Sanguinarine induces apoptosis in human colorectal cancer HCT-116 cells through ROS-mediated Egr-1 activation and mitochondrial dysfunction

Toxicology Letters

Volumn 220, Issue 2, 2013, Pages 157-166

  Han, Min Ho ^a   Kim, Gi Young ^b   Yoo, Young Hyun ^c   Choi, Yung Hyun ^a  

^a Dong Eui University   (South Korea)

^b Jeju National University   (South Korea)

^c Dong A University College of Medicine   (South Korea)

Author keywords

Apoptosis; Egr 1; HCT 116; ROS; Sanguinarine

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; CASPASE 8; CASPASE 9; EARLY GROWTH RESPONSE FACTOR 1; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SANGUINARINE; SMALL INTERFERING RNA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HCT116; CELL VIABILITY; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

APOPTOSIS; BENZOPHENANTHRIDINES; CASPASES; COLORECTAL NEOPLASMS; EARLY GROWTH RESPONSE PROTEIN 1; HCT116 CELLS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; ISOQUINOLINES; MATRIX METALLOPROTEINASES; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84878985976     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.04.020     Document Type: Article

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