메뉴 건너뛰기




Volumn 8, Issue 4, 2013, Pages

Treatment of Colorectal Cancer Using a Combination of Liposomal Irinotecan (Irinophore C™) and 5-Fluorouracil

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; IRINOPHORE C; IRINOTECAN; UNCLASSIFIED DRUG; CAMPTOTHECIN; DRUG COMBINATION; LIPOSOME;

EID: 84876584767     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062349     Document Type: Article
Times cited : (26)

References (73)
  • 2
    • 79959990351 scopus 로고    scopus 로고
    • American Cancer Society, 2nd Edition. Atlanta: American Cancer Society
    • American Cancer Society (2008) Global Cancer Facts & Figures 2nd Edition. Atlanta: American Cancer Society.
    • (2008) Global Cancer Facts & Figures
  • 3
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • Ferlay J, Shin HR, Bray F, Forman D, Mathers C, et al. (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893-2917.
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3    Forman, D.4    Mathers, C.5
  • 4
    • 0003964363 scopus 로고    scopus 로고
    • American Cancer Society, Atlanta: American Cancer Society
    • American Cancer Society (2013) Cancer Facts & Figures 2013. Atlanta: American Cancer Society.
    • (2013) Cancer Facts & Figures 2013
  • 5
    • 79959997219 scopus 로고    scopus 로고
    • American Cancer Society, Atlanta: American Cancer Society
    • American Cancer Society (2011) Colorectal Cancer Facts & Figures 2011-2013. Atlanta: American Cancer Society.
    • (2011) Colorectal Cancer Facts & Figures 2011-2013
  • 6
    • 0035213415 scopus 로고    scopus 로고
    • Identification and activities of human carboxylesterases for the activation of CPT-11, a clinically approved anticancer drug
    • Senter PD, Beam KS, Mixan B, Wahl AF, (2001) Identification and activities of human carboxylesterases for the activation of CPT-11, a clinically approved anticancer drug. Bioconjug Chem 12: 1074-1080.
    • (2001) Bioconjug Chem , vol.12 , pp. 1074-1080
    • Senter, P.D.1    Beam, K.S.2    Mixan, B.3    Wahl, A.F.4
  • 7
    • 0036023423 scopus 로고    scopus 로고
    • Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan
    • Xu G, Zhang W, Ma MK, McLeod HL, (2002) Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan. Clin Cancer Res 8: 2605-2611.
    • (2002) Clin Cancer Res , vol.8 , pp. 2605-2611
    • Xu, G.1    Zhang, W.2    Ma, M.K.3    McLeod, H.L.4
  • 8
    • 0034162687 scopus 로고    scopus 로고
    • Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2
    • Humerickhouse R, Lohrbach K, Li L, Bosron WF, Dolan ME, (2000) Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2. Cancer Res 60: 1189-1192.
    • (2000) Cancer Res , vol.60 , pp. 1189-1192
    • Humerickhouse, R.1    Lohrbach, K.2    Li, L.3    Bosron, W.F.4    Dolan, M.E.5
  • 9
    • 0025996996 scopus 로고
    • Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11
    • Kawato Y, Aonuma M, Hirota Y, Kuga H, Sato K, (1991) Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res 51: 4187-4191.
    • (1991) Cancer Res , vol.51 , pp. 4187-4191
    • Kawato, Y.1    Aonuma, M.2    Hirota, Y.3    Kuga, H.4    Sato, K.5
  • 10
  • 11
    • 0034282809 scopus 로고    scopus 로고
    • Proficient metabolism of irinotecan by a human intestinal carboxylesterase
    • Khanna R, Morton CL, Danks MK, Potter PM, (2000) Proficient metabolism of irinotecan by a human intestinal carboxylesterase. Cancer Res 60: 4725-4728.
    • (2000) Cancer Res , vol.60 , pp. 4725-4728
    • Khanna, R.1    Morton, C.L.2    Danks, M.K.3    Potter, P.M.4
  • 12
    • 0032926512 scopus 로고    scopus 로고
    • CPT-11 converting carboxylesterase and topoisomerase activities in tumour and normal colon and liver tissues
    • Guichard S, Terret C, Hennebelle I, Lochon I, Chevreau P, et al. (1999) CPT-11 converting carboxylesterase and topoisomerase activities in tumour and normal colon and liver tissues. Br J Cancer 80: 364-370.
