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Volumn 9, Issue 3, 2014, Pages 227-234

Cytokines as villains and potential therapeutic targets in thyroid-associated ophthalmopathy: From bench to bedside

Author keywords

Autoimmunity; Cytokines; Graves' disease; Graves' orbitopathy; Inflammation; Interleukins; Thyroid associated ophthalmopathy

Indexed keywords

ADALIMUMAB; BRODALUMAB; CYTOKINE; ETANERCEPT; INFLIXIMAB; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 23 ANTIBODY; INTERLEUKIN 6; IXEKIZUMAB; METHOTREXATE; PLACEBO; RITUXIMAB; SECUKINUMAB; TEPROTUMUMAB; TOCILIZUMAB; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; USTEKINUMAB;

EID: 84901280800     PISSN: 17469899     EISSN: 17469902     Source Type: Journal    
DOI: 10.1586/17469899.2014.917960     Document Type: Review
Times cited : (24)

References (92)
  • 1
    • 0020557747 scopus 로고
    • TSH receptor binding and thyroid stimulation by sera from patients with Graves' disease
    • Ginsberg J, Shewring G, Smith BR. TSH receptor binding and thyroid stimulation by sera from patients with Graves' disease. Clin Endocrinol (Oxf) 1983;19:305-11 (Pubitemid 13037224
    • (1983) Clinical Endocrinology , vol.19 , Issue.3 , pp. 305-311
    • Ginsberg, J.1    Shewring, G.2    Rees Smith, B.3
  • 2
    • 0027280209 scopus 로고
    • Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue
    • DOI 10.1016/0140-6736(93)91475-2
    • Feliciello A, Porcellini A, Ciullo I, et al. Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue. Lancet 1993;342:337-8 (Pubitemid 23227563
    • (1993) Lancet , vol.342 , Issue.8867 , pp. 337-338
    • Feliciello, A.1    Porcellini, A.2    Ciullo, I.3    Bonavolonta, G.4    Avvedimento, E.V.5    Fenzi, G.6
  • 3
    • 0030981965 scopus 로고    scopus 로고
    • TSH receptor transcripts and TSH receptor-like immunoreactivity in orbital and pretibial fibroblasts of patients with Graves' ophthalmopathy and pretibial myxedema
    • Stadlmayr W, Spitzweg C, Bichlmair AM, Heufelder AE. TSH receptor transcripts and TSH receptor-like immunoreactivity in orbital and pretibial fibroblasts of patients with Graves' ophthalmopathy and pretibial myxedema. Thyroid 1997;7:3-12 (Pubitemid 27132889
    • (1997) Thyroid , vol.7 , Issue.1 , pp. 3-12
    • Stadlmayr, W.1    Spitzweg, C.2    Bichlmair, A.-M.3    Heufelder, A.E.4
  • 4
    • 33645060226 scopus 로고    scopus 로고
    • Thyroid-stimulating hormone stimulates interleukin-6 release from 3T3-L1 adipocytes through a cAMP-protein kinase A pathway
    • Antunes TT, Gagnon A, Bell A, Sorisky A. Thyroid-stimulating hormone stimulates interleukin-6 release from 3T3-L1 adipocytes through a cAMP-protein kinase A pathway. Obes Res 2005;13:2066-71
    • (2005) Obes Res , vol.13 , pp. 2066-2071
    • Antunes, T.T.1    Gagnon, A.2    Bell, A.3    Sorisky, A.4
  • 6
    • 75149145428 scopus 로고    scopus 로고
    • Increased generation of fibrocytes in thyroid-Associated ophthalmopathy
    • Douglas RS, Afifiyan NF, Hwang CJ, et al. Increased generation of fibrocytes in thyroid-Associated ophthalmopathy. J Clin Endocrinol Metab 2010;95:430-8
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 430-438
    • Douglas, R.S.1    Afifiyan, N.F.2    Hwang, C.J.3
  • 7
    • 75149141288 scopus 로고    scopus 로고
    • Astimulatory thyrotropin receptor antibody (M22) and thyrotropin increase interleukin-6 expression and secretion in Graves' orbital preadipocyte fibroblasts
    • Kumar S, Schiefer R, Coenen MJ, Bahn RS A stimulatory thyrotropin receptor antibody (M22) and thyrotropin increase interleukin-6 expression and secretion in Graves' orbital preadipocyte fibroblasts. Thyroid 2010;20:59-65
    • (2010) Thyroid , vol.20 , pp. 59-65
    • Kumar, S.1    Schiefer, R.2    Coenen, M.J.3    Bahn, R.S.4
  • 8
    • 84872176452 scopus 로고    scopus 로고
    • Interleukin-6 production in CD40-engaged fibrocytes in thyroid-Associated ophthalmopathy: Involvement of Akt and NF-kB
    • Gillespie EF, Raychaudhuri N, Papageorgiou KI, et al. Interleukin-6 production in CD40-engaged fibrocytes in thyroid-Associated ophthalmopathy: Involvement of Akt and NF-kB. Invest Ophthalmol Vis Sci 2012;53:7746-53
