Dynorphin/KOP and nociceptin/NOP gene expression and epigenetic changes by cocaine in rat striatum and nucleus accumbens

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 49, Issue , 2014, Pages 36-46

  Caputi, Francesca Felicia ^a   Di Benedetto, Manuela ^a   Carretta, Donatella ^a   Bastias del Carmen Candia, Sussy ^a   D'Addario, Claudio ^a   Cavina, Chiara ^a   Candeletti, Sanzio ^a   Romualdi, Patrizia ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Cocaine; Epigenetic; Prodynorphin; Pronociceptin; Rat

Indexed keywords

COCAINE; DYNORPHIN; HISTONE H3; KAPPA OPIATE RECEPTOR; MESSENGER RNA; NOCICEPTIN; NOCICEPTIN RECEPTOR; ENKEPHALIN; HISTONE; OPIATE PEPTIDE; OPIATE RECEPTOR; PREPROENKEPHALIN; PROTEIN PRECURSOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; CONTROLLED STUDY; CORPUS STRIATUM; DOWN REGULATION; EPIGENETICS; GENE EXPRESSION; HISTONE METHYLATION; HISTONE MODIFICATION; MALE; NERVE CELL PLASTICITY; NONHUMAN; NUCLEUS ACCUMBENS; PROMOTER REGION; PUTAMEN; RAT; UPREGULATION; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM;

ANIMALS; COCAINE; CORPUS STRIATUM; DYNORPHINS; ENKEPHALINS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; HISTONES; MALE; NUCLEUS ACCUMBENS; OPIOID PEPTIDES; PROTEIN PRECURSORS; RATS; RECEPTORS, OPIOID; RECEPTORS, OPIOID, KAPPA;

EID: 84888802883     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2013.10.016     Document Type: Article

References (73)