    • (1999) Br J Cancer , vol.80 , pp. 364-370
    • Guichard, S.1    Terret, C.2    Hennebelle, I.3    Lochon, I.4    Chevreau, P.5
  • 13
    • 0029966672 scopus 로고    scopus 로고
    • Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer
    • Rothenberg ML, Eckardt JR, Kuhn JG, Burris HA, 3rd, Nelson J, et al (1996) Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer. J Clin Oncol 14: 1128-1135.
    • (1996) J Clin Oncol , vol.14 , pp. 1128-1135
    • Rothenberg, M.L.1    Eckardt, J.R.2    Kuhn, J.G.3    Burris 3rd, H.A.4    Nelson, J.5
  • 14
    • 0033558004 scopus 로고    scopus 로고
    • A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma
    • Rothenberg ML, Cox JV, DeVore RF, Hainsworth JD, Pazdur R, et al. (1999) A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma. Cancer 85: 786-795.
    • (1999) Cancer , vol.85 , pp. 786-795
    • Rothenberg, M.L.1    Cox, J.V.2    DeVore, R.F.3    Hainsworth, J.D.4    Pazdur, R.5
  • 15
    • 0031926749 scopus 로고    scopus 로고
    • Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment
    • Saliba F, Hagipantelli R, Misset JL, Bastian G, Vassal G, et al. (1998) Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment. J Clin Oncol 16: 2745-2751.
    • (1998) J Clin Oncol , vol.16 , pp. 2745-2751
    • Saliba, F.1    Hagipantelli, R.2    Misset, J.L.3    Bastian, G.4    Vassal, G.5
  • 17
    • 0027096415 scopus 로고
    • A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues
    • Fassberg J, Stella VJ, (1992) A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues. J Pharm Sci 81: 676-684.
    • (1992) J Pharm Sci , vol.81 , pp. 676-684
    • Fassberg, J.1    Stella, V.J.2
  • 18
    • 0028670840 scopus 로고
    • Kinetics of the in vivo interconversion of the carboxylate and lactone forms of irinotecan (CPT-11) and of its metabolite SN-38 in patients
    • Rivory LP, Chatelut E, Canal P, Mathieu-Boue A, Robert J, (1994) Kinetics of the in vivo interconversion of the carboxylate and lactone forms of irinotecan (CPT-11) and of its metabolite SN-38 in patients. Cancer Res 54: 6330-6333.
    • (1994) Cancer Res , vol.54 , pp. 6330-6333
    • Rivory, L.P.1    Chatelut, E.2    Canal, P.3    Mathieu-Boue, A.4    Robert, J.5
  • 19
    • 0028012774 scopus 로고
    • The structural basis of camptothecin interactions with human serum albumin: impact on drug stability
    • Burke TG, Mi Z, (1994) The structural basis of camptothecin interactions with human serum albumin: impact on drug stability. J Med Chem 37: 40-46.
    • (1994) J Med Chem , vol.37 , pp. 40-46
    • Burke, T.G.1    Mi, Z.2
  • 20
    • 33645047575 scopus 로고    scopus 로고
    • Development of a highly active nanoliposomal irinotecan using a novel intraliposomal stabilization strategy
    • Drummond DC, Noble CO, Guo Z, Hong K, Park JW, et al. (2006) Development of a highly active nanoliposomal irinotecan using a novel intraliposomal stabilization strategy. Cancer Res 66: 3271-3277.
    • (2006) Cancer Res , vol.66 , pp. 3271-3277
    • Drummond, D.C.1    Noble, C.O.2    Guo, Z.3    Hong, K.4    Park, J.W.5
  • 21
    • 39749156447 scopus 로고    scopus 로고
    • Irinophore C: a liposome formulation of irinotecan with substantially improved therapeutic efficacy against a panel of human xenograft tumors
    • Ramsay EC, Anantha M, Zastre J, Meijs M, Zonderhuis J, et al. (2008) Irinophore C: a liposome formulation of irinotecan with substantially improved therapeutic efficacy against a panel of human xenograft tumors. Clin Cancer Res 14: 1208-1217.
    • (2008) Clin Cancer Res , vol.14 , pp. 1208-1217
    • Ramsay, E.C.1    Anantha, M.2    Zastre, J.3    Meijs, M.4    Zonderhuis, J.5
  • 22
    • 40749107087 scopus 로고    scopus 로고
    • Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil
    • Nakajima TE, Yasunaga M, Kano Y, Koizumi F, Kato K, et al. (2008) Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil. Int J Cancer 122: 2148-2153.
