PGE2 induces IL-6 in orbital fibroblasts through EP2 receptors and increased gene promoter activity: Implications to thyroid-associated ophthalmopathy

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Raychaudhuri, Nupur ^a   Douglas, Raymond S ^a   Smith, Terry J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CELL SURFACE RECEPTOR; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; EP2 RECEPTOR; INTERLEUKIN 6; MESSENGER RNA; PROSTAGLANDIN E2; PROTEIN P300; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; HISTONE ACETYLTRANSFERASE PCAF; PROSTAGLANDIN; PROSTAGLANDIN E RECEPTOR 2;

ARTICLE; CELL LEVEL; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA SEQUENCE; ENDOCRINE OPHTHALMOPATHY; FIBROBLAST; GENE ACTIVITY; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; NUCLEOTIDE SEQUENCE; ORBITAL FIBROBLAST; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; SKIN FIBROBLAST; TRANSCRIPTION REGULATION; UPREGULATION; DOSE RESPONSE; GRAVES DISEASE; METABOLISM; PHENOTYPE; PHOSPHORYLATION;

CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; GRAVES DISEASE; GRAVES OPHTHALMOPATHY; HUMANS; INTERLEUKIN-6; P300-CBP TRANSCRIPTION FACTORS; PHENOTYPE; PHOSPHORYLATION; PROSTAGLANDINS; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RNA, SMALL INTERFERING;

EID: 78650837135     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015296     Document Type: Article

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