1. Azaryan A.V., Coughlin L.J., Búzás B., Clock B.J., Cox B.M. Effect of chronic cocaine treatment on mu- and delta-opioid receptor mRNA levels in dopaminergically innervated brain regions. J Neurochem 1996, 66:443-448.
2. Azaryan A.V., Clock B.J., Rosenberger J.G., Cox B.M. Transient upregulation of mu opioid receptor mRNA levels in nucleus accumbens during chronic cocaine administration. Can J Physiol Pharmacol 1998, 76:278-283.
3. Bailey A., Gianotti R., Ho A., Kreek M.J. Persistent upregulation of mu-opioid, but not adenosine, receptors in brains of long-term withdrawn escalating dose "binge" cocaine-treated rats. Synapse 2005, 57:160-166.
4. Bailey A., Yuferov V., Bendor J., Schlussman S.D., Zhou Y., Ho A., et al. Immediate withdrawal from chronic "binge" cocaine administration increases mu-opioid receptor mRNA levels in rat frontal cortex. Brain Res 2005, 137:258-262.
5. Butelman E.R., Yuferov V., Kreek M.J. κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction. Trends Neurosci 2012, 35:587-596.
6. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem 1987, 162:156-159.
7. Ciccocioppo R., Angeletti S., Sanna P.P., Weiss F., Massi M. Effect of nociceptin/orphanin FQ on the rewarding properties of morphine. Eur J Pharmacol 2000, 404:153-159.
8. D'Addario C., Di Benedetto M., Izenwasser S., Candeletti S., Romualdi P. Role of serotonin in the regulation of the dynorphinergic system by a kappa-opioid agonist and cocaine treatment in rat CNS. Neuroscience 2007, 144:157-164.
9. D'Addario C., Johansson S., Candeletti S., Romualdi P., Ögren S.O., Terenius L., et al. Ethanol and acetaldehyde exposure induces specific epigenetic modifications in the prodynorphin gene promoter in a human neuroblastoma cell line. FASEB J 2011, 25:1069-1075.
10. D'Addario C., Caputi F.F., Ekström T.J., Di Benedetto M., Maccarrone M., Romualdi P., et al. Ethanol induces epigenetic modulation of prodynorphin and pronociceptin gene expression in the rat amygdala complex. J Mol Neurosci 2013, 49:312-319.
11. D'Addario C., Caputi F.F., Rimondini R., Gandolfi O., Del Borrello E., Candeletti S., et al. Different alcohol exposures induce selective alterations on the expression of dynorphin and nociceptin systems related genes in rat brain. Addict Biol 2013, 18:425-433.
12. Dahl J.A., Collas P. A quick and quantitative chromatin immunoprecipitation assay for small cell samples. Front Biosci 2007, 12:4925-4931.
13. Darvas M., Palmiter R.D. Restricting dopaminergic signaling to either dorsolateral or medial striatum facilitates cognition. J Neurosci 2010, 30:1158-1165.
14. Daunais J.B., McGinty J.F. Cocaine binges differentially alter striatal preprodynorphin and zif/268 mRNAs. Brain Res Mol Brain Res 1995, 29:201-210.
15. Daunais J.B., Roberts D.C., McGinty J.F. Short-term cocaine self administration alters striatal gene expression. Brain Res Bull 1995, 37:523-527.
16. Di Benedetto M., Bastías Candia Sdel C., D'Addario C., Porticella E.E., Cavina C., Candeletti S., Romualdi P. Regulation of opioid gene expression in the rat brainstem by 3,4-methylenedioxymethamphetamine (MDMA): role of serotonin and involvement of CREB and ERK cascade. Naunyn Schmiedebergs Arch Pharmacol 2011, 383:169-178.
17. Dow-Edwards D.L., Hurd Y.L. Perinatal cocaine decreased the expression of prodynorphin mRNA in nucleus accumbens shell in the adult rat. Mol Brain Res 1998, 62:82-85.
18. Fagergren P., Smith H.R., Daunais J.B., Nader M.A., Porrino L.J., Hurd Y.L. Temporal upregulation of prodynorphin mRNA in the primate striatum after cocaine self-administration. Eur J Neurosci 2003, 17:2212-2218.
19. Fuchs R.A., Branham R.K., See R.E. Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen. J Neurosci 2006, 26:3584-3588.
20. Graybiel A.M. Habits, rituals, and the evaluative brain. Annu Rev Neurosci 2008, 31:359-387.
21. Heidbreder C., Shoaib M., Shippenberg T.S. Differential role of delta-opioid receptors in the development and expression of behavioral sensitization to cocaine. Eur J Pharmacol 1996, 298:207-216.
22. Hurd Y.L., Herkenham M. Molecular alterations in the neostriatum of human cocaine addicts. Synapse 1993, 13:357-369.