    • (2008) Int J Cancer , vol.122 , pp. 2148-2153
    • Nakajima, T.E.1    Yasunaga, M.2    Kano, Y.3    Koizumi, F.4    Kato, K.5
  • 23
    • 67349152765 scopus 로고    scopus 로고
    • Novel irinotecan-loaded liposome using phytic acid with high therapeutic efficacy for colon tumors
    • Hattori Y, Shi L, Ding W, Koga K, Kawano K, et al. (2009) Novel irinotecan-loaded liposome using phytic acid with high therapeutic efficacy for colon tumors. J Control Release 136: 30-37.
    • (2009) J Control Release , vol.136 , pp. 30-37
    • Hattori, Y.1    Shi, L.2    Ding, W.3    Koga, K.4    Kawano, K.5
  • 24
    • 77952691329 scopus 로고    scopus 로고
    • Preparation and in vitro evaluation of actively targetable nanoparticles for SN-38 delivery against HT-29 cell lines
    • Ebrahimnejad P, Dinarvand R, Sajadi A, Jaafari MR, Nomani AR, et al. (2010) Preparation and in vitro evaluation of actively targetable nanoparticles for SN-38 delivery against HT-29 cell lines. Nanomedicine 6: 478-485.
    • (2010) Nanomedicine , vol.6 , pp. 478-485
    • Ebrahimnejad, P.1    Dinarvand, R.2    Sajadi, A.3    Jaafari, M.R.4    Nomani, A.R.5
  • 25
    • 67349112911 scopus 로고    scopus 로고
    • Dual chemotherapy and photodynamic therapy in an HT-29 human colon cancer xenograft model using SN-38-loaded chlorin-core star block copolymer micelles
    • Peng CL, Lai PS, Lin FH, Yueh-Hsiu Wu S, Shieh MJ, (2009) Dual chemotherapy and photodynamic therapy in an HT-29 human colon cancer xenograft model using SN-38-loaded chlorin-core star block copolymer micelles. Biomaterials 30: 3614-3625.
    • (2009) Biomaterials , vol.30 , pp. 3614-3625
    • Peng, C.L.1    Lai, P.S.2    Lin, F.H.3    Yueh-Hsiu Wu, S.4    Shieh, M.J.5
  • 26
    • 39849089601 scopus 로고    scopus 로고
    • A novel liposomal irinotecan formulation with significant anti-tumour activity: use of the divalent cation ionophore A23187 and copper-containing liposomes to improve drug retention
    • Ramsay E, Alnajim J, Anantha M, Zastre J, Yan H, et al. (2008) A novel liposomal irinotecan formulation with significant anti-tumour activity: use of the divalent cation ionophore A23187 and copper-containing liposomes to improve drug retention. Eur J Pharm Biopharm 68: 607-617.
    • (2008) Eur J Pharm Biopharm , vol.68 , pp. 607-617
    • Ramsay, E.1    Alnajim, J.2    Anantha, M.3    Zastre, J.4    Yan, H.5
  • 27
    • 33845368651 scopus 로고    scopus 로고
    • Transition metal-mediated liposomal encapsulation of irinotecan (CPT-11) stabilizes the drug in the therapeutically active lactone conformation
    • Ramsay E, Alnajim J, Anantha M, Taggar A, Thomas A, et al. (2006) Transition metal-mediated liposomal encapsulation of irinotecan (CPT-11) stabilizes the drug in the therapeutically active lactone conformation. Pharm Res 23: 2799-2808.
    • (2006) Pharm Res , vol.23 , pp. 2799-2808
    • Ramsay, E.1    Alnajim, J.2    Anantha, M.3    Taggar, A.4    Thomas, A.5
  • 28
    • 79955610767 scopus 로고    scopus 로고
    • The role of the transition metal copper and the ionophore A23187 in the development of Irinophore C
    • Patankar N, Anantha M, Ramsay E, Waterhouse D, Bally M, (2011) The role of the transition metal copper and the ionophore A23187 in the development of Irinophore C. Pharm Res. 28: 848-857.
    • (2011) Pharm Res , vol.28 , pp. 848-857
    • Patankar, N.1    Anantha, M.2    Ramsay, E.3    Waterhouse, D.4    Bally, M.5
  • 29
    • 79953757824 scopus 로고    scopus 로고
    • Vascular normalization in orthotopic glioblastoma following intravenous treatment with lipid-based nanoparticulate formulations of irinotecan (Irinophore C), doxorubicin (Caelyx(R)) or vincristine
    • Verreault M, Strutt D, Masin D, Anantha M, Yung A, et al. (2011) Vascular normalization in orthotopic glioblastoma following intravenous treatment with lipid-based nanoparticulate formulations of irinotecan (Irinophore C), doxorubicin (Caelyx(R)) or vincristine. BMC Cancer 11: 124-141.