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 7746-7753
    • Gillespie, E.F.1    Raychaudhuri, N.2    Papageorgiou, K.I.3
  • 9
    • 84884552072 scopus 로고    scopus 로고
    • Thyrotropin regulates il-6 expression in CD34(+) fibrocytes: Clear delineation of its cAMP-independent actions
    • Raychaudhuri N, Fernando R, Smith TJ. Thyrotropin regulates il-6 expression in CD34(+) fibrocytes: Clear delineation of its cAMP-independent actions. PLoS One 2013;8:e75100
    • (2013) PLoS One , vol.8
    • Raychaudhuri, N.1    Fernando, R.2    Smith, T.J.3
  • 10
    • 84898417162 scopus 로고    scopus 로고
    • Regulation of IL-1 receptor antagonist by TSH in fibrocytes and orbital fibroblasts
    • Li B, Smith TJ. Regulation of IL-1 receptor antagonist by TSH in fibrocytes and orbital fibroblasts. J Clin Endocrinol Metab 2014; 99(4):E625-33
    • (2014) J Clin Endocrinol Metab , vol.99 , Issue.4
    • Li, B.1    Smith, T.J.2
  • 11
    • 84880257603 scopus 로고    scopus 로고
    • How Cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases
    • Baeten DL, Kuchroo VK. How Cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases. Nat Med 2013;19:824-5
    • (2013) Nat Med , vol.19 , pp. 824-825
    • Baeten, D.L.1    Kuchroo, V.K.2
  • 12
    • 84931269017 scopus 로고    scopus 로고
    • Therapeutic human monoclonal antibodies in inflammatory diseases
    • In: Michael Steinitz, editor Volume 1060 Springer Science+Business Media; LLC; PA, USA: 2014
    • Kotsovilis S, Andreakos E. Therapeutic Human Monoclonal Antibodies in inflammatory diseases. In: Michael Steinitz, editor. Human monoclonal antibodies: Methods and protocols, methods in molecular biology. Volume 1060 Springer Science+Business Media; LLC; PA, USA: 2014;36-59
    • Human Monoclonal Antibodies: Methods and Protocols, Methods in Molecular Biology , pp. 36-59
    • Kotsovilis, S.1    Andreakos, E.2
  • 14
    • 0027459740 scopus 로고
    • Detection and localization of cytokine immunoreactivity in retro-ocular connective tissue in Graves' ophthalmopathy
    • Heufelder AE, Bahn RS. Detection and localization of cytokine immunoreactivity in retro-ocular connective tissue in Graves' ophthalmopathy. Eur J Clin Invest 1993;23: 10-17 (Pubitemid 23024965
    • (1993) European Journal of Clinical Investigation , vol.23 , Issue.1 , pp. 10-17
    • Heufelder, A.E.1    Bahn, R.S.2
  • 15
    • 33847665946 scopus 로고    scopus 로고
    • Circulating mononuclear cells from euthyroid patients with thyroid-Associated ophthalmopathy exhibit characteristic phenotypes
    • DOI 10.1111/j.1365-2249.2006.03316.x
    • Douglas RS, Gianoukakis AG, Goldberg RA, et al. Circulating mononuclear cells from euthyroid patients with thyroid-Associated ophthalmopathy exhibit characteristic phenotypes. Clin Exp Immunol 2007;148:64-71 (Pubitemid 46364986
    • (2007) Clinical and Experimental Immunology , vol.148 , Issue.1 , pp. 64-71
    • Douglas, R.S.1    Gianoukakis, A.G.2    Goldberg, R.A.3    Kamat, S.4    Smith, T.J.5
  • 16
    • 33847390014 scopus 로고    scopus 로고
    • Aberrant expression of the insulin-like growth factor-1 receptor by T cells from patients with Graves' disease may carry functional consequences for disease pathogenesis
    • Douglas RS, Gianoukakis AG, Kamat S, Smith TJ. Aberrant expression of the insulin-like growth factor-1 receptor by T cells from patients with Graves' disease may carry functional consequences for disease pathogenesis. J Immunol 2007;178:3281-7 (Pubitemid 46333212
    • (2007) Journal of Immunology , vol.178 , Issue.5 , pp. 3281-3287
    • Douglas, R.S.1    Gianoukakis, A.G.2    Kamat, S.3    Smith, T.J.4
  • 17
    • 54049100737 scopus 로고    scopus 로고
    • B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: Implications for disease pathogenesis
    • Douglas RS, Naik V, Hwang CJ, et al. B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: Implications for disease pathogenesis. J Immunol 2008;181:5768-74
    • (2008) J Immunol , vol.181 , pp. 5768-5774
    • Douglas, R.S.1    Naik, V.2    Hwang, C.J.3
  • 19
