Immediate administration of mineralocorticoid receptor antagonist spironolactone prevents post-infarct left ventricular remodeling associated with suppression of a marker of myocardial collagen synthesis in patients with first anterior acute myocardial infarction

Circulation

Volumn 107, Issue 20, 2003, Pages 2559-2565

  Hayashi, Masaru ^a   Tsutamoto, Takayoshi ^b   Wada, Atsuyuki ^b   Tsutsui, Takashi ^b   Ishii, Chitose ^b   Ohno, Keijin ^b   Fujii, Masanori ^b   Taniguchi, Atsushi ^a   Hamatani, Tomokazu ^a   Nozato, Yoshitaka ^a   Kataoka, Ken ^a   Morigami, Naoki ^a   Ohnishi, Masato ^b   Kinoshita, Masahiko ^b   Horie, Minoru ^b  

^a NAGAHAMA CITY HOSPITAL   (Japan)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Collagen; Myocardial infarction; Remodeling; Ventricles

Indexed keywords

ALDOSTERONE; CANRENOIC ACID; COLLAGEN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; MINERALOCORTICOID ANTAGONIST; MINERALOCORTICOID RECEPTOR; PROCOLLAGEN TYPE 3 AMINOPROPEPTIDE; SPIRONOLACTONE;

ACUTE HEART INFARCTION; ADULT; AGED; AORTA ROOT; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CORONARY SINUS; DISEASE COURSE; EXTRACTION; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART MUSCLE FIBROSIS; HEART MUSCLE REVASCULARIZATION; HEART VENTRICLE REMODELING; HEART VENTRICULOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADRENERGIC BETA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; BIOLOGICAL MARKERS; COLLAGEN; DRUG THERAPY, COMBINATION; FEMALE; HEMODYNAMIC PROCESSES; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; MYOCARDIUM; PEPTIDE FRAGMENTS; PROCOLLAGEN; PROSPECTIVE STUDIES; RECEPTORS, MINERALOCORTICOID; SPIRONOLACTONE; STROKE VOLUME; VENTRICULAR REMODELING;

EID: 0038526268     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000068340.96506.0F     Document Type: Article

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