Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 24, 2005, Pages 5467-5473

  Han, Shulin ^a   Zhou, Vicki ^a   Pan, Shifeng ^a   Liu, Yi ^a   Hornsby, Michael ^a   McMullan, Daniel ^a   Klock, Heath E ^a   Haugen, Justin ^a   Lesley, Scott A ^a   Gray, Nathanael ^a   Caldwell, Jeremy ^a   Gu, Xiang Ju ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

Allosteric Inhibitors; COT; Coumarins; MEK1; RAF; TR FRET

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; AROMATIC AMINE; CLORICROMEN; COUMARIN DERIVATIVE; G 0328; G 8935; GC 63; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PD 318088; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLOSTERISM; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG BINDING SITE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; ENZYME CONFORMATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IC 50; MOLECULAR MODEL;

ALLOSTERIC REGULATION; BINDING SITES; COUMARINS; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; KINETICS; MAP KINASE KINASE 1; MODELS, MOLECULAR; PHOSPHOPEPTIDES; PHOSPHORYLATION; PROTEIN CONFORMATION;

EID: 27644515238     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.08.097     Document Type: Article

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