TSH receptor transcripts and TSH receptor-like immunoreactivity in orbital and pretibial fibroblasts of patients with Graves' ophthalmopathy and pretibial myxedema

Thyroid

Volumn 7, Issue 1, 1997, Pages 3-12

  Stadlmayr, Walter ^a   Spitzweg, Christine ^a   Bichlmair, Anna Maria ^a   Heufelder, Armin E ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; RNA; THYROTROPIN RECEPTOR;

ADIPOSE TISSUE; ANIMAL CELL; ARTICLE; CHO CELL; CONNECTIVE TISSUE; CONTROLLED STUDY; EYE DISEASE; FIBROBLAST; GRAVES DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREACTIVITY; MYXEDEMA; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SKIN DISEASE;

EID: 0030981965     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: 10.1089/thy.1997.7.3     Document Type: Article

References (37)

1. Burch HB, Wartofsky L 1993 Graves' ophthalmopathy: Current concept regarding pathogenesis and management. Endocr Rev 14:747-793.
2. Bahn RS, Heufelder AE 1993 Mechanisms of disease: Pathogenesis of Graves' ophthalmopathy. N Engl J Med 329:1468-1475.
3. Weetman AP 1991 Thyroid associated eye disease: Pathophysiology. Lancet 338:25-32.
4. Fatourechi V, Pajouhi M, Fransway FA 1994 Dermopathy of Graves' disease (pretibial myxedema). Medicine 73:1-7.
5. Heufelder AE, Wenzel BE, Scriba PC 1996 Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital and pretibial tissue in Graves' disease. J Clin Endocrinol Metab 81:3733-3739.
6. + and specifically recognize autologous fibroblasts. J Clin Invest 3:2738-2743.
7. Otto EA, Ochs K, Hansen C, Wall JR, Kahaly GJ 1996 Orbital tissue-derived T-lymphocytes from patients with Graves' ophthalmopathy recognize autologous orbital antigens. J Clin Endocrinol Metab 81:3045-3050.
8. Morris J, Hay ID, Nelson RE, Jiang Nai S 1988 Clinical utility of thyrotropin receptor antibody assays: Comparison of radioreceptor and bioassay methods. Mayo Clin Proc 63:707-712.
9. Heufelder AE, Herterich S, Ernst G, Bahn RS, Scriba PC 1995 Analysis of the T cell antigen receptor repertoire in lymphocytes infiltrating the retroorbital patients with Graves' ophthalmopathy. Eur J Endocrinol 132:266-277.
10. Heufelder AE, Bahn RS, Scriba PC 1995 Analysis of T-cell antigen receptor variable region gene usage in patients with thyroid-related pretibial dermopathy. J Invest Dermatol 105:372-378.
11. Heufelder AE, Bahn RS 1992 Evidence for the presence of a functional TSH-receptor in retroocular fibroblasts from patients with Graves' ophthalmopathy. Exp Clin Endocrinol 100:62-67.
12. Heufelder AE, Dutton CM, Sarkar G, Donovan KA, Bahn RS 1993 Detection of TSH receptor RNA in cultured fibroblasts from patients with Graves' ophthalmopathy and pretibial dermopathy. Thyroid 3:297-300.
13. Mengistu M, Lukes YG, Nagy EV, Burch HB, Carr FE, Lahiri S, Burman KD 1994 TSH receptor gene expression in retroocular fibroblasts. J Endocrinol Invest 17:437-441.
14. Chang T-C, Wu S-L, Hsiao Y-L, Kuo S-T, Chien L-F, Kuo Y-F, Chang C-C, Chang T-J 1994 TSH and TSH receptor antibody-binding sites in fibroblasts of pretibial myxedema are related to the extracellular domain of entire TSH receptor. Clin Immunol Immunopathol 71:113-120.
15. Endo T, Ohno M, Kotani S, Gunji K, Onaya T 1993 Thyrotropin receptor in non-thyroid tissues. Biochem Biophys Res Commun 190:774-779.
16. Endo T, Ohta K, Haraguchi K, Onaya T 1995 Cloning and functional expression of a thyrotropin receptor cDNA from rat fat cells. J Biol Chem 270:10833-10837.
17. Feliciello A, Porcellini A, Ciullo I, Bonavolonta G, Avvedimento EV, Fenzi G 1993 Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue. Lancet 342:337-338.
18. Graves PN, Tomer Y, Davies TF 1992 Cloning and sequencing of a 1.3 kB variant of the human thyrotropin receptor mRNA lacking the transmembrane domain. Biochem Biophys Res Commun 187:1135-1143.