    • 0028535872 scopus 로고
    • Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair
    • Bucala R, Spiegel LA, Chesney J, et al. Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1994;1:71-81
    • (1994) Mol Med , vol.1 , pp. 71-81
    • Bucala, R.1    Spiegel, L.A.2    Chesney, J.3
  • 20
    • 84860708795 scopus 로고    scopus 로고
    • Increased expression of TSH receptor by fibrocytes in thyroid-Associated ophthalmopathy leads to chemokine production
    • Gillespie EF, Papageorgiou KI, Fernando R, et al. Increased expression of TSH receptor by fibrocytes in thyroid-Associated ophthalmopathy leads to chemokine production. J Clin Endocrinol Metab 2012;97:E740-6
    • (2012) J Clin Endocrinol Metab , vol.97
    • Gillespie, E.F.1    Papageorgiou, K.I.2    Fernando, R.3
  • 21
    • 83155177164 scopus 로고    scopus 로고
    • Fibroblasts expressing the thyrotropin receptor overarch thyroid and orbit in Graves' disease
    • Smith TJ, Padovani-Claudio DA, Lu Y, et al. Fibroblasts expressing the thyrotropin receptor overarch thyroid and orbit in Graves' disease. J Clin Endocrinol Metab 2011;96:3827-37
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 3827-3837
    • Smith, T.J.1    Padovani-Claudio, D.A.2    Lu, Y.3
  • 22
    • 84860828338 scopus 로고    scopus 로고
    • Human fibrocytes coexpress thyroglobulin and thyrotropin receptor
    • Fernando R, Atkins S, Raychaudhuri N, et al. Human fibrocytes coexpress thyroglobulin and thyrotropin receptor. Proc Natl Acad Sci U S A 2012;109: 7427-32
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 7427-7432
    • Fernando, R.1    Atkins, S.2    Raychaudhuri, N.3
  • 23
    • 0001975353 scopus 로고
    • Periocular mesenchyme: Neural crest and mesodermal interactions
    • In: Jakobiec FA, editor Harper and Row; Philadelphia, PA, USA:
    • Noden DM. Periocular mesenchyme: Neural crest and mesodermal interactions. In: Jakobiec FA, editor. Ocular anatomy, embryology and teratology. Volume 97 Harper and Row; Philadelphia, PA, USA: 1982. p. 119
    • (1982) Ocular Anatomy, Embryology and Teratology , vol.97 , pp. 119
    • Noden, D.M.1
  • 24
    • 0026753097 scopus 로고
    • Interferon-gamma is an inducer of plasminogen activator inhibitor type 1 in human orbital fibroblasts
    • Smith TJ, Ahmed A, Hogg MG, Higgins PJ. Interferon-gamma is an inducer of plasminogen activator inhibitor type 1 in human orbital fibroblasts. Am J Physiol 1992;263:C24-9
    • (1992) Am J Physiol , vol.263
    • Smith, T.J.1    Ahmed, A.2    Hogg, M.G.3    Higgins, P.J.4
  • 25
    • 0028978019 scopus 로고
    • Transforming growth factor-beta induces plasminogen activator inhibitor type-1 in cultured human orbital fibroblasts
    • Cao HJ, Hogg MG, Martino LJ, Smith TJ. Transforming growth factor-beta induces plasminogen activator inhibitor type-1 in cultured human orbital fibroblasts. Invest Ophthalmol Vis Sci 1995;36:1411-19
    • (1995) Invest Ophthalmol Vis Sci , vol.36 , pp. 1411-1419
    • Cao, H.J.1    Hogg, M.G.2    Martino, L.J.3    Smith, T.J.4
  • 26
    • 0036694589 scopus 로고    scopus 로고
    • IL-6 in autoimmune disease and chronic inflammatory proliferative disease
    • Ishihara K, Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev 2002;13(4-5):357-68
    • (2002) Cytokine Growth Factor Rev , vol.13 , Issue.4-5 , pp. 357-368
    • Ishihara, K.1    Hirano, T.2
  • 27
    • 84872742022 scopus 로고    scopus 로고
    • Cutting edge: IL-6-dependent autoimmune disease: Dendritic cells as a sufficient, but transient, source
    • Leech MD, Barr TA, Turner DG, et al. Cutting edge: IL-6-dependent autoimmune disease: Dendritic cells as a sufficient, but transient, source. J Immunol 2013;190(3): 881-5
    • (2013) J Immunol , vol.190 , Issue.3 , pp. 881-885
    • Leech, M.D.1    Barr, T.A.2    Turner, D.G.3
  • 28
    • 77954096689 scopus 로고    scopus 로고
    • IL-6: Regulator of Treg/Th17 balance
    • Kimura A, Kishimoto T. IL-6: Regulator of Treg/Th17 balance. Eur J Immunol 2010; 40(7):1830-5
    • (2010) Eur J Immunol , vol.40 , Issue.7 , pp. 1830-1835
    • Kimura, A.1    Kishimoto, T.2
  • 29
    • 84887017618 scopus 로고    scopus 로고