    • (2011) BMC Cancer , vol.11 , pp. 124-141
    • Verreault, M.1    Strutt, D.2    Masin, D.3    Anantha, M.4    Yung, A.5
  • 30
    • 5144225469 scopus 로고    scopus 로고
    • Liposomal irinotecan: formulation development and therapeutic assessment in murine xenograft models of colorectal cancer
    • Messerer CL, Ramsay EC, Waterhouse D, Ng R, Simms EM, et al. (2004) Liposomal irinotecan: formulation development and therapeutic assessment in murine xenograft models of colorectal cancer. Clin Cancer Res 10: 6638-6649.
    • (2004) Clin Cancer Res , vol.10 , pp. 6638-6649
    • Messerer, C.L.1    Ramsay, E.C.2    Waterhouse, D.3    Ng, R.4    Simms, E.M.5
  • 31
    • 58149343907 scopus 로고    scopus 로고
    • Irinophore C, a novel nanoformulation of irinotecan, alters tumor vascular function and enhances the distribution of 5-fluorouracil and doxorubicin
    • Baker JH, Lam J, Kyle AH, Sy J, Oliver T, et al. (2008) Irinophore C, a novel nanoformulation of irinotecan, alters tumor vascular function and enhances the distribution of 5-fluorouracil and doxorubicin. Clin Cancer Res 14: 7260-7271.
    • (2008) Clin Cancer Res , vol.14 , pp. 7260-7271
    • Baker, J.H.1    Lam, J.2    Kyle, A.H.3    Sy, J.4    Oliver, T.5
  • 32
    • 0027569924 scopus 로고
    • Dual-attribute continuous monitoring of cell proliferation/cytotoxicity
    • Fields RD, Lancaster MV, (1993) Dual-attribute continuous monitoring of cell proliferation/cytotoxicity. Am Biotechnol Lab 11: 48-50.
    • (1993) Am Biotechnol Lab , vol.11 , pp. 48-50
    • Fields, R.D.1    Lancaster, M.V.2
  • 33
    • 0027249667 scopus 로고
    • A new fluorometric assay for cytotoxicity measurements in vitro
    • Page B, Page M, Noel C, (1993) A new fluorometric assay for cytotoxicity measurements in vitro. Int J Oncol 3: 473-476.
    • (1993) Int J Oncol , vol.3 , pp. 473-476
    • Page, B.1    Page, M.2    Noel, C.3
  • 34
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
    • Chou TC, Talalay P, (1984) Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22: 27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 35
    • 33748794547 scopus 로고    scopus 로고
    • Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
    • Chou TC, (2006) Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58: 621-681.
    • (2006) Pharmacol Rev , vol.58 , pp. 621-681
    • Chou, T.C.1
  • 37
    • 0021909644 scopus 로고
    • Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential
    • Hope MJ, Bally MB, Webb G, Cullis PR, (1985) Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential. Biochim Biophys Acta 812: 55-65.
    • (1985) Biochim Biophys Acta , vol.812 , pp. 55-65
    • Hope, M.J.1    Bally, M.B.2    Webb, G.3    Cullis, P.R.4
  • 38
    • 0020143776 scopus 로고
    • Use of radiolabelled hexadecyl cholesterol ether as a liposome marker
    • Pool GL, French ME, Edwards RA, Huang L, Lumb RH, (1982) Use of radiolabelled hexadecyl cholesterol ether as a liposome marker. Lipids 17: 445-452.
    • (1982) Lipids , vol.17 , pp. 445-452
    • Pool, G.L.1    French, M.E.2    Edwards, R.A.3    Huang, L.4    Lumb, R.H.5
  • 39
    • 0031588364 scopus 로고    scopus 로고
    • Sequence-dependent activity of the irinotecan-5FU combination in human colon-cancer model HT-29 in vitro and in vivo
    • Guichard S, Cussac D, Hennebelle I, Bugat R, Canal P, (1997) Sequence-dependent activity of the irinotecan-5FU combination in human colon-cancer model HT-29 in vitro and in vivo. Int J Cancer 73: 729-734.
