Reduced scytonemin isolated from Nostoc commune suppresses LPS/IFNγ-induced NO production in murine macrophage RAW264 cells by inducing hemeoxygenase-1 expression via the Nrf2/ARE pathway

Food and Chemical Toxicology

Volumn 69, Issue , 2014, Pages 330-338

  Itoh, Tomohiro ^a   Koketsu, Mamoru ^b   Yokota, Naoto ^a   Touho, Shota ^a   Ando, Masashi ^a   Tsukamasa, Yasuyuki ^a  

^a KINKI UNIVERSITY   (Japan)

^b GIFU UNIVERSITY   (Japan)

Author keywords

Heme oxygenase 1; Intracellular ROS; Nitric oxide; Nrf2 ARE signaling; Reduced scytonemin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTIINFLAMMATORY AGENT; GAMMA INTERFERON; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MICROBIAL PRODUCTS NOT CLASSIFIED ELSEWHERE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; REACTIVE OXYGEN METABOLITE; REDUCED SCYTONEMIN; SCYTONEMIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; CYTOSKELETON PROTEIN; INDOLE DERIVATIVE; KEAP1 PROTEIN, MOUSE; NFE2L2 PROTEIN, MOUSE; PHENOL DERIVATIVE; PROTEIN KINASE B; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVITY; MACROPHAGE; MOUSE; NONHUMAN; NOSTOC COMMUNE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIOXIDANT RESPONSE ELEMENTS; CELL LINE; CYTOSKELETAL PROTEINS; HEME OXYGENASE-1; INDOLES; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-E2-RELATED FACTOR 2; NITRIC OXIDE; NOSTOC COMMUNE; PHENOLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84901192359     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.04.019     Document Type: Article

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