    • Anti-cytokine therapies in t1d: Concepts and strategies
    • Nepom GT, Ehlers M, Mandrup-Poulsen T. Anti-cytokine therapies in T1D: Concepts and strategies. Clin Immunol 2013;149(3): 279-85
    • (2013) Clin Immunol , vol.149 , Issue.3 , pp. 279-285
    • Nepom, G.T.1    Ehlers, M.2    Mandrup-Poulsen, T.3
  • 30
    • 0031978328 scopus 로고    scopus 로고
    • Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production
    • Sempowski GD, Rozenblit J, Smith TJ, Phipps RP. Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production. Am J Physiol 1998;274:C707-14
    • (1998) Am J Physiol , vol.274
    • Sempowski, G.D.1    Rozenblit, J.2    Smith, T.J.3    Phipps, R.P.4
  • 31
    • 65549134290 scopus 로고    scopus 로고
    • Orbital fibroblasts from patients with thyroid-Associated ophthalmopathy overexpress cd40: Cd154 hyperinduces il-6, IL-8, and MCP-1
    • Hwang CJ, Afifiyan N, Sand D, et al. Orbital fibroblasts from patients with thyroid-Associated ophthalmopathy overexpress CD40: CD154 hyperinduces IL-6, IL-8, and MCP-1. Invest Ophthalmol Vis Sci 2009;50:2262-8
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 2262-2268
    • Hwang, C.J.1    Afifiyan, N.2    Sand, D.3
  • 32
    • 78650837135 scopus 로고    scopus 로고
    • PGE2 induces IL-6 in orbital fibroblasts through EP2 receptors and increased gene promoter activity: Implications to thyroid-Associated ophthalmopathy
    • Raychaudhuri N, Douglas RS, Smith TJ. PGE2 induces IL-6 in orbital fibroblasts through EP2 receptors and increased gene promoter activity: Implications to thyroid-Associated ophthalmopathy. PLoS One 2010;5:e15296
    • (2010) PLoS One , vol.5
    • Raychaudhuri, N.1    Douglas, R.S.2    Smith, T.J.3
  • 33
    • 0029053846 scopus 로고
    • Serum levels of interleukin 6 and tumor necrosis factoralpha in hyperthyroid patients before and after propylthiouracil treatment
    • Celik I, Akalin S, Erbaş T. Serum levels of interleukin 6 and tumor necrosis factoralpha in hyperthyroid patients before and after propylthiouracil treatment. Eur J Endocrinol 1995;132:668-72
    • (1995) Eur J Endocrinol , vol.132 , pp. 668-672
    • Celik, I.1    Akalin, S.2    Erbaş, T.3
  • 34
    • 0030959502 scopus 로고    scopus 로고
    • High circulating IL-6 level in Graves' ophthalmopathy
    • Molnár I, Balázs C. High circulating IL-6 level in Graves' ophthalmopathy. Autoimmunity 1997;25:91-6 (Pubitemid 27196644
    • (1997) Autoimmunity , vol.25 , Issue.2 , pp. 91-96
    • Molnar, I.1    Balazs, C.2
  • 36
    • 0033856315 scopus 로고    scopus 로고
    • Serum concentrations of proinflammatory cytokines in Graves' disease: Effect of treatment, thyroid function, ophthalmopathy and cigarette smoking
    • Salvi M, Pedrazzoni M, Girasole G, et al. Serum concentrations of proinflammatory cytokines in Graves' disease: Effect of treatment, thyroid function, ophthalmopathy and cigarette smoking. Eur J Endocrinol 2000;143:197-202 (Pubitemid 30622353
    • (2000) European Journal of Endocrinology , vol.143 , Issue.2 , pp. 197-202
    • Salvi, M.1    Pedrazzoni, M.2    Girasole, G.3    Giuliani, N.4    Minelli, R.5    Wall, J.R.6    Roti, E.7
  • 37
    • 77954407587 scopus 로고    scopus 로고
    • Changes of serum cytokines in hyperthyroid Graves' disease patients at diagnosis and during methimazole treatment
    • Pedro AB, Romaldini JH, Takei K. Changes of serum cytokines in hyperthyroid Graves' disease patients at diagnosis and during methimazole treatment. Neuroimmunomodulation 2011;18:45-51
    • (2011) Neuroimmunomodulation , vol.18 , pp. 45-51
    • Pedro, A.B.1    Romaldini, J.H.2    Takei, K.3
  • 38
    • 0016723594 scopus 로고
    • An endotoxin-induced serum factor that causes necrosis of tumors
    • Carswell EA, Old LJ, Kassel RL, et al. An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci U S A 1975;72:3666-70
    • (1975) Proc Natl Acad Sci U S A , vol.72 , pp. 3666-3670
    • Carswell, E.A.1    Old, L.J.2    Kassel, R.L.3
  • 39
    • 84864545633 scopus 로고    scopus 로고
    • Molecular link mechanisms between inflammation and cancer