23. Hurd Y.L., Brown E.E., Finlay J.M., Fibiger H.C., Gerfen C.R. Cocaine self-administration differentially alters mRNA expression of striatal peptides. Brain Res Mol Brain Res 1992, 13:165-170.
24. Izenwasser S., French D., Carroll F.I., Kunko P.M. Continuous infusion of selective dopamine uptake inhibitors or cocaine produces time-dependent changes in rat locomotor activity. Behav Brain Res 1999, 99:201-208.
25. King G.R., Joyner C., Lee T., Kuhn C., Ellinwood E.H. Intermittent and continuous cocaine administration: residual behavioral states during withdrawal. Pharmacol Biochem Behav 1992, 43:243-248.
26. Koob G.F. A role for brain stress systems in addiction. Neuron 2008, 59:11-34.
27. Kotlińska J., Wichmann J., Legowska A., Rolka K., Silberring J. Orphanin FQ/nociceptin but not Ro 65-6570 inhibits the expression of cocaine-induced conditioned place preference. Behav Pharmacol 2002, 13:229-235.
28. Kouzarides T. Chromatin modifications and their function. Cell 2007, 128:693-705.
29. Kreek M.J., LaForge K.S., Butelman E. Pharmacotherapy of addictions. Nat Rev Drug Discov 2002, 1:710-726.
30. Nat Rev Drug Discov 2002, 1:920. Erratum in:.
31. Kumar A., Choi K.H., Renthal W., Tsankova N.M., Theobald D.E., Truong H.T., et al. Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 2005, 48:303-314.
32. Kunko P.M., French D., Izenwasser S. Alterations in locomotor activity during chronic cocaine administration: effect on dopamine receptors and interaction with opioids. J Pharmacol Exp Ther 1998, 285:277-284.
33. Le Merrer J., Becker J.A., Befort K., Kieffer B.L. Reward processing by the opioid system in the brain. Physiol Rev 2009, 89:1379-1412.
34. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Methods 2001, 25:402-408.
35. Lutfy K., Do T., Maidment N.T. Orphanin FQ/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats. Psychopharmacology (Berl) 2001, 154:1-7.
36. Lyon E. Mutation detection using fluorescent hybridization probes and melting curve analysis. Expert Rev Mol Diagn 2001, 1:92-101.
37. Mathieu-Kia A.M., Besson M.J. Repeated administration of cocaine, nicotine and ethanol: effects on preprodynorphin, preprotachykinin A and preproenkephalin mRNA expression in the dorsal and the ventral striatum of the rat. Brain Res Mol Brain Res 1998, 54:141-151.
38. Maze I., Covington H.E., Dietz D.M., LaPlant Q., Renthal W., Russo S.J., et al. Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 2010, 327:213-216.
39. Murphy N.P., Lee Y., Maidment N.T. Orphanin FQ/nociceptin blocks acquisition of morphine place preference. Brain Res 1999, 832:168-170.
40. Nestler E.J. Molecular neurobiology of addiction. Am J Addict 2001, 10:201-217.
41. Olive M.F., Koenig H.N., Nannini M.A., Hodge C.W. Stimulation of endorphin neurotransmission in the nucleus accumbens by ethanol, cocaine, and amphetamine. J Neurosci 2001, 21:RC184.
42. Packard M.G., Knowlton B.J. Learning and memory functions of the basal ganglia. Annu Rev Neurosci 2002, 25:563-593.
43. Paxinos and Watson The rat brain in stereotaxic coordinates 1997, Academic Press, Sydney. Compact 3rd ed.
44. Perrine S.A., Sheikh S.I., Nwaneshiudu C.A., Schroeder J.A., Unterwald E.M. Withdrawal from chronic administration of cocaine decreases delta opioid receptor signaling and increases anxiety-and depression-like behaviors in the rat. Neuropharmacology 2008, 54:355-364.
45. Pettit H.O., Justice J.B. Dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis. Pharmacol Biochem Behav 1989, 34:899-904.
46. Post R.M., Rose H. Increasing effects of repetitive cocaine administration in the rat. Nature 1976, 260:731-732.
47. Reinscheid R.K., Higelin J., Henningsen R.A., Monsma F.J., Civelli O. Structures that delineate orphanin FQ and dynorphin A pharmacological selectivities. J Biol Chem 1998, 273:1490-1495.
48. Renthal W., Nestler E.J. Epigenetic mechanisms in drug addiction. Trends Mol Med 2008, 14:341-350.
49. Romualdi P., Donatini A., Izenwasser S., Cox B.M., Ferri S. Chronic intracerebroventricular cocaine differentially affects prodynorphin gene expression in rat hypothalamus and caudate-putamen. Brain Res Mol Brain Res 1996, 40:153-156.
