Andrographis paniculata extracts and major constituent diterpenoids inhibit growth of intrahepatic cholangiocarcinoma cells by inducing cell cycle arrest and apoptosis

Planta Medica

Volumn 80, Issue 7, 2014, Pages 533-543

  Suriyo, Tawit ^a   Pholphana, Nanthanit ^a   Rangkadilok, Nuchanart ^a,b   Thiantanawat, Apinya ^a,b   Watcharasit, Piyajit ^a,b   Satayavivad, Jutamaad ^a,b,c  

^a Chulabhorn Research Institute   (Thailand)

^b Toxicology and Management of Chemicals   (Thailand)

^c THAILAND CENTER OF EXCELLENCE IN PHYSICS   (Thailand)

Author keywords

Acanthaceae; Andrographis paniculata; andrographolide; apoptosis; bile duct cancer; cell cycle arrest; cholangiocarcinoma

Indexed keywords

11,12 DIDEHYDRO 14 DEOXYANDROGRAPHOLIDE; 14 DEOXYANDROGRAPHOLIDE; ALCOHOL; ANDROGRAPHIS PANICULATA EXTRACT; ANDROGRAPHOLIDE; CASPASE 3; CYCLIN D1; DITERPENOID; ETOPOSIDE; GEMCITABINE; NEOANDROGRAPHOLIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; DITERPENE; PLANT EXTRACT;

APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; CANCER CELL LINE; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SENSITIVITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; PLANT GROWTH; PLANT LEAF; PROTEIN CLEAVAGE; ANDROGRAPHIS; BILE DUCT NEOPLASMS; CELL CYCLE CHECKPOINT; CELL SURVIVAL; CHEMISTRY; CHOLANGIOCARCINOMA; DRUG EFFECTS; IC50; INTRAHEPATIC BILE DUCT; ISOLATION AND PURIFICATION; MEDICINAL PLANT; PHYTOTHERAPY; TUMOR CELL LINE;

ACANTHACEAE; ANDROGRAPHIS PANICULATA;

ANDROGRAPHIS; APOPTOSIS; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL SURVIVAL; CHOLANGIOCARCINOMA; DITERPENES; HUMANS; INHIBITORY CONCENTRATION 50; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL;

EID: 84901188303     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0034-1368399     Document Type: Article

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