    • Vendramini-Costa DB, Carvalho JE. Molecular link mechanisms between inflammation and cancer. Curr Pharm Des 2012;18(26):3831-52
    • (2012) Curr Pharm des , vol.18 , Issue.26 , pp. 3831-3852
    • Vendramini-Costa, D.B.1    Carvalho, J.E.2
  • 41
    • 77952092684 scopus 로고    scopus 로고
    • Graves' disease and gene polymorphism of TNF-A, IL-2, IL-6, IL-12, and IFN-g
    • Anvari M, Khalilzadeh O, Esteghamati A, et al. Graves' disease and gene polymorphism of TNF-A, IL-2, IL-6, IL-12, and IFN-g. Endocrine 2010;37: 344-8
    • (2010) Endocrine , vol.37 , pp. 344-348
    • Anvari, M.1    Khalilzadeh, O.2    Esteghamati, A.3
  • 42
    • 0034048010 scopus 로고    scopus 로고
    • A polymorphism of the 5' flanking region of tumour necrosis factor α gene is associated with thyroid-Associated ophthalmopathy in Japanese
    • DOI 10.1046/j.1365-2265.2000.01011.x
    • Kamizono S, Hiromatsu Y, Seki N, et al. A polymorphism of the 5' flanking region of tumour necrosis factor alpha gene is associated with thyroid-Associated ophthalmopathy in Japanese. Clin Endocrinol (Oxf) 2000;52:759-64 (Pubitemid 30409269
    • (2000) Clinical Endocrinology , vol.52 , Issue.6 , pp. 759-764
    • Kamizono, S.1    Hiromatsu, Y.2    Seki, N.3    Bednarczuk, T.4    Matsumoto, H.5    Kimura, A.6    Itoh, K.7
  • 43
    • 84878522332 scopus 로고    scopus 로고
    • The role of the IL-23/IL-17 axis in the pathogenesis of Graves' disease
    • Zheng L, Ye P, Liu C. The role of the IL-23/IL-17 axis in the pathogenesis of Graves' disease. Endocr J 2013;60:591-7
    • (2013) Endocr J , vol.60 , pp. 591-597
    • Zheng, L.1    Ye, P.2    Liu, C.3
  • 48
    • 55049118394 scopus 로고    scopus 로고
    • Interleukin-17 promotes autoimmunity by triggering a positivefeedback loop via interleukin-6 induction
    • Ogura HL, Murakami M, Okuyama Y, et al. Interleukin-17 promotes autoimmunity by triggering a positivefeedback loop via interleukin-6 induction. Immunity 2008;29(4):628-36
    • (2008) Immunity , vol.29 , Issue.4 , pp. 628-636
    • Ogura, H.L.1    Murakami, M.2    Okuyama, Y.3
  • 50
    • 84870364058 scopus 로고    scopus 로고
    • Genetic association between il-17f gene polymorphisms and the pathogenesis of graves' disease in the han chinese population
    • Guo T, Huo Y, Zhu W, et al. Genetic association between IL-17F gene polymorphisms and the pathogenesis of Graves' Disease in the Han Chinese population. Gene 2013;512:300-4
    • (2013) Gene , vol.512 , pp. 300-304
    • Guo, T.1    Huo, Y.2    Zhu, W.3
  • 51
    • 67650345273 scopus 로고    scopus 로고
    • Increases of the Th1/Th2 cell ratio in severe Hashimoto's disease and in the proportion of Th17 cells in intractable Graves' disease
    • Nanba T, Watanabe M, Inoue N, Iwatani Y. Increases of the Th1/Th2 cell ratio in severe Hashimoto's disease and in the proportion of Th17 cells in intractable Graves' disease. Thyroid 2009;19:495-501
    • (2009) Thyroid , vol.19 , pp. 495-501
    • Nanba, T.1    Watanabe, M.2    Inoue, N.3    Iwatani, Y.4
  • 52
    • 84880055907 scopus 로고    scopus 로고
    • A high frequency of circulating th22 and th17 cells in patients with new onset Graves' disease
    • Peng D, Xu B, Wang Y, et al. A high frequency of circulating th22 and th17 cells in patients with new onset Graves' disease. PLoS One 2013;8:e68446
    • (2013) PLoS One , vol.8
    • Peng, D.1    Xu, B.2    Wang, Y.3
  • 53
    • 84875296971 scopus 로고    scopus 로고
    • Functional interleukin-17 receptor A are present in the thyroid gland in intractable Graves' disease
    • Li JR, Hong FY, Zeng JY, Huang GL. Functional interleukin-17 receptor A are present in the thyroid gland in intractable Graves' disease. Cell Immunol 2013;281: 85-90
    • (2013) Cell Immunol , vol.281 , pp. 85-90
    • Li, J.R.1    Hong, F.Y.2    Zeng, J.Y.3    Huang, G.L.4
  • 54
    • 0027402917 scopus 로고
    • Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody
    • Wendling D, Racadot E, Wijdenes J. Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody. J Rheumatol 1993;20:259-62 (Pubitemid 23066035
    • (1993) Journal of Rheumatology , vol.20 , Issue.2 , pp. 259-262
