11C-Labeling of a potent hydroxyethylamine BACE-1 inhibitor and evaluation in vitro and in vivo

Nuclear Medicine and Biology

Volumn 41, Issue 6, 2014, Pages 536-543

  Nordeman, Patrik ^a   Estrada, Sergio ^a   Odell, Luke R ^a   Larhed, Mats ^a   Antoni, Gunnar ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Alzheimer's disease; BACE 1; PET; Position emission tomography; secretase

Indexed keywords

BETA SECRETASE 1; BROMINE; CARBON 11; ENZYME INHIBITOR; HALIDE; HYDROXYETHYLAMINE BETA SECRETASE 1 INHIBITOR; HYDROXYETHYLAMINE BETA SECRETASE 1 INHIBITOR C 11; LIGAND; METHYL 3 NITROBENZOATE; NITROBENZOIC ACID DERIVATIVE; PALLADIUM; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; TRACER; UNCLASSIFIED DRUG; CARBON; ETHYLAMINE; SECRETASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CARBONYLATION; COMPLEX FORMATION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DRUG BINDING; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG POTENCY; DRUG PURITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME BINDING; EX VIVO STUDY; FROZEN SECTION; IMAGING SYSTEM; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RADIOISOTOPE DECAY; RAT; SMALL INTESTINE; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CHEMISTRY; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC USE; RADIOGRAPHY; SCINTISCANNING; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; AUTORADIOGRAPHY; BRAIN; CARBON RADIOISOTOPES; ENZYME INHIBITORS; ETHYLAMINES; MALE; POSITRON-EMISSION TOMOGRAPHY; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84901202813     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2014.03.024     Document Type: Article

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