    • (1997) Int J Cancer , vol.73 , pp. 729-734
    • Guichard, S.1    Cussac, D.2    Hennebelle, I.3    Bugat, R.4    Canal, P.5
  • 40
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group
    • Saltz LB, Cox JV, Blanke C, Rosen LS, Fehrenbacher L, et al. (2000) Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med 343: 905-914.
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3    Rosen, L.S.4    Fehrenbacher, L.5
  • 41
    • 0035135378 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil/leucovorin for metastatic colorectal cancer: a new survival standard
    • Saltz LB, Douillard JY, Pirotta N, Alakl M, Gruia G, et al. (2001) Irinotecan plus fluorouracil/leucovorin for metastatic colorectal cancer: a new survival standard. Oncologist 6: 81-91.
    • (2001) Oncologist , vol.6 , pp. 81-91
    • Saltz, L.B.1    Douillard, J.Y.2    Pirotta, N.3    Alakl, M.4    Gruia, G.5
  • 42
    • 34548685592 scopus 로고    scopus 로고
    • Increased preclinical efficacy of irinotecan and floxuridine coencapsulated inside liposomes is associated with tumor delivery of synergistic drug ratios
    • Harasym TO, Tardi PG, Harasym NL, Harvie P, Johnstone SA, et al. (2007) Increased preclinical efficacy of irinotecan and floxuridine coencapsulated inside liposomes is associated with tumor delivery of synergistic drug ratios. Oncol Res 16: 361-374.
    • (2007) Oncol Res , vol.16 , pp. 361-374
    • Harasym, T.O.1    Tardi, P.G.2    Harasym, N.L.3    Harvie, P.4    Johnstone, S.A.5
  • 43
    • 79952988377 scopus 로고    scopus 로고
    • Development of a liposomal nanoparticle formulation of 5-fluorouracil for parenteral administration: formulation design, pharmacokinetics and efficacy
    • Thomas AM, Kapanen AI, Hare JI, Ramsay E, Edwards K, et al. (2011) Development of a liposomal nanoparticle formulation of 5-fluorouracil for parenteral administration: formulation design, pharmacokinetics and efficacy. J Control Release 150: 212-219.
    • (2011) J Control Release , vol.150 , pp. 212-219
    • Thomas, A.M.1    Kapanen, A.I.2    Hare, J.I.3    Ramsay, E.4    Edwards, K.5
  • 44
    • 17944376451 scopus 로고    scopus 로고
    • Irinotecan and 5-FU/leucovorin in metastatic colorectal cancer: balancing efficacy, toxicity, and logistics
    • Hwang JJ, (2004) Irinotecan and 5-FU/leucovorin in metastatic colorectal cancer: balancing efficacy, toxicity, and logistics. Oncology (Williston Park) 18: 26-34.
    • (2004) Oncology (Williston Park) , vol.18 , pp. 26-34
    • Hwang, J.J.1
  • 45
    • 0344109583 scopus 로고    scopus 로고
    • Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
    • Meta-analysis Group In Cancer
    • Meta-analysis Group In Cancer (1998) Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol 16: 301-308.
    • (1998) J Clin Oncol , vol.16 , pp. 301-308
  • 46
    • 0036675427 scopus 로고    scopus 로고
    • Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts
    • Liu C, Willingham M, Liu J, Gmeiner WH, (2002) Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts. Int J Oncol 21: 303-308.
    • (2002) Int J Oncol , vol.21 , pp. 303-308
    • Liu, C.1    Willingham, M.2    Liu, J.3    Gmeiner, W.H.4
  • 47
    • 0022370271 scopus 로고
    • Prospective randomized trial of intravenous v intraperitoneal 5-FU in patients with advanced primary colon or rectal cancer
    • Sugarbaker PH, Gianola FJ, Speyer JL, Wesley R, Barofsky I, et al. (1985) Prospective randomized trial of intravenous v intraperitoneal 5-FU in patients with advanced primary colon or rectal cancer. Semin Oncol 12: 101-111.
    • (1985) Semin Oncol , vol.12 , pp. 101-111
    • Sugarbaker, P.H.1    Gianola, F.J.2    Speyer, J.L.3    Wesley, R.4    Barofsky, I.5
  • 48
    • 0018885426 scopus 로고
    • Pharmacokinetics of 5-fluorouracil administered orally, by rapid intravenous and by slow infusion
    • Fraile RJ, Baker LH, Buroker TR, Horwitz J, Vaitkevicius VK, (1980) Pharmacokinetics of 5-fluorouracil administered orally, by rapid intravenous and by slow infusion. Cancer Res 40: 2223-2228.