    • Wendling, D.1    Racadot, E.2    Wijdenes, J.3
  • 55
    • 0031787640 scopus 로고    scopus 로고
    • Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody
    • DOI 10.1007/s002810050033
    • Yoshizaki K, Nishimoto N, Mihara M, Kishimoto T. Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody. Springer Semin Immunopathol 1998;20:247-59 (Pubitemid 28502460
    • (1998) Springer Seminars in Immunopathology , vol.20 , Issue.1-2 , pp. 247-259
    • Yoshizaki, K.1    Nishimoto, N.2    Mihara, M.3    Kishimoto, T.4
  • 56
    • 84859624578 scopus 로고    scopus 로고
    • Systematic review of tocilizumab for rheumatoid arthritis: A new biologic agent targeting the interleukin-6 receptor
    • Navarro-Millán I, Singh JA, Curtis Jr. Systematic review of tocilizumab for rheumatoid arthritis: A new biologic agent targeting the interleukin-6 receptor. Clin Ther 2012;34:788-802
    • (2012) Clin Ther , vol.34 , pp. 788-802
    • Navarro-Millán, I.1    Singh, J.A.2    Curtis, J.R.3
  • 57
    • 84885601463 scopus 로고    scopus 로고
    • Tocilizumab in patients with systemic juvenile idiopathic arthritis: Efficacy data from the placebo-controlled 12-week part of the phase 3 TENDER Trial
    • Chaitow J, De Benedetti F, Brunner H, et al. Tocilizumab in patients with systemic juvenile idiopathic arthritis: Efficacy data from the placebo-controlled 12-week part of the phase 3 TENDER Trial. Ann Rheum Dis 2010;69(Suppl 3):146
    • (2010) Ann Rheum Dis , vol.69 , Issue.SUPPL. 3 , pp. 146
    • Chaitow, J.1    De Benedetti, F.2    Brunner, H.3
  • 58
    • 79952013541 scopus 로고    scopus 로고
    • Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: Systematic literature review and meta-Analysis of randomized controlled trials
    • Campbell L, Chen C, Bhagat SS, et al. Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: Systematic literature review and meta-Analysis of randomized controlled trials. Rheumatology (Oxford) 2011;50: 552-62
    • (2011) Rheumatology (Oxford , vol.50 , pp. 552-562
    • Campbell, L.1    Chen, C.2    Bhagat, S.S.3
  • 59
    • 78650907772 scopus 로고    scopus 로고
    • Tocilizumab for rheumatoid arthritis: A Cochrane systematic review
    • Singh JA, Beg S, Lopez-Olivo MA. Tocilizumab for rheumatoid arthritis: A Cochrane systematic review. J Rheumatol 2011;38:10-20
    • (2011) J Rheumatol , vol.38 , pp. 10-20
    • Singh, J.A.1    Beg, S.2    Lopez-Olivo, M.A.3
  • 60
    • 0033524159 scopus 로고    scopus 로고
    • Infliximab (chimeric anti-Tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: A randomised phase III trial
    • ATTRACT Study Group
    • Maini R, St. Clair EW, Breedveld F, et al. Infliximab (chimeric anti-Tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: A randomised phase III trial. ATTRACT Study Group. Lancet 1999;354:1932-9
    • (1999) Lancet , vol.354 , pp. 1932-1939
    • Maini, R.1    St. Clair, E.W.2    Breedveld, F.3
  • 61
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-Analysis of rare harmful effects in randomized controlled trials
    • DOI 10.1001/jama.295.19.2275
    • Bongartz T, Sutton AJ, Sweeting MJ, et al. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-Analysis of rare harmful effects in randomized controlled trials. JAMA 2006;295:2275-85 (Pubitemid 43736578
    • (2006) Journal of the American Medical Association , vol.295 , Issue.19 , pp. 2275-2285
    • Bongartz, T.1    Sutton, A.J.2    Sweeting, M.J.3    Buchan, I.4    Matteson, E.L.5    Montori, V.6
  • 62
    • 83055173186 scopus 로고    scopus 로고
    • Initiation of tumor necrosis factor-A antagonists and the risk of hospitalization for infection in patients with autoimmune diseases
    • Grijalva CG, Chen L, Delzell E, et al. Initiation of tumor necrosis factor-A antagonists and the risk of hospitalization for infection in patients with autoimmune diseases. JAMA 2011;306:2331-9
    • (2011) JAMA , vol.306 , pp. 2331-2339
    • Grijalva, C.G.1    Chen, L.2    Delzell, E.3
  • 63
  • 64
    • 21344459664 scopus 로고    scopus 로고
    • Infliximab: A novel treatment for sight-Threatening thyroid associated ophthalmopathy
