The role of intracellular linkers in gating and desensitization of human pentameric ligand-gated ion channels

Journal of Neuroscience

Volumn 34, Issue 21, 2014, Pages 7238-7252

  Papke, David ^a   Grosman, Claudio ^a,b  

^a Department of Molecular and Integrative Physiology ^*

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Fast perfusion; Glycine receptors; Ion channel kinetics; Nicotinic receptors; Outside out patches; Patch clamp

Indexed keywords

CHOLINERGIC RECEPTOR; GLYCINE RECEPTOR; HEPTAPEPTIDE; LIGAND GATED ION CHANNEL; M1 M2 LINKER; M3 M4 LINKER; UNCLASSIFIED DRUG;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DESENSITIZATION; ELECTROPHYSIOLOGY; GENE MUTATION; HUMAN; HUMAN CELL; MUTAGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STIMULATION; SYNAPTIC TRANSMISSION;

FAST PERFUSION; GLYCINE RECEPTORS; ION-CHANNEL KINETICS; NICOTINIC RECEPTORS; OUTSIDE-OUT PATCHES; PATCH-CLAMP;

ACETYLCHOLINE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCINE; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ION CHANNEL GATING; LIGAND-GATED ION CHANNELS; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PATCH-CLAMP TECHNIQUES; POTASSIUM CHLORIDE; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, GLYCINE; RECEPTORS, NICOTINIC; TIME FACTORS;

EID: 84901045098     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5105-13.2014     Document Type: Article

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