    • (1980) Cancer Res , vol.40 , pp. 2223-2228
    • Fraile, R.J.1    Baker, L.H.2    Buroker, T.R.3    Horwitz, J.4    Vaitkevicius, V.K.5
  • 49
    • 84868705695 scopus 로고    scopus 로고
    • Delayed repeated intraperitoneal chemotherapy after cytoreductive surgery for colorectal and appendiceal carcinomatosis
    • Fajardo AD, Tan B, Reddy R, Fleshman J, (2012) Delayed repeated intraperitoneal chemotherapy after cytoreductive surgery for colorectal and appendiceal carcinomatosis. Dis Colon Rectum 55: 1044-1052.
    • (2012) Dis Colon Rectum , vol.55 , pp. 1044-1052
    • Fajardo, A.D.1    Tan, B.2    Reddy, R.3    Fleshman, J.4
  • 50
    • 84890431099 scopus 로고    scopus 로고
    • Bi-weekly intraperitoneal (IP) 5FU chemotherapy with systemic oxaliplatin-based therapy in patients with pseudomyxoma peritonei (PP) and peritoneal carcinomatosis (PC) from colorectal cancer (CRC)
    • Tan BR, Mutch M, Picus J, Dietz D, Birnbaum E, et al. (2005) Bi-weekly intraperitoneal (IP) 5FU chemotherapy with systemic oxaliplatin-based therapy in patients with pseudomyxoma peritonei (PP) and peritoneal carcinomatosis (PC) from colorectal cancer (CRC). American Society of Clinical Oncology Meetings: Abstract #272.
    • (2005) American Society of Clinical Oncology Meetings
    • Tan, B.R.1    Mutch, M.2    Picus, J.3    Dietz, D.4    Birnbaum, E.5
  • 51
    • 0034029147 scopus 로고    scopus 로고
    • Adjuvant intraperitoneal 5-fluorouracil in high-risk colon cancer: A multicenter phase III trial
    • Vaillant JC, Nordlinger B, Deuffic S, Arnaud JP, Pelissier E, et al. (2000) Adjuvant intraperitoneal 5-fluorouracil in high-risk colon cancer: A multicenter phase III trial. Ann Surg 231: 449-456.
    • (2000) Ann Surg , vol.231 , pp. 449-456
    • Vaillant, J.C.1    Nordlinger, B.2    Deuffic, S.3    Arnaud, J.P.4    Pelissier, E.5
  • 52
    • 0030883708 scopus 로고    scopus 로고
    • Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin
    • Leichman CG, Lenz HJ, Leichman L, Danenberg K, Baranda J, et al. (1997) Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. J Clin Oncol 15: 3223-3229.
    • (1997) J Clin Oncol , vol.15 , pp. 3223-3229
    • Leichman, C.G.1    Lenz, H.J.2    Leichman, L.3    Danenberg, K.4    Baranda, J.5
  • 53
    • 33645286475 scopus 로고    scopus 로고
    • Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines
    • Miyazaki K, Shibahara T, Sato D, Uchida K, Suzuki H, et al. (2006) Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines. J Gastroenterol 41: 140-150.
    • (2006) J Gastroenterol , vol.41 , pp. 140-150
    • Miyazaki, K.1    Shibahara, T.2    Sato, D.3    Uchida, K.4    Suzuki, H.5
  • 54
    • 0023187085 scopus 로고
    • Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile
    • Heggie GD, Sommadossi JP, Cross DS, Huster WJ, Diasio RB, (1987) Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res 47: 2203-2206.
    • (1987) Cancer Res , vol.47 , pp. 2203-2206
    • Heggie, G.D.1    Sommadossi, J.P.2    Cross, D.S.3    Huster, W.J.4    Diasio, R.B.5
  • 55
    • 0034901306 scopus 로고    scopus 로고
    • Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency
    • van Kuilenburg AB, Muller EW, Haasjes J, Meinsma R, Zoetekouw L, et al. (2001) Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency. Clin Cancer Res 7: 1149-1153.
    • (2001) Clin Cancer Res , vol.7 , pp. 1149-1153
    • van Kuilenburg, A.B.1    Muller, E.W.2    Haasjes, J.3    Meinsma, R.4    Zoetekouw, L.5
  • 56
    • 0031684654 scopus 로고    scopus 로고
    • Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity
    • Mullany S, Svingen PA, Kaufmann SH, Erlichman C, (1998) Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity. Cancer Chemother Pharmacol 42: 391-399.
