Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity

Journal of Medicinal Chemistry

Volumn 57, Issue 10, 2014, Pages 4382-4396

  Kang, Soosung ^a   Tang, Wei ^a   Li, Huiying ^b   Chreifi, Georges ^b   Martásek, Pavel ^c   Roman, Linda J ^c   Poulos, Thomas L ^b   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYL 6 [3 (2 NITROVINYL)PHENETHYL]PYRIDINE; 2 (2,5 DIMETHYL 1H PYRROL 1 YL) 6 [3 [1 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYPYRIDIN 2 YL] 3 NITROPROPAN 2 YL]PHENETHYL] 4 METHYLPYRIDINE; 2 (2,5 DIMETHYL 1H PYRROL 1 YL) 6 [[5 [1 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2 YL] 3 NITROPROPAN 2 YL]PYRIDIN 3 YL]ETHYNYL] 4 METHYLPYRIDINE; 2 (2,5 DIMETHYL 1H PYRROL 1 YL) 6 [[6 [1 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2 YL] 3 NITROPROPAN 2 YL]PYRIDIN 2 YL]ETHYNYL] 4 METHYLPYRIDINE; 2 BROMO 6 (2 NITROVINYL)PYRIDINE; 2 METHYL N [3 [2 (4 METHYLPYRIDIN 2 YL)ETHYL]BENZYLIDENE]PROPANE 2 SULFINAMIDE; 2 [2 (5 BROMOPYRIDIN 3 YL) 3 NITROPROPYL] 6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDINE; 2 [2 (6 BROMOPYRIDIN 2 YL) 3 NITROPROPYL] 6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYPYRIDINE; 2 [2 AZIDO 2 [3 [2 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2 YL]ETHYL]PHENYL]ETHYL] 6 (2,5 DIMETHYL 1H PYRROL 1 YL) 2 METHYLPYRIDIN; 2 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2 YL] 1 [3 [2 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2 YL]ETHYL]PHENYL]ETHANOL; 3 BROMO 5 (2 NITROVINYL)PYRIDINE; 3 [2 (4 METHYLPYRIDIN 2 YL)ETHYL]BENZALDEHYDE; 3 [2 (4 METHYLPYRIDIN 2 YL)ETHYL]BENZONITRILE; 3 [2 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2 YL]ETHYL]BENZALDEHYDE; 3 [2 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2 YL]ETHYL]BENZONITRILE; 3 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2 YL] 2 [6 [2 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2 YL]ETHYL]PHENYL]PROPAN 1 AMINE; 3 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2 YL] 2 [6 [2 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2 YL]ETHYL]PYRIDIN 2 YL]PROPAN 1 AMINE; 6 [2 AMINO 2 [3 [2 (4 METHYLPYRIDIN 2 YL)ETHYL]PHENYL]ETHYL] 4 METHYLPYRIDIN 2 AMINE; 6 [3 AMINO 2 [3 [2 (6 AMINO 4 METHYLPYRIDIN 2 YL)ETHYL]PHENYL]PROPYL] 4 METHYLPYRIDIN 2 AMINE; 6 [3 AMINO 2 [5 [2 (6 AMINO 4 METHYLPYRIDIN 2 YL)ETHYL]PYRIDIN 3 YL]PROPYL] 4 METHYLPYRIDIN 2 AMINE; 6 [3 AMINO 2 [6 [2 (6 AMINO 4 METHYLPYRIDIN 2 YL)ETHYL]PYRIDIN 2 YL]PROPYL] 4 METHYLPYRIDIN 2 AMINE; HEME; N BOC 3 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2 YL] 2 [6 [2 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2 YL]ETHYL]PYRIDIN 2 YL]PROPAN 1 AMINE; N [ 2 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2 YL] 1 [3 [2 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2 YL]ETHYL]PHENYL]ETHYL] 4,7,7 TRIMETHYL 3 OXO 2 OXABICYCLO[2.2.1] HEPTANE 1 CARBOXAMIDE; N [ 2 [6 (2,5 DIMETHYL 1H PYRROL 1 YL) 4 METHYLPYRIDIN 2YL] 4 METHYLPYRIDIN 2 YL] 1 [3 [2 (4 METHYLPYRIDIN 2 YL)ETHYL]PHENYL]ETHYL] 2 METHYLPROPANE 2 SULFINAMIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PROPIONIC ACID; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG INTERACTION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HYDROGEN BOND; IN VIVO STUDY; MOLECULE; NEUROLOGIC DISEASE; PATHOGENESIS; PHYSIOLOGY; PROTEIN DRUG INTERACTION; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION;

BIOPTERIN; ENZYME INHIBITORS; HEME; HUMANS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901261018     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5004182     Document Type: Article

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