    • DOI 10.1080/01676830590912562
    • Durrani OM, Reuser TQ, Murray PI. Infliximab: A novel treatment for sightthreatening thyroid associated ophthalmopathy. Orbit 2005;24:117-19 (Pubitemid 40904566
    • (2005) Orbit , vol.24 , Issue.2 , pp. 117-119
    • Durrani, O.M.1    Reuser, T.Q.2    Murray, P.I.3
  • 65
    • 34247209156 scopus 로고    scopus 로고
    • Tumor necrosis factor antagonists: Preliminary evidence for an emerging approach in the treatment of ocular inflammation
    • DOI 10.1097/MAJ.0b013e3180318fbc, PII 0000698220070400000001
    • Theodossiadis PG, Markomichelakis NN, Sfikakis PP. Tumor necrosis factor antagonists: Preliminary evidence for an emerging approach in the treatment of ocular inflammation. Retina 2007;27:399-413 (Pubitemid 46624278
    • (2007) Retina , vol.27 , Issue.4 , pp. 399-413
    • Theodossiadis, P.G.1    Markomichelakis, N.N.2    Sfikakis, P.P.3
  • 68
    • 37249013214 scopus 로고    scopus 로고
    • Available from:
    • ClinicalTrials.gov. Available from: Http:// clinicaltrials.gov/show/ NCT01868997
    • ClinicalTrials.gov
  • 70
    • 84887992906 scopus 로고    scopus 로고
    • Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: A randomised, double-blind, placebo-controlled trial
    • Baeten D, Baraliakos X, Braun J, et al. Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: A randomised, double-blind, placebo-controlled trial. Lancet 2013;382: 1705-13
    • (2013) Lancet , vol.382 , pp. 1705-1713
    • Baeten, D.1    Baraliakos, X.2    Braun, J.3
  • 71
    • 84863393385 scopus 로고    scopus 로고
    • The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss
    • Eskan MA, Jotwan R, Abe T, et al. The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nat Immunol 2012;13:465-74
    • (2012) Nat Immunol , vol.13 , pp. 465-474
    • Eskan, M.A.1    Jotwan, R.2    Abe, T.3
  • 72
    • 84859918831 scopus 로고    scopus 로고
    • Restraining IL-17: Del-1 deals the blow
    • Khader SA. Restraining IL-17: Del-1 deals the blow. Nat Immunol 2012;13:433-5
    • (2012) Nat Immunol , vol.13 , pp. 433-435
    • Khader, S.A.1
  • 74
    • 84875700814 scopus 로고    scopus 로고
    • P53 controls autoimmune arthritis via STATmediated regulation of the Th17 cell/Treg cell balance in mice
    • Park JS, Lim MA, Cho ML, et al. p53 controls autoimmune arthritis via STATmediated regulation of the Th17 cell/Treg cell balance in mice. Arthritis Rheum 2013;65:949-59
    • (2013) Arthritis Rheum , vol.65 , pp. 949-959
    • Park, J.S.1    Lim, M.A.2    Cho, M.L.3
  • 76
    • 0026691714 scopus 로고
    • Regulation of human cytolytic lymphocyte responses by interleukin-12
    • Gately MK, Wolitzky AG, Quinn PM, Chizzonite R. Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell Immunol 1992;143: 127-42
    • (1992) Cell Immunol , vol.143 , pp. 127-142
    • Gately, M.K.1    Wolitzky, A.G.2    Quinn, P.M.3    Chizzonite, R.4
  • 77
    • 81255210898 scopus 로고    scopus 로고
    • Discovery and mechanism of ustekinumab: A human monoclonal antibody targeting interleukin-12 and interleukin-23 for treatment of immune-mediated disorders
    • Benson JM, Peritt D, Scallon BJ, et al. Discovery and mechanism of ustekinumab: A human monoclonal antibody targeting interleukin-12 and interleukin-23 for treatment of immune-mediated disorders. MAbs 2011;3(6):535-45
    • (2011) MAbs , vol.3 , Issue.6 , pp. 535-545
    • Benson, J.M.1    Peritt, D.2    Scallon, B.J.3
  • 78
    • 43449111187 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1
    • DOI 10.1016/S0140-6736(08)60725-4, PII S0140673608607254
    • Leonardi CL, Kimball AB, Papp KA, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 2008;371:1665-74 (Pubitemid 351671883
    • (2008) The Lancet , vol.371 , Issue.9625 , pp. 1665-1674
    • Leonardi, C.L.1    Kimball, A.B.2    Papp, K.A.3    Yeilding, N.4    Guzzo, C.5    Wang, Y.6    Li, S.7    Dooley, L.T.8    Gordon, K.B.9
  • 79
    • 84871701834 scopus 로고    scopus 로고
    • Ustekinumab induction and maintenance therapy in refractory Crohn's disease
    • Sandborn WJ, Gasink C, Gao LL, et al. Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med 2012;367:1519-28