    • (1998) Cancer Chemother Pharmacol , vol.42 , pp. 391-399
    • Mullany, S.1    Svingen, P.A.2    Kaufmann, S.H.3    Erlichman, C.4
  • 57
    • 0032032201 scopus 로고    scopus 로고
    • Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line
    • Guichard S, Hennebelle I, Bugat R, Canal P, (1998) Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line. Biochem Pharmacol 55: 667-676.
    • (1998) Biochem Pharmacol , vol.55 , pp. 667-676
    • Guichard, S.1    Hennebelle, I.2    Bugat, R.3    Canal, P.4
  • 58
    • 0008461578 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of irinotecan, fluorouracil, and leucovorin in patients with advanced solid tumors
    • Saltz LB, Kanowitz J, Kemeny NE, Schaaf L, Spriggs D, et al. (1996) Phase I clinical and pharmacokinetic study of irinotecan, fluorouracil, and leucovorin in patients with advanced solid tumors. J Clin Oncol 14: 2959-2967.
    • (1996) J Clin Oncol , vol.14 , pp. 2959-2967
    • Saltz, L.B.1    Kanowitz, J.2    Kemeny, N.E.3    Schaaf, L.4    Spriggs, D.5
  • 59
    • 0035424118 scopus 로고    scopus 로고
    • Sequence effect of irinotecan and fluorouracil treatment on pharmacokinetics and toxicity in chemotherapy-naive metastatic colorectal cancer patients
    • Falcone A, Di Paolo A, Masi G, Allegrini G, Danesi R, et al. (2001) Sequence effect of irinotecan and fluorouracil treatment on pharmacokinetics and toxicity in chemotherapy-naive metastatic colorectal cancer patients. J Clin Oncol 19: 3456-3462.
    • (2001) J Clin Oncol , vol.19 , pp. 3456-3462
    • Falcone, A.1    Di Paolo, A.2    Masi, G.3    Allegrini, G.4    Danesi, R.5
  • 60
    • 0029841505 scopus 로고    scopus 로고
    • Irinotecan. A review of its pharmacological properties and clinical efficacy in the management of advanced colorectal cancer
    • Wiseman LR, Markham A, (1996) Irinotecan. A review of its pharmacological properties and clinical efficacy in the management of advanced colorectal cancer. Drugs 52: 606-623.
    • (1996) Drugs , vol.52 , pp. 606-623
    • Wiseman, L.R.1    Markham, A.2
  • 61
    • 0018744377 scopus 로고
    • Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2′-deoxyuridine
    • Houghton JA, Houghton PJ, Wooten RS, (1979) Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2′-deoxyuridine. Cancer Res 39: 2406-2413.
    • (1979) Cancer Res , vol.39 , pp. 2406-2413
    • Houghton, J.A.1    Houghton, P.J.2    Wooten, R.S.3
  • 62
    • 0030931974 scopus 로고    scopus 로고
    • A comprehensive review of 5-fluorouracil and leucovorin in patients with metastatic colorectal carcinoma
    • Machover D, (1997) A comprehensive review of 5-fluorouracil and leucovorin in patients with metastatic colorectal carcinoma. Cancer 80: 1179-1187.
    • (1997) Cancer , vol.80 , pp. 1179-1187
    • Machover, D.1
  • 63
    • 10744223904 scopus 로고    scopus 로고
    • Therapeutic synergy between irinotecan and 5-fluorouracil against human tumor xenografts
    • Azrak RG, Cao S, Slocum HK, Toth K, Durrani FA, et al. (2004) Therapeutic synergy between irinotecan and 5-fluorouracil against human tumor xenografts. Clin Cancer Res 10: 1121-1129.
    • (2004) Clin Cancer Res , vol.10 , pp. 1121-1129
    • Azrak, R.G.1    Cao, S.2    Slocum, H.K.3    Toth, K.4    Durrani, F.A.5
  • 64
    • 0032738164 scopus 로고    scopus 로고
    • Sequence-dependent growth inhibition and DNA damage formation by the irinotecan-5-fluorouracil combination in human colon carcinoma cell lines
    • Mans DR, Grivicich I, Peters GJ, Schwartsmann G, (1999) Sequence-dependent growth inhibition and DNA damage formation by the irinotecan-5-fluorouracil combination in human colon carcinoma cell lines. Eur J Cancer 35: 1851-1861.
