Andrographolide inhibits the activation of NF-κB and MMP-9 activity in H3255 lung cancer cells

Experimental and Therapeutic Medicine

Volumn 6, Issue 3, 2013, Pages 743-746

  Luo, Weimin ^a   Liu, Yuefeng ^a   Zhang, Jun ^a   Luo, Xiangyu ^a   Lin, Chenyi ^a   Guo, Jialong ^a  

^a HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

Andrographolide; Lung cancer cells; MMP 9; NF B

Indexed keywords

ANDROGRAPHOLIDE; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SYNAPTOTAGMIN I;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LUNG CANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ZYMOGRAPHY;

EID: 84880493973     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.1196     Document Type: Article

References (12)

1. Han L, Zhang HW, Zhou WP, Chen GM and Guo KJ: The effects of genistein on transforming growth factor-β1-induced invasion and metastasis in human pancreatic cancer cell line Panc-1 in vitro. Chin Med J (Engl) 125: 2032-2040, 2012.
2. Liu N, Sun Q, Chen J, et al: MicroRNA-9 suppresses uveal melanoma cell migration and invasion through the NF-κB1 pathway. Oncol Rep 28: 961-968, 2012.
3. Rodriguez Faba O, PalouRedorta J, Fernández-Gómez JM, Algaba F, Eiró N, Villavicencio H and Vizoso FJ: Matrix metal-loproteinases and bladder cancer: what is new? ISRN Urol 2012: 581539, 2012.
4. Lee WR, Chung CL, Hsiao CJ, et al: Suppression of matrix metalloproteinase-9 expression by andrographolide in human monocytic THP-1 cells via inhibition of NF-κB activation. Phytomedicine 19: 270-277, 2012.
5. Zhou J, Hu SE, Tan SH, et al: Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autopha-gosome-lysosome fusion in human cancer cells. Autophagy 8: 338-349, 2012.
6. Zheng Y, Liu X and Guo SW: Therapeutic potential of androgra-pholide for treating endometriosis. Hum Reprod 27: 1300-1313, 2012.
7. Lu WJ, Lin KH, Hsu MJ, Chou DS, Hsiao G and Sheu JR: Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade. Biochem Pharmacol 84: 914-924, 2012.
8. Lee YC, Lin HH, Hsu CH, Wang CJ, Chiang TA and Chen JH: Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway. Eur J Pharmacol 632: 23-32, 2010.
9. Kang H, Lee M, Choi KC, Shin DM, Ko J and Jang SW: N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell invasion through suppressing NF-κB activation and inhibiting matrix metalloproteinase-9 expression. J Cell Biochem 113: 2845-2855, 2012.
10. Yu HY, Kim KS, Moon HI, Kim KM, Lee YC and Lee JH: JNP3, a new compound, suppresses PMA-induced tumor cell invasion via NF-κB down regulation in MCF-7 breast cancer cells. Biochem Biophys Res Commun 421: 190-196, 2012.
11. Mittelstadt ML and Patel RC: AP-1 mediated transcriptional repression of matrix metalloproteinase-9 by recruitment of histone deacetylase 1 in response to interferon β. PLoS One 7: e42152, 2012.
12. Ji X, Wang Z, Geamanu A, Sarkar FH and Gupta SV: Inhibition of cell growth and induction of apoptosis in non-small cell lung cancer cells by delta-tocotrienol is associated with notch-1 down-regulation. J Cell Biochem 112: 2773-2783, 2011.