19. Paschke R, Metcalfe A, Alcade L, Vassart G, Weetman A, Ludgate M 1994 Presence of non-functional thyrotropin receptor variant transcripts in retroocular and other tissues. J Clin Endocrinol Metab 79:1234-1238.
20. Heufelder AE, Bahn RS 1992 Modulation of intercellular adhesion molecule-1 (ICAM-1) by cytokines and Graves' IgGs in cultured Graves' retroocular fibroblasts. Eur J Clin Invest 22:529-537.
21. Perret J, Ludgate M, Libert F, Gerard C, Dumont JE, Vassart G, Parmentier M 1990 Stable expression of the human TSH receptor in CHO cells and characterization of differentially expressing clones. Biochem Biophys Res Commun 171:1044-1050.
22. Nagayama Y, Kaufman KD, Seto P, Rapoport B 1989 Molecular cloning, sequence, and expression of the cDNA for the human" thyrotropin receptor. Biochem Biophys Research Commun 165:1184-1190.
23. Smanik PA, Fithian LJ, Jhiang SM 1994 Thyroid peroxidase expression and DNA polymorphisms in thyroid cancer. Biochem Biophys Res Commun 198:948-953.
24. Targovnik HM, Medeiros-Neto G, Varela V, Cochaux P, Wajchenberg BL, Vassart G 1993 A nonsense mutation causes human hereditary congenital goiter with preferential production of a 171-nucleotide-deleted thyroglobulin ribonucleic acid messenger. J Clin Endocrinol Metab 77:210-215.
25. Heufelder AE 1995 Pathogenesis of Graves' ophthalmopathy: recent controversies and progress. Eur J Endocrinol 132:532-541.
26. Soliman M, Kaplan E, Yanagawa T, Hidaka Y, Fisfalen ME, DeGroot LJ 1995 T cells recognize multiple epitopes in the human thyrotropin receptor extracellular domain J Clin Endocrinol Metab 80:905-914.
27. Parmentier M, Libert F, Maenhaut C, Lefort A, Gerard C, Perret J, Van Sande J, Dumont JE, Vassart G 1989 Molecular cloning of the thyrotropin receptor. Science 246:1620-1622.
28. Gross B, Misrahi M, Sar S, Milgrom E 1991 Composite structure of the human thyrotropin receptor gene. Biochem Biophys Res Commun 177:679-687.
29. Bolonkin D, Tate RL, Luber JH, Kohn LD 1975 Experimental exophthalmos. Binding of thyrotropin and an exophthalmogenic factor derived from thyrotropin to retro-orbital tissue plasma membranes. J Biol Chem 250:6516-6521.
30. Iida Y, Amir SM, Ingbar SH 1975 Stabilization, partial purification, and characterization of thyrotropin receptors in solubilized guinea pig fat cell membranes. Endocrinology 121:1627-1636.
31. Davies TF, Teng CS, McLachlan SM, Smith RB, Hall R 1978 Thyrotropin receptors in adipose tissue, retroorbital tissue and lymphocytes. Mol Cell Endocrinol 9:303-310.
32. Rotella CM, Zonefrati R, Toccafondi R, Valente WA, Kohn LD 1986 Ability of monoclonal antibodies to the thyrotropin receptor to increase collagen synthesis in human fibroblasts: An assay which appears to measure exophthalmogenic immunoglobulins in Graves' sera. J Clin Endocrinol Metab 62:357-367.
33. Westermark K, Lilja K, Karlsson FA 1989 Effects of sera and immunoglobulin preparations from patients with endocrine ophthalmopathy on the production of hyaluronate and the incorporation of tritiated thymidine in fibroblasts. Acta Endocrinol 121(Suppl 2):85-89.
34. Paschke R, Vassart G, Ludgate M 1994 Current evidence for and against the TSH receptor being the common antigen in Graves' disease and thyroid associated ophtalmopathy. Clin Endocrinol 42:565-569.
35. Perros P, Kendall-Taylor P 1994 TSH-binding sites are present in orbital connective tissue and are recognized by IgG from patients with thyroid-associated ophthalmopathy. J Endocrinol Invest 17:163-170.
36. Paschke R, Elise R, Vassart G, Ludgate M 1993 Lack of evidence supporting the presence of mRNA for the thyrotropin receptor in extraocular muscle. J Endocrinol Invest 16:329-332
37. Burch HB, Selletti D, Barnes SG, Nagy EV, Bahn RS, Burman KD 1994 Thyrotropin receptor antisera for the detection of immunoreactive protein species in retroocular fibroblasts obtained from patients with Graves' ophthalmopathy. J Clin Endocrinol Metab 78:1384-1391.