    • (1999) Eur J Cancer , vol.35 , pp. 1851-1861
    • Mans, D.R.1    Grivicich, I.2    Peters, G.J.3    Schwartsmann, G.4
  • 65
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy
    • Jain RK, (2001) Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 7: 987-989.
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 66
    • 33846250028 scopus 로고    scopus 로고
    • Schedule-dependent activity of 5-fluorouracil and irinotecan combination in the treatment of human colorectal cancer: in vitro evidence and a phase I dose-escalating clinical trial
    • Barone C, Landriscina M, Quirino M, Basso M, Pozzo C, et al. (2007) Schedule-dependent activity of 5-fluorouracil and irinotecan combination in the treatment of human colorectal cancer: in vitro evidence and a phase I dose-escalating clinical trial. Br J Cancer 96: 21-28.
    • (2007) Br J Cancer , vol.96 , pp. 21-28
    • Barone, C.1    Landriscina, M.2    Quirino, M.3    Basso, M.4    Pozzo, C.5
  • 67
    • 33748326024 scopus 로고    scopus 로고
    • Ratiometric dosing of anticancer drug combinations: controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice
    • Mayer LD, Harasym TO, Tardi PG, Harasym NL, Shew CR, et al. (2006) Ratiometric dosing of anticancer drug combinations: controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice. Mol Cancer Ther 5: 1854-1863.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1854-1863
    • Mayer, L.D.1    Harasym, T.O.2    Tardi, P.G.3    Harasym, N.L.4    Shew, C.R.5
  • 68
    • 34548759797 scopus 로고    scopus 로고
    • Optimizing combination chemotherapy by controlling drug ratios
    • Mayer LD, Janoff AS, (2007) Optimizing combination chemotherapy by controlling drug ratios. Mol Interv 7: 216-223.
    • (2007) Mol Interv , vol.7 , pp. 216-223
    • Mayer, L.D.1    Janoff, A.S.2
  • 69
    • 0035964584 scopus 로고    scopus 로고
    • Effects of the combination of camptothecin and doxorubicin or etoposide on rat glioma cells and camptothecin-resistant variants
    • Pavillard V, Kherfellah D, Richard S, Robert J, Montaudon D, (2001) Effects of the combination of camptothecin and doxorubicin or etoposide on rat glioma cells and camptothecin-resistant variants. Br J Cancer 85: 1077-1083.
    • (2001) Br J Cancer , vol.85 , pp. 1077-1083
    • Pavillard, V.1    Kherfellah, D.2    Richard, S.3    Robert, J.4    Montaudon, D.5
  • 70
    • 68849123638 scopus 로고    scopus 로고
    • Drug ratio-dependent antitumor activity of irinotecan and cisplatin combinations in vitro and in vivo
    • Tardi PG, Dos Santos N, Harasym TO, Johnstone SA, Zisman N, et al. (2009) Drug ratio-dependent antitumor activity of irinotecan and cisplatin combinations in vitro and in vivo. Mol Cancer Ther 8: 2266-2275.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2266-2275
    • Tardi, P.G.1    Dos Santos, N.2    Harasym, T.O.3    Johnstone, S.A.4    Zisman, N.5
  • 71
    • 55049108527 scopus 로고    scopus 로고
    • In vivo maintenance of synergistic cytarabine:daunorubicin ratios greatly enhances therapeutic efficacy
    • Tardi P, Johnstone S, Harasym N, Xie S, Harasym T, et al. (2009) In vivo maintenance of synergistic cytarabine:daunorubicin ratios greatly enhances therapeutic efficacy. Leuk Res 33: 129-139.
    • (2009) Leuk Res , vol.33 , pp. 129-139
    • Tardi, P.1    Johnstone, S.2    Harasym, N.3    Xie, S.4    Harasym, T.5
  • 72
    • 0024564697 scopus 로고
    • Overview of clinical trials using 5-fluorouracil and leucovorin for the treatment of colorectal cancer
    • Arbuck SG, (1989) Overview of clinical trials using 5-fluorouracil and leucovorin for the treatment of colorectal cancer. Cancer 63: 1036-1044.
    • (1989) Cancer , vol.63 , pp. 1036-1044
    • Arbuck, S.G.1
  • 73
    • 0026721532 scopus 로고
    • Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project
    • Advanced Colorectal Cancer Meta-Analysis Project
    • Advanced Colorectal Cancer Meta-Analysis Project (1992) Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project. J Clin Oncol 10: 896-903.
    • (1992) J Clin Oncol , vol.10 , pp. 896-903


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.