    • (2012) N Engl J Med , vol.367 , pp. 1519-1528
    • Sandborn, W.J.1    Gasink, C.2    Gao, L.L.3
  • 80
    • 84864779984 scopus 로고    scopus 로고
    • Development of the IL-12/23 antagonist ustekinumab in psoriasis: Past, present, and future perspectives-An update
    • Yeilding N, Szapary P, Brodmerkel C, et al. Development of the IL-12/23 antagonist ustekinumab in psoriasis: Past, present, and future perspectives-An update. Ann N Y Acad Sci 2012;1263:1-12
    • (2012) Ann N y Acad Sci , vol.1263 , pp. 1-12
    • Yeilding, N.1    Szapary, P.2    Brodmerkel, C.3
  • 81
    • 79955045064 scopus 로고    scopus 로고
    • Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model
    • Nakajima K, Kanda T, Takaishi M, et al. Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model. J Immunol 2011;186:4481-9
    • (2011) J Immunol , vol.186 , pp. 4481-4489
    • Nakajima, K.1    Kanda, T.2    Takaishi, M.3
  • 82
    • 33646433989 scopus 로고    scopus 로고
    • Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
    • Chen Y, Langrish CL, McKenzie B, et al. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest 2006;116:1317-26
    • (2006) J Clin Invest , vol.116 , pp. 1317-1326
    • Chen, Y.1    Langrish, C.L.2    McKenzie, B.3
  • 83
    • 84894082076 scopus 로고    scopus 로고
    • Specific targeting of interleukin-23p19 as effective treatment for psoriasis
    • Levin AA, Gottlieb AB. Specific targeting of interleukin-23p19 as effective treatment for psoriasis. J Am Acad Dermatol 2014;70: 555-61
    • (2014) J Am Acad Dermatol , vol.70 , pp. 555-561
    • Levin, A.A.1    Gottlieb, A.B.2
  • 84
    • 56549093441 scopus 로고    scopus 로고
    • Toll-like receptors in autoimmunity
    • Fischer ML, Ehlers M. Toll-like receptors in autoimmunity. Ann N Y Acad Sci 2008;1143:21-34
    • (2008) Ann N y Acad Sci , vol.1143 , pp. 21-34
    • Fischer, M.L.1    Ehlers, M.2
  • 85
    • 84879410185 scopus 로고    scopus 로고
    • A Tolllike receptor 7, 8, and 9 antagonist inhibits Th1 and Th17 responses and inflammasome activation in a model of IL-23-induced psoriasis
    • Jiang W, Zhu FG, Bhagat L, et al. A Tolllike receptor 7, 8, and 9 antagonist inhibits Th1 and Th17 responses and inflammasome activation in a model of IL-23-induced psoriasis. J Invest Dermatol 2013;133(7):1777-84
    • (2013) J Invest Dermatol , vol.133 , Issue.7 , pp. 1777-1784
    • Jiang, W.1    Zhu, F.G.2    Bhagat, L.3
  • 86
    • 84901260292 scopus 로고    scopus 로고
    • Presented At American Thyroid Association; San Juan Puerto Rico USA
    • Salvi M. Rituximab in Graves' ophthalmopathy. Presented at American Thyroid Association; San Juan, Puerto Rico, USA; 2013
    • (2013) Rituximab in Graves' Ophthalmopathy
    • Salvi, M.1
  • 87
    • 84905982819 scopus 로고    scopus 로고
    • Randomized double-blind placebocontrolled trial of rituximab for treatment of graves' ophthalmopathy
    • San Juan Puerto Rico USA
    • Stan MN, Garrity JA, Thapa P, et al. Randomized double-blind placebocontrolled trial of rituximab for treatment of Graves' ophthalmopathy. Presented at American Thyroid Association; San Juan, Puerto Rico, USA; 2013
    • (2013) Presented at American Thyroid Association
    • Stan, M.N.1    Garrity, J.A.2    Thapa, P.3
  • 90
    • 56749182326 scopus 로고    scopus 로고
    • Rituximab in relapsing Graves' disease, a phase II study
    • Heemstra KA, Toes RE, Sepers J, et al. Rituximab in relapsing Graves' disease, a phase II study. Eur J Endocrinol 2008;159: 609-15
    • (2008) Eur J Endocrinol , vol.159 , pp. 609-615
    • Heemstra, K.A.1    Toes, R.E.2    Sepers, J.3
  • 91
    • 72749085764 scopus 로고    scopus 로고
    • Rituximab treatment of patients with severe, corticosteroid-resistant thyroid-Associated ophthalmopathy
    • Khanna D, Chong KK, Afifiyan NF, et al. Rituximab treatment of patients with severe, corticosteroid-resistant thyroid-Associated ophthalmopathy. Ophthalmology 2010;117: 133-9
    • (2010) Ophthalmology , vol.117 , pp. 133-139
    • Khanna, D.1    Chong, K.K.2    Afifiyan, N.F.3


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