ogawa, H.2    Wakeyama, T.3


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