50. Romualdi P., Donatini A., Capobianco A., Ferri S. Methamphetamine alters prodynorphin gene expression and dynorphin A levels in rat hypothalamus. Eur J Pharmacol 1999, 22:183-186.
51. Romualdi P., D'Addario C., Ferri S., Cox B.M., Izenwasser S. Chronic GBR 12909 administration differentially alters prodynorphin gene expression compared to cocaine. Eur J Pharmacol 2001, 413:207-212.
52. Romualdi P., Landuzzi D., D'Addario C., Candeletti S. Modulation of proorphaninFQ/N gene expression by morphine in the rat mesocorticolimbic system. Neuroreport 2002, 13:645-648.
53. Romualdi P., Di Benedetto M., D'Addario C., Collins S.L., Wade D., Candeletti S., et al. Chronic cocaine produces decreases in N/OFQ peptide levels in select rat brain regions. J Mol Neurosci 2007, 31:159-164.
54. Rozen S., Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000, 132:365-386.
55. Shippenberg T.S., Zapata A., Chefer V.I. Dynorphin and the pathophysiology of drug addiction. Pharmacol Ther 2007, 116:306-321.
56. Sims R.J., Nishiok K., Reinberg D. Histone lysine methylation: a signature for chromatin function. Trends Genet 2003, 19:629-639.
57. Spangler R., Ho A., Zhou Y., Maggos C.E., Yuferov V., Kreek M.J. Regulation of kappa opioid receptor mRNA in the rat brain by "binge" pattern cocaine administration and correlation with preprodynorphin mRNA. Brain Res Mol Brain Res 1996, 38:71-76.
58. Strahl B.D., Allis C.D. The language of covalent histone modifications. Nature 2000, 403:41-45.
59. Svensson P.S., Hurd Y.L. Specific reductions of sriatal prodynorphin and D1 dopamine receptor messenger RNAs during cocaine abstinence. Mol Brain Res 1998, 56:162-168.
60. Turchan J., Przewlocka B., Lason W., Przewlocki R. Effects of repeated psychostimulant administration on the prodynorphin system activity and kappa opioid receptor density in the rat brain. Neuroscience 1998, 85:1051-1059.
61. Turner B.M. Cellular memory and the histone code. Cell 2002, 111:285-291.
62. Ukai M., Mori E., Kameyama T. Cocaine-like discriminative stimulus properties of the delta-selective opioid receptor agonist, [d-Pen2, l-Pen5]enkephalin, in the rat. Eur J Pharmacol 1993, 231:143144.
63. Unterwald E.M., Horne-King J., Kreek M.J. Chronic cocaine alters brain mu opioid receptors. Brain Res 1992, 584:314-318.
64. Unterwald E.M., Rubenfeld J.M., Kreek M.J. Repeated cocaine administration upregulates kappa and mu, but not delta, opioid receptors. Neuroreport 1994, 5:1613-1616.
65. Voorn P., Vanderschuren L.J., Groenewegen H.J., Robbins T.W., Pennartz C.M. Putting a spin on the dorsal-ventral divide of the striatum. Trends Neurosci 2004, 27:468-474.
66. Wee S., Koob F.K. The role of the dynorphin-κ opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology (Berl) 2010, 210:121-135.
67. Weiss F., Paulus M.P., Lorang M.T., Koob G.F. Increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration. J Neurosci 1992, 12:4372-4380.
68. Werme M., Thorén P., Olson L., Brené S. Running and cocaine both upregulate dynorphin mRNA in medial caudate putamen. Eur J Neurosci 2000, 12:2967-2974.
69. Yoo J.H., Kitchen I., Bailey A. The endogenous opioid system in cocaine addiction. What lessons have opioid peptide and receptor knockout mice taught us?. Br J Pharmacol 2012, 166:1993-2014.
70. Zhang Y., Schlussman S.D., Rabkin J., Butelman E.R., Ho A., Kreek M.J. Chronic escalating cocaine exposure, abstinence/withdrawal, and chronic re-exposure: effects on striatal dopamine and opioid systems in C57BL/6J mice. Neuropharmacology 2012, 16(67C):259-266.
71. Zhao X.D., Han X., Chew J.L., Liu J., Chiu K.P., Choo A., et al. Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell 2007, 1:286-298.
72. Zhou Z., Yuan Q., Mash D.C., Goldman D. Substance-specific and shared transcription and epigenetic changes in the human hippocampus chronically exposed to cocaine and alcohol. Proc Natl Acad Sci U S A 2011, 108:6626-6631.
73. Zubieta J.K., Gorelick D.A., Stauffer R., Ravert H.T., Dannals R.F., Frost J.J. Increased mu opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine craving. Nat Med 1996, 2:1225-1229.